This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Charlang, G Articles by Horowitz, R M Search for Related Content PubMed PubMed Citation Articles by Charlang, G Articles by Horowitz, R M

Cellular and extracellular siderophores of Aspergillus nidulans and Penicillium chrysogenum.

Division of Biology, California Institute of Technology, Pasadena 91125.

ABSTRACT

Aspergillus nidulans and Penicillium chrysogenum produce specific cellular siderophores in addition to the well-known siderophores of the culture medium. Since this was found previously in Neurospora crassa, it is probably generally true for filamentous ascomycetes. The cellular siderophore of A. nidulans is ferricrocin; that of P. chrysogenum is ferrichrome. A. nidulans also contains triacetylfusigen, a siderophore without apparent biological activity. Conidia of both species lose siderophores at high salt concentrations and become siderophore dependent. This has also been found in N. crassa, where lowering of the water activity has been shown to be the causal factor. We used an assay procedure based on this dependency to reexamine the extracellular siderophores of these species. During rapid mycelial growth, both A. nidulans and P. chrysogenum produced two highly active, unidentified siderophores which were later replaced by a less active or inactive product--coprogen in the case of P. chrysogenum and triacetylfusigen in the case of A. nidulans. N. crassa secreted coprogen only. Fungal siderophore metabolism is varied and complex.

This article has been cited by other articles:

• Oide, S., Krasnoff, S. B., Gibson, D. M., Turgeon, B. G. (2007). Intracellular Siderophores Are Essential for Ascomycete Sexual Development in Heterothallic Cochliobolus heterostrophus and Homothallic Gibberella zeae. Eukaryot Cell 6: 1339-1353 [Abstract] [Full Text]  
• Eisendle, M., Schrettl, M., Kragl, C., Muller, D., Illmer, P., Haas, H. (2006). The Intracellular Siderophore Ferricrocin Is Involved in Iron Storage, Oxidative-Stress Resistance, Germination, and Sexual Development in Aspergillus nidulans.. Eukaryot Cell 5: 1596-1603 [Abstract] [Full Text]  
• Sipiczki, M. (2006). Metschnikowia Strains Isolated from Botrytized Grapes Antagonize Fungal and Bacterial Growth by Iron Depletion. Appl. Environ. Microbiol. 72: 6716-6724 [Abstract] [Full Text]  
• Oide, S., Moeder, W., Krasnoff, S., Gibson, D., Haas, H., Yoshioka, K., Turgeon, B. G. (2006). NPS6, Encoding a Nonribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, Is a Conserved Virulence Determinant of Plant Pathogenic Ascomycetes. Plant Cell 18: 2836-2853 [Abstract] [Full Text]  
• Fluckinger, M., Haas, H., Merschak, P., Glasgow, B. J., Redl, B. (2004). Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores. Antimicrob. Agents Chemother. 48: 3367-3372 [Abstract] [Full Text]  
• Renshaw, J. C., Halliday, V., Robson, G. D., Trinci, A. P. J., Wiebe, M. G., Livens, F. R., Collison, D., Taylor, R. J. (2003). Development and Application of an Assay for Uranyl Complexation by Fungal Metabolites, Including Siderophores. Appl. Environ. Microbiol. 69: 3600-3606 [Abstract] [Full Text]  
• Moore, R. E., Kim, Y., Philpott, C. C. (2003). The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 100: 5664-5669 [Abstract] [Full Text]  
• Howard, D. H. (1999). Acquisition, Transport, and Storage of Iron by Pathogenic Fungi. Clin. Microbiol. Rev. 12: 394-404 [Abstract] [Full Text]