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Mol Cell Biol. 1990 October; 10(10): 5536-5540
Induction of the proto-oncogene c-jun by angiotensin II.
A J Naftilan,
G K Gilliland,
C S Eldridge and
A S Kraft
Hypertension Program, University of Alabama, Birmingham 35294.
ABSTRACT
Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.
Mol Cell Biol. 1990 October; 10(10): 5536-5540
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