This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diller, L
Right arrow Articles by Vogelstein, B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diller, L
Right arrow Articles by Vogelstein, B

 Previous Article  |  Next Article 

Mol Cell Biol. 1990 November; 10(11): 5772-5781

p53 functions as a cell cycle control protein in osteosarcomas.

L Diller, J Kassel, C E Nelson, M A Gryka, G Litwak, M Gebhardt, B Bressac, M Ozturk, S J Baker and B Vogelstein

Massachusetts General Hospital Cancer Center, Charlestown 02129.

ABSTRACT

Mutations in the p53 gene have been associated with a wide range of human tumors, including osteosarcomas. Although it has been shown that wild-type p53 can block the ability of E1a and ras to cotransform primary rodent cells, it is poorly understood why inactivation of the p53 gene is important for tumor formation. We show that overexpression of the gene encoding wild-type p53 blocks the growth of osteosarcoma cells. The growth arrest was determined to be due to an inability of the transfected cells to progress into S phase. This suggests that the role of the p53 gene as an antioncogene may be in controlling the cell cycle in a fashion analogous to the check-point control genes in Saccharomyces cerevisiae.

Mol Cell Biol. 1990 November; 10(11): 5772-5781




This article has been cited by other articles:

  • Knopp, S, Trope, C, Nesland, J M, Holm, R (2009). A review of molecular pathological markers in vulvar carcinoma: lack of application in clinical practice. J. Clin. Pathol. 62: 212-218 [Abstract] [Full Text]  
  • Sehat, B., Andersson, S., Girnita, L., Larsson, O. (2008). Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis. Cancer Res. 68: 5669-5677 [Abstract] [Full Text]  
  • Oh, J., Sohn, D. H., Ko, M., Chung, H., Jeon, S. H., Seong, R. H. (2008). BAF60a Interacts with p53 to Recruit the SWI/SNF Complex. J. Biol. Chem. 283: 11924-11934 [Abstract] [Full Text]  
  • Cuddihy, A. R., Jalali, F., Coackley, C., Bristow, R. G. (2008). WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells. Molecular Cancer Therapeutics 7: 980-992 [Abstract] [Full Text]  
  • Iizuka, M., Sarmento, O. F., Sekiya, T., Scrable, H., Allis, C. D., Smith, M. M. (2008). Hbo1 Links p53-Dependent Stress Signaling to DNA Replication Licensing. Mol. Cell. Biol. 28: 140-153 [Abstract] [Full Text]  
  • Ichikawa, T, Horie-Inoue, K, Ikeda, K, Blumberg, B, Inoue, S (2007). Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J Mol Endocrinol 39: 239-247 [Abstract] [Full Text]  
  • Faraonio, R., Vergara, P., Di Marzo, D., Pierantoni, M. G., Napolitano, M., Russo, T., Cimino, F. (2006). p53 Suppresses the Nrf2-dependent Transcription of Antioxidant Response Genes. J. Biol. Chem. 281: 39776-39784 [Abstract] [Full Text]  
  • Rizos, H., McKenzie, H. A., Ayub, A. L., Woodruff, S., Becker, T. M., Scurr, L. L., Stahl, J., Kefford, R. F. (2006). Physical and Functional Interaction of the p14ARF Tumor Suppressor with Ribosomes. J. Biol. Chem. 281: 38080-38088 [Abstract] [Full Text]  
  • Ricciardiello, L., Ceccarelli, C., Angiolini, G., Pariali, M., Chieco, P., Paterini, P., Biasco, G., Martinelli, G. N., Roda, E., Bazzoli, F. (2005). High Thymidylate Synthase Expression in Colorectal Cancer with Microsatellite Instability: Implications for Chemotherapeutic Strategies. Clin. Cancer Res. 11: 4234-4240 [Abstract] [Full Text]  
  • Marina, N., Gebhardt, M., Teot, L., Gorlick, R. (2004). Biology and Therapeutic Advances for Pediatric Osteosarcoma. The Oncologist 9: 422-441 [Abstract] [Full Text]  
  • Kooistra, K., Zhang, Y.-H., Henriquez, N. V., Weiss, B., Mumberg, D., Noteborn, M. H. M. (2004). TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells. J. Gen. Virol. 85: 1445-1450 [Abstract] [Full Text]  
  • Horner, S. M., DeFilippis, R. A., Manuelidis, L., DiMaio, D. (2004). Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells. J. Virol. 78: 4063-4073 [Abstract] [Full Text]  
  • Nichols, K. E., Heath, J. A., Friedman, D., Biegel, J. A., Ganguly, A., Mauch, P., Diller, L. (2003). TP53, BRCA1, and BRCA2 Tumor Suppressor Genes Are Not Commonly Mutated in Survivors of Hodgkin's Disease With Second Primary Neoplasms. JCO 21: 4505-4509 [Abstract] [Full Text]  
  • Sell, S. (2003). Mouse Models to Study the Interaction of Risk Factors for Human Liver Cancer. Cancer Res. 63: 7553-7562 [Abstract] [Full Text]  
  • Shan, B., Xu, J., Zhuo, Y., Morris, C. A., Morris, G. F. (2003). Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation. J. Biol. Chem. 278: 44009-44017 [Abstract] [Full Text]  
  • Cook, J. L., Miura, T. A., Ikle, D. N., Lewis, A. M. Jr., Routes, J. M. (2003). E1A Oncogene-induced Sensitization of Human Tumor Cells to Innate Immune Defenses and Chemotherapy-induced Apoptosis in Vitro and in Vivo. Cancer Res. 63: 3435-3443 [Abstract] [Full Text]  
  • Ookawa, K., Kudo, T., Aizawa, S., Saito, H., Tsuchida, S. (2002). Transcriptional Activation of the MUC2 Gene by p53. J. Biol. Chem. 277: 48270-48275 [Abstract] [Full Text]  
  • Ansah, C., Gooderham, N. J. (2002). The Popular Herbal Antimalarial, Extract of Cryptolepis sanguinolenta, Is Potently Cytotoxic. Toxicol Sci 70: 245-251 [Abstract] [Full Text]  
  • Zaika, A. I., Slade, N., Erster, S. H., Sansome, C., Joseph, T. W., Pearl, M., Chalas, E., Moll, U. M. (2002). {Delta}Np73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors. JEM 196: 765-780 [Abstract] [Full Text]  
  • Ren, J., Datta, R., Shioya, H., Li, Y., Oki, E., Biedermann, V., Bharti, A., Kufe, D. (2002). p73beta Is Regulated by Protein Kinase Cdelta Catalytic Fragment Generated in the Apoptotic Response to DNA Damage. J. Biol. Chem. 277: 33758-33765 [Abstract] [Full Text]  
  • Haq, R., Brenton, J. D., Takahashi, M., Finan, D., Rottapel, R., Zanke, B. (2002). Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence. Cancer Res. 62: 5076-5082 [Abstract] [Full Text]  
  • Beachy, T. M., Cole, S. L., Cavender, J. F., Tevethia, M. J. (2002). Regions and Activities of Simian Virus 40 T Antigen That Cooperate with an Activated ras Oncogene in Transforming Primary Rat Embryo Fibroblasts. J. Virol. 76: 3145-3157 [Abstract] [Full Text]  
  • Wang, H., Nan, L., Yu, D., Agrawal, S., Zhang, R. (2001). Antisense Anti-MDM2 Oligonucleotides As a Novel Therapeutic Approach to Human Breast Cancer: In Vitro and in Vivo Activities and Mechanisms. Clin. Cancer Res. 7: 3613-3624 [Abstract] [Full Text]  
  • Galbiati, F., Volonte', D., Liu, J., Capozza, F., Frank, P. G., Zhu, L., Pestell, R. G., Lisanti, M. P. (2001). Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism. Mol. Biol. Cell 12: 2229-2244 [Abstract] [Full Text]  
  • Tweddle, D. A., Malcolm, A. J., Cole, M., Pearson, A. D.J., Lunec, J. (2001). p53 Cellular Localization and Function in Neuroblastoma : Evidence for Defective G1 Arrest Despite WAF1 Induction in MYCN-Amplified Cells. Am. J. Pathol. 158: 2067-2077 [Abstract] [Full Text]  
  • Lebrun, A., Lavery, R., Weinstein, H. (2001). Modeling multi-component protein-DNA complexes: the role of bending and dimerization in the complex of p53 dimers with DNA. Protein Eng Des Sel 14: 233-243 [Abstract] [Full Text]  
  • Trahair, T. N., Alexander, I. E., Rowe, P. B., Smythe, J. A. (2000). The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors. J. Gen. Virol. 81: 2983-2991 [Abstract] [Full Text]  
  • Mannhardt, B., Weinzimer, S. A., Wagner, M., Fiedler, M., Cohen, P., Jansen-Dürr, P., Zwerschke, W. (2000). Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3. Mol. Cell. Biol. 20: 6483-6495 [Abstract] [Full Text]  
  • Honoki, K., Tsujiuchi, T., Tsutsumi, M., Kido, A., Morishita, T., Yoshimoto, M., Miyauchi, Y., Mii, Y., Tamai, S., Konishi, Y. (2000). Possible Involvement of bcl-2 Suppression in Wild-Type p53 Gene-Dependent Cell Growth Repression in Rat Osteosarcoma Cells. Toxicol Pathol 28: 575-579 [Abstract]  
  • Francis, D. A., Schmid, S. I., Howley, P. M. (2000). Repression of the Integrated Papillomavirus E6/E7 Promoter Is Required for Growth Suppression of Cervical Cancer Cells. J. Virol. 74: 2679-2686 [Abstract] [Full Text]  
  • Wölk, B., Sansonno, D., Kräusslich, H.-G., Dammacco, F., Rice, C. M., Blum, H. E., Moradpour, D. (2000). Subcellular Localization, Stability, and trans-Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines. J. Virol. 74: 2293-2304 [Abstract] [Full Text]  
  • Danila, D. C., Zhang, X., Zhou, Y., Dickersin, G. R., Fletcher, J. A., Hedley-Whyte, E. T., Selig, M. K., Johnson, S. R., Klibanski, A. (2000). A Human Pituitary Tumor-Derived Folliculostellate Cell Line. J. Clin. Endocrinol. Metab. 85: 1180-1187 [Abstract] [Full Text]  
  • Perry, M. E., Mendrysa, S. M., Saucedo, L. J., Tannous, P., Holubar, M. (2000). p76MDM2 Inhibits the Ability of p90MDM2 to Destabilize p53. J. Biol. Chem. 275: 5733-5738 [Abstract] [Full Text]  
  • KASTAN, M.B., LIM, D.-S., KIM, S.-T., XU, B., CANMAN, C. (2000). Multiple Signaling Pathways Involving ATM. Cold Spring Harb Symp Quant Biol 65: 521-526 [Abstract]  
  • Tam, A. S., Foley, J. F., Devereux, T. R., Maronpot, R. R., Massey, T. E. (1999). High Frequency and Heterogeneous Distribution of p53 Mutations in Aflatoxin B1-induced Mouse Lung Tumors. Cancer Res. 59: 3634-3640 [Abstract] [Full Text]  
  • Chang, B.-D., Broude, E. V., Dokmanovic, M., Zhu, H., Ruth, A., Xuan, Y., Kandel, E. S., Lausch, E., Christov, K., Roninson, I. B. (1999). A Senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents. Cancer Res. 59: 3761-3767 [Abstract] [Full Text]  
  • Harada, J. N., Berk, A. J. (1999). p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication. J. Virol. 73: 5333-5344 [Abstract] [Full Text]  
  • Clayman, G. L., Frank, D. K., Bruso, P. A., Goepfert, H. (1999). Adenovirus-mediated Wild-Type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers. Clin. Cancer Res. 5: 1715-1722 [Abstract] [Full Text]  
  • Shinobu, N., Maeda, T., Aso, T., Ito, T., Kondo, T., Koike, K., Hatakeyama, M. (1999). Physical Interaction and Functional Antagonism between the RNA Polymerase II Elongation Factor ELL and p53. J. Biol. Chem. 274: 17003-17010 [Abstract] [Full Text]  
  • Kachnic, L. A., Wu, B., Wunsch, H., Mekeel, K. L., DeFrank, J. S., Tang, W., Powell, S. N. (1999). The Ability of p53 to Activate Downstream Genes p21WAF1/cip1 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase. J. Biol. Chem. 274: 13111-13117 [Abstract] [Full Text]  
  • Subbaramaiah, K., Altorki, N., Chung, W. J., Mestre, J. R., Sampat, A., Dannenberg, A. J. (1999). Inhibition of Cyclooxygenase-2 Gene Expression by p53. J. Biol. Chem. 274: 10911-10915 [Abstract] [Full Text]  
  • McConnell, B. B., Gregory, F. J., Stott, F. J., Hara, E., Peters, G. (1999). Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes. Mol. Cell. Biol. 19: 1981-1989 [Abstract] [Full Text]  
  • Freedman, D. A. (1999). Regulation of the p53 Protein by the MDM2 Oncoprotein--Thirty-eighth G. H. A. Clowes Memorial Award Lecture. Cancer Res. 59: 1-7 [Full Text]  
  • Goodrum, F. D., Ornelles, D. A. (1998). p53 Status Does Not Determine Outcome of E1B 55-Kilodalton Mutant Adenovirus Lytic Infection. J. Virol. 72: 9479-9490 [Abstract] [Full Text]  
  • Marin, M. C., Jost, C. A., Irwin, M. S., DeCaprio, J. A., Caput, D., Kaelin, W. G. Jr. (1998). Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73. Mol. Cell. Biol. 18: 6316-6324 [Abstract] [Full Text]  
  • Tang, H.-y., Zhao, K., Pizzolato, J. F., Fonarev, M., Langer, J. C., Manfredi, J. J. (1998). Constitutive Expression of the Cyclin-dependent Kinase Inhibitor p21 Is Transcriptionally Regulated by the Tumor Suppressor Protein p53. J. Biol. Chem. 273: 29156-29163 [Abstract] [Full Text]  
  • Iwabuchi, K., Li, B., Massa, H. F., Trask, B. J., Date, T., Fields, S. (1998). Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2. J. Biol. Chem. 273: 26061-26068 [Abstract] [Full Text]  
  • Pise-Masison, C. A., Radonovich, M., Sakaguchi, K., Appella, E., Brady, J. N. (1998). Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells. J. Virol. 72: 6348-6355 [Abstract] [Full Text]  
  • Zhou, G., Kuo, M. T. (1998). Wild-type p53-mediated Induction of Rat mdr1b Expression by the Anticancer Drug Daunorubicin. J. Biol. Chem. 273: 15387-15394 [Abstract] [Full Text]  
  • Tentori, L., Lacal, P. M., Benincasa, E., Franco, D., Faraoni, I., Bonmassar, E., Graziani, G. (1998). Role of Wild-Type p53 on the Antineoplastic Activity of Temozolomide Alone or Combined with Inhibitors of Poly(ADP-Ribose) Polymerase. J. Pharmacol. Exp. Ther. 285: 884-893 [Abstract] [Full Text]  
  • Chen, L., Marechal, V., Moreau, J., Levine, A. J., Chen, J. (1997). Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis. J. Biol. Chem. 272: 22966-22973 [Abstract] [Full Text]  
  • Kupfer, G. M., Yamashita, T., Naf, D., Suliman, A., Asano, S., D'Andrea, A. D. (1997). The Fanconi Anemia Polypeptide, FAC, Binds to the Cyclin-Dependent Kinase, cdc2. Blood 90: 1047-1054 [Abstract] [Full Text]  
  • Hwang, J.-K., Lin, C.-T. (1997). Co-localization of Endogenous and Exogenous p53 Proteins in Nasopharyngeal Carcinoma Cells. J. Histochem. Cytochem. 45: 991-1004 [Abstract] [Full Text]  
  • Lee, H., Larner, J. M., Hamlin, J. L. (1997). A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA 94: 526-531 [Abstract] [Full Text]  
  • Walker, K. K., Levine, A. J. (1996). Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc. Natl. Acad. Sci. USA 93: 15335-15340 [Abstract] [Full Text]  
  • Jones, S. N., Sands, A. T., Hancock, A. R., Vogel, H., Donehower, L. A., Linke, S. P., Wahl, G. M., Bradley, A. (1996). The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc. Natl. Acad. Sci. USA 93: 14106-14111 [Abstract] [Full Text]  
  • Li, X., Coffino, P. (1996). Identification of a Region of p53 That Confers Lability. J. Biol. Chem. 271: 4447-4451 [Abstract] [Full Text]  
  • Ferreira, A, Kosik, K. (1996). Accelerated neuronal differentiation induced by p53 suppression. J. Cell Sci. 109: 1509-1516 [Abstract]  
  • Maheswaran, S, Englert, C, Bennett, P, Heinrich, G, Haber, D A (1995). The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.. Genes Dev. 9: 2143-2156 [Abstract]  
  • Sabbatini, P, Lin, J, Levine, A J, White, E (1995). Essential role for p53-mediated transcription in E1A-induced apoptosis.. Genes Dev. 9: 2184-2192 [Abstract]  
  • Akashi, M., Hachiya, M., Osawa, Y., Spirin, K., Suzuki, G., Koeffler, H. P. (1995). Irradiation Induces WAF1 Expression through a p53-independent Pathway in KG-1 Cells. J. Biol. Chem. 270: 19181-19187 [Abstract] [Full Text]  
  • Ewen, M E, Oliver, C J, Sluss, H K, Miller, S J, Peeper, D S (1995). p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.. Genes Dev. 9: 204-217 [Abstract]  
  • Mahdi, T, Brizard, A, Millet, C, Dore, P, Tanzer, J, Kitzis, A (1995). In vitro p53 and/or Rb antisense oligonucleotide treatment in association with growth factors induces the proliferation of peripheral hematopoietic progenitors. J. Cell Sci. 108: 1287-1293 [Abstract]  
  • Wagner, A J, Kokontis, J M, Hay, N (1994). Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.. Genes Dev. 8: 2817-2830 [Abstract]  
  • Barak, Y, Gottlieb, E, Juven-Gershon, T, Oren, M (1994). Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.. Genes Dev. 8: 1739-1749 [Abstract]  
  • Friend, S (1994). p53: a glimpse at the puppet behind the shadow play. Science 265: 334-335  
  • Iavarone, A, Garg, P, Lasorella, A, Hsu, J, Israel, M A (1994). The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.. Genes Dev. 8: 1270-1284 [Abstract]  
  • Lin, J, Chen, J, Elenbaas, B, Levine, A J (1994). Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.. Genes Dev. 8: 1235-1246 [Abstract]  
  • Yew, P R, Liu, X, Berk, A J (1994). Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.. Genes Dev. 8: 190-202 [Abstract]  
  • Canman, C.E., Chen, C.-Y., Lee, M.-H., Kastan, M.B. (1994). DNA Damage Responses: p53 Induction, Cell Cycle Perturbations, and Apoptosis. Cold Spring Harb Symp Quant Biol 59: 277-286 [Abstract]  
  • White, E., Chiou, S.-K., Rao, L., Sabbatini, P., Lin, H.-J. (1994). Control of p53-dependent Apoptosis by E1B, Bcl-2, and Ha-ras Proteins. Cold Spring Harb Symp Quant Biol 59: 395-402 [Abstract]  
  • Williams, B.O., Morgenbesser, S.D., DePinho, R.A., Jacks, T. (1994). Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53. Cold Spring Harb Symp Quant Biol 59: 449-457 [Abstract]  
  • Haber, D., Park, S, Maheswaran, S, Englert, C, Re, G., Hazen-Martin, D., Sens, D., Garvin, A. (1993). WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant. Science 262: 2057-2059 [Abstract]  
  • Harris, C. C., Hollstein, M. (1993). Clinical Implications of the p53 Tumor-Suppressor Gene. NEJM 329: 1318-1327 [Full Text]  
  • Knudson, A. Jr (1993). Genetics of Tumors of the Head and Neck. Arch Otolaryngol Head Neck Surg 119: 735-737 [Abstract]  
  • Zhu, L, van den Heuvel, S, Helin, K, Fattaey, A, Ewen, M, Livingston, D, Dyson, N, Harlow, E (1993). Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.. Genes Dev. 7: 1111-1125 [Abstract]  
  • Debbas, M, White, E (1993). Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.. Genes Dev. 7: 546-554 [Abstract]  
  • Agoff, S., Hou, J, Linzer, D., Wu, B (1993). Regulation of the human hsp70 promoter by p53. Science 259: 84-87 [Abstract]  
  • Qin, X Q, Chittenden, T, Livingston, D M, Kaelin, W G (1992). Identification of a growth suppression domain within the retinoblastoma gene product.. Genes Dev. 6: 953-964 [Abstract]  
  • Kern, S., Pietenpol, J., Thiagalingam, S, Seymour, A, Kinzler, K., Vogelstein, B (1992). Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256: 827-830 [Abstract]  
  • Ulrich, E, Boehmelt, G, Bird, A, Beug, H (1992). Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.. Genes Dev. 6: 876-887 [Abstract]  
  • Harvey, D M, Levine, A J (1991). p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.. Genes Dev. 5: 2375-2385 [Abstract]  
  • Hollstein, M, Sidransky, D, Vogelstein, B, Harris, C. (1991). p53 mutations in human cancers. Science 253: 49-53 [Abstract]  
  • Kern, S., Kinzler, K., Bruskin, A, Jarosz, D, Friedman, P, Prives, C, Vogelstein, B (1991). Identification of p53 as a sequence-specific DNA-binding protein. Science 252: 1708-1711 [Abstract]  
  • Sidransky, D, Von Eschenbach, A, Tsai, Y., Jones, P, Summerhayes, I, Marshall, F, Paul, M, Green, P, Hamilton, SR, Frost, P, et, al. (1991). Identification of p53 gene mutations in bladder cancers and urine samples. Science 252: 706-709 [Abstract]  
  • Zambetti, G.P., Quartin, R.S., Martinez, J., Georgoff, I., Momand, J., Dittmer, D., Finlay, C.A., Levine, A.J. (1991). Regulation of Transformation and the Cell Cycle by p53. Cold Spring Harb Symp Quant Biol 56: 219-225 [Abstract]  
  • Prives, C., Bargonetti, J., Friedman, P.N., Manfredi, J.J., Wang, E.H. (1991). Functional Consequences of the Interactions of the p53 Tumor Suppressor Protein and SV40 Large Tumor Antigen. Cold Spring Harb Symp Quant Biol 56: 227-235 [Abstract]  
  • Trump, B. F. (1991). Molecular Mechanisms of Genetic Deregulation in Toxicity and Carcinogenesis July 20-25, 1991, The Gant Conference Center, Aspen, Colorado: Program and Abstracts. Toxicol Pathol 19: 625-669  
  • Malkin, D, Li, F., Strong, L., Fraumeni, J. Jr, Nelson, C., Kim, D., Kassel, J, Gryka, M., Bischoff, F., Tainsky, M., et, al. (1990). Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250: 1233-1238 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»