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Mol Cell Biol. 1990 February; 10(2): 518-527

Structure and variability of human chromosome ends.

T de Lange, L Shiue, R M Myers, D R Cox, S L Naylor, A M Killery and H E Varmus

Department of Microbiology and Immunology, University of California, San Francisco 94143.

ABSTRACT

Mammalian telomeres are thought to be composed of a tandem array of TTAGGG repeats. To further define the type and arrangement of sequences at the ends of human chromosomes, we developed a direct cloning strategy for telomere-associated DNA. The method involves a telomere enrichment procedure based on the relative lack of restriction endonuclease cutting sites near the ends of human chromosomes. Nineteen (TTAGGG)n-bearing plasmids were isolated, two of which contain additional human sequences proximal to the telomeric repeats. These telomere-flanking sequences detect BAL 31-sensitive loci and thus are located close to chromosome ends. One of the flanking regions is part of a subtelomeric repeat that is present at 10 to 25% of the chromosome ends in the human genome. This sequence is not conserved in rodent DNA and therefore should be a helpful tool for physical characterization of human chromosomes in human-rodent hybrid cell lines; some of the chromosomes that may be analyzed in this manner have been identified, i.e., 7, 16, 17, and 21. The minimal size of the subtelomeric repeat is 4 kilobases (kb); it shows a high frequency of restriction fragment length polymorphisms and undergoes extensive de novo methylation in somatic cells. Distal to the subtelomeric repeat, the chromosomes terminate in a long region (up to 14 kb) that may be entirely composed of TTAGGG repeats. This terminal segment is unusually variable. Although sperm telomeres are 10 to 14 kb long, telomeres in somatic cells are several kilobase pairs shorter and very heterogeneous in length. Additional telomere reduction occurs in primary tumors, indicating that somatic telomeres are unstable and may continuously lose sequences from their termini.

Mol Cell Biol. 1990 February; 10(2): 518-527




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  • Shay, J. W., Zou, Y., Hiyama, E., Wright, W. E. (2001). Telomerase and cancer. Hum Mol Genet 10: 677-685 [Abstract] [Full Text]  
  • Gallego, M. E., White, C. I. (2001). RAD50 function is essential for telomere maintenance in Arabidopsis. Proc. Natl. Acad. Sci. USA 98: 1711-1716 [Abstract] [Full Text]  
  • Nagele, R., Velasco, A., Anderson, W., McMahon, D., Thomson, Z, Fazekas, J, Wind, K, Lee, H (2001). Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology. J. Cell Sci. 114: 377-388 [Abstract]  
  • Gineitis, A. A., Zalenskaya, I. A., Yau, P. M., Bradbury, E. M., Zalensky, A. O. (2000). Human Sperm Telomere-Binding Complex Involves Histone H2b and Secures Telomere Membrane Attachment. JCB 151: 1591-1598 [Abstract] [Full Text]  
  • Scherthan, H., Jerratsch, M., Li, B., Smith, S., Hultén, M., Lock, T., de Lange, T. (2000). Mammalian Meiotic Telomeres: Protein Composition and Redistribution in Relation to Nuclear Pores. Mol. Biol. Cell 11: 4189-4203 [Abstract] [Full Text]  
  • Achi, M. V., Ravindranath, N., Dym, M. (2000). Telomere Length in Male Germ Cells Is Inversely Correlated with Telomerase Activity. Biol. Reprod. 63: 591-598 [Abstract] [Full Text]  
  • Meyerson, M. (2000). Role of Telomerase in Normal and Cancer Cells. JCO 18: 2626-2634 [Abstract] [Full Text]  
  • Savre-Train, I., Gollahon, L. S., Holt, S. E. (2000). Clonal Heterogeneity in Telomerase Activity and Telomere Length in Tumor-Derived Cell Lines. Exp. Biol. Med. 223: 379-388 [Abstract] [Full Text]  
  • Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., de Lange, T. (2000). Control of Human Telomere Length by TRF1 and TRF2. Mol. Cell. Biol. 20: 1659-1668 [Abstract] [Full Text]  
  • Ofir, R., Wong, A. C. C., McDermid, H. E., Skorecki, K. L., Selig, S. (1999). Position effect of human telomeric repeats on replication timing. Proc. Natl. Acad. Sci. USA 96: 11434-11439 [Abstract] [Full Text]  
  • Shiraishi, M., Chuu, Y. H., Sekiya, T. (1999). Isolation of DNA fragments associated with methylated CpG islands in human adenocarcinomas of the lung using a methylated DNA binding column and denaturing gradient gel electrophoresis. Proc. Natl. Acad. Sci. USA 96: 2913-2918 [Abstract] [Full Text]  
  • Halvorsen, T. L., Leibowitz, G., Levine, F. (1999). Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis. Mol. Cell. Biol. 19: 1864-1870 [Abstract] [Full Text]  
  • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., de Lange, T. (1999). p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2. Science 283: 1321-1325 [Abstract] [Full Text]  
  • Shay, J. W. (1999). Toward Identifying a Cellular Determinant of Telomerase Repression. JNCI J Natl Cancer Inst 91: 4-6 [Full Text]  
  • Venkatesan, R. N., Price, C. (1998). Telomerase expression in chickens: Constitutive activity in somatic tissues and down-regulation in culture. Proc. Natl. Acad. Sci. USA 95: 14763-14768 [Abstract] [Full Text]  
  • Bryan, T. M., Sperger, J. M., Chapman, K. B., Cech, T. R. (1998). Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc. Natl. Acad. Sci. USA 95: 8479-8484 [Abstract] [Full Text]  
  • Frenck, R. W. Jr., Blackburn, E. H., Shannon, K. M. (1998). The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA 95: 5607-5610 [Abstract] [Full Text]  
  • Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., Wright, W. E. (1998). Extension of Life-Span by Introduction of Telomerase into Normal Human Cells. Science 279: 349-352 [Abstract] [Full Text]  
  • Greider, C. W. (1998). Telomerase activity, cell proliferation, and cancer. Proc. Natl. Acad. Sci. USA 95: 90-92 [Full Text]  
  • Bassham, S., Beam, A., Shampay, J. (1998). Telomere Variation in Xenopus laevis. Mol. Cell. Biol. 18: 269-275 [Abstract] [Full Text]  
  • Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B., Luzzatto, L. (1997). In vivo telomere dynamics of human hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 94: 13782-13785 [Abstract] [Full Text]  
  • Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D., Shay, J. W. (1997). Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11: 2801-2809 [Abstract] [Full Text]  
  • Lansdorp, P. M. (1997). Lessons from Mice without Telomerase. JCB 139: 309-312 [Full Text]  
  • Holt, S. E., Aisner, D. L., Shay, J. W., Wright, W. E. (1997). Lack of cell cycle regulation of telomerase activity in human cells. Proc. Natl. Acad. Sci. USA 94: 10687-10692 [Abstract] [Full Text]  
  • Weng, N.-p., Granger, L., Hodes, R. J. (1997). Telomere lengthening and telomerase activation during human B cell differentiation. Proc. Natl. Acad. Sci. USA 94: 10827-10832 [Abstract] [Full Text]  
  • Rosenberg, M., Hui, L., Ma, J., Nusbaum, H. C., Clark, K., Robinson, L., Dziadzio, L., Swain, P. M., Keith, T., Hudson, T. J., Biesecker, L. G., Flint, J. (1997). Characterization of Short Tandem Repeats from Thirty-One Human Telomeres. Genome Res 7: 917-923 [Abstract] [Full Text]  
  • Engelhardt, M., Kumar, R., Albanell, J., Pettengell, R., Han, W., Moore, M. A.S. (1997). Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells. Blood 90: 182-193 [Abstract] [Full Text]  
  • Eid, J. E., Sollner-Webb, B. (1997). ST-2, a Telomere and Subtelomere Duplex and G-strand Binding Protein Activity in Trypanosoma brucei. J. Biol. Chem. 272: 14927-14936 [Abstract] [Full Text]  
  • Stoppler, H., Hartmann, D.-P., Sherman, L., Schlegel, R. (1997). The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Dissociate Cellular Telomerase Activity from the Maintenance of Telomere Length. J. Biol. Chem. 272: 13332-13337 [Abstract] [Full Text]  
  • Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., de Lange, T. (1995). A Human Telomeric Protein. Science 270: 1663-1667 [Abstract]  
  • Feng, J, Funk, W., Wang, S., Weinrich, S., Avilion, A., Chiu, C., Adams, R., Chang, E, Allsopp, R., Yu, J, al., e. (1995). The RNA component of human telomerase. Science 269: 1236-1241 [Abstract]  
  • Haber, D. A. (1995). Telomeres, Cancer, and Immortality. NEJM 332: 955-956 [Full Text]  
  • Cardenas, M E, Bianchi, A, de Lange, T (1993). A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.. Genes Dev. 7: 883-894 [Abstract]  
  • Greider, C.W. (1993). Telomerase and Telomere-length Regulation: Lessons from Small Eukaryotes to Mammals. Cold Spring Harb Symp Quant Biol 58: 719-723 [Abstract]  
  • Blackburn, E. (1990). Telomeres and their synthesis. Science 249: 489-490  
  • Forsythe, H. L., Jarvis, J. L., Turner, J. W., Elmore, L. W., Holt, S. E. (2001). Stable Association of hsp90 and p23, but Not hsp70, with Active Human Telomerase. J. Biol. Chem. 276: 15571-15574 [Abstract] [Full Text]  


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