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Mol Cell Biol. 1990 February; 10(2): 539-548

The Adh gene promoters of Drosophila melanogaster and Drosophila orena are functionally conserved and share features of sequence structure and nuclease-protected sites.

K Moses, U Heberlein and M Ashburner

Howard Hughes Medical Institute Research Laboratories, University of California, Berkeley 94720.

ABSTRACT

The sibling species Drosophila melanogaster and D. orena show similar patterns of alcohol dehydrogenase expression, both spatially and temporally. These two species diverged from a common ancestor 6 million to 15 million years ago, and the DNA sequences of the promoter regions of their Adh genes show a mosaic pattern of conservation and change. By interspecific transformation of D. orena sequences into D. melanogaster, we demonstrate a functional equivalence between these sequences. Using both D. melanogaster embryo extracts and purified transcription factor Adf-1, we compare the protection of these promoter sequences from nuclease, demonstrating considerable conservation.

Mol Cell Biol. 1990 February; 10(2): 539-548




This article has been cited by other articles:

  • Abel, T., Michelson, A. M., Maniatis, T. (1993). A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119: 623-633 [Abstract]  
  • Abel, T, Bhatt, R, Maniatis, T (1992). A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.. Genes Dev. 6: 466-480 [Abstract]  


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