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Mol Cell Biol. 1990 March; 10(3): 1234-1238

Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain.

M A Stevenson and S K Calderwood

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

ABSTRACT

The 70-kilodalton heat shock protein (hsp70) family members appear to be essential components in a number cellular protein-protein interactions. We report here on the characterization of a new functional region in hsp70, a calmodulin-binding site. We have identified a 21-amino-acid sequence within the hsp70 protein that contains a calmodulin-binding domain. The peptide formed a potential amphipathic alpha helix and bound calmodulin with high affinity. Comparison of amino acid homology of this calmodulin-binding sequence with analogous hsp70 sequences from other species showed a high degree of conservation.

Mol Cell Biol. 1990 March; 10(3): 1234-1238




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