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Mol Cell Biol. 1990 March; 10(3): 1265-1269

The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

G C Prendergast, L E Diamond, D Dahl and M D Cole

Department of Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014.

ABSTRACT

The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.

Mol Cell Biol. 1990 March; 10(3): 1265-1269




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