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Mol Cell Biol. 1990 April; 10(4): 1492-1497

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

S J Kim, P Angel, R Lafyatis, K Hattori, K Y Kim, M B Sporn, M Karin and A B Roberts

Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.

ABSTRACT

The multifunctional actions of transforming growth factor beta 1 (TGF-beta 1) indicate that it has a pivotal control function in many physiological and pathological processes. An important property of TGF-beta 1 is its ability to activate its own mRNA expression and thereby increase its own secretion. Two distinct regions of the promoter of the TGF-beta 1 gene are responsive to autoregulation: one 5' to the upstream transcriptional start site and another located between the two major start sites. In both promoter regions, autoinduction is mediated by binding of the AP-1 (Jun-Fos) complex. An important contribution to this positive regulation is the autoactivation of c-jun transcription by AP-1. Cotransfection of antisense c-jun or antisense c-fos expression vectors prevents TGF-beta 1 autoinduction. These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction. Induction of jun expression by TGF-beta 1, as well as jun autoinduction, may amplify the action of TGF-beta 1 during normal development and oncogenesis.

Mol Cell Biol. 1990 April; 10(4): 1492-1497




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  • Meier, M., King, G. L (2000). Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med 5: 173-185 [Abstract]  
  • Fahmi, H., Cochet, C., Hmama, Z., Opolon, P., Joab, I. (2000). Transforming Growth Factor Beta 1 Stimulates Expression of the Epstein-Barr Virus BZLF1 Immediate-Early Gene Product ZEBRA by an Indirect Mechanism Which Requires the MAPK Kinase Pathway. J. Virol. 74: 5810-5818 [Abstract] [Full Text]  
  • Chess, P. R., Toia, L., Finkelstein, J. N. (2000). Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L43-L51 [Abstract] [Full Text]  
  • Symes, A. J., Pitts, R. L., Conover, J., Kos, K., Coulombe, J. (2000). Synergy of Activin and Ciliary Neurotrophic Factor Signaling Pathways in the Induction of Vasoactive Intestinal Peptide Gene Expression. Mol. Endocrinol. 14: 429-439 [Abstract] [Full Text]  
  • Kim, S., Iwao, H. (2000). Molecular and Cellular Mechanisms of Angiotensin II-Mediated Cardiovascular and Renal Diseases. Pharmacol. Rev. 52: 11-34 [Abstract] [Full Text]  
  • Miyazono, K (2000). Positive and negative regulation of TGF-beta signaling. J. Cell Sci. 113: 1101-1109 [Abstract]  
  • HAMAGUCHI, A., KIM, S., IZUMI, Y., IWAO, H. (2000). Chronic Activation of Glomerular Mitogen-Activated Protein Kinases in Dahl Salt-Sensitive Rats. J. Am. Soc. Nephrol. 11: 39-46 [Abstract] [Full Text]  
  • IL KIM, S., HAN, D. C., LEE, H. B. (2000). Lovastatin Inhibits Transforming Growth Factor-{beta}1 Expression in Diabetic Rat Glomeruli and Cultured Rat Mesangial Cells. J. Am. Soc. Nephrol. 11: 80-87 [Abstract] [Full Text]  
  • Wyss-Coray, T., Lin, C., Sanan, D. A., Mucke, L., Masliah, E. (2000). Chronic Overproduction of Transforming Growth Factor-{beta}1 by Astrocytes Promotes Alzheimer’s Disease-Like Microvascular Degeneration in Transgenic Mice. Am. J. Pathol. 156: 139-150 [Abstract] [Full Text]  
  • Koski, C., Saharinen, J., Keski-Oja, J. (1999). Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-beta Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner. J. Biol. Chem. 274: 32619-32630 [Abstract] [Full Text]  
  • HAN, D. C., ISONO, M., HOFFMAN, B. B., ZIYADEH, F. N. (1999). High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts: Mediation by Autocrine Activation ofTGF-{beta}. J. Am. Soc. Nephrol. 10: 1891-1899 [Abstract] [Full Text]  
  • Hollnagel, A., Oehlmann, V., Heymer, J., Ruther, U., Nordheim, A. (1999). Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells. J. Biol. Chem. 274: 19838-19845 [Abstract] [Full Text]  
  • Grewal, J. S., Mukhin, Y. V., Garnovskaya, M. N., Raymond, J. R., Greene, E. L. (1999). Serotonin 5-HT2A receptor induces TGF-beta 1 expression in mesangial cells via ERK: proliferative and fibrotic signals. Am. J. Physiol. Renal Physiol. 276: F922-F930 [Abstract] [Full Text]  
  • Vodovotz, Y., Chesler, L., Chong, H., Kim, S.-J., Simpson, J. T., DeGraff, W., Cox, G. W., Roberts, A. B., Wink, D. A., Barcellos-Hoff, M. H. (1999). Regulation of Transforming Growth Factor {beta}1 by Nitric Oxide. Cancer Res. 59: 2142-2149 [Abstract] [Full Text]  
  • Fang, K. C., Wolters, P. J., Steinhoff, M., Bidgol, A., Blount, J. L., Caughey, G. H. (1999). Mast Cell Expression of Gelatinases A and B Is Regulated by kit Ligand and TGF-{beta}. J. Immunol. 162: 5528-5535 [Abstract] [Full Text]  
  • Eickelberg, O., Pansky, A., Mussmann, R., Bihl, M., Tamm, M., Hildebrand, P., Perruchoud, A. P., Roth, M. (1999). Transforming Growth Factor-beta 1 Induces Interleukin-6 Expression via Activating Protein-1 Consisting of JunD Homodimers in Primary Human Lung Fibroblasts. J. Biol. Chem. 274: 12933-12938 [Abstract] [Full Text]  
  • Liberati, N. T., Datto, M. B., Frederick, J. P., Shen, X., Wong, C., Rougier-Chapman, E. M., Wang, X.-F. (1999). Smads bind directly to the Jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. USA 96: 4844-4849 [Abstract] [Full Text]  
  • Stroschein, S. L., Wang, W., Luo, K. (1999). Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor beta -induced Smad-dependent Transcriptional Activation. J. Biol. Chem. 274: 9431-9441 [Abstract] [Full Text]  
  • Ariazi, E. A., Satomi, Y., Ellis, M. J., Haag, J. D., Shi, W., Sattler, C. A., Gould, M. N. (1999). Activation of the Transforming Growth Factor {beta} Signaling Pathway and Induction of Cytostasis and Apoptosis in Mammary Carcinomas Treated with the Anticancer Agent Perillyl Alcohol. Cancer Res. 59: 1917-1928 [Abstract] [Full Text]  
  • Shah, M., Revis, D., Herrick, S., Baillie, R., Thorgeirson, S., Ferguson, M., Roberts, A. (1999). Role of Elevated Plasma Transforming Growth Factor-ß1 Levels in Wound Healing. Am. J. Pathol. 154: 1115-1124 [Abstract] [Full Text]  
  • Wong, C., Rougier-Chapman, E. M., Frederick, J. P., Datto, M. B., Liberati, N. T., Li, J.-M., Wang, X.-F. (1999). Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor beta. Mol. Cell. Biol. 19: 1821-1830 [Abstract] [Full Text]  
  • Shi, M.-J., Stavnezer, J. (1998). CBF{alpha}3 (AML2) Is Induced by TGF-{beta}1 to Bind and Activate the Mouse Germline Ig {alpha} Promoter. J. Immunol. 161: 6751-6760 [Abstract] [Full Text]  
  • Grande, J P (1998). Mechanisms of progression of renal damage in lupus nephritis:Pathogenesis of renal scarring. Lupus 7: 604-610 [Abstract]  
  • Yano, M., Kim, S., Izumi, Y., Yamanaka, S., Iwao, H. (1998). Differential Activation of Cardiac c-Jun Amino-Terminal Kinase and Extracellular Signal-Regulated Kinase in Angiotensin II–Mediated Hypertension. Circ. Res. 83: 752-760 [Abstract] [Full Text]  
  • Lu, C., Giordano, F. J., Bao, X., Morris, K. C., Rothman, A. (1998). Antisense fosB RNA Inhibits Thrombin-Induced Hypertrophy in Cultured Pulmonary Arterial Smooth Muscle Cells. Circulation 98: 596-603 [Abstract] [Full Text]  
  • Virolle, T., Monthouel, M.-N., Djabari, Z., Ortonne, J.-P., Meneguzzi, G., Aberdam, D. (1998). Three Activator Protein-1-binding Sites Bound by the Fra-2·JunD Complex Cooperate for the Regulation of Murine Laminin alpha 3A (lama3A) Promoter Activity by Transforming Growth Factor-beta. J. Biol. Chem. 273: 17318-17325 [Abstract] [Full Text]  
  • Kawata, Y., Mizukami, Y., Fujii, Z., Sakumura, T., Yoshida, K.-i., Matsuzaki, M. (1998). Applied Pressure Enhances Cell Proliferation through Mitogen-activated Protein Kinase Activation in Mesangial Cells. J. Biol. Chem. 273: 16905-16912 [Abstract] [Full Text]  
  • Kim, S., Izumi, Y., Yano, M., Hamaguchi, A., Miura, K., Yamanaka, S., Miyazaki, H., Iwao, H. (1998). Angiotensin Blockade Inhibits Activation of Mitogen-Activated Protein Kinases in Rat Balloon-Injured Artery. Circulation 97: 1731-1737 [Abstract] [Full Text]  
  • Uria, J. A., Jimenez, M. G., Balbin, M., Freije, J. M. P., Lopez-Otin, C. (1998). Differential Effects of Transforming Growth Factor-beta on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts. J. Biol. Chem. 273: 9769-9777 [Abstract] [Full Text]  
  • Shimizu, N., Yoshiyama, M., Omura, T., Hanatani, A., Kim, S., Takeuchi, K., Iwao, H., Yoshikawa, J. (1998). Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats. Cardiovasc Res 38: 116-124 [Abstract] [Full Text]  
  • Lei, J., Silbiger, S., Ziyadeh, F. N., Neugarten, J. (1998). Serum-stimulated alpha 1 type IV collagen gene transcription is mediated by TGF-beta and inhibited by estradiol. Am. J. Physiol. Renal Physiol. 274: F252-F258 [Abstract] [Full Text]  
  • Pilbeam, C., Rao, Y., Voznesensky, O., Kawaguchi, H., Alander, C., Raisz, L., Herschman, H. (1997). Transforming Growth Factor-{beta}1 Regulation of Prostaglandin G/H Synthase-2 Expression in Osteoblastic MC3T3-E1 Cells. Endocrinology 138: 4672-4682 [Abstract] [Full Text]  
  • Hu, Y., Cheng, L., Hochleitner, B.-W., Xu, Q. (1997). Activation of Mitogen-Activated Protein Kinases (ERK/JNK) and AP-1 Transcription Factor in Rat Carotid Arteries After Balloon Injury. Arterioscler. Thromb. Vasc. Bio. 17: 2808-2816 [Abstract] [Full Text]  
  • Riesgo-Escovar, J. R., Hafen, E. (1997). Common and Distinct Roles of DFos and DJun During Drosophila Development. Science 278: 669-672 [Abstract] [Full Text]  
  • Jin, G., Howe, P. H. (1997). Regulation of Clusterin Gene Expression by Transforming Growth Factor beta. J. Biol. Chem. 272: 26620-26626 [Abstract] [Full Text]  
  • Wang, W., Zhou, G., Hu, M. C.-T., Yao, Z., Tan, T.-H. (1997). Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor beta  (TGF-beta )-activated Kinase (TAK1), a Kinase Mediator of TGF beta  Signal Transduction. J. Biol. Chem. 272: 22771-22775 [Abstract] [Full Text]  
  • Riesgo-Escovar, J R, Hafen, E (1997). Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.. Genes Dev. 11: 1717-1727 [Abstract]  
  • Aebert, H., Cornelius, T., Ehr, T., Holmer, S. R., Birnbaum, D. E., Riegger, G. A. J., Schunkert, H. (1997). Expression of Immediate Early Genes After Cardioplegic Arrest and Reperfusion. Ann. Thorac. Surg. 63: 1669-1675 [Abstract] [Full Text]  
  • Döhr, O., Sinning, R., Vogel, C., Münzel, P., Abel, J. (1997). Effect of Transforming Growth Factor-beta 1 on Expression of Aryl Hydrocarbon Receptor and Genes of Ah Gene Battery: Clues for Independent Down-Regulation in A549 Cells. Mol. Pharmacol. 51: 703-710 [Abstract] [Full Text]  
  • Fleur, M. L., Underwood, J. L., Rappolee, D. A., Werb, Z. (1996). Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1. JEM 184: 2311-2326 [Abstract] [Full Text]  
  • Alevizopoulos, A., Mermod, N. (1996). Antagonistic Regulation of a Proline-rich Transcription Factor by Transforming Growth Factor beta and Tumor Necrosis Factor alpha. J. Biol. Chem. 271: 29672-29681 [Abstract] [Full Text]  
  • Shi, Y., O'Brien, J. E., Fard, A., Zalewski, A. (1996). Transforming Growth Factor-ß1 Expression and Myofibroblast Formation During Arterial Repair. Arterioscler. Thromb. Vasc. Bio. 16: 1298-1305 [Abstract] [Full Text]  
  • Inoue, N., Venema, R. C., Sayegh, H. S., Ohara, Y., Murphy, T. J., Harrison, D. G. (1995). Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–ß1. Arterioscler. Thromb. Vasc. Bio. 15: 1255-1261 [Abstract] [Full Text]  
  • Moggio, R. A., Ding, J.-Z., Smith, C. J., Tota, R. R., Stemerman, M. B., Reed, G. E. (1995). Immediate-early gene expression in human saphenous veins harvested during coronary artery bypass graft operations. J. Thorac. Cardiovasc. Surg. 110: 209-213 [Abstract] [Full Text]  
  • Hartsough, M. T., Mulder, K. M. (1995). Transforming Growth Factor beta Activation of p44[IMAGE] in Proliferating Cultures of Epithelial Cells. J. Biol. Chem. 270: 7117-7124 [Abstract] [Full Text]  
  • Chang, E., Goldberg, H. (1995). Requirements for Transforming Growth Factor-beta Regulation of the Pro-alpha2(I) Collagen and Plasminogen Activator Inhibitor-1 Promoters. J. Biol. Chem. 270: 4473-4477 [Abstract] [Full Text]  
  • Schunkert, H., Sadoshima, J.-i., Cornelius, T., Kagaya, Y., Weinberg, E. O., Izumo, S., Riegger, G., Lorell, B. H. (1995). Angiotensin II–Induced Growth Responses in Isolated Adult Rat Hearts : Evidence for Load-Independent Induction of Cardiac Protein Synthesis by Angiotensin II. Circ. Res. 76: 489-497 [Abstract] [Full Text]  
  • Ribeiro, S., Schultz-Cherry, S, Murphy-Ullrich, J. (1995). Heparin-binding vitronectin up-regulates latent TGF-beta production by bovine aortic endothelial cells. J. Cell Sci. 108: 1553-1561 [Abstract]  
  • Border, W. A., Noble, N. A. (1994). Transforming Growth Factor {beta} in Tissue Fibrosis. NEJM 331: 1286-1292 [Full Text]  
  • Kramer, I., Patel, R, Spargo, D, Riley, P (1994). Initiation of growth inhibition by TGF beta 1 is unlikely to occur in G1. J. Cell Sci. 107: 3469-3475 [Abstract]  
  • Filvaroff, E., Ebner, R, Derynck, R (1994). Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. Development 120: 1085-1095 [Abstract]  
  • Yue, J., Mulder, K. M. (2000). Requirement of Ras/MAPK Pathway Activation by Transforming Growth Factor beta for Transforming Growth Factor beta 1 Production in a Smad-dependent Pathway. J. Biol. Chem. 275: 30765-30773 [Abstract] [Full Text]  
  • Finlay, G. A., Thannickal, V. J., Fanburg, B. L., Paulson, K. E. (2000). Transforming Growth Factor-beta 1-induced Activation of the ERK Pathway/Activator Protein-1 in Human Lung Fibroblasts Requires the Autocrine Induction of Basic Fibroblast Growth Factor. J. Biol. Chem. 275: 27650-27656 [Abstract] [Full Text]  


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