This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McGowan, C H
Right arrow Articles by Reed, S I
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGowan, C H
Right arrow Articles by Reed, S I

 Previous Article  |  Next Article 

Mol Cell Biol. 1990 July; 10(7): 3847-3851

Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle.

C H McGowan, P Russell and S I Reed

Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.

ABSTRACT

The product of the CDC2Hs gene is the protein kinase subunit of the M-phase promoting factor, which is required for entry into mitosis. The activity of this kinase is regulated in a cell cycle-dependent manner by reversible phosphorylation and through association with other proteins. We report here that in HeLa cells, the abundance of the CDC2Hs mRNA and the rate of synthesis of the encoded protein, p34, vary in a cell cycle-dependent manner.

Mol Cell Biol. 1990 July; 10(7): 3847-3851




This article has been cited by other articles:

  • Martinsson-Ahlzen, H.-S., Liberal, V., Grunenfelder, B., Chaves, S. R., Spruck, C. H., Reed, S. I. (2008). Cyclin-Dependent Kinase-Associated Proteins Cks1 and Cks2 Are Essential during Early Embryogenesis and for Cell Cycle Progression in Somatic Cells. Mol. Cell. Biol. 28: 5698-5709 [Abstract] [Full Text]  
  • Westbrook, L., Manuvakhova, M., Kern, F. G., Estes, N. R. II, Ramanathan, H. N., Thottassery, J. V. (2007). Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells. Cancer Res. 67: 11393-11401 [Abstract] [Full Text]  
  • Sanchez, V., McElroy, A. K., Spector, D. H. (2003). Mechanisms Governing Maintenance of Cdk1/Cyclin B1 Kinase Activity in Cells Infected with Human Cytomegalovirus. J. Virol. 77: 13214-13224 [Abstract] [Full Text]  
  • Turowski, P., Franckhauser, C., Morris, M. C., Vaglio, P., Fernandez, A., Lamb, N. J. C. (2003). Functional cdc25C Dual-Specificity Phosphatase Is Required for S-Phase Entry in Human Cells. Mol. Biol. Cell 14: 2984-2998 [Abstract] [Full Text]  
  • Manes, T., Zheng, D.-Q., Tognin, S., Woodard, A. S., Marchisio, P. C., Languino, L. R. (2003). {alpha}v{beta}3 integrin expression up-regulates cdc2, which modulates cell migration. JCB 161: 817-826 [Abstract] [Full Text]  
  • Sorrell, D. A., Menges, M., Healy, J.M. S., Deveaux, Y., Amano, C., Su, Y., Nakagami, H., Shinmyo, A., Doonan, J. H., Sekine, M., Murray, J. A.H. (2001). Cell Cycle Regulation of Cyclin-Dependent Kinases in Tobacco Cultivar Bright Yellow-2 Cells. Plant Physiol. 126: 1214-1223 [Abstract] [Full Text]  
  • Badie, C., Itzhaki, J. E., Sullivan, M. J., Carpenter, A. J., Porter, A. C. G. (2000). Repression of CDK1 and Other Genes with CDE and CHR Promoter Elements during DNA Damage-Induced G2/M Arrest in Human Cells. Mol. Cell. Biol. 20: 2358-2366 [Abstract] [Full Text]  
  • Park, M., Chae, H.-D., Yun, J., Jung, M., Kim, Y.-S., Kim, S.-H., Han, M. H., Shin, D. Y. (2000). Constitutive Activation of Cyclin B1-associated cdc2 Kinase Overrides p53-mediated G2-M Arrest. Cancer Res. 60: 542-545 [Abstract] [Full Text]  
  • Yun, J., Chae, H.-D., Choy, H. E., Chung, J., Yoo, H.-S., Han, M.-H., Shin, D. Y. (1999). p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor. J. Biol. Chem. 274: 29677-29682 [Abstract] [Full Text]  
  • Liu, Z.-J., Ueda, T., Miyazaki, T., Tanaka, N., Mine, S., Tanaka, Y., Taniguchi, T., Yamamura, H., Minami, Y. (1998). A Critical Role for Cyclin C in Promotion of the Hematopoietic Cell Cycle by Cooperation with c-Myc. Mol. Cell. Biol. 18: 3445-3454 [Abstract] [Full Text]  
  • Grant, K. M., Hassan, P., Anderson, J. S., Mottram, J. C. (1998). The crk3 Gene of Leishmania mexicana Encodes a Stage-regulated cdc2-related Histone H1 Kinase That Associates with p12cks1. J. Biol. Chem. 273: 10153-10159 [Abstract] [Full Text]  
  • Weinstein, J. (1997). Cell Cycle-regulated Expression, Phosphorylation, and Degradation of p55Cdc. A MAMMALIAN HOMOLOG OF CDC20/Fizzy/slp1. J. Biol. Chem. 272: 28501-28511 [Abstract] [Full Text]  
  • Lubec, B., Labudova, O., Hoeger, H., Muehl, A., Fang-Kircher, S., Marx, M., Mosgoeller, W., Gialamas, J. (1996). Homocysteine Increases Cyclin-Dependent Kinase in Aortic Rat Tissue. Circulation 94: 2620-2625 [Abstract] [Full Text]  
  • Furukawa, Y., Iwase, S., Terui, Y., Kikuchi, J., Sakai, T., Nakamura, M., Kitagawa, S., Kitagawa, M. (1996). Transcriptional Activation of the cdc2 Gene Is Associated with Fas-induced Apoptosis of Human Hematopoietic Cells. J. Biol. Chem. 271: 28469-28477 [Abstract] [Full Text]  
  • Chen, H., Campisi, J., Padmanabhan, R. (1996). SV40 Large T Antigen Transactivates the Human cdc2 Promoter by Inducing a CCAAT Box Binding Factor. J. Biol. Chem. 271: 13959-13967 [Abstract] [Full Text]  
  • Monticello, T. M., Barton, D., Xinfang Ma, , Babish, J. G., Durham, S. K. (1995). Comparison of Acute Hepatocellular Proliferating Cell Nuclear Antigen Labeling Indices and Growth Fractions, p34cdc2 Kinases, and Serum Enzymes in Carbon Tetrachloride-Treated Rats. Toxicol Pathol 23: 439-446 [Abstract]  
  • Chevalier, S, Tassan, J., Cox, R, Philippe, M, Ford, C (1995). Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts. J. Cell Sci. 108: 1831-1841 [Abstract]  
  • Mendenhall, M. (1993). An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259: 216-219 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»