This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nesterov, A
Right arrow Articles by Nikolsky, N
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nesterov, A
Right arrow Articles by Nikolsky, N

 Previous Article  |  Next Article 

Mol Cell Biol. 1990 September; 10(9): 5011-5014

Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells.

A Nesterov, G Reshetnikova, N Vinogradova and N Nikolsky

Institute of Cytology of the Academy of Sciences of the USSR, Leningrad.

ABSTRACT

Functional state of internalized epidermal growth factor (EGF) receptor in A-431 cells has been studied. The use of photoaffinity [125I]EGF derivative allowed us to establish that inside the cell the EGF retains its connection with the receptor. With the help of polyclonal antibodies to phosphotyrosine, it has been shown that EGF-receptor complexes maintain their phosphorylated state during internalization. The internalized EGF receptor kinase as well as that localized in the plasma membrane appeared to be able to phosphorylate synthetic peptide substrate introduced into the cell.

Mol Cell Biol. 1990 September; 10(9): 5011-5014




This article has been cited by other articles:

  • Haugh, J. M. (2002). Localization of Receptor-Mediated Signal Transduction Pathways: The Inside Story. Mol. Interv. 2: 292-307 [Abstract] [Full Text]  
  • Jiang, X., Sorkin, A. (2002). Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells. Mol. Biol. Cell 13: 1522-1535 [Abstract] [Full Text]  
  • Brock, R., Jovin, T. M. (2001). Heterogeneity of signal transduction at the subcellular level: microsphere-based focal EGF receptor activation and stimulation of Shc translocation. J. Cell Sci. 114: 2437-2447 [Abstract] [Full Text]  
  • Sorkina, T, Bild, A, Tebar, F, Sorkin, A (1999). Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors. J. Cell Sci. 112: 317-327 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»