This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bacher, N
Right arrow Articles by Livneh, E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bacher, N
Right arrow Articles by Livneh, E

 Previous Article  |  Next Article 

Mol Cell Biol. 1991 January; 11(1): 126-133

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

N Bacher, Y Zisman, E Berent and E Livneh

Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT

We have isolated and characterized a new human cDNA, coding for a protein kinase, related to the protein kinase C (PKC) gene family. Although this protein kinase shares some homologous sequences and structural features with the four members of the PKC family initially isolated (alpha, beta I, beta II, and gamma), it shows more homology with the recently described PKC-related subfamily, encoded by the cDNAs delta, epsilon, and zeta. The transcript for this gene product, termed PKC-L, is most abundant in lung tissue, less expressed in heart and skin tissue, and exhibited very low expression in brain tissue. Thus, its tissue distribution is different from that described for other mammalian members of the PKC gene family, their expression being enriched in brain tissues. PKC-L is also expressed in several human cell lines, including the human epidermoid carcinoma line A431. The ability of phorbol esters to bind to and stimulate the kinase activity of PKC-L was revealed by introducing the cDNA into COS cells.

Mol Cell Biol. 1991 January; 11(1): 126-133




This article has been cited by other articles:

  • Raveh-Amit, H., Maissel, A., Poller, J., Marom, L., Elroy-Stein, O., Shapira, M., Livneh, E. (2009). Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames. Mol. Cell. Biol. 29: 6140-6148 [Abstract] [Full Text]  
  • Lachmann, S., Rommeleare, J., Nuesch, J. P. F. (2003). Novel PKC{eta} Is Required To Activate Replicative Functions of the Major Nonstructural Protein NS1 of Minute Virus of Mice. J. Virol. 77: 8048-8060 [Abstract] [Full Text]  
  • Chida, K., Hara, T., Hirai, T., Konishi, C., Nakamura, K., Nakao, K., Aiba, A., Katsuki, M., Kuroki, T. (2003). Disruption of Protein Kinase C{eta} Results in Impairment of Wound Healing and Enhancement of Tumor Formation in Mouse Skin Carcinogenesis. Cancer Res. 63: 2404-2408 [Abstract] [Full Text]  
  • Gundersen, C. B., Kohan, S. A., Chen, Q., Iagnemma, J., Umbach, J. A. (2002). Activation of protein kinase C{eta} triggers cortical granule exocytosis in Xenopus oocytes. J. Cell Sci. 115: 1313-1320 [Abstract] [Full Text]  
  • Wang, S.-Y., Cruts, M., Del-Favero, J., Zhang, Y., Tissir, F., Potier, M.-C., Patterson, D., Nizetic, D., Bosch, A., Chen, H., Bennett, L., Estivill, X., Kessling, A., Antonarakis, S. E., van Broeckhoven, C. (1999). A High-Resolution Physical Map of Human Chromosome 21p Using Yeast Artificial Chromosomes. Genome Res 9: 1059-1073 [Abstract] [Full Text]  
  • Quan, T., Fisher, G. J. (1999). Cloning and Characterization of the Human Protein Kinase C-eta Promoter. J. Biol. Chem. 274: 28566-28574 [Abstract] [Full Text]  
  • Morrow, T. A., Muljo, S. A., Zhang, J., Hardwick, J. M., Schlissel, M. S. (1999). Pro-B-Cell-Specific Transcription and Proapoptotic Function of Protein Kinase Ceta. Mol. Cell. Biol. 19: 5608-5618 [Abstract] [Full Text]  
  • Gobran, L. I., Xu, Z.-X., Rooney, S. A. (1998). PKC isoforms and other signaling proteins involved in surfactant secretion in developing rat type II cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L901-L907 [Abstract] [Full Text]  
  • Ueda, E., Ohno, S., Kuroki, T., Livneh, E., Yamada, K., Yamanishi, K., Yasuno, H. (1996). The [IMAGE] Isoform of Protein Kinase C Mediates Transcriptional Activation of the Human Transglutaminase 1 Gene. J. Biol. Chem. 271: 9790-9794 [Abstract] [Full Text]  
  • Kielbassa, K., Müller, H.-J., Meyer, H. E., Marks, F., Gschwendt, M. (1995). Protein Kinase C[IMAGE]-specific Phosphorylation of the Elongation Factor eEF-1alpha and an eEF-1alpha Peptide at Threonine 431. J. Biol. Chem. 270: 6156-6162 [Abstract] [Full Text]  
  • DeLa Herreros, A., Fabre, M, Batlle, E, Balague, C, Real, F. (1993). The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells. J. Cell Sci. 105: 1165-1172 [Abstract]  
  • Nishizuka, Y (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614 [Abstract]  
  • Hubbard, SR, Bishop, W., Kirschmeier, P, George, S., Cramer, S., Hendrickson, W. (1991). Identification and characterization of zinc binding sites in protein kinase C. Science 254: 1776-1779 [Abstract]  
  • Hussaini, I. M., Karns, L. R., Vinton, G., Carpenter, J. E., Redpath, G. T., Sando, J. J., VandenBerg, S. R. (2000). Phorbol 12-Myristate 13-Acetate Induces Protein Kinase Ceta -specific Proliferative Response in Astrocytic Tumor Cells. J. Biol. Chem. 275: 22348-22354 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»