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Mol Cell Biol. 1991 January; 11(1): 568-572

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

ABSTRACT

We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic transcript.

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