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Mol Cell Biol. 1991 October; 11(10): 5113-5124

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

H Wu, A B Reynolds, S B Kanner, R R Vines and J T Parsons

Department of Microbiology, Health Sciences Center, Charlottesville, Virginia 22908.

ABSTRACT

Transformation of cells by the src oncogene results in elevated tyrosine phosphorylation of two related proteins, p80 and p85 (p80/85). Immunostaining with specific monoclonal antibodies revealed a striking change of subcellular localization of p80/85 in src-transformed cells. p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. Sequence analysis of cDNA clones encoding p80/85 revealed an amino-terminal domain composed of six copies of a direct tandem repeat, each repeat containing 37 amino acids, a carboxyl-terminal SH3 domain, and an interdomain region composed of a highly charged acidic region and a region rich in proline, serine, and threonine. The multidomain structure of p80/85 and its colocalization with F-actin in normal and src-transformed cells suggest that these proteins may associate with components of the cytoskeleton and contribute to organization of cell structure.

Mol Cell Biol. 1991 October; 11(10): 5113-5124




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  • ZIMMERMANN, P., DAVID, G. (1999). The syndecans, tuners of transmembrane signaling. FASEB J. 13: 91-100 [Abstract] [Full Text]  
  • Angers-Loustau, A., Cote, J.-F., Charest, A., Dowbenko, D., Spencer, S., Lasky, L. A., Tremblay, M. L. (1999). Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts. JCB 144: 1019-1031 [Abstract] [Full Text]  
  • Dumenil, G., Olivo, J.C., Pellegrini, S., Fellous, M., Sansonetti, P.J., Nhieu, G. T. V. (1998). Interferon {alpha} Inhibits a Src-mediated Pathway Necessary for Shigella-induced Cytoskeletal Rearrangements in Epithelial Cells. JCB 143: 1003-1012 [Abstract] [Full Text]  
  • Wu, Y., Dowbenko, D., Lasky, L. A. (1998). PSTPIP 2, a Second Tyrosine Phosphorylated, Cytoskeletal-associated Protein That Binds a PEST-type Protein-tyrosine Phosphatase. J. Biol. Chem. 273: 30487-30496 [Abstract] [Full Text]  
  • Katsube, T., Takahisa, M., Ueda, R., Hashimoto, N., Kobayashi, M., Togashi, S. (1998). Cortactin Associates with the Cell-Cell Junction Protein ZO-1 in both Drosophila and Mouse. J. Biol. Chem. 273: 29672-29677 [Abstract] [Full Text]  
  • Huang, C., Liu, J., Haudenschild, C. C., Zhan, X. (1998). The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells. J. Biol. Chem. 273: 25770-25776 [Abstract] [Full Text]  
  • Wu, H., Montone, K. T. (1998). Cortactin Localization in Actin-containing Adult and Fetal tissues. J. Histochem. Cytochem. 46: 1189-1192 [Abstract] [Full Text]  
  • Du, Y., Weed, S. A., Xiong, W.-C., Marshall, T. D., Parsons, J. T. (1998). Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons. Mol. Cell. Biol. 18: 5838-5851 [Abstract] [Full Text]  
  • Kim, L., Wong, T. W. (1998). Growth Factor-dependent Phosphorylation of the Actin-binding Protein Cortactin Is Mediated by the Cytoplasmic Tyrosine Kinase FER. J. Biol. Chem. 273: 23542-23548 [Abstract] [Full Text]  
  • Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H. B., Rauvala, H. (1998). Cortactin-Src Kinase Signaling Pathway Is Involved in N-syndecan-dependent Neurite Outgrowth. J. Biol. Chem. 273: 10702-10708 [Abstract] [Full Text]  
  • Jalali, S., Li, Y.-S., Sotoudeh, M., Yuan, S., Li, S., Chien, S., Shyy, J. Y-J. (1998). Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells. Arterioscler. Thromb. Vasc. Bio. 18: 227-234 [Abstract] [Full Text]  
  • Weed, S., Du, Y, Parsons, J. (1998). Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111: 2433-2443 [Abstract]  
  • McMahon, G. A., Garfinkel, S., Prudovsky, I., Hu, X., Maciag, T. (1997). Intracellular Precursor Interleukin (IL)-1alpha , but Not Mature IL-1alpha , Is Able to Regulate Human Endothelial Cell Migration in Vitro. J. Biol. Chem. 272: 28202-28205 [Abstract] [Full Text]  
  • McManus, M. J., Lingle, W. L., Salisbury, J. L., Maihle, N. J. (1997). A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-ErbB signaling to actin stress fiber disassembly. Proc. Natl. Acad. Sci. USA 94: 11351-11356 [Abstract] [Full Text]  
  • Schaller, M. D., Sasaki, T. (1997). Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase beta. J. Biol. Chem. 272: 25319-25325 [Abstract] [Full Text]  
  • Spencer, S., Dowbenko, D., Cheng, J., Li, W., Brush, J., Utzig, S., Simanis, V., Lasky, L. A. (1997). PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow-associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase. JCB 138: 845-860 [Abstract] [Full Text]  
  • Huang, C., Tandon, N. N., Greco, N. J., Ni, Y., Wang, T., Zhan, X. (1997). Proteolysis of Platelet Cortactin by Calpain. J. Biol. Chem. 272: 19248-19252 [Abstract] [Full Text]  
  • Huby, R. D.J., Iwashima, M., Weiss, A., Ley, S. C. (1997). ZAP-70 Protein Tyrosine Kinase Is Constitutively Targeted to the T Cell Cortex Independently of its SH2 Domains. JCB 137: 1639-1649 [Abstract] [Full Text]  
  • Huang, C., Ni, Y., Wang, T., Gao, Y., Haudenschild, C. C., Zhan, X. (1997). Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation. J. Biol. Chem. 272: 13911-13915 [Abstract] [Full Text]  
  • van Damme, H., Brok, H., Schuuring-Scholtes, E., Schuuring, E. (1997). The Redistribution of Cortactin into Cell-Matrix Contact Sites in Human Carcinoma Cells with 11q13 Amplification Is Associated with Both Overexpression and Post-translational Modification. J. Biol. Chem. 272: 7374-7380 [Abstract] [Full Text]  
  • Zhan, X., Haudenschild, C. C., Ni, Y., Smith, E., Huang, C. (1997). Upregulation of Cortactin Expression During the Maturation of Megakaryocytes. Blood 89: 457-464 [Abstract] [Full Text]  
  • Ichinohe, T., Takayama, H., Ezumi, Y., Arai, M., Yamamoto, N., Takahashi, H., Okuma, M. (1997). Collagen-stimulated Activation of Syk but Not c-Src Is Severely Compromised in Human Platelets Lacking Membrane Glycoprotein VI. J. Biol. Chem. 272: 63-68 [Abstract] [Full Text]  
  • Harte, M. T., Hildebrand, J. D., Burnham, M. R., Bouton, A. H., Parsons, J. T. (1996). p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase. J. Biol. Chem. 271: 13649-13655 [Abstract] [Full Text]  
  • Maruyama, S., Kurosaki, T., Sada, K., Yamanashi, Y., Yamamoto, T., Yamamura, H. (1996). Physical and Functional Association of Cortactin with Syk in Human Leukemic Cell Line K562. J. Biol. Chem. 271: 6631-6635 [Abstract] [Full Text]  
  • Rigacci, S., Degl'Innocenti, D., Bucciantini, M., Cirri, P., Berti, A., Ramponi, G. (1996). pp60[IMAGE][IMAGE] Phosphorylates and Activates Low Molecular Weight Phosphotyrosine-protein Phosphatase. J. Biol. Chem. 271: 1278-1281 [Abstract] [Full Text]  
  • Okamura, H., Resh, M. D. (1995). p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells. J. Biol. Chem. 270: 26613-26618 [Abstract] [Full Text]  
  • Dai, Z, Pendergast, A M (1995). Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.. Genes Dev. 9: 2569-2582 [Abstract]  
  • Klint, P., Kanda, S., Claesson-Welsh, L. (1995). Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells. J. Biol. Chem. 270: 23337-23344 [Abstract] [Full Text]  
  • Vuori, K., Ruoslahti, E. (1995). Tyrosine Phosphorylation of p130[IMAGE] and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix. J. Biol. Chem. 270: 22259-22262 [Abstract] [Full Text]  
  • Calautti, E, Missero, C, Stein, P L, Ezzell, R M, Dotto, G P (1995). fyn tyrosine kinase is involved in keratinocyte differentiation control.. Genes Dev. 9: 2279-2291 [Abstract]  
  • Williams, M. E., Gaffey, M. J., Weiss, L. M., Wilczynski, S. P., Schuuring, E., Levine, P. A. (1993). Chromosome 11Q13 Amplification in Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg 119: 1238-1243 [Abstract]  
  • Kapus, A., Di Ciano, C., Sun, J., Zhan, X., Kim, L., Wong, T. W., Rotstein, O. D. (2000). Cell Volume-dependent Phosphorylation of Proteins of the Cortical Cytoskeleton and Cell-Cell Contact Sites. THE ROLE OF Fyn AND FER KINASES. J. Biol. Chem. 275: 32289-32298 [Abstract] [Full Text]  
  • Li, Y., Liu, J., Zhan, X. (2000). Tyrosine Phosphorylation of Cortactin Is Required for H2O2-mediated Injury of Human Endothelial Cells. J. Biol. Chem. 275: 37187-37193 [Abstract] [Full Text]  
  • Bourguignon, L. Y. W., Zhu, H., Shao, L., Chen, Y.-W. (2001). CD44 Interaction with c-Src Kinase Promotes Cortactin-mediated Cytoskeleton Function and Hyaluronic Acid-dependent Ovarian Tumor Cell Migration. J. Biol. Chem. 276: 7327-7336 [Abstract] [Full Text]  


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