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Mol Cell Biol. 1991 December; 11(12): 6041-6049

A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.

T Morinaga, H Yasuda, T Hashimoto, K Higashio and T Tamaoki

Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Japan.

ABSTRACT

We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that this is the largest DNA-binding protein (306 kDa) known to date, containing four homeodomains, 17 zinc finger motifs, and a number of segments potentially involved in transcriptional regulation. Although the exact function of this protein has not been determined, these structural features suggest that ATBF1 plays a transcriptional regulatory role.

Mol Cell Biol. 1991 December; 11(12): 6041-6049




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