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Mol Cell Biol. 1991 February; 11(2): 1156-1160

B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.

C Murre, A Voronova and D Baltimore

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

ABSTRACT

Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.

Mol Cell Biol. 1991 February; 11(2): 1156-1160




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