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Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein.

Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232.

ABSTRACT

FBR murine sarcoma virus (gag-fos) protein, a virally transduced Fos protein, exhibits decreased gene transactivation in comparison with the cellular Fos protein. Biochemical analysis suggests that myristylation of the virally encoded N-terminal gag region results in decreased DNA binding and transcriptional activation without affecting heterodimerization with Jun protein. These findings demonstrate that protein myristylation can modulate gene regulation by a DNA-binding protein.

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