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Mol Cell Biol. 1991 March; 11(3): 1724-1728

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

J M Ruppert, B Vogelstein and K W Kinzler

Johns Hopkins Oncology Center, Baltimore, Maryland 21231-1001.

ABSTRACT

The GLI gene was previously isolated by virtue of its amplification in human glioblastomas. We have now found that GLI expression can result in the in vitro transformation of both primary and secondary rodent cells. When coexpressed with adenovirus E1A, the GLI protein functions analogously to RAS, resulting in the formation of dense foci of cells which are tumorigenic in nude mice.

Mol Cell Biol. 1991 March; 11(3): 1724-1728




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