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Mol Cell Biol. 1991 March; 11(3): 1739-1744

Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.

X He, R Gerrero, D M Simmons, R E Park, C J Lin, L W Swanson and M G Rosenfeld

Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648.

ABSTRACT

Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.

Mol Cell Biol. 1991 March; 11(3): 1739-1744




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