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Mol Cell Biol. 1991 April; 11(4): 2189-2199

Developmental expression of Sp1 in the mouse.

J D Saffer, S P Jackson and M B Annarella

Jackson Laboratory, Bar Harbor, Maine 04609.

ABSTRACT

The expression of the trans-acting transcription factor Sp1 in mice was defined by a combination of RNA analysis and immunohistochemical localization of the Sp1 protein. Although ubiquitously expressed, there was an unexpected difference of at least 100-fold in the amount of Sp1 message in different cell types. Sp1 protein levels showed corresponding marked differences. Substantial variations in Sp1 expression were also found in some cell types at different stages of development. Sp1 levels appeared to be highest in developing hematopoietic cells, fetal cells, and spermatids, suggesting that an elevated Sp1 level is associated with the differentiation process. These results indicate that Sp1 has a regulatory function in addition to its general role in the transcription of housekeeping genes.

Mol Cell Biol. 1991 April; 11(4): 2189-2199




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  • Her, S., Bell, R. A., Bloom, A. K., Siddall, B. J., Wong, D. L. (1999). Phenylethanolamine N-Methyltransferase Gene Expression. SP1 AND MAZ POTENTIAL FOR TISSUE-SPECIFIC EXPRESSION. J. Biol. Chem. 274: 8698-8707 [Abstract] [Full Text]  
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  • McClure, R. F., Heppelmann, C. J., Paya, C. V. (1999). Constitutive Fas Ligand Gene Transcription in Sertoli Cells Is Regulated By Sp1. J. Biol. Chem. 274: 7756-7762 [Abstract] [Full Text]  
  • Lan, Z.-J., Lye, R. J., Holic, N., Labus, J. C., Hinton, B. T. (1999). Involvement of Polyomavirus Enhancer Activator 3 in the Regulation of Expression of Gamma-Glutamyl Transpeptidase Messenger Ribonucleic Acid-IV in the Rat Epididymis. Biol. Reprod. 60: 664-673 [Abstract] [Full Text]  
  • Campos-Caro, A., Carrasco-Serrano, C., Valor, L. M., Viniegra, S., Ballesta, J. J., Criado, M. (1999). Multiple Functional Sp1 Domains in the Minimal Promoter Region of the Neuronal Nicotinic Receptor alpha 5 Subunit Gene. J. Biol. Chem. 274: 4693-4701 [Abstract] [Full Text]  
  • Ray, A., Schatten, H., Ray, B. K. (1999). Activation of Sp1 and Its Functional Co-operation with Serum Amyloid A-activating Sequence Binding Factor in Synoviocyte Cells Trigger Synergistic Action of Interleukin-1 and Interleukin-6 in Serum Amyloid A Gene Expression. J. Biol. Chem. 274: 4300-4308 [Abstract] [Full Text]  
  • Wildhage, I., Trusheim, H., Göke, B., Lankat-Buttgereit, B. (1999). Gene Expression of the Human Glucagon-Like Peptide-1 Receptor Is Regulated by Sp1 and Sp3. Endocrinology 140: 624-631 [Abstract] [Full Text]  
  • Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., Inoue, M. (1999). Cloning of Human Telomerase Catalytic Subunit (hTERT) Gene Promoter and Identification of Proximal Core Promoter Sequences Essential for Transcriptional Activation in Immortalized and Cancer Cells. Cancer Res. 59: 551-557 [Abstract] [Full Text]  
  • Marziali, G., Perrotti, E., Ilari, R., Coccia, E. M., Mantovani, R., Testa, U., Battistini, A. (1999). The Activity of the CCAAT-box Binding Factor NF-Y Is Modulated Through the Regulated Expression of Its A Subunit During Monocyte to Macrophage Differentiation: Regulation of Tissue-Specific Genes Through a Ubiquitous Transcription Factor. Blood 93: 519-526 [Abstract] [Full Text]  
  • Nuchprayoon, I., Shang, J., Simkevich, C. P., Luo, M., Rosmarin, A. G., Friedman, A. D. (1999). An Enhancer Located between the Neutrophil Elastase and Proteinase 3 Promoters Is Activated by Sp1 and an Ets Factor. J. Biol. Chem. 274: 1085-1091 [Abstract] [Full Text]  
  • Hauses, M., Tonjes, R. R., Grez, M. (1998). The Transcription Factor Sp1 Regulates the Myeloid-specific Expression of the Human Hematopoietic Cell Kinase (HCK) Gene through Binding to Two Adjacent GC Boxes within the HCK Promoter-Proximal Region. J. Biol. Chem. 273: 31844-31852 [Abstract] [Full Text]  
  • Li, J., Qu, X., Schmidt, A. M. (1998). Sp1-binding Elements in the Promoter of RAGE Are Essential for Amphoterin-mediated Gene Expression in Cultured Neuroblastoma Cells. J. Biol. Chem. 273: 30870-30878 [Abstract] [Full Text]  
  • Rajakumar, R. A., Thamotharan, S., Menon, R. K., Devaskar, S. U. (1998). Sp1 and Sp3 Regulate Transcriptional Activity of the Facilitative Glucose Transporter Isoform-3 Gene in Mammalian Neuroblasts and Trophoblasts. J. Biol. Chem. 273: 27474-27483 [Abstract] [Full Text]  
  • Ko, J. L., Liu, H.-C., Minnerath, S. R., Loh, H. H. (1998). Transcriptional Regulation of Mouse µ-Opioid Receptor Gene. J. Biol. Chem. 273: 27678-27685 [Abstract] [Full Text]  


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