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Mol Cell Biol. 1991 May; 11(5): 2460-2466

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

Department of Microbiology and Immunology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

ABSTRACT

Transient expression of some proto-oncogenes, cytokines, and transcription factors occurs as a cellular response to growth factors, 12-O-tetradecanoylphorbol-13-acetate, antigen stimulation, or inflammation. Expression of these genes is mediated in part by the rapid turnover of their mRNAs. A + U-rich elements in the 3' untranslated regions of these mRNAs serve as one recognition signal targeting the mRNAs for rapid degradation. I report the identification of a cytosolic factor that both binds to the proto-oncogene c-myc A + U-rich element and specifically destabilizes c-myc mRNA in a cell-free mRNA decay system which reconstitutes mRNA decay processes found in cells. Proteinase K treatment of the factor abolishes its c-myc mRNA degradation activity without affecting its RNA-binding capacity. Thus, RNA substrate binding and degradation appear to be separable functions. These findings should aid in understanding how the cell selectively targets mRNAs for rapid turnover.

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• Lin, S., Wang, W., Wilson, G. M., Yang, X., Brewer, G., Holbrook, N. J., Gorospe, M. (2000). Down-Regulation of Cyclin D1 Expression by Prostaglandin A2 Is Mediated by Enhanced Cyclin D1 mRNA Turnover. Mol. Cell. Biol. 20: 7903-7913 [Abstract] [Full Text]  
• Farhana, L., Boyanapalli, M., Tschang, S.-H. R., Sun, R.-J., Hsu, C. K. A., Zhang, Y.-X., Fontana, J. A., Rishi, A. K. (2000). Okadaic Acid-mediated Induction of the c-fos Gene in Estrogen Receptor-negative Human Breast Carcinoma Cells Utilized, in Part, Posttranscriptional Mechanisms Involving Adenosine-Uridine-rich Elements. Cell Growth Differ. 11: 541-550 [Abstract] [Full Text]  
• Zhao, Z., Chang, F.-C., Furneaux, H. M. (2000). The identification of an endonuclease that cleaves within an HuR binding site in mRNA. Nucleic Acids Res 28: 2695-2701 [Abstract] [Full Text]  
• Mbella, E. G. M., Bertrand, S., Huez, G., Octave, J.-N. (2000). A GG Nucleotide Sequence of the 3' Untranslated Region of Amyloid Precursor Protein mRNA Plays a Key Role in the Regulation of Translation and the Binding of Proteins. Mol. Cell. Biol. 20: 4572-4579 [Abstract] [Full Text]  
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• Stoecklin, G., Ming, X.-F., Looser, R., Moroni, C. (2000). Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway. Mol. Cell. Biol. 20: 3753-3763 [Abstract] [Full Text]  
• Janz, A., Sevignani, C., Kenyon, K., Ngo, C. V., Thomas-Tikhonenko, A. (2000). Activation of the Myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA. Nucleic Acids Res 28: 2268-2275 [Abstract] [Full Text]  
• Chen, C.-Y., Gherzi, R., Andersen, J. S., Gaietta, G., Jürchott, K., Royer, H.-D., Mann, M., Karin, M. (2000). Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 14: 1236-1248 [Abstract] [Full Text]  
• Shetty, S., Idell, S. (2000). Post-transcriptional Regulation of Urokinase mRNA. IDENTIFICATION OF A NOVEL UROKINASE mRNA-BINDING PROTEIN IN HUMAN LUNG EPITHELIAL CELLS IN VITRO. J. Biol. Chem. 275: 13771-13779 [Abstract] [Full Text]  
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• Blaxall, B. C., Pellett, A. C., Wu, S. C., Pende, A., Port, J. D. (2000). Purification and Characterization of beta -Adrenergic Receptor mRNA-binding Proteins. J. Biol. Chem. 275: 4290-4297 [Abstract] [Full Text]  
• Sheflin, L. G., Spaulding, S. W. (2000). Testosterone and dihydrotestosterone regulate AUF1 isoforms in a tissue-specific fashion in the mouse. Am. J. Physiol. Endocrinol. Metab. 278: E50-E57 [Abstract] [Full Text]  
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• Wilson, G. M., Sun, Y., Lu, H., Brewer, G. (1999). Assembly of AUF1 Oligomers on U-rich RNA Targets by Sequential Dimer Association. J. Biol. Chem. 274: 33374-33381 [Abstract] [Full Text]  
• Aulak, K. S., Mishra, R., Zhou, L., Hyatt, S. L., de Jonge, W., Lamers, W., Snider, M., Hatzoglou, M. (1999). Post-transcriptional Regulation of the Arginine Transporter Cat-1 by Amino Acid Availability. J. Biol. Chem. 274: 30424-30432 [Abstract] [Full Text]  
• Poon, M., Liu, B., Taubman, M. B. (1999). Identification of a Novel Dexamethasone-Sensitive RNA-Destabilizing Region on Rat Monocyte Chemoattractant Protein 1 mRNA. Mol. Cell. Biol. 19: 6471-6478 [Abstract] [Full Text]  
• Morris, A. J., Malbon, C. C. (1999). Physiological Regulation of G Protein-Linked Signaling. Physiol. Rev. 79: 1373-1430 [Abstract] [Full Text]  
• Stevens, M. J., Hosaka, Y., Masterson, J. A., Jones, S. M., Thomas, T. P., Larkin, D. D. (1999). Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells. Am. J. Physiol. Endocrinol. Metab. 277: E760-E771 [Abstract] [Full Text]  
• Searles, C. D., Miwa, Y., Harrison, D. G., Ramasamy, S. (1999). Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase During Cell Growth. Circ. Res. 85: 588-595 [Abstract] [Full Text]  
• Loflin, P., Chen, C.-Y. A., Shyu, A.-B. (1999). Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev. 13: 1884-1897 [Abstract] [Full Text]  
• Wang, Z., Day, N., Trifillis, P., Kiledjian, M. (1999). An mRNA Stability Complex Functions with Poly(A)-Binding Protein To Stabilize mRNA In Vitro. Mol. Cell. Biol. 19: 4552-4560 [Abstract] [Full Text]  
• Brewer, G. (1999). Evidence for a 3'-5' Decay Pathway for c-myc mRNA in Mammalian Cells. J. Biol. Chem. 274: 16174-16179 [Abstract] [Full Text]  
• Wilson, G. M., Sun, Y., Sellers, J., Lu, H., Penkar, N., Dillard, G., Brewer, G. (1999). Regulation of AUF1 Expression via Conserved Alternatively Spliced Elements in the 3' Untranslated Region. Mol. Cell. Biol. 19: 4056-4064 [Abstract] [Full Text]  
• Laroia, G., Cuesta, R., Brewer, G., Schneider, R. J. (1999). Control of mRNA Decay by Heat Shock-Ubiquitin-Proteasome Pathway. Science 284: 499-502 [Abstract] [Full Text]  
• Jarrousse, A.-S., Petit, F., Kreutzer-Schmid, C., Gaedigk, R., Schmid, H.-P. (1999). Possible Involvement of Proteasomes (Prosomes) in AUUUA-mediated mRNA Decay. J. Biol. Chem. 274: 5925-5930 [Abstract] [Full Text]  
• Sokolowski, M., Furneaux, H., Schwartz, S. (1999). The Inhibitory Activity of the AU-Rich RNA Element in the Human Papillomavirus Type 1 Late 3' Untranslated Region Correlates with Its Affinity for the elav-Like HuR Protein. J. Virol. 73: 1080-1091 [Abstract] [Full Text]  
• Shih, S.-C., Claffey, K. P. (1999). Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L. J. Biol. Chem. 274: 1359-1365 [Abstract] [Full Text]  
• Ford, L. P., Watson, J., Keene, J. D., Wilusz, J. (1999). ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev. 13: 188-201 [Abstract] [Full Text]  
• Heise, T., Guidotti, L. G., Cavanaugh, V. J., Chisari, F. V. (1999). Hepatitis B Virus RNA-Binding Proteins Associated with Cytokine-Induced Clearance of Viral RNA from the Liver of Transgenic Mice. J. Virol. 73: 474-481 [Abstract] [Full Text]  
• Sivak, L. E., Pont-Kingdon, G., Le, K., Mayr, G., Tai, K.-F., Stevens, B. T., Carroll, W. L. (1999). A Novel Intron Element Operates Posttranscriptionally To Regulate Human N-myc Expression. Mol. Cell. Biol. 19: 155-163 [Abstract] [Full Text]  
• Nair, A. P. K., Hirsch, H. H., Colombi, M., Moroni, C. (1999). Cyclosporin A Promotes Translational Silencing of Autocrine Interleukin-3 via Ribosome-Associated Deadenylation. Mol. Cell. Biol. 19: 889-898 [Abstract] [Full Text]  
• Brewer, G. (1998). Characterization of c-myc 3' to 5' mRNA Decay Activities in an in Vitro System. J. Biol. Chem. 273: 34770-34774 [Abstract] [Full Text]  
• Fan, X. C., Steitz, J. A. (1998). HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc. Natl. Acad. Sci. USA 95: 15293-15298 [Abstract] [Full Text]  
• Zhou, J., Wu, K., Fernandes, C. L., Cheng, A. L., Finch, P. W. (1998). Keratinocyte Growth Factor Down-regulates Expression of the Sucrase-Isomaltase Gene in Caco-2 Intestinal Epithelial Cells. J. Biol. Chem. 273: 33367-33373 [Abstract] [Full Text]  
• Chiaberge, S., Cassarino, E., Mangiarotti, G. (1998). The Phosphorylation of Protein S6 Modulates the Interaction of the 40 S Ribosomal Subunit with the 5'-Untranslated Region of a Dictyostelium Pre-spore-specific mRNA and Controls Its Stability. J. Biol. Chem. 273: 27070-27075 [Abstract] [Full Text]  
• Fraboulet, S., Boudouresque, F., Delfino, C., Ouafik, L'H. (1998). Identification of a Novel cis-Element in the 3'-Untranslated Region of Mammalian Peptidylglycine {alpha}-Amidating Monooxygenase Messenger Ribonucleic Acid. Endocrinology 139: 894-904 [Abstract] [Full Text]  
• Claffey, K. P., Shih, S.-C., Mullen, A., Dziennis, S., Cusick, J. L., Abrams, K. R., Lee, S. W., Detmar, M. (1998). Identification of a Human VPF/VEGF 3' Untranslated Region Mediating Hypoxia-induced mRNA Stability. Mol. Biol. Cell 9: 469-481 [Abstract] [Full Text]  
• Hamilton, B. J., Burns, C. M., Nichols, R. C., Rigby, W. F. C. (1997). Modulation of AUUUA Response Element Binding by Heterogeneous Nuclear Ribonucleoprotein A1 in Human T Lymphocytes. THE ROLES OF CYTOPLASMIC LOCATION, TRANSCRIPTION, AND PHOSPHORYLATION. J. Biol. Chem. 272: 28732-28741 [Abstract] [Full Text]  
• Qian, J. X., Lee, S. m., Suen, Y., Knoppel, E., van de Ven, C., Cairo, M. S. (1997). Decreased Interleukin-15 From Activated Cord Versus Adult Peripheral Blood Mononuclear Cells and the Effect of Interleukin-15 in Upregulating Antitumor Immune Activity and Cytokine Production in Cord Blood. Blood 90: 3106-3117 [Abstract] [Full Text]  
• Fan, X. C., Myer, V. E., Steitz, J. A. (1997). AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation. Genes Dev. 11: 2557-2568 [Abstract] [Full Text]  
• Tholanikunnel, B. G., Malbon, C. C. (1997). A 20-Nucleotide (A+U)-rich Element of beta 2-Adrenergic Receptor (beta 2AR) mRNA Mediates Binding to beta 2AR-binding Protein and Is Obligate for Agonist-induced Destabilization of Receptor mRNA. J. Biol. Chem. 272: 11471-11478 [Abstract] [Full Text]  
• Wada, S., Udagawa, N., Akatsu, T., Nagata, N., Martin, T. J., Findlay, D. M. (1997). Regulation by Calcitonin and Glucocorticoids of Calcitonin Receptor Gene Expression in Mouse Osteoclasts. Endocrinology 138: 521-529 [Abstract] [Full Text]  
• Lai, E., Posakony, J. (1997). The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development 124: 4847-4856 [Abstract]  
• Chagnovich, D., Cohn, S. L. (1996). Binding of a 40-kDa Protein to the N-myc 3'-Untranslated Region Correlates with Enhanced N-myc Expression in Human Neuroblastoma. J. Biol. Chem. 271: 33580-33586 [Abstract] [Full Text]  
• Rajagopalan, L. E., Malter, J. S. (1996). Turnover and Translation of in Vitro Synthesized Messenger RNAs in Transfected, Normal Cells. J. Biol. Chem. 271: 19871-19876 [Abstract] [Full Text]  
• Amara, F. M., Sun, J., Wright, J. A. (1996). Defining a Novel cis-Element in the 3'-Untranslated Region of Mammalian Ribonucleotide Reductase Component R2 mRNA. cis-trans-INTERACTIONS AND MESSAGE STABILITY. J. Biol. Chem. 271: 20126-20131 [Abstract] [Full Text]  
• Amara, F. M., Entwistle, J., Kuschak, T. I., Turley, E. A., Wright, J. A. (1996). Transforming Growth Factor-beta 1 Stimulates Multiple Protein Interactions at a Unique cis-Element in the 3'-Untranslated Region of the Hyaluronan Receptor RHAMM mRNA. J. Biol. Chem. 271: 15279-15284 [Abstract] [Full Text]  
• Winzen, R., Kafert, S., Mylius-Spencker, B. P. H. A., Resch, K., Holtmann, H. (1996). Interaction between the mRNA of the 55-kDa Tumor Necrosis Factor Receptor and Cellular Proteins. POSSIBLE INVOLVEMENT IN POST-TRANSCRIPTIONAL REGULATION OF RECEPTOR EXPRESSION. J. Biol. Chem. 271: 13461-13467 [Abstract] [Full Text]  
• DeMaria, C. T., Brewer, G. (1996). AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation. J. Biol. Chem. 271: 12179-12184 [Abstract] [Full Text]  
• Pende, A., Tremmel, K. D., DeMaria, C. T., Blaxall, B. C., Minobe, W. A., Sherman, J. A., Bisognano, J. D., Bristow, M. R., Brewer, G., Port, J. D. (1996). Regulation of the mRNA-binding Protein AUF1 by Activation of the beta-Adrenergic Receptor Signal Transduction Pathway. J. Biol. Chem. 271: 8493-8501 [Abstract] [Full Text]  
• Shi, M. M., Godleski, J. J., Paulauskis, J. D. (1996). Regulation of Macrophage Inflammatory Protein-1alpha mRNA by Oxidative Stress. J. Biol. Chem. 271: 5878-5883 [Abstract] [Full Text]  
• Margot, J. B., Williams, D. L. (1996). Estrogen Induces the Assembly of a Multiprotein Messenger Ribonucleoprotein Complex on the 3`-Untranslated Region of Chicken Apolipoprotein II mRNA. J. Biol. Chem. 271: 4452-4460 [Abstract] [Full Text]  
• Magnaldo, T, Barrandon, Y (1996). CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells. J. Cell Sci. 109: 3035-3045 [Abstract]  
• Peng, H., Lever, J. E. (1995). Regulation of Na[IMAGE]-coupled Glucose Transport in LLC-PK(1) Cells. J. Biol. Chem. 270: 23996-24003 [Abstract] [Full Text]  
• Caponigro, G, Parker, R (1995). Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.. Genes Dev. 9: 2421-2432 [Abstract]  
• Tholanikunnel, B. G., Granneman, J. G., Malbon, C. C. (1995). The M[IMAGE] 35,000 [IMAGE]-Adrenergic Receptor mRNA-binding Protein Binds Transcripts of G-protein-linked Receptors Which Undergo Agonist-induced Destabilization. J. Biol. Chem. 270: 12787-12793 [Abstract] [Full Text]  
• Dompenciel, R. E., Garnepudi, V. R., Schoenberg, D. R. (1995). Purification and Characterization of an Estrogen-regulated Xenopus Liver Polysomal Nuclease Involved in the Selective Destabilization of Albumin mRNA. J. Biol. Chem. 270: 6108-6118 [Abstract] [Full Text]  
• Nagy, E., Rigby, W. F. C. (1995). Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD[IMAGE]-binding Region (Rossmann Fold). J. Biol. Chem. 270: 2755-2763 [Abstract] [Full Text]  
• Sadot, E, Barg, J, Rasouly, D, Lazarovici, P, Ginzburg, I (1995). Short- and long-term mechanisms of tau regulation in PC12 cells. J. Cell Sci. 108: 2857-2864 [Abstract]  
• Pulak, R, Anderson, P (1993). mRNA surveillance by the Caenorhabditis elegans smg genes.. Genes Dev. 7: 1885-1897 [Abstract]  
• Brown, B D, Zipkin, I D, Harland, R M (1993). Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila.. Genes Dev. 7: 1620-1631 [Abstract]  
• Lowell, J E, Rudner, D Z, Sachs, A B (1992). 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.. Genes Dev. 6: 2088-2099 [Abstract]  
• Muhlrad, D, Parker, R (1992). Mutations affecting stability and deadenylation of the yeast MFA2 transcript.. Genes Dev. 6: 2100-2111 [Abstract]  
• Bernstein, P L, Herrick, D J, Prokipcak, R D, Ross, J (1992). Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant.. Genes Dev. 6: 642-654 [Abstract]