This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yamagoe, S Articles by Oishi, M Search for Related Content PubMed PubMed Citation Articles by Yamagoe, S Articles by Oishi, M

 Previous Article  |  Next Article 

Mol Cell Biol. 1991 July; 11(7): 3522-3527

Poly(ADP-ribose) polymerase inhibitors suppress UV-induced human immunodeficiency virus type 1 gene expression at the posttranscriptional level.

S Yamagoe, T Kohda and M Oishi

Institute of Applied Microbiology, University of Tokyo, Japan.

ABSTRACT

Gene expression of human immunodeficiency virus type 1 (HIV-1) is induced not only by trans activation mediated through a gene product (tat) encoded by the virus but also by treatment of virus-carrying cells with DNA-damaging agents such as UV light. Employing an artificially constructed DNA in which the chloramphenicol acetyltransferase gene was placed under the control of the HIV-1 long terminal repeat, we analyzed the induction process in HeLa cells and found that inhibitors of poly(ADP-ribose) polymerase suppressed UV-induced HIV-1 gene expression but not tat-mediated expression. We also found that suppression occurs at the posttranscriptional level. These results indicate that HIV-1 gene expression is activated by at least two different mechanisms, one of which involves poly-ADP ribosylation. A possible new role of poly-ADP ribosylation in the regulation of specific gene expression is also discussed.

---

Mol Cell Biol. 1991 July; 11(7): 3522-3527

This article has been cited by other articles:

• Parent, M., Yung, T. M. C., Rancourt, A., Ho, E. L. Y., Vispe, S., Suzuki-Matsuda, F., Uehara, A., Wada, T., Handa, H., Satoh, M. S. (2005). Poly(ADP-ribose) Polymerase-1 Is a Negative Regulator of HIV-1 Transcription through Competitive Binding to TAR RNA with Tat{middle dot}Positive Transcription Elongation Factor b (p-TEFb) Complex. J. Biol. Chem. 280: 448-457 [Abstract] [Full Text]  
• Virag, L., Szabo, C. (2002). The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors. Pharmacol. Rev. 54: 375-429 [Abstract] [Full Text]  
• Corroyer, S., Maitre, B., Cazals, V., Clement, A. (1996). Altered Regulation of G1 Cyclins in Oxidant-induced Growth Arrest of Lung Alveolar Epithelial Cells. ACCUMULATION OF INACTIVE CYCLIN E-CDK2 COMPLEXES. J. Biol. Chem. 271: 25117-25125 [Abstract] [Full Text]  
• Mosgoeller, W, Steiner, M, Hozak, P, Penner, E, Wesierska-Gadek, J (1996). Nuclear architecture and ultrastructural distribution of poly(ADP-ribosyl)transferase, a multifunctional enzyme. J. Cell Sci. 109: 409-418 [Abstract]