This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garrett, S
Right arrow Articles by Broach, J R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garrett, S
Right arrow Articles by Broach, J R

 Previous Article  |  Next Article 

Mol Cell Biol. 1991 August; 11(8): 4045-4052

The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle.

S Garrett, M M Menold and J R Broach

Section of Cell Growth, Regulation and Oncogenesis, Duke University Medical Center, Durham, North Carolina 27710.

ABSTRACT

Null mutations in the gene YAK1, which encodes a protein with sequence homology to known protein kinases, suppress the cell cycle arrest phenotype of mutants lacking the cyclic AMP-dependent protein kinase (A kinase). That is, loss of the YAK1 protein specifically compensates for loss of the A kinase. Here, we show that the protein encoded by YAK1 has protein kinase activity. Yak1 kinase activity is low during exponential growth but is induced at least 50-fold by arrest of cells prior to the completion of S phase. Induction is not observed by arrest at stages later in the cell cycle. Depending on the arrest regimen, induction can occur either by an increase in Yak1 protein levels or by an increase in Yak1 specific activity. Finally, an increase in Yak1 protein levels causes growth arrest of cells with attenuated A kinase activity. These results suggest that Yak1 acts in a pathway parallel to that of the A kinase to negatively regulate cell proliferation.

Mol Cell Biol. 1991 August; 11(8): 4045-4052




This article has been cited by other articles:

  • Deminoff, S. J., Ramachandran, V., Herman, P. K. (2009). Distal Recognition Sites in Substrates Are Required for Efficient Phosphorylation by the cAMP-Dependent Protein Kinase. Genetics 182: 529-539 [Abstract] [Full Text]  
  • Goyard, S., Knechtle, P., Chauvel, M., Mallet, A., Prevost, M.-C., Proux, C., Coppee, J.-Y., Schwartz, P., Dromer, F., Park, H., Filler, S. G., Janbon, G., d'Enfert, C. (2008). The Yak1 Kinase Is Involved in the Initiation and Maintenance of Hyphal Growth in Candida albicans. Mol. Biol. Cell 19: 2251-2266 [Abstract] [Full Text]  
  • Aragon, A. D., Rodriguez, A. L., Meirelles, O., Roy, S., Davidson, G. S., Tapia, P. H., Allen, C., Joe, R., Benn, D., Werner-Washburne, M. (2008). Characterization of Differentiated Quiescent and Nonquiescent Cells in Yeast Stationary-Phase Cultures. Mol. Biol. Cell 19: 1271-1280 [Abstract] [Full Text]  
  • Ren, M., Santhanam, A., Lee, P., Caplan, A., Garrett, S. (2007). Alteration of the Protein Kinase Binding Domain Enhances Function of the Saccharomyces cerevisiae Molecular Chaperone Cdc37. Eukaryot Cell 6: 1363-1372 [Abstract] [Full Text]  
  • Moir, R. D., Lee, J., Haeusler, R. A., Desai, N., Engelke, D. R., Willis, I. M. (2006). Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1. Proc. Natl. Acad. Sci. USA 103: 15044-15049 [Abstract] [Full Text]  
  • Budovskaya, Y. V., Stephan, J. S., Deminoff, S. J., Herman, P. K. (2005). An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 102: 13933-13938 [Abstract] [Full Text]  
  • Eguez, L., Chung, Y.-S., Kuchibhatla, A., Paidhungat, M., Garrett, S. (2004). Yeast Mn2+ Transporter, Smf1p, Is Regulated by Ubiquitin-Dependent Vacuolar Protein Sorting. Genetics 167: 107-117 [Abstract] [Full Text]  
  • Deng, X., Ewton, D. Z., Pawlikowski, B., Maimone, M., Friedman, E. (2003). Mirk/dyrk1B Is a Rho-induced Kinase Active in Skeletal Muscle Differentiation. J. Biol. Chem. 278: 41347-41354 [Abstract] [Full Text]  
  • Alvarez, M., Estivill, X., de la Luna, S. (2003). DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. J. Cell Sci. 116: 3099-3107 [Abstract] [Full Text]  
  • Jacquet, M., Renault, G., Lallet, S., De Mey, J., Goldbeter, A. (2003). Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. JCB 161: 497-505 [Abstract] [Full Text]  
  • Raich, W. B., Moorman, C., Lacefield, C. O., Lehrer, J., Bartsch, D., Plasterk, R. H. A., Kandel, E. R., Hobert, O. (2003). Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1A. Genetics 163: 571-580 [Abstract] [Full Text]  
  • Li, K., Zhao, S., Karur, V., Wojchowski, D. M. (2002). DYRK3 Activation, Engagement of Protein Kinase A/cAMP Response Element-binding Protein, and Modulation of Progenitor Cell Survival. J. Biol. Chem. 277: 47052-47060 [Abstract] [Full Text]  
  • Gauthier, L., Dziak, R., Kramer, D. J. H., Leishman, D., Song, X., Ho, J., Radovic, M., Bentley, D., Yankulov, K. (2002). The Role of the Carboxyterminal Domain of RNA Polymerase II in Regulating Origins of DNA Replication in Saccharomyces cerevisiae. Genetics 162: 1117-1129 [Abstract] [Full Text]  
  • Fotaki, V., Dierssen, M., Alcantara, S., Martinez, S., Marti, E., Casas, C., Visa, J., Soriano, E., Estivill, X., Arbones, M. L. (2002). Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice. Mol. Cell. Biol. 22: 6636-6647 [Abstract] [Full Text]  
  • Taminato, A., Bagattini, R., Gorjao, R., Chen, G., Kuspa, A., Souza, G. M. (2002). Role for YakA, cAMP, and Protein Kinase A in Regulation of Stress Responses of Dictyostelium discoideum Cells. Mol. Biol. Cell 13: 2266-2275 [Abstract] [Full Text]  
  • Yang, E. J., Ahn, Y. S., Chung, K. C. (2001). Protein Kinase Dyrk1 Activates cAMP Response Element-binding Protein during Neuronal Differentiation in Hippocampal Progenitor Cells. J. Biol. Chem. 276: 39819-39824 [Abstract] [Full Text]  
  • Moriya, H., Shimizu-Yoshida, Y., Omori, A., Iwashita, S., Katoh, M., Sakai, A. (2001). Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev. 15: 1217-1228 [Abstract] [Full Text]  
  • Zhang, Z., Smith, M. M., Mymryk, J. S. (2001). Interaction of the E1A Oncoprotein with Yak1p, a Novel Regulator of Yeast Pseudohyphal Differentiation, and Related Mammalian Kinases. Mol. Biol. Cell 12: 699-710 [Abstract] [Full Text]  
  • Geiger, J. N., Knudsen, G. T., Panek, L., Pandit, A. K., Yoder, M. D., Lord, K. A., Creasy, C. L., Burns, B. M., Gaines, P., Dillon, S. B., Wojchowski, D. M. (2001). mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Blood 97: 901-910 [Abstract] [Full Text]  
  • Qi, H., Zakian, V. A. (2000). The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein. Genes Dev. 14: 1777-1788 [Abstract] [Full Text]  
  • Irniger, S., Bäumer, M., Braus, G. H. (2000). Glucose and Ras Activity Influence the Ubiquitin Ligases APC/C and SCF in Saccharomyces cerevisiae. Genetics 154: 1509-1521 [Abstract] [Full Text]  
  • Souza, G., da Silva, A., Kuspa, A (1999). Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway. Development 126: 3263-3274 [Abstract]  
  • Becker, W., Weber, Y., Wetzel, K., Eirmbter, K., Tejedor, F. J., Joost, H.-G. (1998). Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases. J. Biol. Chem. 273: 25893-25902 [Abstract] [Full Text]  
  • Jaspersen, S. L., Charles, J. F., Tinker-Kulberg, R. L., Morgan, D. O. (1998). A Late Mitotic Regulatory Network Controlling Cyclin Destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9: 2803-2817 [Abstract] [Full Text]  
  • Reinders, A., Bürckert, N., Boller, T., Wiemken, A., De Virgilio, C. (1998). Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev. 12: 2943-2955 [Abstract] [Full Text]  
  • Moilanen, A.-M., Karvonen, U., Poukka, H., Jänne, O. A., Palvimo, J. J. (1998). Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase. Mol. Biol. Cell 9: 2527-2543 [Abstract] [Full Text]  
  • Souza, G., Lu, S, Kuspa, A (1998). YakA, a protein kinase required for the transition from growth to development in Dictyostelium. Development 125: 2291-2302 [Abstract]  
  • Kentrup, H., Becker, W., Heukelbach, Jör., Wilmes, A., Schürmann, A., Huppertz, C., Kainulainen, H., Joost, H.-G. (1996). Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII. J. Biol. Chem. 271: 3488-3495 [Abstract] [Full Text]  
  • Zhai, L., Graves, P. R., Robinson, L. C., Italiano, M., Culbertson, M. R., Rowles, J., Cobb, M. H., DePaoli-Roach, A. A., Roach, P. J. (1995). Casein Kinase I[IMAGE] Subfamily. J. Biol. Chem. 270: 12717-12724 [Abstract] [Full Text]  
  • van Es, S., Weening, K. E., Devreotes, P. N. (2001). The Protein Kinase YakA Regulates G-protein-linked Signaling Responses during Growth and Development of Dictyostelium. J. Biol. Chem. 276: 30761-30765 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»