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Mol Cell Biol. 1992 December; 12(12): 5581-5592

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT

Mutations in the p53 gene are most frequent in cancer. Many p53 mutants possess transforming activity in vitro. In cells transformed by such mutants, the mutant protein is oligomerized with endogenous cell p53. To determine the relevance of oligomerization for transformation, miniproteins containing C-terminal portions of p53 were generated. These miniproteins, although carrying no point mutation, transformed at least as efficiently as full-length mutant p53. Transforming activity was coupled with the ability to oligomerize with wild-type p53, as well as with the ability to abrogate sequence-specific DNA binding by coexpressed wild-type p53. These findings suggest that p53-mediated transformation may operate through a dominant negative mechanism, involving the generation of DNA binding-incompetent oligomers.

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• Webb, B. L., Jimenez, E., Martin, G. S. (2000). v-Src Generates a p53-Independent Apoptotic Signal. Mol. Cell. Biol. 20: 9271-9280 [Abstract] [Full Text]  
• Sigal, A., Rotter, V. (2000). Oncogenic Mutations of the p53 Tumor Suppressor: The Demons of the Guardian of the Genome. Cancer Res. 60: 6788-6793 [Abstract] [Full Text]  
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• Blander, G., Kipnis, J., Leal, J. F. M., Yu, C.-E., Schellenberg, G. D., Oren, M. (1999). Physical and Functional Interaction between p53 and the Werner's Syndrome Protein. J. Biol. Chem. 274: 29463-29469 [Abstract] [Full Text]  
• Seavey, S. E., Holubar, M., Saucedo, L. J., Perry, M. E. (1999). The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF. J. Virol. 73: 7590-7598 [Abstract] [Full Text]  
• Kasof, G. M., Goyal, L., White, E. (1999). Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins. Mol. Cell. Biol. 19: 4390-4404 [Abstract] [Full Text]  
• Juin, P., Hueber, A.-O., Littlewood, T., Evan, G. (1999). c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev. 13: 1367-1381 [Abstract] [Full Text]  
• Selivanova, G., Ryabchenko, L., Jansson, E., Iotsova, V., Wiman, K. G. (1999). Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain. Mol. Cell. Biol. 19: 3395-3402 [Abstract] [Full Text]  
• Delphin, C., Ronjat, M., Deloulme, J. C., Garin, G., Debussche, L., Higashimoto, Y., Sakaguchi, K., Baudier, J. (1999). Calcium-dependent Interaction of S100B with the C-terminal Domain of the Tumor Suppressor p53. J. Biol. Chem. 274: 10539-10544 [Abstract] [Full Text]  
• Mateu, M. G., Fersht, A. R. (1999). Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization. Proc. Natl. Acad. Sci. USA 96: 3595-3599 [Abstract] [Full Text]  
• Di Como, C. J., Gaiddon, C., Prives, C. (1999). p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells. Mol. Cell. Biol. 19: 1438-1449 [Abstract] [Full Text]  
• Gottifredi, V, Peschiaroli, A, Fimia, G., Maione, R (1999). p53-independent apoptosis induced by muscle differentiation stimuli in polyomavirus large T-expressing myoblasts. J. Cell Sci. 112: 2397-2407 [Abstract]  
• Bennett, M., Macdonald, K., Chan, S., Luzio, J. P., Simari, R., Weissberg, P. (1998). Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis. Science 282: 290-293 [Abstract] [Full Text]  
• Frazier, M. W., He, X., Wang, J., Gu, Z., Cleveland, J. L., Zambetti, G. P. (1998). Activation of c-myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain. Mol. Cell. Biol. 18: 3735-3743 [Abstract] [Full Text]  
• Robanus-Maandag, E., Dekker, M., van der Valk, M., Carrozza, M.-L., Jeanny, J.-C., Dannenberg, J.-H., Berns, A., te Riele, H. (1998). p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12: 1599-1609 [Abstract] [Full Text]  
• Bennett, M. R., Macdonald, K., Chan, S.-W., Boyle, J. J., Weissberg, P. L. (1998). Cooperative Interactions Between RB and p53 Regulate Cell Proliferation, Cell Senescence, and Apoptosis in Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques. Circ. Res. 82: 704-712 [Abstract] [Full Text]  
• Bennett, M. R., Littlewood, T. D., Schwartz, S. M., Weissberg, P. L. (1997). Increased Sensitivity of Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques to p53-Mediated Apoptosis. Circ. Res. 81: 591-599 [Abstract] [Full Text]  
• Silva, A., Wyllie, A., Collins, M. K.L. (1997). p53 Is Not Required for Regulation of Apoptosis or Radioprotection by Interleukin-3. Blood 89: 2717-2722 [Abstract] [Full Text]  
• Ronca, F., Chan, S.-L., Yu, V. C. (1997). 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine Induces Apoptosis in Human Neuroblastoma Cells, SH-SY5Y, through a p53-dependent Pathway. J. Biol. Chem. 272: 4252-4260 [Abstract] [Full Text]  
• Ostermeyer, A. G., Runko, E., Winkfield, B., Ahn, B., Moll, U. M. (1996). Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide. Proc. Natl. Acad. Sci. USA 93: 15190-15194 [Abstract] [Full Text]  
• Minn, A J, Boise, L H, Thompson, C B (1996). Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.. Genes Dev. 10: 2621-2631 [Abstract]  
• Sepehrnia, B., Paz, I. B., Dasgupta, G., Momand, J. (1996). Heat Shock Protein 84Forms a Complex with Mutant p53 Protein Predominantly within a Cytoplasmic Compartment of the Cell. J. Biol. Chem. 271: 15084-15090 [Abstract] [Full Text]  
• Ko, L J, Prives, C (1996). p53: puzzle and paradigm.. Genes Dev. 10: 1054-1072  
• Bowman, T, Symonds, H, Gu, L, Yin, C, Oren, M, Van Dyke, T (1996). Tissue-specific inactivation of p53 tumor suppression in the mouse.. Genes Dev. 10: 826-835 [Abstract]  
• Hansen, S., Hupp, T. R., Lane, D. P. (1996). Allosteric Regulation of the Thermostability and DNA Binding Activity of Human p53 by Specific Interacting Proteins. J. Biol. Chem. 271: 3917-3924 [Abstract] [Full Text]  
• Haupt, Y, Rowan, S, Shaulian, E, Vousden, K H, Oren, M (1995). Induction of apoptosis in HeLa cells by trans-activation-deficient p53.. Genes Dev. 9: 2170-2183 [Abstract]  
• Hsu, Y.-S., Tang, F.-M., Liu, W.-L., Chuang, J.-Y., Lai, M.-Y., Lin, Y.-S. (1995). Transcriptional Regulation by p53. J. Biol. Chem. 270: 6966-6974 [Abstract] [Full Text]  
• Jeffrey, P., Gorina, S, Pavletich, N. (1995). Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science 267: 1498-1502 [Abstract]  
• Miki, Y, Swensen, J, Shattuck-Eidens, D, Futreal, P., Harshman, K, Tavtigian, S, Liu, Q, Cochran, C, Bennett, L., Ding, W, et, al. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71 [Abstract]  
• Barak, Y, Gottlieb, E, Juven-Gershon, T, Oren, M (1994). Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.. Genes Dev. 8: 1739-1749 [Abstract]  
• Pavletich, N P, Chambers, K A, Pabo, C O (1993). The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.. Genes Dev. 7: 2556-2564 [Abstract]  
• Bargonetti, J, Manfredi, J J, Chen, X, Marshak, D R, Prives, C (1993). A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.. Genes Dev. 7: 2565-2574 [Abstract]  
• Wang, Y, Reed, M, Wang, P, Stenger, J E, Mayr, G, Anderson, M E, Schwedes, J F, Tegtmeyer, P (1993). p53 domains: identification and characterization of two autonomous DNA-binding regions.. Genes Dev. 7: 2575-2586 [Abstract]  
• Strano, S., Munarriz, E., Rossi, M., Cristofanelli, B., Shaul, Y., Castagnoli, L., Levine, A. J., Sacchi, A., Cesareni, G., Oren, M., Blandino, G. (2000). Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73. J. Biol. Chem. 275: 29503-29512 [Abstract] [Full Text]  
• Zaika, A., Irwin, M., Sansome, C., Moll, U. M. (2001). Oncogenes Induce and Activate Endogenous p73 Protein. J. Biol. Chem. 276: 11310-11316 [Abstract] [Full Text]  
• Manni, I., Mazzaro, G., Gurtner, A., Mantovani, R., Haugwitz, U., Krause, K., Engeland, K., Sacchi, A., Soddu, S., Piaggio, G. (2001). NF-Y Mediates the Transcriptional Inhibition of the cyclin B1, cyclin B2, and cdc25C Promoters upon Induced G2 Arrest. J. Biol. Chem. 276: 5570-5576 [Abstract] [Full Text]  
• Gentil, B. J., Delphin, C., Mbele, G. O., Deloulme, J. C., Ferro, M., Garin, J., Baudier, J. (2001). The Giant Protein AHNAK Is a Specific Target for the Calcium- and Zinc-binding S100B Protein. POTENTIAL IMPLICATIONS FOR Ca2+ HOMEOSTASIS REGULATION BY S100B. J. Biol. Chem. 276: 23253-23261 [Abstract] [Full Text]  
• Chinnaiyan, A. M., Prasad, U., Shankar, S., Hamstra, D. A., Shanaiah, M., Chenevert, T. L., Ross, B. D., Rehemtulla, A. (2000). Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc. Natl. Acad. Sci. USA 97: 1754-1759 [Abstract] [Full Text]  
• Scott, S., O'Sullivan, M., Hafizi, S., Shapiro, L. M., Bennett, M. R. (2002). Human Vascular Smooth Muscle Cells From Restenosis or In-Stent Stenosis Sites Demonstrate Enhanced Responses to p53: Implications for Brachytherapy and Drug Treatment for Restenosis. Circ. Res. 90: 398-404 [Abstract] [Full Text]