This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burrus, L W Articles by Olwin, B B Search for Related Content PubMed PubMed Citation Articles by Burrus, L W Articles by Olwin, B B

 Previous Article  |  Next Article 

Mol Cell Biol. 1992 December; 12(12): 5600-5609

Identification of a cysteine-rich receptor for fibroblast growth factors.

Department of Biochemistry, University of Wisconsin, Madison 53706.

ABSTRACT

The fibroblast growth factor (FGF) family consists of seven members whose activities are thought to be mediated by multiple receptors. Here we describe the cDNA cloning, expression, and characterization of a cysteine-rich FGF receptor (CFR) that is distinct from previously identified FGF receptors. The deduced amino acid sequence for CFR suggests that it is an integral membrane protein containing a large extracellular domain comprising 16 cysteine-rich repeated units and an intracellular domain of 13 amino acids. No reported sequences exhibit significant homologies to either the repeated extracellular motif or to the entire CFR amino acid sequence. Several CFR transcripts are present in embryonic chick tissue, suggesting that CFR undergoes alternate mRNA splicing or that related genes are present. Chinese hamster ovary cells transfected with the CFR cDNA express a 150-kDa polypeptide that binds FGF-1, FGF-2, and FGF-4 but does not bind several non-FGF family members. The high degree of evolutionary conservation among vertebrate CFRs and its ability to bind three different FGFs with high affinity suggest that this unique receptor plays an important role in FGF biology.

This article has been cited by other articles:

• Ahn, J., Febbraio, M., Silverstein, R. L. (2005). A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. J. Cell Sci. 118: 1725-1731 [Abstract] [Full Text]  
• Pohle, T., Brandlein, S., Ruoff, N., Muller-Hermelink, H. K., Vollmers, H. P. (2004). Lipoptosis: Tumor-Specific Cell Death by Antibody-Induced Intracellular Lipid Accumulation. Cancer Res. 64: 3900-3906 [Abstract] [Full Text]  
• Brandlein, S., Pohle, T., Ruoff, N., Wozniak, E., Muller-Hermelink, H.-K., Vollmers, H. P. (2003). Natural IgM Antibodies and Immunosurveillance Mechanisms against Epithelial Cancer Cells in Humans. Cancer Res. 63: 7995-8005 [Abstract] [Full Text]  
• Brandlein, S., Beyer, I., Eck, M., Bernhardt, W., Hensel, F., Muller-Hermelink, H. K., Vollmers, H. P. (2003). Cysteine-rich Fibroblast Growth Factor Receptor 1, a New Marker for Precancerous Epithelial Lesions Defined by the Human Monoclonal Antibody PAM-1. Cancer Res. 63: 2052-2061 [Abstract] [Full Text]  
• Reimers, K., Antoine, M., Zapatka, M., Blecken, V., Dickson, C., Kiefer, P. (2001). NoBP, a Nuclear Fibroblast Growth Factor 3 Binding Protein, Is Cell Cycle Regulated and Promotes Cell Growth. Mol. Cell. Biol. 21: 4996-5007 [Abstract] [Full Text]  
• Beer, H.-D., Vindevoghel, L., Gait, M. J., Revest, J.-M., Duan, D. R., Mason, I., Dickson, C., Werner, S. (2000). Fibroblast Growth Factor (FGF) Receptor 1-IIIb Is a Naturally Occurring Functional Receptor for FGFs That Is Preferentially Expressed in the Skin and the Brain. J. Biol. Chem. 275: 16091-16097 [Abstract] [Full Text]  
• Klingenberg, O, Wiedlocha, A, Rapak, A, Khnykin, D, Citores, L, Olsnes, S (2000). Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus. J. Cell Sci. 113: 1827-1838 [Abstract]  
• Citores, L., Wesche, J., Kolpakova, E., Olsnes, S. (1999). Uptake and Intracellular Transport of Acidic Fibroblast Growth Factor: Evidence for Free and Cytoskeleton-anchored Fibroblast Growth Factor Receptors. Mol. Biol. Cell 10: 3835-3848 [Abstract] [Full Text]  
• Thompson, S. D., Franklyn, J. A., Watkinson, J. C., Verhaeg, J. M., Sheppard, M. C., Eggo, M. C. (1998). Fibroblast Growth Factors 1 and 2 and Fibroblast Growth Factor Receptor 1 Are Elevated in Thyroid Hyperplasia. J. Clin. Endocrinol. Metab. 83: 1336-1341 [Abstract] [Full Text]  
• Gonatas, J., Chen, Y., Stieber, A, Mourelatos, Z, Gonatas, N. (1998). Truncations of the C-terminal cytoplasmic domain of MG160, a medial Golgi sialoglycoprotein, result in its partial transport to the plasma membrane and filopodia. J. Cell Sci. 111: 249-260 [Abstract]  
• Zhou, Z., Zuber, M. E., Burrus, L. W., Olwin, B. B. (1997). Identification and Characterization of a Fibroblast Growth Factor (FGF) Binding Domain in the Cysteine-rich FGF Receptor. J. Biol. Chem. 272: 5167-5174 [Abstract] [Full Text]  
• Bikfalvi, A., Klein, S., Pintucci, G., Rifkin, D. B. (1997). Biological Roles of Fibroblast Growth Factor-2. Endocr. Rev. 18: 26-45 [Abstract] [Full Text]  
• Steegmaier, M, Borges, E, Berger, J, Schwarz, H, Vestweber, D (1997). The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. J. Cell Sci. 110: 687-694 [Abstract]  
• Roghani, M., Mohammadi, M., Schlessinger, J., Moscatelli, D. (1996). Induction of Urokinase-type Plasminogen Activator by Fibroblast Growth Factor (FGF)-2 Is Dependent on Expression of FGF Receptors and Does Not Require Activation of Phospholipase Cgamma 1. J. Biol. Chem. 271: 31154-31159 [Abstract] [Full Text]  
• Gonatas, J., Mourelatos, Z, Stieber, A, Lane, W., Brosius, J, Gonatas, N. (1995). MG-160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, binds basic fibroblast growth factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor. J. Cell Sci. 108: 457-467 [Abstract]  
• Krieger-Brauer, H. I., Medda, P., Kather, H. (2000). Basic Fibroblast Growth Factor Utilizes Both Types of Component Subunits of Gs for Dual Signaling in Human Adipocytes. STIMULATION OF ADENYLYL CYCLASE VIA Galpha s AND INHIBITION OF NADPH OXIDASE BY Gbeta gamma s. J. Biol. Chem. 275: 35920-35925 [Abstract] [Full Text]  
• Kohl, R., Antoine, M., Olwin, B. B., Dickson, C., Kiefer, P. (2000). Cysteine-rich Fibroblast Growth Factor Receptor Alters Secretion and Intracellular Routing of Fibroblast Growth Factor 3. J. Biol. Chem. 275: 15741-15748 [Abstract] [Full Text]