This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tsukiyama, T Articles by Niwa, O Search for Related Content PubMed PubMed Citation Articles by Tsukiyama, T Articles by Niwa, O

 Previous Article  |  Next Article 

Mol Cell Biol. 1992 March; 12(3): 1286-1291

Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.

Department of Pathology, Hiroshima University, Japan.

ABSTRACT

The embryonal long terminal repeat-binding protein, ELP, is present in undifferentiated mouse embryonal carcinoma cells. It binds to and suppresses transcription of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. We report here that ELP is a mouse homolog of Drosophila FTZ-F1, which positively regulates transcription of the fushi tarazu gene in blastoderm-stage embryos of the fly. As members of the steroid receptor superfamily, ELP and FTZ-F1 have both DNA binding and putative ligand binding domains which are well conserved between the two. ELP and FTZ-F1 function in cells in the extremely early stage of development. A high degree of conservation between the two transcription factors during the evolution of these species indicates the importance of their functions in early-stage embryogenesis. In addition, the sequence elements they recognize do not contain repeat units, in contrast to other steroid receptors, which usually bind to either palindromic or direct repeat sequences.

This article has been cited by other articles:

• Shima, Y., Zubair, M., Komatsu, T., Oka, S., Yokoyama, C., Tachibana, T., Hjalt, T. A., Drouin, J., Morohashi, K.-i. (2008). Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer. Mol. Endocrinol. 22: 1633-1646 [Abstract] [Full Text]  
• Suzuki, T., Miki, Y., Moriya, T., Shimada, N., Ishida, T., Hirakawa, H., Ohuchi, N., Sasano, H. (2004). Estrogen-Related Receptor {alpha} in Human Breast Carcinoma as a Potent Prognostic Factor. Cancer Res. 64: 4670-4676 [Abstract] [Full Text]  
• Liu, D., Zhang, Z., Gladwell, W., Teng, C. T. (2003). Estrogen Stimulates Estrogen-Related Receptor {alpha} Gene Expression through Conserved Hormone Response Elements. Endocrinology 144: 4894-4904 [Abstract] [Full Text]  
• Gu, B.-W., Xiong, H., Zhou, Y., Chen, B., Wang, L., Dong, S., Yu, Z.-Y., Lu, L.-F., Zhong, M., Yin, H.-F., Zhu, G.-F., Huang, W., Ren, S.-X., Gallagher, R. E., Waxman, S., Chen, G.-Q., Wang, Z.-G., Chen, Z., Fu, G., Chen, S.-J. (2002). Variant-type PML-RARalpha fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RARalpha gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc. Natl. Acad. Sci. USA 99: 7640-7645 [Abstract] [Full Text]  
• Pfeifer, A., Ikawa, M., Dayn, Y., Verma, I. M. (2002). Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc. Natl. Acad. Sci. USA 99: 2140-2145 [Abstract] [Full Text]  
• Parker, K. L., Rice, D. A., Lala, D. S., Ikeda, Y., Luo, X., Wong, M., Bakke, M., Zhao, L., Frigeri, C., Hanley, N. A., Stallings, N., Schimmer, B. P. (2002). Steroidogenic Factor 1: an Essential Mediator of Endocrine Development. Recent Prog Horm Res 57: 19-36 [Abstract] [Full Text]  
• Reuss, F. U., Berdel, B., Ploss, M., Heber, R. (2001). Replication of enhancer-deficient amphotropic murine leukemia virus in human cells. Proc. Natl. Acad. Sci. USA 10.1073/pnas.191182098v1 [Abstract] [Full Text]  
• Cherry, S. R., Biniszkiewicz, D., van Parijs, L., Baltimore, D., Jaenisch, R. (2000). Retroviral Expression in Embryonic Stem Cells and Hematopoietic Stem Cells. Mol. Cell. Biol. 20: 7419-7426 [Abstract] [Full Text]  
• Corley, D.R., Li, X., Lei, Z.M., Rao, Ch.V. (2000). Potential regulation of GnRH gene by a steroidogenic factor-1-like protein. Mol Hum Reprod 6: 671-676 [Abstract] [Full Text]  
• Dang, Q., Auten, J., Plavec, I. (2000). Human Beta Interferon Scaffold Attachment Region Inhibits De Novo Methylation and Confers Long-Term, Copy Number-Dependent Expression to a Retroviral Vector. J. Virol. 74: 2671-2678 [Abstract] [Full Text]  
• Barnea, E., Bergman, Y. (2000). Synergy of SF1 and RAR in Activation of Oct-3/4 Promoter. J. Biol. Chem. 275: 6608-6619 [Abstract] [Full Text]  
• Romano, G., Micheli, P., Pacilio, C., Giordano, A. (2000). Latest Developments in Gene Transfer Technology: Achievements, Perspectives, and Controversies over Therapeutic Applications. Stem Cells 18: 19-39 [Abstract] [Full Text]  
• Williams, D. A., Nienhuis, A. W., Hawley, R. G., Smith, F. O. (2000). Gene Therapy 2000. ASH Education Book 2000: 376-393 [Abstract] [Full Text]  
• Giguère, V. (1999). Orphan Nuclear Receptors: From Gene to Function. Endocr. Rev. 20: 689-725 [Abstract] [Full Text]  
• Li, M., Xie, Y.-H., Kong, Y.-Y., Wu, X., Zhu, L., Wang, Y. (1998). Cloning and Characterization of a Novel Human Hepatocyte Transcription Factor, hB1F, Which Binds and Activates Enhancer II of Hepatitis B Virus. J. Biol. Chem. 273: 29022-29031 [Abstract] [Full Text]  
• Robbins, P. B., Skelton, D. C., Yu, X.-J., Halene, S., Leonard, E. H., Kohn, D. B. (1998). Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 95: 10182-10187 [Abstract] [Full Text]  
• Ito, M., Yu, R. N., Jameson, J. L. (1998). Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1. Mol. Endocrinol. 12: 290-301 [Abstract] [Full Text]  
• Laker, C., Meyer, J., Schopen, A., Friel, J., Heberlein, C., Ostertag, W., Stocking, C. (1998). Host cis-Mediated Extinction of a Retrovirus Permissive for Expression in Embryonal Stem Cells during Differentiation. J. Virol. 72: 339-348 [Abstract] [Full Text]  
• Sem, D. S., Casimiro, D. R., Kliewer, S. A., Provencal, J., Evans, R. M., Wright, P. E. (1997). NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2. THE CARBOXYL-TERMINAL EXTENSION TO THE ZINC-FINGER REGION IS UNSTRUCTURED IN THE FREE FORM OF THE PROTEIN. J. Biol. Chem. 272: 18038-18043 [Abstract] [Full Text]  
• Parker, K. L., Schimmer, B. P. (1997). Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function. Endocr. Rev. 18: 361-377 [Abstract] [Full Text]  
• Liu, D., Le Drean, Y., Ekker, M., Xiong, F., Hew, C. L. (1997). Teleost FTZ-F1 Homolog and Its Splicing Variant Determine the Expression of the Salmon Gonadotropin II{beta} Subunit Gene. Mol. Endocrinol. 11: 877-890 [Abstract] [Full Text]  
• Nomura, M., Bärtsch, S., Nawata, H., Omura, T., Morohashi, K.-i. (1995). An E Box Element Is Required for the Expression of the ad4bp Gene, a Mammalian Homologue of ftz-f1 Gene, Which Is Essential for Adrenal and Gonadal Development. J. Biol. Chem. 270: 7453-7461 [Abstract] [Full Text]  
• Suchanek, B., Seeburg, P. H., Sprengel, R. (1995). Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C. J. Biol. Chem. 270: 41-44 [Abstract] [Full Text]  
• Giguere, V, Tini, M, Flock, G, Ong, E, Evans, R M, Otulakowski, G (1994). Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.. Genes Dev. 8: 538-553 [Abstract]  
• Reuss, F. U., Berdel, B., Ploss, M., Heber, R. (2001). Replication of enhancer-deficient amphotropic murine leukemia virus in human cells. Proc. Natl. Acad. Sci. USA 98: 10898-10903 [Abstract] [Full Text]