This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, R H
Right arrow Articles by Blenis, J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, R H
Right arrow Articles by Blenis, J

 Previous Article  |  Next Article 

Mol Cell Biol. 1992 March; 12(3): 915-927

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

R H Chen, C Sarnecki and J Blenis

Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115.

ABSTRACT

We demonstrate that members of the erk-encoded family of mitogen-activated protein (MAP) kinases (pp44/42mapk/erk) and members of the rsk-encoded protein kinases (RSKs or pp90rsk) are present in the cytoplasm and nucleus of HeLa cells. Addition of growth factors to serum-deprived cells results in increased tyrosine and threonine phosphorylation and in the activation of cytosolic and nuclear MAP kinases. Activated MAP kinases then phosphorylate (serine/threonine) and activate RSKs. Concurrently, a fraction of the activated MAP kinases and RSKs enter the nucleus. In addition, a distinct growth-regulated RSK-kinase activity (an enzyme[s] that phosphorylates recombinant RSK in vitro and that may be another member of the erk-encoded family of MAP kinases) was found associated with a postnuclear membrane fraction. Regulation of nuclear MAP kinase and RSK activities by growth factors and phorbol ester is coordinate with immediate-early gene expression. Indeed, in vitro, MAP kinase and/or RSK phosphorylates histone H3 and the recombinant c-Fos and c-Jun polypeptides, transcription factors phosphorylated in a variety of cells in response to growth stimuli. These in vitro studies raise the possibility that the MAP kinase/RSK signal transduction pathway represents a protein-Tyr/Ser/Thr phosphorylation cascade with the spatial distribution and temporal regulation that can account for the rapid transmission of growth-regulating information from the membrane, through the cytoplasm, and to the nucleus.


Mol Cell Biol. 1992 March; 12(3): 915-927




This article has been cited by other articles:

  • Abe, Y., Yoon, S.-O., Kubota, K., Mendoza, M. C., Gygi, S. P., Blenis, J. (2009). p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling. J. Biol. Chem. 284: 14939-14948 [Abstract] [Full Text]  
  • Armstrong, S. P., Caunt, C. J., McArdle, C. A. (2009). Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases. Mol. Endocrinol. 23: 510-519 [Abstract] [Full Text]  
  • Kakugawa, S., Shimojima, M., Goto, H., Horimoto, T., Oshimori, N., Neumann, G., Yamamoto, T., Kawaoka, Y. (2009). Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection. J. Virol. 83: 2510-2517 [Abstract] [Full Text]  
  • Levin-Salomon, V., Kogan, K., Ahn, N. G., Livnah, O., Engelberg, D. (2008). Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases. J. Biol. Chem. 283: 34500-34510 [Abstract] [Full Text]  
  • Caunt, C. J., Armstrong, S. P., Rivers, C. A., Norman, M. R., McArdle, C. A. (2008). Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases. J. Biol. Chem. 283: 26612-26623 [Abstract] [Full Text]  
  • Kajiya, M., Shiba, H., Fujita, T., Ouhara, K., Takeda, K., Mizuno, N., Kawaguchi, H., Kitagawa, M., Takata, T., Tsuji, K., Kurihara, H. (2008). Brain-derived Neurotrophic Factor Stimulates Bone/Cementum-related Protein Gene Expression in Cementoblasts. J. Biol. Chem. 283: 16259-16267 [Abstract] [Full Text]  
  • Zhang, H.-M., Li, L., Papadopoulou, N., Hodgson, G., Evans, E., Galbraith, M., Dear, M., Vougier, S., Saxton, J., Shaw, P. E. (2008). Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res 36: 2594-2607 [Abstract] [Full Text]  
  • Ma, C., Bower, K. A., Chen, G., Shi, X., Ke, Z.-J., Luo, J. (2008). Interaction between ERK and GSK3{beta} Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells. J. Biol. Chem. 283: 9248-9256 [Abstract] [Full Text]  
  • Wang, J., Yen, A. (2008). A MAPK-positive Feedback Mechanism for BLR1 Signaling Propels Retinoic Acid-triggered Differentiation and Cell Cycle Arrest. J. Biol. Chem. 283: 4375-4386 [Abstract] [Full Text]  
  • Lin, J.-X., Spolski, R., Leonard, W. J. (2008). Critical role for Rsk2 in T-lymphocyte activation. Blood 111: 525-533 [Abstract] [Full Text]  
  • Yazicioglu, M. N., Goad, D. L., Ranganathan, A., Whitehurst, A. W., Goldsmith, E. J., Cobb, M. H. (2007). Mutations in ERK2 Binding Sites Affect Nuclear Entry. J. Biol. Chem. 282: 28759-28767 [Abstract] [Full Text]  
  • Lee, N. Y., Blobe, G. C. (2007). The Interaction of Endoglin with beta-Arrestin2 Regulates Transforming Growth Factor-beta-mediated ERK Activation and Migration in Endothelial Cells. J. Biol. Chem. 282: 21507-21517 [Abstract] [Full Text]  
  • Jimenez, C., Cossio, B. R., Rivard, C. J., Berl, T., Capasso, J. M. (2007). Cell division in the unicellular microalga Dunaliella viridis depends on phosphorylation of extracellular signal-regulated kinases (ERKs). J Exp Bot 58: 1001-1011 [Abstract] [Full Text]  
  • Costa, M., Marchi, M., Cardarelli, F., Roy, A., Beltram, F., Maffei, L., Ratto, G. M. (2006). Dynamic regulation of ERK2 nuclear translocation and mobility in living cells. J. Cell Sci. 119: 4952-4963 [Abstract] [Full Text]  
  • Godeny, M. D., Sayeski, P. P. (2006). ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am. J. Physiol. Cell Physiol. 291: C1308-C1317 [Abstract] [Full Text]  
  • Kicka, S., Bonnet, C., Sobering, A. K., Ganesan, L. P., Silar, P. (2006). A mitotically inheritable unit containing a MAP kinase module. Proc. Natl. Acad. Sci. USA 103: 13445-13450 [Abstract] [Full Text]  
  • Hazan-Eitan, Z., Weinstein, Y., Hadad, N., Konforty, A., Levy, R. (2006). Induction of Fc{gamma}RIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2. Blood 108: 1758-1766 [Abstract] [Full Text]  
  • Chaturvedi, D., Poppleton, H. M., Stringfield, T., Barbier, A., Patel, T. B. (2006). Subcellular Localization and Biological Actions of Activated RSK1 Are Determined by Its Interactions with Subunits of Cyclic AMP-Dependent Protein Kinase. Mol. Cell. Biol. 26: 4586-4600 [Abstract] [Full Text]  
  • Ranganathan, A., Yazicioglu, M. N., Cobb, M. H. (2006). The Nuclear Localization of ERK2 Occurs by Mechanisms Both Independent of and Dependent on Energy. J. Biol. Chem. 281: 15645-15652 [Abstract] [Full Text]  
  • Kondoh, K., Terasawa, K., Morimoto, H., Nishida, E. (2006). Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.. Mol. Cell. Biol. 26: 1679-1690 [Abstract] [Full Text]  
  • Rey, O., Papazyan, R., Waldron, R. T., Young, S. H., Lippincott-Schwartz, J., Jacamo, R., Rozengurt, E. (2006). The Nuclear Import of Protein Kinase D3 Requires Its Catalytic Activity. J. Biol. Chem. 281: 5149-5157 [Abstract] [Full Text]  
  • Marenda, D. R., Vrailas, A. D., Rodrigues, A. B., Cook, S., Powers, M. A., Lorenzen, J. A., Perkins, L. A., Moses, K. (2006). MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development 133: 43-51 [Abstract] [Full Text]  
  • Sigoillot, F. D., Kotsis, D. H., Serre, V., Sigoillot, S. M., Evans, D. R., Guy, H. I. (2005). Nuclear Localization and Mitogen-activated Protein Kinase Phosphorylation of the Multifunctional Protein CAD. J. Biol. Chem. 280: 25611-25620 [Abstract] [Full Text]  
  • MacKeigan, J. P., Murphy, L. O., Dimitri, C. A., Blenis, J. (2005). Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells. Mol. Cell. Biol. 25: 4676-4682 [Abstract] [Full Text]  
  • Singh, R. R., Song, C., Yang, Z., Kumar, R. (2005). Nuclear Localization and Chromatin Targets of p21-activated Kinase 1. J. Biol. Chem. 280: 18130-18137 [Abstract] [Full Text]  
  • Refojo, D., Echenique, C., Muller, M. B., Reul, J. M. H. M., Deussing, J. M., Wurst, W., Sillaber, I., Paez-Pereda, M., Holsboer, F., Arzt, E. (2005). Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proc. Natl. Acad. Sci. USA 102: 6183-6188 [Abstract] [Full Text]  
  • Subramaniam, S., Shahani, N., Strelau, J., Laliberte, C., Brandt, R., Kaplan, D., Unsicker, K. (2005). Insulin-Like Growth Factor 1 Inhibits Extracellular Signal-Regulated Kinase to Promote Neuronal Survival via the Phosphatidylinositol 3-Kinase/Protein Kinase A/c-Raf Pathway. J. Neurosci. 25: 2838-2852 [Abstract] [Full Text]  
  • Mandl, M., Slack, D. N., Keyse, S. M. (2005). Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5. Mol. Cell. Biol. 25: 1830-1845 [Abstract] [Full Text]  
  • Yang, T. T. C., Xiong, Q., Graef, I. A., Crabtree, G. R., Chow, C.-W. (2005). Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex. Mol. Cell. Biol. 25: 907-920 [Abstract] [Full Text]  
  • Whitehurst, A., Cobb, M. H., White, M. A. (2004). Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways. Mol. Cell. Biol. 24: 10145-10150 [Abstract] [Full Text]  
  • Chen, J., Rusnak, M., Luedtke, R. R., Sidhu, A. (2004). D1 Dopamine Receptor Mediates Dopamine-induced Cytotoxicity via the ERK Signal Cascade. J. Biol. Chem. 279: 39317-39330 [Abstract] [Full Text]  
  • Hafizi, S., Wang, X., Chester, A. H., Yacoub, M. H., Proud, C. G. (2004). ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 287: H1232-H1238 [Abstract] [Full Text]  
  • See, V., Rajala, N. K.M., Spiller, D. G., White, M. R.H. (2004). Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-{kappa}B pathway in Swiss 3T3 cells. JCB 166: 661-672 [Abstract] [Full Text]  
  • Blois, J. T., Mataraza, J. M., Mecklenbrauker, I., Tarakhovsky, A., Chiles, T. C. (2004). B Cell Receptor-induced cAMP-response Element-binding Protein Activation in B Lymphocytes Requires Novel Protein Kinase C{delta}. J. Biol. Chem. 279: 30123-30132 [Abstract] [Full Text]  
  • Hu, Y., Fang, X., Dunham, S. M., Prada, C., Stachowiak, E. K., Stachowiak, M. K. (2004). 90-kDa Ribosomal S6 Kinase Is a Direct Target for the Nuclear Fibroblast Growth Factor Receptor 1 (FGFR1): ROLE IN FGFR1 SIGNALING. J. Biol. Chem. 279: 29325-29335 [Abstract] [Full Text]  
  • Bohuslav, J., Chen, L.-f., Kwon, H., Mu, Y., Greene, W. C. (2004). p53 Induces NF-{kappa}B Activation by an I{kappa}B Kinase-independent Mechanism Involving Phosphorylation of p65 by Ribosomal S6 Kinase 1. J. Biol. Chem. 279: 26115-26125 [Abstract] [Full Text]  
  • Imamura, Y., Katahira, T., Kitamura, D. (2004). Identification and Characterization of a Novel BASH N Terminus-associated Protein, BNAS2. J. Biol. Chem. 279: 26425-26432 [Abstract] [Full Text]  
  • Roux, P. P., Blenis, J. (2004). ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiol. Mol. Biol. Rev. 68: 320-344 [Abstract] [Full Text]  
  • Dalle, S., Longuet, C., Costes, S., Broca, C., Faruque, O., Fontes, G., Hani, E. H., Bataille, D. (2004). Glucagon Promotes cAMP-response Element-binding Protein Phosphorylation via Activation of ERK1/2 in MIN6 Cell Line and Isolated Islets of Langerhans. J. Biol. Chem. 279: 20345-20355 [Abstract] [Full Text]  
  • Woo, M. S., Ohta, Y., Rabinovitz, I., Stossel, T. P., Blenis, J. (2004). Ribosomal S6 Kinase (RSK) Regulates Phosphorylation of Filamin A on an Important Regulatory Site. Mol. Cell. Biol. 24: 3025-3035 [Abstract] [Full Text]  
  • Andresen, B. T., Romero, G. G., Jackson, E. K. (2004). AT2 Receptors Attenuate AT1 Receptor-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells. J. Pharmacol. Exp. Ther. 309: 425-431 [Abstract] [Full Text]  
  • Whitehurst, A. W., Robinson, F. L., Moore, M. S., Cobb, M. H. (2004). The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions. J. Biol. Chem. 279: 12840-12847 [Abstract] [Full Text]  
  • Boguslawski, G., McGlynn, P. W., Harvey, K. A., Kovala, A. T. (2004). SU1498, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Causes Accumulation of Phosphorylated ERK Kinases and Inhibits Their Activity in Vivo and in Vitro. J. Biol. Chem. 279: 5716-5724 [Abstract] [Full Text]  
  • Fingar, D. C., Richardson, C. J., Tee, A. R., Cheatham, L., Tsou, C., Blenis, J. (2004). mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E. Mol. Cell. Biol. 24: 200-216 [Abstract] [Full Text]  
  • Sananbenesi, F., Fischer, A., Schrick, C., Spiess, J., Radulovic, J. (2003). Mitogen-Activated Protein Kinase Signaling in the Hippocampus and Its Modulation by Corticotropin-Releasing Factor Receptor 2: A Possible Link between Stress and Fear Memory. J. Neurosci. 23: 11436-11443 [Abstract] [Full Text]  
  • Butcher, G. Q., Lee, B., Obrietan, K. (2003). Temporal Regulation of Light-Induced Extracellular Signal-Regulated Kinase Activation in the Suprachiasmatic Nucleus. J. Neurophysiol. 90: 3854-3863 [Abstract] [Full Text]  
  • Paruchuri, S., Sjolander, A. (2003). Leukotriene D4 Mediates Survival and Proliferation via Separate but Parallel Pathways in the Human Intestinal Epithelial Cell Line Int 407. J. Biol. Chem. 278: 45577-45585 [Abstract] [Full Text]  
  • Julien, C., Coulombe, P., Meloche, S. (2003). Nuclear Export of ERK3 by a CRM1-dependent Mechanism Regulates Its Inhibitory Action on Cell Cycle Progression. J. Biol. Chem. 278: 42615-42624 [Abstract] [Full Text]  
  • Nilsen, J., Brinton, R. D. (2003). Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc. Natl. Acad. Sci. USA 100: 10506-10511 [Abstract] [Full Text]  
  • Pei, J.-J., Gong, C.-X., An, W.-L., Winblad, B., Cowburn, R. F., Grundke-Iqbal, I., Iqbal, K. (2003). Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease. Am. J. Pathol. 163: 845-858 [Abstract] [Full Text]  
  • Kumar, J. P., Hsiung, F., Powers, M. A., Moses, K. (2003). Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye. Development 130: 3703-3714 [Abstract] [Full Text]  
  • Roux, P. P., Richards, S. A., Blenis, J. (2003). Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity. Mol. Cell. Biol. 23: 4796-4804 [Abstract] [Full Text]  
  • Torsoni, M. A., Carvalheira, J. B., Pereira-Da-Silva, M., de Carvalho-Filho, M. A., Saad, M. J. A., Velloso, L. A. (2003). Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am. J. Physiol. Endocrinol. Metab. 285: E216-E223 [Abstract] [Full Text]  
  • Zhao, L., Brinton, R. D. (2003). Vasopressin-Induced Cytoplasmic and Nuclear Calcium Signaling in Embryonic Cortical Astrocytes: Dynamics of Calcium and Calcium-Dependent Kinase Translocation. J. Neurosci. 23: 4228-4239 [Abstract] [Full Text]  
  • Schedlich, L. J., Nilsen, T., John, A. P., Jans, D. A., Baxter, R. C. (2003). Phosphorylation of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid-Dependent Protein Kinase Reduces Ligand Binding and Enhances Nuclear Accumulation. Endocrinology 144: 1984-1993 [Abstract] [Full Text]  
  • Wang, Z., Zhang, B., Wang, M., Carr, B. I. (2003). Persistent ERK Phosphorylation Negatively Regulates cAMP Response Element-binding Protein (CREB) Activity via Recruitment of CREB-binding Protein to pp90RSK. J. Biol. Chem. 278: 11138-11144 [Abstract] [Full Text]  
  • Williamson, D, Gallagher, P, Harber, M, Hollon, C, Trappe, S (2003). Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J. Physiol. 547: 977-987 [Abstract] [Full Text]  
  • Santamaria, A., Fernandez, P. L., Farre, X., Benedit, P., Reventos, J., Morote, J., Paciucci, R., Thomson, T. M. (2003). PTOV-1, a Novel Protein Overexpressed in Prostate Cancer, Shuttles between the Cytoplasm and the Nucleus and Promotes Entry into the S Phase of the Cell Division Cycle. Am. J. Pathol. 162: 897-905 [Abstract] [Full Text]  
  • Buitrago, C. G., Pardo, V. G., de Boland, A. R., Boland, R. (2003). Activation of RAF-1 through Ras and Protein Kinase Calpha Mediates 1alpha ,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells. J. Biol. Chem. 278: 2199-2205 [Abstract] [Full Text]  
  • Bai, J., Nakamura, H., Kwon, Y.-W., Hattori, I., Yamaguchi, Y., Kim, Y.-C., Kondo, N., Oka, S.-i., Ueda, S., Masutani, H., Yodoi, J. (2003). Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells. J. Neurosci. 23: 503-509 [Abstract] [Full Text]  
  • Seternes, O. M., Johansen, B., Hegge, B., Johannessen, M., Keyse, S. M., Moens, U. (2002). Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress. Mol. Cell. Biol. 22: 6931-6945 [Abstract] [Full Text]  
  • Bjorndal, B., Helleland, C., Boe, S.-O., Gudbrandsen, O. A., Kalland, K.-H., Bohov, P., Berge, R. K., Lillehaug, J. R. (2002). Nuclear import of factors involved in signaling is inhibited in C3H/10T1/2 cells treated with tetradecylthioacetic acid. J. Lipid Res. 43: 1630-1640 [Abstract] [Full Text]  
  • GOUNI-BERTHOLD, I., SACHINIDIS, A. (2002). Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?. FASEB J. 16: 1477-1487 [Abstract] [Full Text]  
  • Shibayama, S., Shibata-Seita, R., Miura, K., Kirino, Y., Takishima, K. (2002). Identification of a C-terminal Region That Is Required for the Nuclear Translocation of ERK2 by Passive Diffusion. J. Biol. Chem. 277: 37777-37782 [Abstract] [Full Text]  
  • Noshita, N., Sugawara, T., Hayashi, T., Lewen, A., Omar, G., Chan, P. H. (2002). Copper/Zinc Superoxide Dismutase Attenuates Neuronal Cell Death by Preventing Extracellular Signal-Regulated Kinase Activation after Transient Focal Cerebral Ischemia in Mice. J. Neurosci. 22: 7923-7930 [Abstract] [Full Text]  
  • Eblen, S. T., Slack, J. K., Weber, M. J., Catling, A. D. (2002). Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes. Mol. Cell. Biol. 22: 6023-6033 [Abstract] [Full Text]  
  • Nguyen, A. N., Ikner, A. D., Shiozaki, M., Warren, S. M., Shiozaki, K. (2002). Cytoplasmic Localization of Wis1 MAPKK by Nuclear Export Signal Is Important for Nuclear Targeting of Spc1/Sty1 MAPK in Fission Yeast. Mol. Biol. Cell 13: 2651-2663 [Abstract] [Full Text]  
  • Tanimura, S., Nomura, K., Ozaki, K.-i., Tsujimoto, M., Kondo, T., Kohno, M. (2002). Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Kinase 1/2 Is Required for Hepatocyte Growth Factor-induced Cell Motility. J. Biol. Chem. 277: 28256-28264 [Abstract] [Full Text]  
  • Pusl, T., Wu, J. J., Zimmerman, T. L., Zhang, L., Ehrlich, B. E., Berchtold, M. W., Hoek, J. B., Karpen, S. J., Nathanson, M. H., Bennett, A. M. (2002). Epidermal Growth Factor-mediated Activation of the ETS Domain Transcription Factor Elk-1 Requires Nuclear Calcium. J. Biol. Chem. 277: 27517-27527 [Abstract] [Full Text]  
  • Fingar, D. C., Salama, S., Tsou, C., Harlow, E., Blenis, J. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16: 1472-1487 [Abstract] [Full Text]  
  • Robinson, M. J., Xu, B.-e, Stippec, S., Cobb, M. H. (2002). Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificity in Vivo. J. Biol. Chem. 277: 5094-5100 [Abstract] [Full Text]  
  • Young, M. R., Nair, R., Bucheimer, N., Tulsian, P., Brown, N., Chapp, C., Hsu, T.-C., Colburn, N. H. (2002). Transactivation of Fra-1 and Consequent Activation of AP-1 Occur Extracellular Signal-Regulated Kinase Dependently. Mol. Cell. Biol. 22: 587-598 [Abstract] [Full Text]  
  • Aplin, A. E., Hogan, B. P., Tomeu, J., Juliano, R. L. (2002). Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases. J. Cell Sci. 115: 2781-2790 [Abstract] [Full Text]  
  • Lu, Q., Dunn, R. L., Angeles, R., Smith, G. D. (2002). Regulation of Spindle Formation by Active Mitogen-Activated Protein Kinase and Protein Phosphatase 2A During Mouse Oocyte Meiosis. Biol. Reprod. 66: 29-37 [Abstract] [Full Text]  
  • Yang, Z., Madinova, A., Kozai, T., Joch, H., Aebi, U., Luscher, T. F (2002). Felodipine inhibits nuclear translocation of p42/44 mitogen-activated protein kinase and human smooth muscle cell growth. Cardiovasc Res 53: 227-231 [Abstract] [Full Text]  
  • Matsubayashi, Y., Fukuda, M., Nishida, E. (2001). Evidence for Existence of a Nuclear Pore Complex-mediated, Cytosol-independent Pathway of Nuclear Translocation of ERK MAP Kinase in Permeabilized Cells. J. Biol. Chem. 276: 41755-41760 [Abstract] [Full Text]  
  • Richards, S. A., Dreisbach, V. C., Murphy, L. O., Blenis, J. (2001). Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1. Mol. Cell. Biol. 21: 7470-7480 [Abstract] [Full Text]  
  • Ballif, B. A., Blenis, J. (2001). Molecular Mechanisms Mediating Mammalian Mitogen-activated Protein Kinase (MAPK) Kinase (MEK)-MAPK Cell Survival Signals. Cell Growth Differ. 12: 397-408 [Full Text]  
  • Xu, A., Suh, P.-G., Marmy-Conus, N., Pearson, R. B., Seok, O. Y., Cocco, L., Gilmour, R. S. (2001). Phosphorylation of Nuclear Phospholipase C {beta}1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I. Mol. Cell. Biol. 21: 2981-2990 [Abstract] [Full Text]  
  • Aplin, A. E., Stewart, S. A., Assoian, R. K., Juliano, R.L. (2001). Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1. JCB 153: 273-282 [Abstract] [Full Text]  
  • Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.-e, Karandikar, M., Berman, K., Cobb, M. H. (2001). Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions. Endocr. Rev. 22: 153-183 [Abstract] [Full Text]  
  • Buder-Hoffmann, S., Palmer, C., Vacek, P., Taatjes, D., Mossman, B. (2001). Different Accumulation of Activated Extracellular Signal-Regulated Kinases (ERK 1/2) and Role in Cell-Cycle Alterations by Epidermal Growth Factor, Hydrogen Peroxide, or Asbestos in Pulmonary Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 24: 405-413 [Abstract] [Full Text]  
  • Kyriakis, J. M., Avruch, J. (2001). Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation. Physiol. Rev. 81: 807-869 [Abstract] [Full Text]  
  • Morgan, M. A., Dolp, O., Reuter, C. W. M. (2001). Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood 97: 1823-1834 [Abstract] [Full Text]  
  • Webb, D. J., Thomas, K. S., Gonias, S. L. (2001). Plasminogen Activator Inhibitor 1 Functions as a Urokinase Response Modifier at the Level of Cell Signaling and Thereby Promotes Mcf-7 Cell Growth. JCB 152: 741-752 [Abstract] [Full Text]  
  • Osman, A. A., Hancock, J., Hunt, D. G., Ivy, J. L., Mandarino, L. J. (2001). Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats. J. Appl. Physiol. 90: 454-460 [Abstract] [Full Text]  
  • Harum, K. H., Alemi, L., Johnston, M. V. (2001). Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology 56: 207-214 [Abstract] [Full Text]  
  • Volmat, V., Camps, M., Arkinstall, S., Pouyssegur, J., Lenormand, P. (2001). The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases. J. Cell Sci. 114: 3433-3443 [Abstract] [Full Text]  
  • Lorenzen, J., Baker, S., Denhez, F, Melnick, M., Brower, D., Perkins, L. (2001). Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin. Development 128: 1403-1414 [Abstract]  
  • Eblen, S. T., Catling, A. D., Assanah, M. C., Weber, M. J. (2001). Biochemical and Biological Functions of the N-Terminal, Noncatalytic Domain of Extracellular Signal-Regulated Kinase 2. Mol. Cell. Biol. 21: 249-259 [Abstract] [Full Text]  
  • Boss, V., Roback, J. D., Young, A. N., Roback, L. J., Weisenhorn, D. M. V., Medina-Flores, R., Wainer, B. H. (2001). Nerve Growth Factor, But Not Epidermal Growth Factor, Increases Fra-2 Expression and Alters Fra-2/JunD Binding to AP-1 and CREB Binding Elements in Pheochromocytoma (PC12) Cells. J. Neurosci. 21: 18-26 [Abstract] [Full Text]  
  • JAFFREZOU, J.-P., BRUNO, A. P., MOISAND, A., LEVADE, T., LAURENT, G. (2001). Activation of a nuclear sphingomyelinase in radiation-induced apoptosis. FASEB J. 15: 123-133 [Abstract] [Full Text]  
  • Zhou, X., Richon, V. M., Wang, A. H., Yang, X.-J., Rifkind, R. A., Marks, P. A. (2000). Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. Proc. Natl. Acad. Sci. USA 10.1073/pnas.250494697v1 [Abstract] [Full Text]  
  • Valjent, E., Corvol, J.-C., Pages, C., Besson, M.-J., Maldonado, R., Caboche, J. (2000). Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties. J. Neurosci. 20: 8701-8709 [Abstract] [Full Text]  
  • Jeng, Y.-J., Liebenthal, D., Strakova, Z., Ives, K. L., Hellmich, M. R., Soloff, M. S. (2000). Complementary Mechanisms of Enhanced Oxytocin-Stimulated Prostaglandin E2 Synthesis in Rabbit Amnion at the End of Gestation. Endocrinology 141: 4136-4145 [Abstract] [Full Text]  
  • Schwertfeger, K. L., Hunter, S., Heasley, L. E., Levresse, V., Leon, R. P., DeGregori, J., Anderson, S. M. (2000). Prolactin Stimulates Activation of c-jun N-Terminal Kinase (JNK). Mol. Endocrinol. 14: 1592-1602 [Abstract] [Full Text]  
  • Kikuchi, Y., Hirano, M., Seto, M., Takatsu, K. (2000). Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int Immunol 12: 1397-1408 [Abstract] [Full Text]