This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guy, C T
Right arrow Articles by Muller, W J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guy, C T
Right arrow Articles by Muller, W J

 Previous Article  |  Next Article 

Mol Cell Biol. 1992 March; 12(3): 954-961

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

C T Guy, R D Cardiff and W J Muller

Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada.

ABSTRACT

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.

Mol Cell Biol. 1992 March; 12(3): 954-961




This article has been cited by other articles:

  • Crawford, N. P. S., Yang, H., Mattaini, K. R., Hunter, K. W. (2009). The Metastasis Efficiency Modifier Ribosomal RNA Processing 1 Homolog B (RRP1B) Is a Chromatin-associated Factor. J. Biol. Chem. 284: 28660-28673 [Abstract] [Full Text]  
  • Andrechek, E. R., Cardiff, R. D., Chang, J. T., Gatza, M. L., Acharya, C. R., Potti, A., Nevins, J. R. (2009). Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. Proc. Natl. Acad. Sci. USA 106: 16387-16392 [Abstract] [Full Text]  
  • Izumchenko, E., Singh, M. K., Plotnikova, O. V., Tikhmyanova, N., Little, J. L., Serebriiskii, I. G., Seo, S., Kurokawa, M., Egleston, B. L., Klein-Szanto, A., Pugacheva, E. N., Hardy, R. R., Wolfson, M., Connolly, D. C., Golemis, E. A. (2009). NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development. Cancer Res. 69: 7198-7206 [Abstract] [Full Text]  
  • Fluck, M. M., Schaffhausen, B. S. (2009). Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen. Microbiol. Mol. Biol. Rev. 73: 542-563 [Abstract] [Full Text]  
  • Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., Brekken, R. A., Scherer, P. E. (2009). Hypoxia-Inducible Factor 1{alpha} Induces Fibrosis and Insulin Resistance in White Adipose Tissue. Mol. Cell. Biol. 29: 4467-4483 [Abstract] [Full Text]  
  • Stewart, T. J., Liewehr, D. J., Steinberg, S. M., Greeneltch, K. M., Abrams, S. I. (2009). Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells. J. Immunol. 183: 117-128 [Abstract] [Full Text]  
  • Hahn, T., Fried, K., Hurley, L. H., Akporiaye, E. T. (2009). Orally active {alpha}-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer. Molecular Cancer Therapeutics 8: 1570-1578 [Abstract] [Full Text]  
  • Landskroner-Eiger, S., Qian, B., Muise, E. S., Nawrocki, A. R., Berger, J. P., Fine, E. J., Koba, W., Deng, Y., Pollard, J. W., Scherer, P. E. (2009). Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo. Clin. Cancer Res. 15: 3265-3276 [Abstract] [Full Text]  
  • Denzel, M. S., Hebbard, L. W., Shostak, G., Shapiro, L., Cardiff, R. D., Ranscht, B. (2009). Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer. Clin. Cancer Res. 15: 3256-3264 [Abstract] [Full Text]  
  • Hernandez, L., Smirnova, T., Kedrin, D., Wyckoff, J., Zhu, L., Stanley, E. R., Cox, D., Muller, W. J., Pollard, J. W., Van Rooijen, N., Segall, J. E. (2009). The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Heregulin {beta}1 and CXCL12. Cancer Res. 69: 3221-3227 [Abstract] [Full Text]  
  • Wong, C. H., Baehner, F. L., Spassov, D. S., Ahuja, D., Wang, D., Hann, B., Blair, J., Shokat, K., Welm, A. L., Moasser, M. M. (2009). Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers. Clin. Cancer Res. 15: 2311-2322 [Abstract] [Full Text]  
  • Ojalvo, L. S., King, W., Cox, D., Pollard, J. W. (2009). High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors. Am. J. Pathol. 174: 1048-1064 [Abstract] [Full Text]  
  • Sotgia, F., Casimiro, M. C., Bonuccelli, G., Liu, M., Whitaker-Menezes, D., Er, O., Daumer, K. M., Mercier, I., Witkiewicz, A. K., Minetti, C., Capozza, F., Gormley, M., Quong, A. A., Rui, H., Frank, P. G., Milliman, J. N., Knudsen, E. S., Zhou, J., Wang, C., Pestell, R. G., Lisanti, M. P. (2009). Loss of Caveolin-3 Induces a Lactogenic Microenvironment that Is Protective Against Mammary Tumor Formation. Am. J. Pathol. 174: 613-629 [Abstract] [Full Text]  
  • Luo, M., Fan, H., Nagy, T., Wei, H., Wang, C., Liu, S., Wicha, M. S., Guan, J.-L. (2009). Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells. Cancer Res. 69: 466-474 [Abstract] [Full Text]  
  • Wang, S., Yuan, Y., Liao, L., Kuang, S.-Q., Tien, J. C.-Y., O'Malley, B. W., Xu, J. (2009). Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc. Natl. Acad. Sci. USA 106: 151-156 [Abstract] [Full Text]  
  • Eude-Le Parco, I., Gendronneau, G., Dang, T., Delacour, D., Thijssen, V. L, Edelmann, W., Peuchmaur, M., Poirier, F. (2009). Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice. Glycobiology 19: 68-75 [Abstract] [Full Text]  
  • Bitler, B. G., Menzl, I., Huerta, C. L., Sands, B., Knowlton, W., Chang, A., Schroeder, J. A. (2009). Intracellular MUC1 Peptides Inhibit Cancer Progression. Clin. Cancer Res. 15: 100-109 [Abstract] [Full Text]  
  • La Merrill, M., Baston, D. S., Denison, M. S., Birnbaum, L. S., Pomp, D., Threadgill, D. W. (2009). Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am. J. Physiol. Endocrinol. Metab. 296: E203-E210 [Abstract] [Full Text]  
  • Studebaker, A. W., Storci, G., Werbeck, J. L., Sansone, P., Sasser, A. K., Tavolari, S., Huang, T., Chan, M. W.Y., Marini, F. C., Rosol, T. J., Bonafe, M., Hall, B. M. (2008). Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6-Dependent Manner. Cancer Res. 68: 9087-9095 [Abstract] [Full Text]  
  • Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E., Keely, P. J. (2008). Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer. Am. J. Pathol. 173: 1551-1565 [Abstract] [Full Text]  
  • Qin, L., Liao, L., Redmond, A., Young, L., Yuan, Y., Chen, H., O'Malley, B. W., Xu, J. (2008). The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression. Mol. Cell. Biol. 28: 5937-5950 [Abstract] [Full Text]  
  • Song, H., Shahverdi, K., Huso, D. L., Wang, Y., Fox, J. J., Hobbs, R. F., Gimi, B., Gabrielson, K. L., Pomper, M. G., Tsui, B. M., Bhujwalla, Z., Reilly, R. T., Sgouros, G. (2008). An Immunotolerant HER-2/neu Transgenic Mouse Model of Metastatic Breast Cancer. Clin. Cancer Res. 14: 6116-6124 [Abstract] [Full Text]  
  • Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. (2008). Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. DMM 1: 155-167 [Abstract] [Full Text]  
  • Versteeg, H. H., Schaffner, F., Kerver, M., Ellies, L. G., Andrade-Gordon, P., Mueller, B. M., Ruf, W. (2008). Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice. Cancer Res. 68: 7219-7227 [Abstract] [Full Text]  
  • Almholt, K., Juncker-Jensen, A., Laerum, O. D., Dano, K., Johnsen, M., Lund, L. R., Romer, J. (2008). Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model. Molecular Cancer Therapeutics 7: 2758-2767 [Abstract] [Full Text]  
  • Martin, M. D., Carter, K. J., Jean-Philippe, S. R., Chang, M., Mobashery, S., Thiolloy, S., Lynch, C. C., Matrisian, L. M., Fingleton, B. (2008). Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background. Cancer Res. 68: 6251-6259 [Abstract] [Full Text]  
  • Liby, K., Risingsong, R., Royce, D. B., Williams, C. R., Yore, M. M., Honda, T., Gribble, G. W., Lamph, W. W., Vannini, N., Sogno, I., Albini, A., Sporn, M. B. (2008). Prevention and Treatment of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268. Clin. Cancer Res. 14: 4556-4563 [Abstract] [Full Text]  
  • Raulic, S., Ramos-Valdes, Y., DiMattia, G. E (2008). Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro. J Endocrinol 197: 517-529 [Abstract] [Full Text]  
  • Northey, J. J., Chmielecki, J., Ngan, E., Russo, C., Annis, M. G., Muller, W. J., Siegel, P. M. (2008). Signaling through ShcA Is Required for Transforming Growth Factor {beta}- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion. Mol. Cell. Biol. 28: 3162-3176 [Abstract] [Full Text]  
  • Whalen, K. A., Weber, G. F., Benjamin, T. L., Schaffhausen, B. S. (2008). Polyomavirus Middle T Antigen Induces the Transcription of Osteopontin, a Gene Important for the Migration of Transformed Cells. J. Virol. 82: 4946-4954 [Abstract] [Full Text]  
  • Bierie, B., Stover, D. G., Abel, T. W., Chytil, A., Gorska, A. E., Aakre, M., Forrester, E., Yang, L., Wagner, K.-U., Moses, H. L. (2008). Transforming Growth Factor-{beta} Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment. Cancer Res. 68: 1809-1819 [Abstract] [Full Text]  
  • Hebbard, L. W., Garlatti, M., Young, L. J.T., Cardiff, R. D., Oshima, R. G., Ranscht, B. (2008). T-cadherin Supports Angiogenesis and Adiponectin Association with the Vasculature in a Mouse Mammary Tumor Model. Cancer Res. 68: 1407-1416 [Abstract] [Full Text]  
  • Trimboli, A. J., Fukino, K., de Bruin, A., Wei, G., Shen, L., Tanner, S. M., Creasap, N., Rosol, T. J., Robinson, M. L., Eng, C., Ostrowski, M. C., Leone, G. (2008). Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer. Cancer Res. 68: 937-945 [Abstract] [Full Text]  
  • Hedlund, M., Ng, E., Varki, A., Varki, N. M. (2008). {alpha}2-6 Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In vivo. Cancer Res. 68: 388-394 [Abstract] [Full Text]  
  • Dong, D., Ni, M., Li, J., Xiong, S., Ye, W., Virrey, J. J., Mao, C., Ye, R., Wang, M., Pen, L., Dubeau, L., Groshen, S., Hofman, F. M., Lee, A. S. (2008). Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development. Cancer Res. 68: 498-505 [Abstract] [Full Text]  
  • Lahlou, H., Sanguin-Gendreau, V., Zuo, D., Cardiff, Robert. D., McLean, G. W., Frame, M. C., Muller, W. J. (2007). Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc. Natl. Acad. Sci. USA 104: 20302-20307 [Abstract] [Full Text]  
  • Ursini-Siegel, J., Rajput, A. B., Lu, H., Sanguin-Gendreau, V., Zuo, D., Papavasiliou, V., Lavoie, C., Turpin, J., Cianflone, K., Huntsman, D. G., Muller, W. J. (2007). Elevated Expression of DecR1 Impairs ErbB2/Neu-Induced Mammary Tumor Development. Mol. Cell. Biol. 27: 6361-6371 [Abstract] [Full Text]  
  • Hanahan, D., Wagner, E. F., Palmiter, R. D. (2007). The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer. Genes Dev. 21: 2258-2270 [Abstract] [Full Text]  
  • Deeb, K. K., Michalowska, A. M., Yoon, C.-y., Krummey, S. M., Hoenerhoff, M. J., Kavanaugh, C., Li, M.-c., Demayo, F. J., Linnoila, I., Deng, C.-x., Lee, E. Y-H.P., Medina, D., Shih, J. H., Green, J. E. (2007). Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis. Cancer Res. 67: 8065-8080 [Abstract] [Full Text]  
  • Stewart, T. J., Abrams, S. I. (2007). Altered Immune Function during Long-Term Host-Tumor Interactions Can Be Modulated to Retard Autochthonous Neoplastic Growth. J. Immunol. 179: 2851-2859 [Abstract] [Full Text]  
  • Utermark, T., Schaffhausen, B. S., Roberts, T. M., Zhao, J. J. (2007). The p110{alpha} Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation. J. Virol. 81: 7069-7076 [Abstract] [Full Text]  
  • Hedlund, M., Tangvoranuntakul, P., Takematsu, H., Long, J. M., Housley, G. D., Kozutsumi, Y., Suzuki, A., Wynshaw-Boris, A., Ryan, A. F., Gallo, R. L., Varki, N., Varki, A. (2007). N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution. Mol. Cell. Biol. 27: 4340-4346 [Abstract] [Full Text]  
  • Nolan, D. J., Ciarrocchi, A., Mellick, A. S., Jaggi, J. S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M. R., Scheinberg, D. A., Benezra, R., Mittal, V. (2007). Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 21: 1546-1558 [Abstract] [Full Text]  
  • Welm, A. L., Sneddon, J. B., Taylor, C., Nuyten, D. S. A., van de Vijver, M. J., Hasegawa, B. H., Bishop, J. M. (2007). The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc. Natl. Acad. Sci. USA 104: 7570-7575 [Abstract] [Full Text]  
  • Hulit, J., Suyama, K., Chung, S., Keren, R., Agiostratidou, G., Shan, W., Dong, X., Williams, T. M., Lisanti, M. P., Knudsen, K., Hazan, R. B. (2007). N-Cadherin Signaling Potentiates Mammary Tumor Metastasis via Enhanced Extracellular Signal-Regulated Kinase Activation. Cancer Res. 67: 3106-3116 [Abstract] [Full Text]  
  • Varticovski, L., Hollingshead, M. G., Robles, A. I., Wu, X., Cherry, J., Munroe, D. J., Lukes, L., Anver, M. R., Carter, J. P., Borgel, S. D., Stotler, H., Bonomi, C. A., Nunez, N. P., Hursting, S. D., Qiao, W., Deng, C. X., Green, J. E., Hunter, K. W., Merlino, G., Steeg, P. S., Wakefield, L. M., Barrett, J. C. (2007). Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models. Clin. Cancer Res. 13: 2168-2177 [Abstract] [Full Text]  
  • Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-f., Goswami, S., Stanley, E. R., Segall, J. E., Pollard, J. W., Condeelis, J. (2007). Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors. Cancer Res. 67: 2649-2656 [Abstract] [Full Text]  
  • Kirmiz, C., Li, B., An, H. J., Clowers, B. H., Chew, H. K., Lam, K. S., Ferrige, A., Alecio, R., Borowsky, A. D., Sulaimon, S., Lebrilla, C. B., Miyamoto, S. (2007). A Serum Glycomics Approach to Breast Cancer Biomarkers. Mol. Cell. Proteomics 6: 43-55 [Abstract] [Full Text]  
  • Ma, Z., Gibson, S. L., Byrne, M. A., Zhang, J., White, M. F., Shaw, L. M. (2006). Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis. Mol. Cell. Biol. 26: 9338-9351 [Abstract] [Full Text]  
  • Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-n., Pollard, J. W. (2006). Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer. Cancer Res. 66: 11238-11246 [Abstract] [Full Text]  
  • Du, Z., Podsypanina, K., Huang, S., McGrath, A., Toneff, M. J., Bogoslovskaia, E., Zhang, X., Moraes, R. C., Fluck, M., Allred, D. C., Lewis, M. T., Varmus, H. E., Li, Y. (2006). Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc. Natl. Acad. Sci. USA 103: 17396-17401 [Abstract] [Full Text]  
  • Williams, T. M., Sotgia, F., Lee, H., Hassan, G., Di Vizio, D., Bonuccelli, G., Capozza, F., Mercier, I., Rui, H., Pestell, R. G., Lisanti, M. P. (2006). Stromal and Epithelial Caveolin-1 Both Confer a Protective Effect Against Mammary Hyperplasia and Tumorigenesis: Caveolin-1 Antagonizes Cyclin D1 Function in Mammary Epithelial Cells. Am. J. Pathol. 169: 1784-1801 [Abstract] [Full Text]  
  • Akakura, N., Hoogland, C., Takada, Y. K., Saegusa, J., Ye, X., Liu, F.-T., Cheung, A. T.-W., Takada, Y. (2006). The COOH-Terminal Globular Domain of Fibrinogen {gamma} Chain Suppresses Angiogenesis and Tumor Growth. Cancer Res. 66: 9691-9697 [Abstract] [Full Text]  
  • Basu, G. D., Tinder, T. L., Bradley, J. M., Tu, T., Hattrup, C. L., Pockaj, B. A., Mukherjee, P. (2006). Cyclooxygenase-2 Inhibitor Enhances the Efficacy of a Breast Cancer Vaccine: Role of IDO. J. Immunol. 177: 2391-2402 [Abstract] [Full Text]  
  • Klinakis, A., Szabolcs, M., Politi, K., Kiaris, H., Artavanis-Tsakonas, S., Efstratiadis, A. (2006). From the Cover: Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl. Acad. Sci. USA 103: 9262-9267 [Abstract] [Full Text]  
  • Kaminski, R., Zagozdzon, R., Fu, Y., Mroz, P., Fu, W., Seng, S., Avraham, S., Avraham, H. K. (2006). Role of Src Kinases in Neu-Induced Tumorigenesis: Challenging the Paradigm Using Csk Homologous Kinase Transgenic Mice. Cancer Res. 66: 5757-5762 [Abstract] [Full Text]  
  • Vasiljeva, O., Papazoglou, A., Kruger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B. S., Almholt, K., Bogyo, M., Peters, C., Reinheckel, T. (2006). Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.. Cancer Res. 66: 5242-5250 [Abstract] [Full Text]  
  • Namba, R., Young, L. J.T., Abbey, C. K., Kim, L., Damonte, P., Borowsky, A. D., Qi, J., Tepper, C. G., MacLeod, C. L., Cardiff, R. D., Gregg, J. P. (2006). Rapamycin Inhibits Growth of Premalignant and Malignant Mammary Lesions in a Mouse Model of Ductal Carcinoma In situ. Clin. Cancer Res. 12: 2613-2621 [Abstract] [Full Text]  
  • Zhang, H., Stephens, L. C., Kumar, R. (2006). Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer. Clin. Cancer Res. 12: 1479-1486 [Abstract] [Full Text]  
  • Cecena, G., Wen, F., Cardiff, R. D., Oshima, R. G. (2006). Differential Sensitivity of Mouse Epithelial Tissues to the Polyomavirus Middle T Oncogene. Am. J. Pathol. 168: 310-320 [Abstract] [Full Text]  
  • Cully, M., Shiu, J., Piekorz, R. P., Muller, W. J., Done, S. J., Mak, T. W. (2005). Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis. Cancer Res. 65: 10363-10370 [Abstract] [Full Text]  
  • Hodgson, J. G., Malek, T., Bornstein, S., Hariono, S., Ginzinger, D. G., Muller, W. J., Gray, J. W. (2005). Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase Signaling. Cancer Res. 65: 9695-9704 [Abstract] [Full Text]  
  • Peduto, L., Reuter, V. E., Shaffer, D. R., Scher, H. I., Blobel, C. P. (2005). Critical Function for ADAM9 in Mouse Prostate Cancer. Cancer Res. 65: 9312-9319 [Abstract] [Full Text]  
  • Bowen, T.J., Yakushiji, H., Montagna, C., Jain, S., Ried, T., Wynshaw-Boris, A. (2005). Atm Heterozygosity Cooperates with Loss of Brca1 to Increase the Severity of Mammary Gland Cancer and Reduce Ductal Branching. Cancer Res. 65: 8736-8746 [Abstract] [Full Text]  
  • Bishop, J. R., Crawford, B. E., Esko, J. D. (2005). Cell Surface Heparan Sulfate Promotes Replication of Toxoplasma gondii. Infect. Immun. 73: 5395-5401 [Abstract] [Full Text]  
  • Hakem, A., Sanchez-Sweatman, O., You-Ten, A., Duncan, G., Wakeham, A., Khokha, R., Mak, T. W. (2005). RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 19: 1974-1979 [Abstract] [Full Text]  
  • Lopez, J. I., Camenisch, T. D., Stevens, M. V., Sands, B. J., McDonald, J., Schroeder, J. A. (2005). CD44 Attenuates Metastatic Invasion during Breast Cancer Progression. Cancer Res. 65: 6755-6763 [Abstract] [Full Text]  
  • Pedersen, T. X., Pennington, C. J., Almholt, K., Christensen, I. J., Nielsen, B. S., Edwards, D. R., Romer, J., Dano, K., Johnsen, M. (2005). Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas. Carcinogenesis 26: 1233-1240 [Abstract] [Full Text]  
  • Curino, A. C., Engelholm, L. H., Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, N., Nielsen, B. S., Bugge, T. H. (2005). Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. JCB 169: 977-985 [Abstract] [Full Text]  
  • Kveiborg, M., Frohlich, C., Albrechtsen, R., Tischler, V., Dietrich, N., Holck, P., Kronqvist, P., Rank, F., Mercurio, A. M., Wewer, U. M. (2005). A Role for ADAM12 in Breast Tumor Progression and Stromal Cell Apoptosis. Cancer Res. 65: 4754-4761 [Abstract] [Full Text]  
  • Liu, K., Caldwell, S. A., Abrams, S. I. (2005). Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-{gamma}-Regulated Gene Expression. Cancer Res. 65: 4376-4388 [Abstract] [Full Text]  
  • Sangrar, W., Zirgnibl, R. A., Gao, Y., Muller, W. J., Jia, Z., Greer, P. A. (2005). An Identity Crisis for fps/fes: Oncogene or Tumor Suppressor?. Cancer Res. 65: 3518-3522 [Abstract] [Full Text]  
  • Forrester, E., Chytil, A., Bierie, B., Aakre, M., Gorska, A. E., Sharif-Afshar, A.-R., Muller, W. J., Moses, H. L. (2005). Effect of Conditional Knockout of the Type II TGF-{beta} Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis. Cancer Res. 65: 2296-2302 [Abstract] [Full Text]  
  • Khanna, C., Hunter, K. (2005). Modeling metastasis in vivo. Carcinogenesis 26: 513-523 [Abstract] [Full Text]  
  • Peace, B. E., Toney-Earley, K., Collins, M. H., Waltz, S. E. (2005). Ron Receptor Signaling Augments Mammary Tumor Formation and Metastasis in a Murine Model of Breast Cancer. Cancer Res. 65: 1285-1293 [Abstract] [Full Text]  
  • Stringer, J. R., Larson, J. S., Fischer, J. M., Medvedovic, M., Hersh, M. N., Boivin, G. P., Stringer, S. L. (2005). Modeling variation in tumors in vivo. Proc. Natl. Acad. Sci. USA 102: 2408-2413 [Abstract] [Full Text]  
  • Liu, K., Caldwell, S. A., Abrams, S. I. (2005). Cooperative Disengagement of Fas and Intercellular Adhesion Molecule-1 Function in Neoplastic Cells Confers Enhanced Colonization Efficiency. Cancer Res. 65: 1045-1054 [Abstract] [Full Text]  
  • Roberts, D. M., Anderson, A. L., Hidaka, M., Swetenburg, R. L., Patterson, C., Stanford, W. L., Bautch, V. L. (2004). A Vascular Gene Trap Screen Defines RasGRP3 as an Angiogenesis-Regulated Gene Required for the Endothelial Response to Phorbol Esters. Mol. Cell. Biol. 24: 10515-10528 [Abstract] [Full Text]  
  • Muraoka-Cook, R. S., Kurokawa, H., Koh, Y., Forbes, J. T., Roebuck, L. R., Barcellos-Hoff, M. H., Moody, S. E., Chodosh, L. A., Arteaga, C. L. (2004). Conditional Overexpression of Active Transforming Growth Factor {beta}1 In vivo Accelerates Metastases of Transgenic Mammary Tumors. Cancer Res. 64: 9002-9011 [Abstract] [Full Text]  
  • Williams, T. M., Medina, F., Badano, I., Hazan, R. B., Hutchinson, J., Muller, W. J., Chopra, N. G., Scherer, P. E., Pestell, R. G., Lisanti, M. P. (2004). Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo: ROLE OF CAV-1 IN CELL INVASIVENESS AND MATRIX METALLOPROTEINASE (MMP-2/9) SECRETION. J. Biol. Chem. 279: 51630-51646 [Abstract] [Full Text]  
  • Zinser, G. M., Welsh, J. (2004). Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Carcinogenesis 25: 2361-2372 [Abstract] [Full Text]  
  • Nagle, J. A., Ma, Z., Byrne, M. A., White, M. F., Shaw, L. M. (2004). Involvement of Insulin Receptor Substrate 2 in Mammary Tumor Metastasis. Mol. Cell. Biol. 24: 9726-9735 [Abstract] [Full Text]  
  • Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J., Mukherjee, P. (2004). Cyclooxygenase-2 Inhibitor Induces Apoptosis in Breast Cancer Cells in an In vivo Model of Spontaneous Metastatic Breast Cancer. Mol Cancer Res 2: 632-642 [Abstract] [Full Text]  
  • Wyckoff, J., Wang, W., Lin, E. Y., Wang, Y., Pixley, F., Stanley, E. R., Graf, T., Pollard, J. W., Segall, J., Condeelis, J. (2004). A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors. Cancer Res. 64: 7022-7029 [Abstract] [Full Text]  
  • Zhang, H., Kuang, S.-Q., Liao, L., Zhou, S., Xu, J. (2004). Haploid Inactivation of the Amplified-in-Breast Cancer 3 Coactivator Reduces the Inhibitory Effect of Peroxisome Proliferator-Activated Receptor {gamma} and Retinoid X Receptor on Cell Proliferation and Accelerates Polyoma Middle-T Antigen-Induced Mammary Tumorigenesis in Mice. Cancer Res. 64: 7169-7177 [Abstract] [Full Text]  
  • Qiu, T. H., Chandramouli, G. V. R., Hunter, K. W., Alkharouf, N. W., Green, J. E., Liu, E. T. (2004). Global Expression Profiling Identifies Signatures of Tumor Virulence in MMTV-PyMT-Transgenic Mice: Correlation to Human Disease. Cancer Res. 64: 5973-5981 [Abstract] [Full Text]  
  • Nicol, C. J., Yoon, M., Ward, J. M., Yamashita, M., Fukamachi, K., Peters, J. M., Gonzalez, F. J. (2004). PPAR{gamma} influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. Carcinogenesis 25: 1747-1755 [Abstract] [Full Text]  
  • Yamazaki, M., Akahane, T., Buck, T., Yoshiji, H., Gomez, D. E., Schoeffner, D. J., Okajima, E., Harris, S. R., Bunce, O. R., Thorgeirsson, S. S., Thorgeirsson, U. P. (2004). Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice. Carcinogenesis 25: 1735-1746 [Abstract] [Full Text]  
  • Abbey, C. K., Borowsky, A. D., McGoldrick, E. T., Gregg, J. P., Maglione, J. E., Cardiff, R. D., Cherry, S. R. (2004). In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. Proc. Natl. Acad. Sci. USA 101: 11438-11443 [Abstract] [Full Text]  
  • Namba, R., Maglione, J. E., Young, L. J.T., Borowsky, A. D., Cardiff, R. D., MacLeod, C. L., Gregg, J. P. (2004). Molecular Characterization of the Transition to Malignancy in a Genetically Engineered Mouse-Based Model of Ductal Carcinoma In situ. Mol Cancer Res 2: 453-463 [Abstract] [Full Text]  
  • Maglione, J. E., McGoldrick, E. T., Young, L. J.T., Namba, R., Gregg, J. P., Liu, L., Moghanaki, D., Ellies, L. G., Borowsky, A. D., Cardiff, R. D., MacLeod, C. L. (2004). Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: Single origin, divergent evolution, and multiple outcomes. Molecular Cancer Therapeutics 3: 941-953 [Abstract] [Full Text]  
  • Lin, S.-C. J., Lee, K.-F., Nikitin, A. Yu., Hilsenbeck, S. G., Cardiff, R. D., Li, A., Kang, K.-W., Frank, S. A., Lee, W.-H., Lee, E. Y-H. P. (2004). Somatic Mutation of p53 Leads to Estrogen Receptor {alpha}-Positive and -Negative Mouse Mammary Tumors with High Frequency of Metastasis. Cancer Res. 64: 3525-3532 [Abstract] [Full Text]  
  • Albright, C. D., Salganik, R. I., Van Dyke, T. (2004). Dietary Depletion of Vitamin E and Vitamin A Inhibits Mammary Tumor Growth and Metastasis in Transgenic Mice. J. Nutr. 134: 1139-1144 [Abstract] [Full Text]  
  • Galang, C. K., Muller, W. J., Foos, G., Oshima, R. G., Hauser, C. A. (2004). Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and Tumors. J. Biol. Chem. 279: 11281-11292 [Abstract] [Full Text]  
  • Saez, E., Rosenfeld, J., Livolsi, A., Olson, P., Lombardo, E., Nelson, M., Banayo, E., Cardiff, R. D., Izpisua-Belmonte, J. C., Evans, R. M. (2004). PPAR{gamma} signaling exacerbates mammary gland tumor development. Genes Dev. 18: 528-540 [Abstract] [Full Text]  
  • Kogai, T., Kanamoto, Y., Che, L. H., Taki, K., Moatamed, F., Schultz, J. J., Brent, G. A. (2004). Systemic Retinoic Acid Treatment Induces Sodium/Iodide Symporter Expression and Radioiodide Uptake in Mouse Breast Cancer Models. Cancer Res. 64: 415-422 [Abstract] [Full Text]  
  • Cardiff, R. D., Rosner, A., Hogarth, M. A., Galvez, J. J., Borowsky, A. D., Gregg, J. P. (2004). Validation: The New Challenge for Pathology. Toxicol Pathol 32: 31-39 [Abstract]  
  • Green, J. E., Desai, K. V., Yumei Ye, , Kavanaugh, C., Calvo, A., Huh, J.-I. (2004). Application of Gene Expression Profiling for Validating Models of Human Breast Cancer. Toxicol Pathol 32: 84-89 [Abstract]  
  • Li, Y., Welm, B., Podsypanina, K., Huang, S., Chamorro, M., Zhang, X., Rowlands, T., Egeblad, M., Cowin, P., Werb, Z., Tan, L. K., Rosen, J. M., Varmus, H. E. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA 100: 15853-15858 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»