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Mol Cell Biol. 1992 July; 12(7): 3070-3077

Transcriptional repression by a novel member of the bZIP family of transcription factors.

I G Cowell, A Skinner and H C Hurst

Gene Transcription Laboratory, Imperial Cancer Research Fund, Hammersmith Hospital, London, England.

ABSTRACT

We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors.

Mol Cell Biol. 1992 July; 12(7): 3070-3077




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