This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hubler, L Articles by Heideman, W Search for Related Content PubMed PubMed Citation Articles by Hubler, L Articles by Heideman, W

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 October; 13(10): 6274-6282

Connections between the Ras-cyclic AMP pathway and G1 cyclin expression in the budding yeast Saccharomyces cerevisiae.

School of Pharmacy, University of Wisconsin, Madison 53706.

ABSTRACT

We have identified two processes in the G1 phase of the Saccharomyces cerevisiae cell cycle that are required before nutritionally arrested cells are able to return to proliferative growth. The first process requires protein synthesis and is associated with increased expression of the G1 cyclin gene CLN3. This process requires nutrients but is independent of Ras and cyclic AMP (cAMP). The second process requires cAMP. This second process is rapid, is independent of protein synthesis, and produces a rapid induction of START-specific transcripts, including CLN1 and CLN2. The ability of a nutritionally arrested cell to respond to cAMP is dependent on completion of the first process, and this is delayed in cells carrying a CLN3 deletion. Mating pheromone blocks the cAMP response but does not alter the process upstream of Ras-cAMP. These results suggest a model linking the Ras-cAMP pathway with regulation of G1 cyclin expression.

This article has been cited by other articles:

• Slattery, M. G., Liko, D., Heideman, W. (2008). Protein Kinase A, TOR, and Glucose Transport Control the Response to Nutrient Repletion in Saccharomyces cerevisiae. Eukaryot Cell 7: 358-367 [Abstract] [Full Text]  
• Santangelo, G. M. (2006). Glucose Signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 70: 253-282 [Abstract] [Full Text]  
• Alberghina, L., Rossi, R. L., Querin, L., Wanke, V., Vanoni, M. (2004). A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast. J. Cell Biol. 167: 433-443 [Abstract] [Full Text]  
• Laabs, T. L., Markwardt, D. D., Slattery, M. G., Newcomb, L. L., Stillman, D. J., Heideman, W. (2003). ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 100: 10275-10280 [Abstract] [Full Text]  
• Wang, B.-D., Kuo, T.-T. (2001). Induction of a Mitosis Delay and Cell Lysis by High-Level Secretion of Mouse {alpha}-Amylase from Saccharomyces cerevisiae. Appl. Environ. Microbiol. 67: 3693-3701 [Abstract] [Full Text]  
• Zimmerman, Z. A., Kellogg, D. R. (2001). The Sda1 Protein Is Required for Passage through Start. Mol. Biol. Cell 12: 201-219 [Abstract] [Full Text]  
• Griffioen, G., Anghileri, P., Imre, E., Baroni, M. D., Ruis, H. (2000). Nutritional Control of Nucleocytoplasmic Localization of cAMP-dependent Protein Kinase Catalytic and Regulatory Subunits in Saccharomyces cerevisiae. J. Biol. Chem. 275: 1449-1456 [Abstract] [Full Text]  
• Wu, M., Newcomb, L., Heideman, W. (1999). Regulation of Gene Expression by Glucose in Saccharomyces cerevisiae: a Role for ADA2 and ADA3/NGG1. J. Bacteriol. 181: 4755-4760 [Abstract] [Full Text]  
• Mendenhall, M. D., Hodge, A. E. (1998). Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62: 1191-1243 [Abstract] [Full Text]  
• Görner, W., Durchschlag, E., Martinez-Pastor, M. T., Estruch, F., Ammerer, G., Hamilton, B., Ruis, H., Schüller, C. (1998). Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12: 586-597 [Abstract] [Full Text]  
• Parviz, F., Heideman, W. (1998). Growth-Independent Regulation of CLN3 mRNA Levels by Nutrients in Saccharomyces cerevisiae. J. Bacteriol. 180: 225-230 [Abstract] [Full Text]  
• Polymenis, M., Schmidt, E. V. (1997). Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev. 11: 2522-2531 [Abstract] [Full Text]  
• Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A., Pestell, R. G. (1995). Transforming p21[IMAGE] Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions. J. Biol. Chem. 270: 23589-23597 [Abstract] [Full Text]