This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yonish-Rouach, E
Right arrow Articles by Oren, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yonish-Rouach, E
Right arrow Articles by Oren, M

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 March; 13(3): 1415-1423

p53-mediated cell death: relationship to cell cycle control.

E Yonish-Rouach, D Grunwald, S Wilder, A Kimchi, E May, J J Lawrence, P May and M Oren

Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT

M1 clone S6 myeloid leukemic cells do not express detectable p53 protein. When stably transfected with a temperature-sensitive mutant of p53, these cells undergo rapid cell death upon induction of wild-type (wt) p53 activity at the permissive temperature. This process has features of apoptosis. In a number of other cell systems, wt p53 activation has been shown to induce a growth arrest. Yet, wt 53 fails to induce a measurable growth arrest in M1 cells, and cell cycle progression proceeds while viability is being lost. There exists, however, a relationship between the cell cycle and p53-mediated death, and cells in G1 appear to be preferentially susceptible to the death-inducing activity of wt p53. In addition, p53-mediated M1 cell death can be inhibited by interleukin-6. The effect of the cytokine is specific to p53-mediated death, since apoptosis elicited by serum deprivation is refractory to interleukin-6. Our data imply that p53-mediated cell death is not dependent on the induction of a growth arrest but rather may result from mutually incompatible growth-regulatory signals.

Mol Cell Biol. 1993 March; 13(3): 1415-1423




This article has been cited by other articles:

  • Garner, E., Martinon, F., Tschopp, J., Beard, P., Raj, K. (2007). Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6. Cancer Res. 67: 7631-7637 [Abstract] [Full Text]  
  • Rho, J. K., Choi, Y. J., Ryoo, B.-Y., Na, I. I., Yang, S. H., Kim, C. H., Lee, J. C. (2007). p53 Enhances Gefitinib-Induced Growth Inhibition and Apoptosis by Regulation of Fas in Non-Small Cell Lung Cancer. Cancer Res. 67: 1163-1169 [Abstract] [Full Text]  
  • Tesfaigzi, Y. (2006). Roles of Apoptosis in Airway Epithelia. Am. J. Respir. Cell Mol. Bio. 34: 537-547 [Abstract] [Full Text]  
  • Wang, L., Bowman, L., Lu, Y., Rojanasakul, Y., Mercer, R. R., Castranova, V., Ding, M. (2005). Essential role of p53 in silica-induced apoptosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L488-L496 [Abstract] [Full Text]  
  • Fujioka, S., Schmidt, C., Sclabas, G. M., Li, Z., Pelicano, H., Peng, B., Yao, A., Niu, J., Zhang, W., Evans, D. B., Abbruzzese, J. L., Huang, P., Chiao, P. J. (2004). Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-{kappa}B. J. Biol. Chem. 279: 27549-27559 [Abstract] [Full Text]  
  • Chen, S., Yin, X., Zhu, X., Yan, J., Ji, S., Chen, C., Cai, M., Zhang, S., Zong, H., Hu, Y., Yuan, Z., Shen, Z., Gu, J. (2003). The C-terminal Kinase Domain of the p34cdc2-related PITSLRE Protein Kinase (p110C) Associates with p21-activated Kinase 1 and Inhibits Its Activity during Anoikis. J. Biol. Chem. 278: 20029-20036 [Abstract] [Full Text]  
  • Minter, L. M., Dickinson, E. S., Naber, S. P., Jerry, D. J. (2003). Epithelial cell cycling predicts p53 responsiveness to {gamma}-irradiation during post-natal mammary gland development. Development 129: 2997-3008 [Abstract] [Full Text]  
  • Yamagishi, S.-i., Inagaki, Y., Okamoto, T., Amano, S., Koga, K., Takeuchi, M., Makita, Z. (2002). Advanced Glycation End Product-induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Human-cultured Mesangial Cells. J. Biol. Chem. 277: 20309-20315 [Abstract] [Full Text]  
  • Greenway, A. L., McPhee, D. A., Allen, K., Johnstone, R., Holloway, G., Mills, J., Azad, A., Sankovich, S., Lambert, P. (2002). Human Immunodeficiency Virus Type 1 Nef Binds to Tumor Suppressor p53 and Protects Cells against p53-Mediated Apoptosis. J. Virol. 76: 2692-2702 [Abstract] [Full Text]  
  • Teoh, G., Tai, Y.-T., Urashima, M., Shirahama, S., Matsuzaki, M., Chauhan, D., Treon, S. P., Raje, N., Hideshima, T., Shima, Y., Anderson, K. C. (2000). CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines. Blood 95: 1039-1046 [Abstract] [Full Text]  
  • McCarthy, N. J., Bennett, M. (2000). The regulation of vascular smooth muscle cell apoptosis. Cardiovasc Res 45: 747-755 [Abstract] [Full Text]  
  • Lotem, J., Kama, R., Sachs, L. (1999). Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proc. Natl. Acad. Sci. USA 96: 12016-12020 [Abstract] [Full Text]  
  • Haas, M. J., Dragan, Y. P., Hikita, H., Shimel, R., Takimoto, K., Heath, S., Vaughan, J., Pitot, H. C. (1999). Transgene Expression and Repression in Transgenic Rats Bearing the Phosphoenolpyruvate Carboxykinase-Simian Virus 40 T Antigen or the Phosphoenolpyruvate Carboxykinase-Transforming Growth Factor-{alpha} Constructs. Am. J. Pathol. 155: 183-192 [Abstract] [Full Text]  
  • WANG, E. (1999). Age-dependent atrophy and microgravity travel: what do they have in common?. FASEB J. 13: 167-174 [Abstract] [Full Text]  
  • Macdonald, K., Bennett, M. R. (1999). cdc25A Is Necessary but Not Sufficient for Optimal c-myc–Induced Apoptosis and Cell Proliferation of Vascular Smooth Muscle Cells. Circ. Res. 84: 820-830 [Abstract] [Full Text]  
  • Elkeles, A., Juven-Gershon, T., Israeli, D., Wilder, S., Zalcenstein, A., Oren, M. (1999). The c-fos Proto-Oncogene Is a Target for Transactivation by the p53 Tumor Suppressor. Mol. Cell. Biol. 19: 2594-2600 [Abstract] [Full Text]  
  • Tessitore, L., Sesca, E., Bosco, M., Vance, D. E. (1999). Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats. Carcinogenesis 20: 561-567 [Abstract] [Full Text]  
  • Frederick, M. J., Holton, P. R., Hudson, M., Wang, M., Clayman, G. L. (1999). Expression of Apoptosis-related Genes in Human Head and Neck Squamous Cell Carcinomas Undergoing p53-mediated Programmed Cell Death. Clin. Cancer Res. 5: 361-369 [Abstract] [Full Text]  
  • Huang, R.-F. S., Ho, Y.-H., Lin, H.-L., Wei, J.-S., Liu, T.-Z. (1999). Folate Deficiency Induces a Cell Cycle-Specific Apoptosis in HepG2 Cells. J. Nutr. 129: 25-31 [Abstract] [Full Text]  
  • Altura, R. A., Inukai, T., Ashmun, R. A., Zambetti, G. P., Roussel, M. F., Look, A. T. (1998). The Chimeric E2A-HLF Transcription Factor Abrogates p53-Induced Apoptosis in Myeloid Leukemia Cells. Blood 92: 1397-1405 [Abstract] [Full Text]  
  • Quelle, F. W., Wang, J., Feng, J., Wang, D., Cleveland, J. L., Ihle, J. N., Zambetti, G. P. (1998). Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev. 12: 1099-1107 [Abstract] [Full Text]  
  • O'Reilly, M. A., Staversky, R. J., Stripp, B. R., Finkelstein, J. N. (1998). Exposure to Hyperoxia Induces p53 Expression in Mouse Lung Epithelium. Am. J. Respir. Cell Mol. Bio. 18: 43-50 [Abstract] [Full Text]  
  • Lotem, J., Sachs, L. (1997). Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis. Proc. Natl. Acad. Sci. USA 94: 9349-9353 [Abstract] [Full Text]  
  • Kikuchi, A., Nishikawa, T. (1997). Apoptotic and Proliferating Cells in Cutaneous Lymphoproliferative Diseases. Arch Dermatol 133: 829-833 [Abstract]  
  • Syed, N. A., Nork, T. M., Poulsen, G. L., Riis, R. C., George, C., Albert, D. M. (1997). Retinoblastoma in a Dog. Arch Ophthalmol 115: 758-763 [Abstract]  
  • Thomaidou, D., Mione, M. C., Cavanagh, J. F. R., Parnavelas, J. G. (1997). Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex. J. Neurosci. 17: 1075-1085 [Abstract] [Full Text]  
  • Dorsch, M., Goff, S. P. (1996). Increased sensitivity to apoptotic stimuli in c-abl-deficient progenitor B-cell lines. Proc. Natl. Acad. Sci. USA 93: 13131-13136 [Abstract] [Full Text]  
  • Ko, L J, Prives, C (1996). p53: puzzle and paradigm.. Genes Dev. 10: 1054-1072  
  • Meikrantz, W., Schlegel, R. (1996). Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases. J. Biol. Chem. 271: 10205-10209 [Abstract] [Full Text]  
  • Park, D. S., Farinelli, S. E., Greene, L. A. (1996). Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons. J. Biol. Chem. 271: 8161-8169 [Abstract] [Full Text]  
  • Han, J, Sabbatini, P, Perez, D, Rao, L, Modha, D, White, E (1996). The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.. Genes Dev. 10: 461-477 [Abstract]  
  • Humphreys, R., Krajewska, M, Krnacik, S, Jaeger, R, Weiher, H, Krajewski, S, Reed, J., Rosen, J. (1996). Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122: 4013-4022 [Abstract]  
  • Herrup, K, Busser, J. (1995). The induction of multiple cell cycle events precedes target-related neuronal death. Development 121: 2385-2395 [Abstract]  
  • Hartwell, L., Kastan, M. (1994). Cell cycle control and cancer. Science 266: 1821-1828 [Abstract]  
  • Wagner, A J, Kokontis, J M, Hay, N (1994). Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.. Genes Dev. 8: 2817-2830 [Abstract]  
  • Di Leonardo, A, Linke, S P, Clarkin, K, Wahl, G M (1994). DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.. Genes Dev. 8: 2540-2551 [Abstract]  
  • Barak, Y, Gottlieb, E, Juven-Gershon, T, Oren, M (1994). Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.. Genes Dev. 8: 1739-1749 [Abstract]  
  • Howes, K A, Ransom, N, Papermaster, D S, Lasudry, J G, Albert, D M, Windle, J J (1994). Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.. Genes Dev. 8: 1300-1310 [Abstract]  
  • White, A E, Livanos, E M, Tlsty, T D (1994). Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.. Genes Dev. 8: 666-677 [Abstract]  
  • Moles, J., Schiller, J., Tesniere, A, Leigh, I., Guilhou, J., Basset-Seguin, N (1994). Analysis of HPV16 E6 and mutant p53-transfected keratinocytes in reconstituted epidermis suggests that wild-type p53 inhibits cytokeratin 19 expression. J. Cell Sci. 107: 435-441 [Abstract]  
  • Barak, Y., Lupo, A., Zauberman, A., Juven, T., Aloni-Grinstein, R., Gottlieb, E., Rotter, V., Oren, M. (1994). Targets for Transcriptional Activation by Wild-type p53: Endogenous Retroviral LTR, Immunoglobulin-like Promoter, and an Internal Promoter of the mdm2 Gene. Cold Spring Harb Symp Quant Biol 59: 225-235 [Abstract]  
  • Symonds, H., Krall, L., Remington, L., Saenz Robles, M., Jacks, T., Van Dyke, T. (1994). p53-Dependent Apoptosis In Vivo: Impact of p53 Inactivation on Tumorigenesis. Cold Spring Harb Symp Quant Biol 59: 247-257 [Abstract]  
  • Tlsty, T.D., White, A., Livanos, E., Sage, M., Roelofs, H., Briot, A., Poulose, B. (1994). Genomic Integrity and the Genetics of Cancer. Cold Spring Harb Symp Quant Biol 59: 265-275 [Abstract]  
  • Di Leonardo, A., Linke, S.P., Yin, Y., Wahl, G.M. (1993). Cell Cycle Regulation of Gene Amplification. Cold Spring Harb Symp Quant Biol 58: 655-667 [Abstract]  
  • Nadimpalli, R., Yalpani, N., Johal, G. S., Simmons, C. R. (2000). Prohibitins, Stomatins, and Plant Disease Response Genes Compose a Protein Superfamily That Controls Cell Proliferation, Ion Channel Regulation, and Death. J. Biol. Chem. 275: 29579-29586 [Abstract] [Full Text]  
  • Maxwell, S. A., Davis, G. E. (2000). Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Proc. Natl. Acad. Sci. USA 97: 13009-13014 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»