This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arceci, R J
Right arrow Articles by Wilson, D B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arceci, R J
Right arrow Articles by Wilson, D B

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 April; 13(4): 2235-2246

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.

R J Arceci, A A King, M C Simon, S H Orkin and D B Wilson

Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Massachusetts.

ABSTRACT

We report the cDNA cloning and characterization of mouse GATA-4, a new member of the family of zinc finger transcription factors that bind a core GATA motif. GATA-4 cDNA was identified by screening a 6.5-day mouse embryo library with oligonucleotide probes corresponding to a highly conserved region of the finger domains. Like other proteins of the family, GATA-4 is approximately 50 kDa in size and contains two zinc finger domains of the form C-X-N-C-(X17)-C-N-X-C. Cotransfection assays in heterologous cells demonstrate that GATA-4 trans activates reporter constructs containing GATA promoter elements. Northern (RNA) analysis and in situ hybridization show that GATA-4 mRNA is expressed in the heart, intestinal epithelium, primitive endoderm, and gonads. Retinoic acid-induced differentiation of mouse F9 cells into visceral or parietal endoderm is accompanied by increased expression of GATA-4 mRNA and protein. In vitro differentiation of embryonic stem cells into embryoid bodies is also associated with increased GATA-4 expression. We conclude that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor. On the basis of its tissue distribution, we speculate that GATA-4 plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads.

Mol Cell Biol. 1993 April; 13(4): 2235-2246




This article has been cited by other articles:

  • Thurisch, B., Liang, S. Y, Sarioglu, N., Schomburg, L., Bungert, J., Dame, C. (2009). Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads. J Mol Endocrinol 43: 157-169 [Abstract] [Full Text]  
  • Lindholm, P M, Soini, Y, Myllarniemi, M, Knuutila, S, Heikinheimo, M, Kinnula, V L, Salmenkivi, K (2009). Expression of GATA-6 transcription factor in pleural malignant mesothelioma and metastatic pulmonary adenocarcinoma. J. Clin. Pathol. 62: 339-344 [Abstract] [Full Text]  
  • Lowry, J. A., Gamsjaeger, R., Thong, S. Y., Hung, W., Kwan, A. H., Broitman-Maduro, G., Matthews, J. M., Maduro, M., Mackay, J. P. (2009). Structural Analysis of MED-1 Reveals Unexpected Diversity in the Mechanism of DNA Recognition by GATA-type Zinc Finger Domains. J. Biol. Chem. 284: 5827-5835 [Abstract] [Full Text]  
  • Reinecke, H., Minami, E., Zhu, W.-Z., Laflamme, M. A. (2008). Cardiogenic Differentiation and Transdifferentiation of Progenitor Cells. Circ. Res. 103: 1058-1071 [Abstract] [Full Text]  
  • Kyronlahti, A., Ramo, M., Tamminen, M., Unkila-Kallio, L., Butzow, R., Leminen, A., Nemer, M., Rahman, N., Huhtaniemi, I., Heikinheimo, M., Anttonen, M. (2008). GATA-4 Regulates Bcl-2 Expression in Ovarian Granulosa Cell Tumors. Endocrinology 149: 5635-5642 [Abstract] [Full Text]  
  • Rojas, A., Kong, S. W., Agarwal, P., Gilliss, B., Pu, W. T., Black, B. L. (2008). GATA4 Is a Direct Transcriptional Activator of Cyclin D2 and Cdk4 and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived Myocardium. Mol. Cell. Biol. 28: 5420-5431 [Abstract] [Full Text]  
  • Ohguchi, H., Tanaka, T., Uchida, A., Magoori, K., Kudo, H., Kim, I., Daigo, K., Sakakibara, I., Okamura, M., Harigae, H., Sasaki, T., Osborne, T. F., Gonzalez, F. J., Hamakubo, T., Kodama, T., Sakai, J. (2008). Hepatocyte Nuclear Factor 4{alpha} Contributes to Thyroid Hormone Homeostasis by Cooperatively Regulating the Type 1 Iodothyronine Deiodinase Gene with GATA4 and Kruppel-Like Transcription Factor 9. Mol. Cell. Biol. 28: 3917-3931 [Abstract] [Full Text]  
  • Vuorenoja, S., Rivero-Muller, A., Ziecik, A. J, Huhtaniemi, I., Toppari, J., Rahman, N. A (2008). Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin {beta} conjugate. Endocr Relat Cancer 15: 635-648 [Abstract] [Full Text]  
  • Takaya, T., Kawamura, T., Morimoto, T., Ono, K., Kita, T., Shimatsu, A., Hasegawa, K. (2008). Identification of p300-targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes. J. Biol. Chem. 283: 9828-9835 [Abstract] [Full Text]  
  • Bhardwaj, A., Rao, M. K., Kaur, R., Buttigieg, M. R., Wilkinson, M. F. (2008). GATA Factors and Androgen Receptor Collaborate To Transcriptionally Activate the Rhox5 Homeobox Gene in Sertoli Cells. Mol. Cell. Biol. 28: 2138-2153 [Abstract] [Full Text]  
  • Clugston, R. D., Zhang, W., Greer, J. J. (2008). Gene expression in the developing diaphragm: significance for congenital diaphragmatic hernia. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L665-L675 [Abstract] [Full Text]  
  • Laugwitz, K.-L., Moretti, A., Caron, L., Nakano, A., Chien, K. R. (2008). Islet1 cardiovascular progenitors: a single source for heart lineages?. Development 135: 193-205 [Abstract] [Full Text]  
  • Bakre, M. M., Hoi, A., Mong, J. C. Y., Koh, Y. Y., Wong, K. Y., Stanton, L. W. (2007). Generation of Multipotential Mesendodermal Progenitors from Mouse Embryonic Stem Cells via Sustained Wnt Pathway Activation. J. Biol. Chem. 282: 31703-31712 [Abstract] [Full Text]  
  • Sumi, K., Tanaka, T., Uchida, A., Magoori, K., Urashima, Y., Ohashi, R., Ohguchi, H., Okamura, M., Kudo, H., Daigo, K., Maejima, T., Kojima, N., Sakakibara, I., Jiang, S., Hasegawa, G., Kim, I., Osborne, T. F., Naito, M., Gonzalez, F. J., Hamakubo, T., Kodama, T., Sakai, J. (2007). Cooperative Interaction between Hepatocyte Nuclear Factor 4{alpha} and GATA Transcription Factors Regulates ATP-Binding Cassette Sterol Transporters ABCG5 and ABCG8. Mol. Cell. Biol. 27: 4248-4260 [Abstract] [Full Text]  
  • Belaguli, N. S., Zhang, M., Rigi, M., Aftab, M., Berger, D. H. (2007). Cooperation between GATA4 and TGF-beta signaling regulates intestinal epithelial gene expression. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1520-G1533 [Abstract] [Full Text]  
  • Yang, D.-H., Cai, K. Q., Roland, I. H., Smith, E. R., Xu, X.-X. (2007). Disabled-2 Is an Epithelial Surface Positioning Gene. J. Biol. Chem. 282: 13114-13122 [Abstract] [Full Text]  
  • Kwintkiewicz, J., Cai, Z., Stocco, C. (2007). Follicle-Stimulating Hormone-Induced Activation of Gata4 Contributes in the Up-Regulation of Cyp19 Expression in Rat Granulosa Cells. Mol. Endocrinol. 21: 933-947 [Abstract] [Full Text]  
  • Mazaud Guittot, S., Tetu, A., Legault, E., Pilon, N., Silversides, D. W., Viger, R. S. (2007). The Proximal Gata4 Promoter Directs Reporter Gene Expression to Sertoli Cells During Mouse Gonadal Development. Biol. Reprod. 76: 85-95 [Abstract] [Full Text]  
  • Anttonen, M, Parviainen, H, Kyronlahti, A, Bielinska, M, Wilson, D B, Ritvos, O, Heikinheimo, M (2006). GATA-4 is a granulosa cell factor employed in inhibin-{alpha} activation by the TGF-{beta} pathway.. J Mol Endocrinol 36: 557-568 [Abstract] [Full Text]  
  • Ding, B., Liu, C.-j., Huang, Y., Hickey, R. P., Yu, J., Kong, W., Lengyel, P. (2006). p204 Is Required for the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes: ITS EXPRESSION IS ACTIVATED BY THE CARDIAC GATA4, NKX2.5, AND TBX5 PROTEINS. J. Biol. Chem. 281: 14882-14892 [Abstract] [Full Text]  
  • Kato, T., Heike, T., Okawa, K., Haruyama, M., Shiraishi, K., Yoshimoto, M., Nagato, M., Shibata, M., Kumada, T., Yamanaka, Y., Hattori, H., Nakahata, T. (2006). A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells. Proc. Natl. Acad. Sci. USA 103: 6019-6024 [Abstract] [Full Text]  
  • Jadrich, J. L., O'Connor, M. B., Coucouvanis, E. (2006). The TGF{beta} activated kinase TAK1 regulates vascular development in vivo.. Development 133: 1529-1541 [Abstract] [Full Text]  
  • Kurimoto, K., Yabuta, Y., Ohinata, Y., Ono, Y., Uno, K. D., Yamada, R. G., Ueda, H. R., Saitou, M. (2006). An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis. Nucleic Acids Res 34: e42-e42 [Abstract] [Full Text]  
  • Miyamoto, S., Kawamura, T., Morimoto, T., Ono, K., Wada, H., Kawase, Y., Matsumori, A., Nishio, R., Kita, T., Hasegawa, K. (2006). Histone Acetyltransferase Activity of p300 Is Required for the Promotion of Left Ventricular Remodeling After Myocardial Infarction in Adult Mice In Vivo. Circulation 113: 679-690 [Abstract] [Full Text]  
  • Zheng, J., Kitajima, K., Sakai, E., Kimura, T., Minegishi, N., Yamamoto, M., Nakano, T. (2006). Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells. Blood 107: 520-527 [Abstract] [Full Text]  
  • Komiya, S., Shimizu, M., Ikenouchi, J., Yonemura, S., Matsui, T., Fukunaga, Y., Liu, H., Endo, F., Tsukita, S., Nagafuchi, A. (2005). Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells. GENES CELLS 10: 1065-1080 [Abstract] [Full Text]  
  • Hermann, B. P., Heckert, L. L. (2005). Silencing of Fshr Occurs through a Conserved, Hypersensitive Site in the First Intron. Mol. Endocrinol. 19: 2112-2131 [Abstract] [Full Text]  
  • Rojas, A., De Val, S., Heidt, A. B., Xu, S.-M., Bristow, J., Black, B. L. (2005). Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132: 3405-3417 [Abstract] [Full Text]  
  • Tesar, P. J. (2005). Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos. Proc. Natl. Acad. Sci. USA 102: 8239-8244 [Abstract] [Full Text]  
  • Phan, D., Rasmussen, T. L., Nakagawa, O., McAnally, J., Gottlieb, P. D., Tucker, P. W., Richardson, J. A., Bassel-Duby, R., Olson, E. N. (2005). BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development 132: 2669-2678 [Abstract] [Full Text]  
  • Keller, G. (2005). Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 19: 1129-1155 [Abstract] [Full Text]  
  • Martinez-Ceballos, E., Chambon, P., Gudas, L. J. (2005). Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal. J. Biol. Chem. 280: 16484-16498 [Abstract] [Full Text]  
  • Kunath, T., Arnaud, D., Uy, G. D., Okamoto, I., Chureau, C., Yamanaka, Y., Heard, E., Gardner, R. L., Avner, P., Rossant, J. (2005). Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development 132: 1649-1661 [Abstract] [Full Text]  
  • Ritz-Laser, B., Mamin, A., Brun, T., Avril, I., Schwitzgebel, V. M., Philippe, J. (2005). The Zinc Finger-Containing Transcription Factor Gata-4 Is Expressed in the Developing Endocrine Pancreas and Activates Glucagon Gene Expression. Mol. Endocrinol. 19: 759-770 [Abstract] [Full Text]  
  • Okumura-Nakanishi, S., Saito, M., Niwa, H., Ishikawa, F. (2005). Oct-3/4 and Sox2 Regulate Oct-3/4 Gene in Embryonic Stem Cells. J. Biol. Chem. 280: 5307-5317 [Abstract] [Full Text]  
  • Lee, M. K., Hande, M. P., Sabapathy, K. (2005). Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis. J. Cell Sci. 118: 819-829 [Abstract] [Full Text]  
  • Chandrasekar, B., Mummidi, S., Claycomb, W. C., Mestril, R., Nemer, M. (2005). Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes. J. Biol. Chem. 280: 4553-4567 [Abstract] [Full Text]  
  • Liang, S.-H., Hassett, C., Omiecinski, C. J. (2005). Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1). Mol. Pharmacol. 67: 220-230 [Abstract] [Full Text]  
  • Futaki, S., Hayashi, Y., Emoto, T., Weber, C. N., Sekiguchi, K. (2004). Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression. Mol. Cell. Biol. 24: 10492-10503 [Abstract] [Full Text]  
  • Divine, J. K., Staloch, L. J., Haveri, H., Jacobsen, C. M., Wilson, D. B., Heikinheimo, M., Simon, T. C. (2004). GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1{alpha}. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G1086-G1099 [Abstract] [Full Text]  
  • Rahman, N. A., Kiiveri, S., Rivero-Muller, A., Levallet, J., Vierre, S., Kero, J., Wilson, D. B., Heikinheimo, M., Huhtaniemi, I. (2004). Adrenocortical Tumorigenesis in Transgenic Mice Expressing the Inhibin {alpha}-Subunit Promoter/Simian Virus 40 T-Antigen Transgene: Relationship between Ectopic Expression of Luteinizing Hormone Receptor and Transcription Factor GATA-4. Mol. Endocrinol. 18: 2553-2569 [Abstract] [Full Text]  
  • van Wering, H. M., Bosse, T., Musters, A., de Jong, E., de Jong, N., Hogen Esch, C. E., Boudreau, F., Swain, G. P., Dowling, L. N., Montgomery, R. K., Grand, R. J., Krasinski, S. D. (2004). Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G899-G909 [Abstract] [Full Text]  
  • Lee, K.-H., Evans, S., Ruan, T. Y., Lassar, A. B. (2004). SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. Development 131: 4709-4723 [Abstract] [Full Text]  
  • Niimi, T., Hayashi, Y., Futaki, S., Sekiguchi, K. (2004). SOX7 and SOX17 Regulate the Parietal Endoderm-specific Enhancer Activity of Mouse Laminin {alpha}1 Gene. J. Biol. Chem. 279: 38055-38061 [Abstract] [Full Text]  
  • Dodou, E., Verzi, M. P., Anderson, J. P., Xu, S.-M., Black, B. L. (2004). Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development 131: 3931-3942 [Abstract] [Full Text]  
  • Pikkarainen, S., Tokola, H., Kerkela, R., Ruskoaho, H. (2004). GATA transcription factors in the developing and adult heart. Cardiovasc Res 63: 196-207 [Abstract] [Full Text]  
  • Murakami, A., Shen, H., Ishida, S., Dickson, C. (2004). SOX7 and GATA-4 Are Competitive Activators of Fgf-3 Transcription. J. Biol. Chem. 279: 28564-28573 [Abstract] [Full Text]  
  • Viger, R. S., Taniguchi, H., Robert, N. M., Tremblay, J. J. (2004). The 25th Volume: Role of the GATA Family of Transcription Factors in Andrology. J Androl 25: 441-452 [Full Text]  
  • Tenhunen, O., Sarman, B., Kerkela, R., Szokodi, I., Papp, L., Toth, M., Ruskoaho, H. (2004). Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart. J. Biol. Chem. 279: 24852-24860 [Abstract] [Full Text]  
  • Park, C., Afrikanova, I., Chung, Y. S., Zhang, W. J., Arentson, E., Fong, G. h., Rosendahl, A., Choi, K. (2004). A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development 131: 2749-2762 [Abstract] [Full Text]  
  • Martindale, M. Q., Pang, K., Finnerty, J. R. (2004). Investigating the origins of triploblasty: `mesodermal' gene expression in a diploblastic animal, the sea anemone Nematostella vectensis (phylum, Cnidaria; class, Anthozoa). Development 131: 2463-2474 [Abstract] [Full Text]  
  • Smith, E. R., Smedberg, J. L., Rula, M. E., Xu, X.-X. (2004). Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells. JCB 164: 689-699 [Abstract] [Full Text]  
  • Dame, C., Sola, M. C., Lim, K.-C., Leach, K. M., Fandrey, J., Ma, Y., Knopfle, G., Engel, J. D., Bungert, J. (2004). Hepatic Erythropoietin Gene Regulation by GATA-4. J. Biol. Chem. 279: 2955-2961 [Abstract] [Full Text]  
  • Futaki, S., Hayashi, Y., Yamashita, M., Yagi, K., Bono, H., Hayashizaki, Y., Okazaki, Y., Sekiguchi, K. (2003). Molecular Basis of Constitutive Production of Basement Membrane Components: GENE EXPRESSION PROFILES OF ENGELBRETH-HOLM-SWARM TUMOR AND F9 EMBRYONAL CARCINOMA CELLS. J. Biol. Chem. 278: 50691-50701 [Abstract] [Full Text]  
  • Capo-chichi, C. D., Roland, I. H., Vanderveer, L., Bao, R., Yamagata, T., Hirai, H., Cohen, C., Hamilton, T. C., Godwin, A. K., Xu, X.-X. (2003). Anomalous Expression of Epithelial Differentiation-determining GATA Factors in Ovarian Tumorigenesis. Cancer Res. 63: 4967-4977 [Abstract] [Full Text]  
  • Klinedinst, S. L., Bodmer, R. (2003). Gata factor Pannier is required to establish competence for heart progenitor formation. Development 130: 3027-3038 [Abstract] [Full Text]  
  • Kawajiri, K., Ikuta, T., Suzuki, T., Kusaka, M., Muramatsu, M., Fujieda, K., Tachibana, M., Morohashi, K.-i. (2003). Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1). Mol. Endocrinol. 17: 994-1004 [Abstract] [Full Text]  
  • Shimozaki, K., Nakashima, K., Niwa, H., Taga, T. (2003). Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development 130: 2505-2512 [Abstract] [Full Text]  
  • Dusing, M. R., Florence, E. A., Wiginton, D. A. (2003). High-level activation by a duodenum-specific enhancer requires functional GATA binding sites. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G1053-G1065 [Abstract] [Full Text]  
  • Yanazume, T., Hasegawa, K., Morimoto, T., Kawamura, T., Wada, H., Matsumori, A., Kawase, Y., Hirai, M., Kita, T. (2003). Cardiac p300 Is Involved in Myocyte Growth with Decompensated Heart Failure. Mol. Cell. Biol. 23: 3593-3606 [Abstract] [Full Text]  
  • Ketola, I., Toppari, J., Vaskivuo, T., Herva, R., Tapanainen, J. S., Heikinheimo, M. (2003). Transcription Factor GATA-6, Cell Proliferation, Apoptosis, and Apoptosis-Related Proteins Bcl-2 and Bax in Human Fetal Testis. J. Clin. Endocrinol. Metab. 88: 1858-1865 [Abstract] [Full Text]  
  • Anttonen, M., Ketola, I., Parviainen, H., Pusa, A.-K., Heikinheimo, M. (2003). FOG-2 and GATA-4 Are Coexpressed in the Mouse Ovary and Can Modulate Mullerian-Inhibiting Substance Expression. Biol. Reprod. 68: 1333-1340 [Abstract] [Full Text]  
  • Clabby, M. L., Robison, T. A., Quigley, H. F., Wilson, D. B., Kelly, D. P. (2003). Retinoid X Receptor alpha Represses GATA-4-mediated Transcription via a Retinoid-dependent Interaction with the Cardiac-enriched Repressor FOG-2. J. Biol. Chem. 278: 5760-5767 [Abstract] [Full Text]  
  • Kitta, K., Day, R. M., Kim, Y., Torregroza, I., Evans, T., Suzuki, Y. J. (2003). Hepatocyte Growth Factor Induces GATA-4 Phosphorylation and Cell Survival in Cardiac Muscle Cells. J. Biol. Chem. 278: 4705-4712 [Abstract] [Full Text]  
  • Kim, Y., Ma, A.-G., Kitta, K., Fitch, S. N., Ikeda, T., Ihara, Y., Simon, A. R., Evans, T., Suzuki, Y. J. (2003). Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis. Mol. Pharmacol. 63: 368-377 [Abstract] [Full Text]  
  • Gillio-Meina, C., Hui, Y. Y., LaVoie, H. A. (2003). GATA-4 and GATA-6 Transcription Factors: Expression, Immunohistochemical Localization, and Possible Function in the Porcine Ovary. Biol. Reprod. 68: 412-422 [Abstract] [Full Text]  
  • Kelley, C. G., Givens, M. L., Rave-Harel, N., Nelson, S. B., Anderson, S., Mellon, P. L. (2002). Neuron-Restricted Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by a Cell-Specific Protein Complex that Binds Repeated CAATT Elements. Mol. Endocrinol. 16: 2413-2425 [Abstract] [Full Text]  
  • Boudreau, F., Rings, E. H. H. M., van Wering, H. M., Kim, R. K., Swain, G. P., Krasinski, S. D., Moffett, J., Grand, R. J., Suh, E. R., Traber, P. G. (2002). Hepatocyte Nuclear Factor-1alpha , GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription. IMPLICATION FOR THE DEVELOPMENTAL REGULATION OF THE SUCRASE-ISOMALTASE GENE. J. Biol. Chem. 277: 31909-31917 [Abstract] [Full Text]  
  • Kiiveri, S., Liu, J., Westerholm-Ormio, M., Narita, N., Wilson, D. B., Voutilainen, R., Heikinheimo, M. (2002). Differential Expression of GATA-4 and GATA-6 in Fetal and Adult Mouse and Human Adrenal Tissue. Endocrinology 143: 3136-3143 [Abstract] [Full Text]  
  • van Wering, H. M., Huibregtse, I. L., van der Zwan, S. M., de Bie, M. S., Dowling, L. N., Boudreau, F., Rings, E. H. H. M., Grand, R. J., Krasinski, S. D. (2002). Physical Interaction between GATA-5 and Hepatocyte Nuclear Factor-1alpha Results in Synergistic Activation of the Human Lactase-Phlorizin Hydrolase Promoter. J. Biol. Chem. 277: 27659-27667 [Abstract] [Full Text]  
  • Taylor, D. A., Hruban, R., Rodriguez, E.R., Goldschmidt-Clermont, P. J. (2002). Cardiac Chimerism as a Mechanism for Self-Repair: Does It Happen and If So to What Degree?. Circulation 106: 2-4 [Full Text]  
  • He, Q., Mendez, M., LaPointe, M. C. (2002). Regulation of the human brain natriuretic peptide gene by GATA-4. Am. J. Physiol. Endocrinol. Metab. 283: E50-E57 [Abstract] [Full Text]  
  • Kerkela, R., Pikkarainen, S., Majalahti-Palviainen, T., Tokola, H., Ruskoaho, H. (2002). Distinct Roles of Mitogen-activated Protein Kinase Pathways in GATA-4 Transcription Factor-mediated Regulation of B-type Natriuretic Peptide Gene. J. Biol. Chem. 277: 13752-13760 [Abstract] [Full Text]  
  • Zhang, Z., Wu, A. Z., Feng, Z.-M., Mruk, D., Cheng, C. Y., Chen, C.-L. C. (2002). Gonadotropins, via cAMP, Negatively Regulate GATA-1 Gene Expression in Testicular Cells. Endocrinology 143: 829-836 [Abstract] [Full Text]  
  • Murakami, A., Ishida, S., Dickson, C. (2002). GATA-4 interacts distinctively with negative and positive regulatory elements in the Fgf-3 promoter. Nucleic Acids Res 30: 1056-1064 [Abstract] [Full Text]  
  • Smith, E. R., Capo-chichi, C. D., He, J., Smedberg, J. L., Yang, D.-H., Prowse, A. H., Godwin, A. K., Hamilton, T. C., Xu, X.-X. (2001). Disabled-2 Mediates c-Fos Suppression and the Cell Growth Regulatory Activity of Retinoic Acid in Embryonic Carcinoma Cells. J. Biol. Chem. 276: 47303-47310 [Abstract] [Full Text]  
  • Rossi, J. M., Dunn, N. R., Hogan, B. L.M., Zaret, K. S. (2001). Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 15: 1998-2009 [Abstract] [Full Text]  
  • Krasinski, S. D., Van Wering, H. M., Tannemaat, M. R., Grand, R. J. (2001). Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1{alpha}. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G69-G84 [Abstract] [Full Text]  
  • Monzen, K., Hiroi, Y., Kudoh, S., Akazawa, H., Oka, T., Takimoto, E., Hayashi, D., Hosoda, T., Kawabata, M., Miyazono, K., Ishii, S., Yazaki, Y., Nagai, R., Komuro, I. (2001). Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation. JCB 153: 687-698 [Abstract] [Full Text]  
  • Costa, R. H., Kalinichenko, V. V., Lim, L. (2001). Transcription factors in mouse lung development and function. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L823-L838 [Abstract] [Full Text]  
  • Ranganath, S., Murphy, K. M. (2001). Structure and Specificity of GATA Proteins in Th2 Development. Mol. Cell. Biol. 21: 2716-2725 [Abstract] [Full Text]  
  • Crispino, J. D., Lodish, M. B., Thurberg, B. L., Litovsky, S. H., Collins, T., Molkentin, J. D., Orkin, S. H. (2001). Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15: 839-844 [Abstract] [Full Text]  
  • Gazda, H., Lipton, J. M., Willig, T.-N., Ball, S., Niemeyer, C. M., Tchernia, G., Mohandas, N., Daly, M. J., Ploszynska, A., Orfali, K. A., Vlachos, A., Glader, B. E., Rokicka-Milewska, R., Ohara, A., Baker, D., Pospisilova, D., Webber, A., Viskochil, D. H., Nathan, D. G., Beggs, A. H., Sieff, C. A. (2001). Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood 97: 2145-2150 [Abstract] [Full Text]  
  • Murray, P, Edgar, D (2001). Regulation of the differentiation and behaviour of extra-embryonic endodermal cells by basement membranes. J. Cell Sci. 114: 931-939 [Abstract]  
  • Keijzer, R, van Tuyl, M, Meijers, C, Post, M, Tibboel, D, Grosveld, F, Koutsourakis, M (2001). The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development. Development 128: 503-511 [Abstract]  
  • Fang, R., Olds, L. C., Santiago, N. A., Sibley, E. (2001). GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G58-G67 [Abstract] [Full Text]  
  • Djabali, K, Aita, V., Christiano, A. (2001). Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix. J. Cell Sci. 114: 367-376 [Abstract]  
  • Xanthos, J., Kofron, M, Wylie, C, Heasman, J (2001). Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development 128: 167-180 [Abstract]  
  • Shamblott, M. J., Axelman, J., Littlefield, J. W., Blumenthal, P. D., Huggins, G. R., Cui, Y., Cheng, L., Gearhart, J. D. (2000). Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc. Natl. Acad. Sci. USA 10.1073/pnas.021537998v1 [Abstract] [Full Text]  
  • Feng, Z.-M., Wu, A. Z., Zhang, Z., Chen, C.-L. C. (2000). GATA-1 and GATA-4 Transactivate Inhibin/Activin {beta}-B-Subunit Gene Transcription in Testicular Cells. Mol. Endocrinol. 14: 1820-1835 [Abstract] [Full Text]  
  • Ketola, I., Pentikäinen, V., Vaskivuo, T., Ilvesmäki, V., Herva, R., Dunkel, L., Tapanainen, J. S., Toppari, J., Heikinheimo, M. (2000). Expression of Transcription Factor GATA-4 during Human Testicular Development and Disease. J. Clin. Endocrinol. Metab. 85: 3925-3931 [Abstract] [Full Text]  
  • Laitinen, M. P. E., Anttonen, M., Ketola, I., Wilson, D. B., Ritvos, O., Butzow, R., Heikinheimo, M. (2000). Transcription Factors GATA-4 and GATA-6 and a GATA Family Cofactor, FOG-2, Are Expressed in Human Ovary and Sex Cord-Derived Ovarian Tumors. J. Clin. Endocrinol. Metab. 85: 3476-3483 [Abstract] [Full Text]  
  • Molkentin, J. D., Tymitz, K. M., Richardson, J. A., Olson, E. N. (2000). Abnormalities of the Genitourinary Tract in Female Mice Lacking GATA5. Mol. Cell. Biol. 20: 5256-5260 [Abstract] [Full Text]  
  • Deconinck, A. E., Mead, P. E., Tevosian, S. G., Crispino, J. D., Katz, S. G., Zon, L. I., Orkin, S. H. (2000). FOG acts as a repressor of red blood cell development in Xenopus. Development 127: 2031-2040 [Abstract]  
  • Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Wada, H., Yanazume, T., Sasayama, S. (2000). Phosphorylation of GATA-4 Is Involved in alpha 1-Adrenergic Agonist-responsive Transcription of the Endothelin-1 Gene in Cardiac Myocytes. J. Biol. Chem. 275: 13721-13726 [Abstract] [Full Text]  
  • Shoichet, S. A., Malik, T. H., Rothman, J. H., Shivdasani, R. A. (2000). Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc. Natl. Acad. Sci. USA 97: 4076-4081 [Abstract] [Full Text]  
  • McFadden, D., Charite, J, Richardson, J., Srivastava, D, Firulli, A., Olson, E. (2000). A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-5341 [Abstract]  
  • Bossard, P, Zaret, K. (2000). Repressive and restrictive mesodermal interactions with gut endoderm: possible relation to Meckel's Diverticulum. Development 127: 4915-4923 [Abstract]  
  • Faloon, P, Arentson, E, Kazarov, A, Deng, C., Porcher, C, Orkin, S, Choi, K (2000). Basic fibroblast growth factor positively regulates hematopoietic development. Development 127: 1931-1941 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»