This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ziegler, S F Articles by Baumann, H Search for Related Content PubMed PubMed Citation Articles by Ziegler, S F Articles by Baumann, H

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 April; 13(4): 2384-2390

Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction.

Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101.

ABSTRACT

Using two different cell systems, we show that the cytoplasmic domain of the granulocyte-colony-stimulating factor receptor (G-CSFR) may be composed of at least two functional regions. The first, within the membrane-proximal 57 amino acids, is absolutely required to deliver a proliferative signal. This region contains two sequence motifs conserved between members of the hematopoietin receptor family. The second functional region resides between amino acids 57 and 96. This region is required for the induction of acute-phase plasma protein gene expression when the G-CSFR is transfected into human hepatoma cell lines. The G-CSFR-transfected hepatoma cells respond to G-CSF by increasing the production of the same set of plasma proteins as stimulated by interleukin-6, suggesting that the two cytokines share a common signal transduction pathway.

This article has been cited by other articles:

• Germeshausen, M., Ballmaier, M., Welte, K. (2007). Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey. Blood 109: 93-99 [Abstract] [Full Text]  
• Ahr, B., Denizot, M., Robert-Hebmann, V., Brelot, A., Biard-Piechaczyk, M. (2005). Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation. J. Biol. Chem. 280: 6692-6700 [Abstract] [Full Text]  
• Druhan, L. J., Ai, J., Massullo, P., Kindwall-Keller, T., Ranalli, M. A., Avalos, B. R. (2005). Novel mechanism of G-CSF refractoriness in patients with severe congenital neutropenia. Blood 105: 584-591 [Abstract] [Full Text]  
• Hunter, M. G., Jacob, A., O'Donnell, L. C., Agler, A., Druhan, L. J., Coggeshall, K. M., Avalos, B. R. (2004). Loss of SHIP and CIS Recruitment to the Granulocyte Colony-Stimulating Factor Receptor Contribute to Hyperproliferative Responses in Severe Congenital Neutropenia/Acute Myelogenous Leukemia. J. Immunol. 173: 5036-5045 [Abstract] [Full Text]  
• Bahrenberg, G., Behrmann, I., Barthel, A., Hekerman, P., Heinrich, P. C., Joost, H.-G., Becker, W. (2002). Identification of the Critical Sequence Elements in the Cytoplasmic Domain of Leptin Receptor Isoforms Required for Janus Kinase/Signal Transducer and Activator of Transcription Activation by Receptor Heterodimers. Mol. Endocrinol. 16: 859-872 [Abstract] [Full Text]  
• Akbarzadeh, S., Ward, A. C., McPhee, D. O. M., Alexander, W. S., Lieschke, G. J., Layton, J. E. (2002). Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells. Blood 99: 879-887 [Abstract] [Full Text]  
• Martino, A., Holmes, J. H. IV, Lord, J. D., Moon, J. J., Nelson, B. H. (2001). Stat5 and Sp1 Regulate Transcription of the Cyclin D2 Gene in Response to IL-2. J. Immunol. 166: 1723-1729 [Abstract] [Full Text]  
• White, S. M., Alarcon, M. H., Tweardy, D. J. (2000). Inhibition of granulocyte colony-stimulating factor-mediated myeloid maturation by low level expression of the differentiation-defective class IV granulocyte colony-stimulating factor receptor isoform. Blood 95: 3335-3340 [Abstract] [Full Text]  
• Lord, J. D., McIntosh, B. C., Greenberg, P. D., Nelson, B. H. (2000). The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5. J. Immunol. 164: 2533-2541 [Abstract] [Full Text]  
• Isaksen, D. E., Baumann, H., Trobridge, P. A., Farr, A. G., Levin, S. D., Ziegler, S. F. (1999). Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction. J. Immunol. 163: 5971-5977 [Abstract] [Full Text]  
• Wang, X., Scott, E., Sawyers, C. L., Friedman, A. D. (1999). C/EBPalpha Bypasses Granulocyte Colony-Stimulating Factor Signals to Rapidly Induce PU.1 Gene Expression, Stimulate Granulocytic Differentiation, and Limit Proliferation in 32D cl3 Myeloblasts. Blood 94: 560-571 [Abstract] [Full Text]  
• Koay, D. C., Sartorelli, A. C. (1999). Functional Differentiation Signals Mediated by Distinct Regions of the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor Receptor. Blood 93: 3774-3784 [Abstract] [Full Text]  
• Ernst, M., Novak, U., Nicholson, S. E., Layton, J. E., Dunn, A. R. (1999). The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. INVOLVEMENT OF STAT3. J. Biol. Chem. 274: 9729-9737 [Abstract] [Full Text]  
• Tanaka, M., Hara, T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Miyajima, A. (1999). Reconstitution of the Functional Mouse Oncostatin M (OSM) Receptor: Molecular Cloning of the Mouse OSM Receptor beta  Subunit. Blood 93: 804-815 [Abstract] [Full Text]  
• Chakraborty, A., Dyer, K. F., Cascio, M., Mietzner, T. A., Tweardy, D. J. (1999). Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor. Blood 93: 15-24 [Abstract] [Full Text]  
• Ward, A. C., Hermans, M. H.A., Smith, L., van Aesch, Y. M., Schelen, A. M., Antonissen, C., Touw, I. P. (1999). Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration. Blood 93: 113-124 [Abstract] [Full Text]  
• Dong, F., Liu, X., de Koning, J. P., Touw, I. P., Henninghausen, L., Larner, A., Grimley, P. M. (1998). Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor. J. Immunol. 161: 6503-6509 [Abstract] [Full Text]  
• Strehlow, I., Schindler, C. (1998). Amino-terminal Signal Transducer and Activator of Transcription (STAT) Domains Regulate Nuclear Translocation and STAT Deactivation. J. Biol. Chem. 273: 28049-28056 [Abstract] [Full Text]  
• Jacob, J., Haug, J. S., Raptis, S., Link, D. C. (1998). Specific Signals Generated by the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Not Required for G-CSF-Dependent Granulocytic Differentiation. Blood 92: 353-361 [Abstract] [Full Text]  
• Inoue, K., Tamaki, H., Ogawa, H., Oka, Y., Soma, T., Tatekawa, T., Oji, Y., Tsuboi, A., Kim, E. H., Kawakami, M., Akiyama, T., Kishimoto, T., Sugiyama, H. (1998). Wilms' Tumor Gene (WT1) Competes With Differentiation-Inducing Signal in Hematopoietic Progenitor Cells. Blood 91: 2969-2976 [Abstract] [Full Text]  
• de Koning, J. P., Soede-Bobok, A. A., Schelen, A. M., Smith, L., van Leeuwen, D., Santini, V., Burgering, B. M.T., Bos, J. L., Lowenberg, B., Touw, I. P. (1998). Proliferation Signaling and Activation of Shc, p21Ras, and Myc Via Tyrosine 764 of Human Granulocyte Colony-Stimulating Factor Receptor. Blood 91: 1924-1933 [Abstract] [Full Text]  
• Liu, F., Poursine-Laurent, J., Wu, H. Y., Link, D. C. (1997). Interleukin-6 and the Granulocyte Colony-Stimulating Factor Receptor Are Major Independent Regulators of Granulopoiesis In Vivo But Are Not Required for Lineage Commitment or Terminal Differentiation. Blood 90: 2583-2590 [Abstract] [Full Text]  
• Kuropatwinski, K. K., De Imus, C., Gearing, D., Baumann, H., Mosley, B. (1997). Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6. J. Biol. Chem. 272: 15135-15144 [Abstract] [Full Text]  
• White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., Tartaglia, L. A. (1997). Leptin Receptor (OB-R) Signaling. CYTOPLASMIC DOMAIN MUTATIONAL ANALYSIS AND EVIDENCE FOR RECEPTOR HOMO-OLIGOMERIZATION. J. Biol. Chem. 272: 4065-4071 [Abstract] [Full Text]  
• Mosley, B., De Imus, C., Friend, D., Boiani, N., Thoma, B., Park, L. S., Cosman, D. (1996). Dual Oncostatin M (OSM) Receptors. CLONING AND CHARACTERIZATION OF AN ALTERNATIVE SIGNALING SUBUNIT CONFERRING OSM-SPECIFIC RECEPTOR ACTIVATION. J. Biol. Chem. 271: 32635-32643 [Abstract] [Full Text]  
• Nicholson, S. E., Starr, R., Novak, U., Hilton, D. J., Layton, J. E. (1996). Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells. J. Biol. Chem. 271: 26947-26953 [Abstract] [Full Text]  
• Kordula, T., Ripperger, J., Morella, K. K., Travis, J., Baumann, H. (1996). Two Separate Signal Transducer and Activator of Transcription Proteins Regulate Transcription of the Serine Proteinase Inhibitor-3 Gene in Hepatic Cells. J. Biol. Chem. 271: 6752-6757 [Abstract] [Full Text]  
• Dong, F., Brynes, R. K., Tidow, N., Welte, K., Lowenberg, B., Touw, I. P. (1995). Mutations in the Gene for the Granulocyte Colony-Stimulating-Factor Receptor in Patients with Acute Myeloid Leukemia Preceded by Severe Congenital Neutropenia. NEJM 333: 487-493 [Abstract] [Full Text]  
• Lebrun, J.-J., Ali, S., Ullrich, A., Kelly, P. A. (1995). Proline-rich Sequence-mediated Jak2 Association to the Prolactin Receptor Is Required but Not Sufficient for Signal Transduction. J. Biol. Chem. 270: 10664-10670 [Abstract] [Full Text]  
• Morella, K. K., Lai, C.-f., Kumaki, S., Kumaki, N., Wang, Y., Bluman, E. M., Witthuhn, B. A., Ihle, J. N., Giri, J., Gearing, D. P., Cosman, D., Ziegler, S. F., Tweardy, D. J., Campos, S. P., Baumann, H. (1995). The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts. J. Biol. Chem. 270: 8298-8310 [Abstract] [Full Text]  
• Tanner, J. W., Chen, W., Young, R. L., Longmore, G. D., Shaw, A. S. (1995). The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases. J. Biol. Chem. 270: 6523-6530 [Abstract] [Full Text]  
• D'Andrea, A. D. (1994). Cytokine Receptors in Congenital Hematopoietic Disease. NEJM 330: 839-846 [Full Text]