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Mol Cell Biol. 1993 April; 13(4): 2524-2535

Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.

M J Stewart and R Denell

Center for Basic Cancer Research, Kansas State University, Manhattan 66506.

ABSTRACT

We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop grossly hypertrophied hematopoietic organs because of increased cell proliferation and extra rounds of endoreduplication in some hematopoietic cells. Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.

Mol Cell Biol. 1993 April; 13(4): 2524-2535




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