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Mol Cell Biol. 1993 May; 13(5): 3076-3083

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

K Irie, M Takase, K S Lee, D E Levin, H Araki, K Matsumoto and Y Oshima

Department of Molecular Biology, Faculty of Science, Nagoya University, Japan.

ABSTRACT

The PKC1 gene of Saccharomyces cerevisiae encodes a homolog of mammalian protein kinase C that is required for normal growth and division of yeast cells. We report here the isolation of the yeast MKK1 and MKK2 (for mitogen-activated protein [MAP] kinase-kinase) genes which, when overexpressed, suppress the cell lysis defect of a temperature-sensitive pkc1 mutant. The MKK genes encode protein kinases most similar to the STE7 product of S. cerevisiae, the byr1 product of Schizosaccharomyces pombe, and vertebrate MAP kinase-kinases. Deletion of either MKK gene alone did not cause any apparent phenotypic defects, but deletion of both MKK1 and MKK2 resulted in a temperature-sensitive cell lysis defect that was suppressed by osmotic stabilizers. This phenotypic defect is similar to that associated with deletion of the BCK1 gene, which is thought to function in the pathway mediated by PCK1. The BCK1 gene also encodes a predicted protein kinase. Overexpression of MKK1 suppressed the growth defect caused by deletion of BCK1, whereas an activated allele of BCK1 (BCK1-20) did not suppress the defect of the mkk1 mkk2 double disruption. Furthermore, overexpression of MPK1, which encodes a protein kinase closely related to vertebrate MAP kinases, suppressed the defect of the mkk1 mkk2 double mutant. These results suggest that MKK1 and MKK2 function in a signal transduction pathway involving the protein kinases encoded by PKC1, BCK1, and MPK1. Genetic epistasis experiments indicated that the site of action for MKK1 and MKK2 is between BCK1 and MPK1.

Mol Cell Biol. 1993 May; 13(5): 3076-3083




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  • Philip, B., Levin, D. E. (2001). Wsc1 and Mid2 Are Cell Surface Sensors for Cell Wall Integrity Signaling That Act through Rom2, a Guanine Nucleotide Exchange Factor for Rho1. Mol. Cell. Biol. 21: 271-280 [Abstract] [Full Text]  
  • Tomlin, G. C., Hamilton, G. E., Gardner, D. C. J., Walmsley, R. M., Stateva, L. I., Oliver, S. G. (2000). Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wall biogenesis. Microbiology 146: 2133-2146 [Abstract] [Full Text]  
  • Khalfan, W., Ivanovska, I., Rose, M. D. (2000). Functional Interaction Between the PKC1 Pathway and CDC31 Network of SPB Duplication Genes. Genetics 155: 1543-1559 [Abstract] [Full Text]  
  • Kim, Y.-K., Kawano, T., Li, D., Kolattukudy, P. E. (2000). A Mitogen-Activated Protein Kinase Kinase Required for Induction of Cytokinesis and Appressorium Formation by Host Signals in the Conidia of Colletotrichum gloeosporioides. Plant Cell 12: 1331-1344 [Abstract] [Full Text]  
  • Cullen, P. J., Schultz, J., Horecka, J., Stevenson, B. J., Jigami, Y., Sprague, G. F. , Jr. (2000). Defects in Protein Glycosylation Cause SHO1-Dependent Activation of a STE12 Signaling Pathway in Yeast. Genetics 155: 1005-1018 [Abstract] [Full Text]  
  • Furukawa, K., Mizushima, N., Noda, T., Ohsumi, Y. (2000). A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes. J. Biol. Chem. 275: 7462-7465 [Abstract] [Full Text]  
  • George, M. D., Baba, M., Scott, S. V., Mizushima, N., Garrison, B. S., Ohsumi, Y., Klionsky, D. J. (2000). Apg5p Functions in the Sequestration Step in the Cytoplasm-to-Vacuole Targeting and Macroautophagy Pathways. Mol. Biol. Cell 11: 969-982 [Abstract] [Full Text]  
  • Martin, H., Rodriguez-Pachon, J. M., Ruiz, C., Nombela, C., Molina, M. (2000). Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae. J. Biol. Chem. 275: 1511-1519 [Abstract] [Full Text]  
  • Andrews, P., Stark, M. (2000). Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J. Cell Sci. 113: 507-520 [Abstract]  
  • Loewith, R, Hubberstey, A, Young, D (2000). Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe. J. Cell Sci. 113: 153-160 [Abstract]  
  • Mattison, C. P., Spencer, S. S., Kresge, K. A., Lee, J., Ota, I. M. (1999). Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3. Mol. Cell. Biol. 19: 7651-7660 [Abstract] [Full Text]  
  • Lodder, A. L., Lee, T. K., Ballester, R. (1999). Characterization of the Wsc1 Protein, a Putative Receptor in the Stress Response of Saccharomyces cerevisiae. Genetics 152: 1487-1499 [Abstract] [Full Text]  
  • Rajavel, M., Philip, B., Buehrer, B. M., Errede, B., Levin, D. E. (1999). Mid2 Is a Putative Sensor for Cell Integrity Signaling in Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 3969-3976 [Abstract] [Full Text]  
  • Ketela, T., Green, R., Bussey, H. (1999). Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of the PKC1-MPK1 Cell Integrity Pathway. J. Bacteriol. 181: 3330-3340 [Abstract] [Full Text]  
  • Tao, W., Deschenes, R. J., Fassler, J. S. (1999). Intracellular Glycerol Levels Modulate the Activity of Sln1p, a Saccharomyces cerevisiae Two-component Regulator. J. Biol. Chem. 274: 360-367 [Abstract] [Full Text]  
  • WIDMANN, C., GIBSON, S., JARPE, M. B., JOHNSON, G. L. (1999). Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human. Physiol. Rev. 79: 143-180 [Abstract] [Full Text]  
  • Gustin, M. C., Albertyn, J., Alexander, M., Davenport, K. (1998). MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62: 1264-1300 [Abstract] [Full Text]  
  • Philips, J., Herskowitz, I. (1998). Identification of Kel1p, a Kelch Domain-containing Protein Involved in Cell Fusion and Morphology in Saccharomyces cerevisiae. JCB 143: 375-389 [Abstract] [Full Text]  
  • Engelberg, D., Mimran, A., Martinetto, H., Otto, J., Simchen, G., Karin, M., Fink, G. R. (1998). Multicellular Stalk-Like Structures in Saccharomyces cerevisiae. J. Bacteriol. 180: 3992-3996 [Abstract] [Full Text]  
  • Sheu, Y.-J., Santos, B., Fortin, N., Costigan, C., Snyder, M. (1998). Spa2p Interacts with Cell Polarity Proteins and Signaling Components Involved in Yeast Cell Morphogenesis. Mol. Cell. Biol. 18: 4053-4069 [Abstract] [Full Text]  
  • Banuett, F. (1998). Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi. Microbiol. Mol. Biol. Rev. 62: 249-274 [Abstract] [Full Text]  
  • Zhao, C., Jung, U. S., Garrett-Engele, P., Roe, T., Cyert, M. S., Levin, D. E. (1998). Temperature-Induced Expression of Yeast FKS2 Is under the Dual Control of Protein Kinase C and Calcineurin. Mol. Cell. Biol. 18: 1013-1022 [Abstract] [Full Text]  
  • Erickson, J. R., Wu, J. J., Goddard, J. G., Tigyi, G., Kawanishi, K., Tomei, L. D., Kiefer, M. C. (1998). Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid. J. Biol. Chem. 273: 1506-1510 [Abstract] [Full Text]  
  • Verna, J., Lodder, A., Lee, K., Vagts, A., Ballester, R. (1997). A family of genes required for maintenance of cell wall integrity and for the stress response in cerevisiae. Proc. Natl. Acad. Sci. USA 94: 13804-13809 [Abstract] [Full Text]  
  • Uesono, Y., Toh-e, A., Kikuchi, Y. (1997). Ssd1p of Saccharomyces cerevisiae Associates with RNA. J. Biol. Chem. 272: 16103-16109 [Abstract] [Full Text]  
  • Wilson, L. K., Dhillon, N., Thorner, J., Martin, G. S. (1997). Casein Kinase II Catalyzes Tyrosine Phosphorylation of the Yeast Nucleolar Immunophilin Fpr3. J. Biol. Chem. 272: 12961-12967 [Abstract] [Full Text]  
  • Madden, K., Sheu, Y.-J., Baetz, K., Andrews, B., Snyder, M. (1997). SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway. Science 275: 1781-1784 [Abstract] [Full Text]  
  • Batiza, A. F., Schulz, T., Masson, P. H. (1996). Yeast Respond to Hypotonic Shock with a Calcium Pulse. J. Biol. Chem. 271: 23357-23362 [Abstract] [Full Text]  
  • Thompson, L. J., Fields, A. P. (1996). beta II Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle. J. Biol. Chem. 271: 15045-15053 [Abstract] [Full Text]  
  • Davenport, K. R., Sohaskey, M., Kamada, Y., Levin, D. E., Gustin, M. C. (1995). A Second Osmosensing Signal Transduction Pathway in Yeast. J. Biol. Chem. 270: 30157-30161 [Abstract] [Full Text]  
  • English, J. M., Vanderbilt, C. A., Xu, S., Marcus, S., Cobb, M. H. (1995). Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms. J. Biol. Chem. 270: 28897-28902 [Abstract] [Full Text]  
  • Maeda, T, Takekawa, M, Saito, H (1995). Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269: 554-558 [Abstract]  
  • Wu, C., Whiteway, M., Thomas, D. Y., Leberer, E. (1995). Molecular Characterization of Ste20p, a Potential Mitogen-activated Protein or Extracellular Signal-regulated Kinase Kinase (MEK) Kinase Kinase from Saccharomycescerevisiae. J. Biol. Chem. 270: 15984-15992 [Abstract] [Full Text]  
  • Kamada, Y, Jung, U S, Piotrowski, J, Levin, D E (1995). The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.. Genes Dev. 9: 1559-1571 [Abstract]  
  • Sudol, M., Bork, P., Einbond, A., Kastury, K., Druck, T., Negrini, M., Huebner, K., Lehman, D. (1995). Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain. J. Biol. Chem. 270: 14733-14741 [Abstract] [Full Text]  
  • Lin, A, Minden, A, Martinetto, H, Claret, F., Lange-Carter, C, Mercurio, F, Johnson, G., Karin, M (1995). Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268: 286-290 [Abstract]  
  • Raingeaud, J.ėl, Gupta, S., Dickens, M., Han, J. (1995). Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine. J. Biol. Chem. 270: 7420-7426 [Abstract] [Full Text]  
  • Krisak, L, Strich, R, Winters, R S, Hall, J P, Mallory, M J, Kreitzer, D, Tuan, R S, Winter, E (1994). SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae.. Genes Dev. 8: 2151-2161 [Abstract]  
  • Banuett, F, Herskowitz, I (1994). Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle.. Genes Dev. 8: 1367-1378 [Abstract]  
  • Shintani, T., Suzuki, K., Kamada, Y., Noda, T., Ohsumi, Y. (2001). Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure. J. Biol. Chem. 276: 30452-30460 [Abstract] [Full Text]  


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