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Mol Cell Biol. 1993 June; 13(6): 3301-3310

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

A A Beg, T S Finco, P V Nantermet and A S Baldwin Jr

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599.

ABSTRACT

Nuclear factor kappa B (NF-kappa B) is a critical regulator of several genes which are involved in immune and inflammation responses. NF-kappa B, consisting of a 50-kDa protein (p50) and a 65-kDa protein (p65), is bound to a cytoplasmic retention protein called I kappa B. Stimulation of cells with a variety of inducers, including cytokines such as tumor necrosis factor and interleukin-1, leads to the activation and the translocation of p50/65 NF-kappa B into the nucleus. However, the in vivo mechanism of the activation process remains unknown. Here, we provide the first evidence that the in vivo mechanism of NF-kappa B activation is through the phosphorylation and subsequent loss of its inhibitor, I kappa B alpha. We also show that both I kappa B alpha loss and NF-kappa B activation are inhibited in the presence of antioxidants, demonstrating that the loss of I kappa B alpha is a prerequisite for NF-kappa B activation. Finally, we demonstrate that I kappa B alpha is rapidly resynthesized after loss, indicating that an autoregulatory mechanism is involved in the regulation of NF-kappa B function. We propose a mechanism for the activation of NF-kappa B through the modification and loss of I kappa B alpha, thereby establishing its role as a mediator of NF-kappa B activation.

Mol Cell Biol. 1993 June; 13(6): 3301-3310




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  • Droge, W. (2002). Free Radicals in the Physiological Control of Cell Function. Physiol. Rev. 82: 47-95 [Abstract] [Full Text]  
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  • Wolf, J. S., Chen, Z., Dong, G., Sunwoo, J. B., Bancroft, C. C., Capo, D. E., Yeh, N. T., Mukaida, N., Waes, C. V. (2001). IL (Interleukin)-1{{alpha}} Promotes Nuclear Factor-{{kappa}}B and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas. Clin. Cancer Res. 7: 1812-1820 [Abstract] [Full Text]  
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  • Inan, M. S., Tolmacheva, V., Wang, Q.-S., Rosenberg, D. W., Giardina, C. (2000). Transcription factor NF-kappa B participates in regulation of epithelial cell turnover in the colon. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G1282-G1291 [Abstract] [Full Text]  
  • Sayeed, M. M. (2000). Signaling Mechanisms of Altered Cellular Responses in Trauma, Burn, and Sepsis: Role of Ca2+. Arch Surg 135: 1432-1442 [Abstract] [Full Text]  
  • Bureau, F., Delhalle, S., Bonizzi, G., Fievez, L., Dogne, S., Kirschvink, N., Vanderplasschen, A., Merville, M.-P., Bours, V., Lekeux, P. (2000). Mechanisms of Persistent NF-{kappa}B Activity in the Bronchi of an Animal Model of Asthma. J. Immunol. 165: 5822-5830 [Abstract] [Full Text]  
  • Foehr, E. D., Lin, X., O'Mahony, A., Geleziunas, R., Bradshaw, R. A., Greene, W. C. (2000). NF-kappa B Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells. J. Neurosci. 20: 7556-7563 [Abstract] [Full Text]  
  • Khoshnan, A., Tindell, C., Laux, I., Bae, D., Bennett, B., Nel, A. E. (2000). The NF-{kappa}B Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes. J. Immunol. 165: 1743-1754 [Abstract] [Full Text]  
  • Yamashita, N., Hoshida, S., Otsu, K., Taniguchi, N., Kuzuya, T., Hori, M. (2000). Involvement of Cytokines in the Mechanism of Whole-Body Hyperthermia-Induced Cardioprotection. Circulation 102: 452-457 [Abstract] [Full Text]  
  • Li, S., Liang, Z.-G., Wang, G.-Y., Yavetz, B., Kim, E. D., Goldberg, E. (2000). Molecular Cloning and Characterization of Functional Domains of a Human Testis-Specific Isoform of Calpastatin. Biol. Reprod. 63: 172-178 [Abstract] [Full Text]  
  • Yamamoto, Y., Yin, M.-J., Gaynor, R. B. (2000). Ikappa B Kinase alpha (IKKalpha ) Regulation of IKKbeta Kinase Activity. Mol. Cell. Biol. 20: 3655-3666 [Abstract] [Full Text]  
  • Luberto, C., Yoo, D. S., Suidan, H. S., Bartoli, G. M., Hannun, Y. A. (2000). Differential Effects of Sphingomyelin Hydrolysis and Resynthesis on the Activation of NF-kappa B in Normal and SV40-transformed Human Fibroblasts. J. Biol. Chem. 275: 14760-14766 [Abstract] [Full Text]  
  • Nadeau, S., Rivest, S. (2000). Role of Microglial-Derived Tumor Necrosis Factor in Mediating CD14 Transcription and Nuclear Factor kappa B Activity in the Brain during Endotoxemia. J. Neurosci. 20: 3456-3468 [Abstract] [Full Text]  
  • Muenchen, H. J., Lin, D.-L., Walsh, M. A., Keller, E. T., Pienta, K. J. (2000). Tumor Necrosis Factor-{{alpha}}-induced Apoptosis in Prostate Cancer Cells through Inhibition of Nuclear Factor-{{kappa}}B by an I{{kappa}}B{{alpha}} "Super-Repressor". Clin. Cancer Res. 6: 1969-1977 [Abstract] [Full Text]  
  • Vann, L. R., Twitty, S., Spiegel, S., Milstien, S. (2000). Divergence in Regulation of Nitric-oxide Synthase and Its Cofactor Tetrahydrobiopterin by Tumor Necrosis Factor-alpha . CERAMIDE POTENTIATES NITRIC OXIDE SYNTHESIS WITHOUT AFFECTING GTP CYCLOHYDROLASE I ACTIVITY. J. Biol. Chem. 275: 13275-13281 [Abstract] [Full Text]  
  • BUREAU, F., BONIZZI, G., KIRSCHVINK, N., DELHALLE, S., DESMECHT, D., MERVILLE, M.-P., BOURS, V., LEKEUX, P. (2000). Correlation between Nuclear Factor-kappa B Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma. Am. J. Respir. Crit. Care Med. 161: 1314-1321 [Abstract] [Full Text]  
  • Ye, J., Xie, X., Tarassishin, L., Horwitz, M. S. (2000). Regulation of the NF-kappa B Activation Pathway by Isolated Domains of FIP3/IKKgamma , a Component of the Ikappa B-alpha Kinase Complex. J. Biol. Chem. 275: 9882-9889 [Abstract] [Full Text]  
  • Zamanian-Daryoush, M., Mogensen, T. H., DiDonato, J. A., Williams, B. R. G. (2000). NF-kappa B Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kappa B-Inducing Kinase and Ikappa B Kinase. Mol. Cell. Biol. 20: 1278-1290 [Abstract] [Full Text]  
  • Wu, K., Fuchs, S. Y., Chen, A., Tan, P., Gomez, C., Ronai, Z.'e., Pan, Z.-Q. (2000). The SCFHOS/beta -TRCP-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation. Mol. Cell. Biol. 20: 1382-1393 [Abstract] [Full Text]  
  • Jefferies, C. A., O'Neill, L. A. J. (2000). Rac1 Regulates Interleukin 1-induced Nuclear Factor kappa B Activation in an Inhibitory Protein kappa Balpha -independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression. J. Biol. Chem. 275: 3114-3120 [Abstract] [Full Text]  
  • Murakami, S., Lefebvre, V., de Crombrugghe, B. (2000). Potent Inhibition of the Master Chondrogenic Factor Sox9 Gene by Interleukin-1 and Tumor Necrosis Factor-alpha. J. Biol. Chem. 275: 3687-3692 [Abstract] [Full Text]  
  • Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., Laflamme, N. (2000). How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli. Exp. Biol. Med. 223: 22-38 [Abstract] [Full Text]  
  • Carlotti, F., Chapman, R., Dower, S. K., Qwarnstrom, E. E. (1999). Activation of Nuclear Factor kappa B in Single Living Cells. DEPENDENCE OF NUCLEAR TRANSLOCATION AND ANTI-APOPTOTIC FUNCTION ON EGFPRELA CONCENTRATION. J. Biol. Chem. 274: 37941-37949 [Abstract] [Full Text]  
  • Zhang, Y.-k., Sun, X., Muraoka, K.-i., Ikeda, A., Miyamoto, S., Shimizu, H., Yoshioka, K., Yamamoto, K.-i. (1999). Immunosuppressant FK506 Activates NF-kappa B through the Proteasome-mediated Degradation of Ikappa Balpha . REQUIREMENT FOR Ikappa Balpha N-TERMINAL PHOSPHORYLATION BUT NOT UBIQUITINATION SITES. J. Biol. Chem. 274: 34657-34662 [Abstract] [Full Text]  
  • Khoshnan, A., Kempiak, S. J., Bennett, B. L., Bae, D., Xu, W., Manning, A. M., June, C. H., Nel, A. E. (1999). Primary Human CD4+ T Cells Contain Heterogeneous I{kappa}B Kinase Complexes: Role in Activation of the IL-2 Promoter. J. Immunol. 163: 5444-5452 [Abstract] [Full Text]  


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