This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stein, B Articles by Baldwin, A S Search for Related Content PubMed PubMed Citation Articles by Stein, B Articles by Baldwin, A S, Jr

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 July; 13(7): 3964-3974

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599.

ABSTRACT

NF-kappa B and C/EBP represent distinct families of transcription factors that target unique DNA enhancer elements. The heterodimeric NF-kappa B complex is composed of two subunits, a 50- and a 65-kDa protein. All members of the NF-kappa B family, including the product of the proto-oncogene c-rel, are characterized by their highly homologous approximately 300-amino-acid N-terminal region. This Rel homology domain mediates DNA binding, dimerization, and nuclear targeting of these proteins. C/EBP contains the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. We now demonstrated the unexpected cross-coupling of members of the NF-kappa B family three members of the C/EBP family. NF-kappa B p65, p50, and Rel functionally synergize with C/EBP alpha, C/EBP beta, and C/EBP delta. This cross-coupling results in the inhibition of promoters with kappa B enhancer motifs and in the synergistic stimulation of promoters with C/EBP binding sites. These studies demonstrate that NF-kappa B augments gene expression mediated by a multimerized c-fos serum response element in the presence of C/EBP. We show a direct physical association of the bZIP region of C/EBP with the Rel homology domain of NF-kappa B. The cross-coupling of NF-kappa B with C/EBP highlights a mechanism of gene regulation involving an interaction between distinct transcription factor families.

This article has been cited by other articles:

• Kijima, I., Ye, J., Glackin, C., Chen, S. (2008). CCAAT/Enhancer Binding Protein {delta} Up-regulates Aromatase Promoters I.3/II in Breast Cancer Epithelial Cells. Cancer Res. 68: 4455-4464 [Abstract] [Full Text]  
• Chumakov, A. M., Silla, A., Williamson, E. A., Koeffler, H. P. (2007). Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway. Blood 109: 4209-4219 [Abstract] [Full Text]  
• Shaw, J., Zhang, T., Rzeszutek, M., Yurkova, N., Baetz, D., Davie, J. R., Kirshenbaum, L. A. (2006). Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-{kappa}B and Histone Deacetylase 1 in Ventricular Myocytes. Circ. Res. 99: 1347-1354 [Abstract] [Full Text]  
• Soloff, M. S., Izban, M. G., Cook, D. L. Jr, Jeng, Y.-J., Mifflin, R. C. (2006). Interleukin-1-induced NF-{kappa}B recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells. Mol Hum Reprod 12: 619-624 [Abstract] [Full Text]  
• Borger, P., Tamm, M., Black, J. L., Roth, M. (2006). Asthma: Is It Due to an Abnormal Airway Smooth Muscle Cell?. Am. J. Respir. Crit. Care Med. 174: 367-372 [Abstract] [Full Text]  
• Faour, W. H., He, Q., Mancini, A., Jovanovic, D., Antoniou, J., Di Battista, J. A. (2006). Prostaglandin E2 Stimulates p53 Transactivational Activity through Specific Serine 15 Phosphorylation in Human Synovial Fibroblasts: ROLE IN SUPPRESSION OF c/EBP/NF-{kappa}B-MEDIATED MEKK1-INDUCED MMP-1 EXPRESSION. J. Biol. Chem. 281: 19849-19860 [Abstract] [Full Text]  
• Zwergal, A., Quirling, M., Saugel, B., Huth, K. C., Sydlik, C., Poli, V., Neumeier, D., Ziegler-Heitbrock, H. W. L., Brand, K. (2006). C/EBPbeta Blocks p65 Phosphorylation and Thereby NF-{kappa}B-Mediated Transcription in TNF-Tolerant Cells. J. Immunol. 177: 665-672 [Abstract] [Full Text]  
• Terzidou, V., Lee, Y., Lindstrom, T., Johnson, M., Thornton, S., Bennett, P. R. (2006). Regulation of the Human Oxytocin Receptor by Nuclear Factor-{kappa}B and CCAAT/Enhancer-Binding Protein-{beta}. J. Clin. Endocrinol. Metab. 91: 2317-2326 [Abstract] [Full Text]  
• Schneider-Merck, T., Pohnke, Y., Kempf, R., Christian, M., Brosens, J. J., Gellersen, B. (2006). Physical Interaction and Mutual Transrepression between CCAAT/Enhancer-binding Protein {beta} and the p53 Tumor Suppressor. J. Biol. Chem. 281: 269-278 [Abstract] [Full Text]  
• Listman, J. A., Wara-aswapati, N., Race, J. E., Blystone, L. W., Walker-Kopp, N., Yang, Z., Auron, P. E. (2005). Conserved ETS Domain Arginines Mediate DNA Binding, Nuclear Localization, and a Novel Mode of bZIP Interaction. J. Biol. Chem. 280: 41421-41428 [Abstract] [Full Text]  
• Baetz, D., Regula, K. M., Ens, K., Shaw, J., Kothari, S., Yurkova, N., Kirshenbaum, L. A. (2005). Nuclear Factor-{kappa}B-Mediated Cell Survival Involves Transcriptional Silencing of the Mitochondrial Death Gene BNIP3 in Ventricular Myocytes. Circulation 112: 3777-3785 [Abstract] [Full Text]  
• Paz-Priel, I., Cai, D. H., Wang, D., Kowalski, J., Blackford, A., Liu, H., Heckman, C. A., Gombart, A. F., Koeffler, H. P., Boxer, L. M., Friedman, A. D. (2005). CCAAT/Enhancer Binding Protein {alpha} (C/EBP{alpha}) and C/EBP{alpha} Myeloid Oncoproteins Induce Bcl-2 via Interaction of Their Basic Regions with Nuclear Factor-{kappa}B p50. Mol Cancer Res 3: 585-596 [Abstract] [Full Text]  
• Voleti, B., Agrawal, A. (2005). Regulation of Basal and Induced Expression of C-Reactive Protein through an Overlapping Element for OCT-1 and NF-{kappa}B on the Proximal Promoter. J. Immunol. 175: 3386-3390 [Abstract] [Full Text]  
• Todorov, V. T., Volkl, S., Friedrich, J., Kunz-Schughart, L. A., Hehlgans, T., Vermeulen, L., Haegeman, G., Schmitz, M. L., Kurtz, A. (2005). Role of CREB1 and NF{kappa}B-p65 in the Down-regulation of Renin Gene Expression by Tumor Necrosis Factor {alpha}. J. Biol. Chem. 280: 24356-24362 [Abstract] [Full Text]  
• Jaulmes, A., Janvier, B., Andreani, M., Raymondjean, M. (2005). Autocrine and Paracrine Transcriptional Regulation of Type IIA Secretory Phospholipase A2 Gene in Vascular Smooth Muscle Cells. Arterioscler. Thromb. Vasc. Bio. 25: 1161-1167 [Abstract] [Full Text]  
• Meng, Q., Raha, A., Roy, S., Hu, J., Kalvakolanu, D. V. (2005). IFN-{gamma}-Stimulated Transcriptional Activation by IFN-{gamma}-Activated Transcriptional Element-Binding Factor 1 Occurs via an Inducible Interaction with CAAAT/Enhancer-Binding Protein-{beta}. J. Immunol. 174: 6203-6211 [Abstract] [Full Text]  
• Chen, J., Zhao, M., Rao, R., Inoue, H., Hao, C.-M. (2005). C/EBP{beta} and Its Binding Element Are Required for NF{kappa}B-induced COX2 Expression Following Hypertonic Stress. J. Biol. Chem. 280: 16354-16359 [Abstract] [Full Text]  
• Giresi, P. G., Stevenson, E. J., Theilhaber, J., Koncarevic, A., Parkington, J., Fielding, R. A., Kandarian, S. C. (2005). Identification of a molecular signature of sarcopenia. Physiol. Genomics 21: 253-263 [Abstract] [Full Text]  
• Burkart, A. D., Mukherjee, A., Sterneck, E., Johnson, P. F., Mayo, K. E. (2005). Repression of the Inhibin {alpha}-Subunit Gene by the Transcription Factor CCAAT/Enhancer-Binding Protein-{beta}. Endocrinology 146: 1909-1921 [Abstract] [Full Text]  
• Kwon, H.-J., Breese, E. H., Vig-Varga, E., Luo, Y., Lee, Y., Goebl, M. G., Harrington, M. A. (2004). Tumor Necrosis Factor Alpha Induction of NF-{kappa}B Requires the Novel Coactivator SIMPL. Mol. Cell. Biol. 24: 9317-9326 [Abstract] [Full Text]  
• Schrem, H., Klempnauer, J., Borlak, J. (2004). Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation. Pharmacol. Rev. 56: 291-330 [Abstract] [Full Text]  
• Hong, C. Y., Park, J. H., Ahn, R. S., Im, S. Y., Choi, H.-S., Soh, J., Mellon, S. H., Lee, K. (2004). Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha. Mol. Cell. Biol. 24: 2593-2604 [Abstract] [Full Text]  
• Yu, Z., Kone, B. C. (2004). The STAT3 DNA-Binding Domain Mediates Interaction with NF-{kappa}B p65 and Inducible Nitric Oxide Synthase Transrepression in Mesangial Cells. J. Am. Soc. Nephrol. 15: 585-591 [Abstract] [Full Text]  
• Yoshida, Y., Kumar, A., Koyama, Y., Peng, H., Arman, A., Boch, J. A., Auron, P. E. (2004). Interleukin 1 Activates STAT3/Nuclear Factor-{kappa}B Cross-talk via a Unique TRAF6- and p65-dependent Mechanism. J. Biol. Chem. 279: 1768-1776 [Abstract] [Full Text]  
• Papin, S., Cazeneuve, C., Duquesnoy, P., Jeru, I., Sahali, D., Amselem, S. (2003). The Tumor Necrosis Factor {alpha}-dependent Activation of the Human Mediterranean Fever (MEFV) Promoter Is Mediated by a Synergistic Interaction between C/EBP{beta} and NF{kappa}B p65. J. Biol. Chem. 278: 48839-48847 [Abstract] [Full Text]  
• Okada, S., Obata, S., Hatano, M., Tokuhisa, T. (2003). Dominant-negative effect of the c-fos family gene products on inducible NO synthase expression in macrophages. Int Immunol 15: 1275-1282 [Abstract] [Full Text]  
• Hong, C. Y., Park, J. H., Seo, K. H., Kim, J.-M., Im, S. Y., Lee, J. W., Choi, H.-S., Lee, K. (2003). Expression of MIS in the Testis Is Downregulated by Tumor Necrosis Factor Alpha through the Negative Regulation of SF-1 Transactivation by NF-{kappa}B. Mol. Cell. Biol. 23: 6000-6012 [Abstract] [Full Text]  
• Loncar, M B, Al-azzeh, E-d, Sommer, P S M, Marinovic, M, Schmehl, K, Kruschewski, M, Blin, N, Stohwasser, R, Gott, P, Kayademir, T (2003). Tumour necrosis factor {alpha} and nuclear factor {kappa}B inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 52: 1297-1303 [Abstract] [Full Text]  
• Guo, Z., Boekhoudt, G. H., Boss, J. M. (2003). Role of the Intronic Enhancer in Tumor Necrosis Factor-mediated Induction of Manganous Superoxide Dismutase. J. Biol. Chem. 278: 23570-23578 [Abstract] [Full Text]  
• Weber, M., Sydlik, C., Quirling, M., Nothdurfter, C., Zwergal, A., Heiss, P., Bell, S., Neumeier, D., Ziegler-Heitbrock, H. W. L., Brand, K. (2003). Transcriptional Inhibition of Interleukin-8 Expression in Tumor Necrosis Factor-tolerant Cells: EVIDENCE FOR INVOLVEMENT OF C/EBP{beta}. J. Biol. Chem. 278: 23586-23593 [Abstract] [Full Text]  
• Edelstein, L. C., Lagos, L., Simmons, M., Tirumalai, H., Gelinas, C. (2003). NF-{kappa}B-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1. Mol. Cell. Biol. 23: 2749-2761 [Abstract] [Full Text]  
• Xie, Y., Zhong, R., Chen, C., Calderwood, S. K. (2003). Heat Shock Factor 1 Contains Two Functional Domains That Mediate Transcriptional Repression of the c-fos and c-fms Genes. J. Biol. Chem. 278: 4687-4698 [Abstract] [Full Text]  
• Kleemann, R., Gervois, P. P., Verschuren, L., Staels, B., Princen, H. M. G., Kooistra, T. (2003). Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood 101: 545-551 [Abstract] [Full Text]  
• Mao, X., Moerman, A. M., Barger, S. W. (2002). Neuronal kappa B-binding Factors Consist of Sp1-related Proteins. FUNCTIONAL IMPLICATIONS FOR AUTOREGULATION OF N-METHYL-D-ASPARTATE RECEPTOR-1 EXPRESSION. J. Biol. Chem. 277: 44911-44919 [Abstract] [Full Text]  
• Piwien-Pilipuk, G., MacDougald, O., Schwartz, J. (2002). Dual Regulation of Phosphorylation and Dephosphorylation of C/EBPbeta Modulate Its Transcriptional Activation and DNA Binding in Response to Growth Hormone. J. Biol. Chem. 277: 44557-44565 [Abstract] [Full Text]  
• Hershko, D. D., Robb, B. W., Luo, G., Hasselgren, P.-O. (2002). Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R1140-R1148 [Abstract] [Full Text]  
• Vales, L. D., Friedl, E. M. (2002). Binding of C/EBP and RBP (CBF1) to Overlapping Sites Regulates Interleukin-6 Gene Expression. J. Biol. Chem. 277: 42438-42446 [Abstract] [Full Text]  
• Lethimonier, C., Flouriot, G., Kah, O., Ducouret, B. (2002). The Glucocorticoid Receptor Represses the Positive Autoregulation of the Trout Estrogen Receptor Gene by Preventing the Enhancer Effect of a C/EBP{beta}-Like Protein. Endocrinology 143: 2961-2974 [Abstract] [Full Text]  
• Tamura, M., Sebastian, S., Yang, S., Gurates, B., Ferrer, K., Sasano, H., Okamura, K., Bulun, S. E. (2002). Up-regulation of Cyclooxygenase-2 Expression and Prostaglandin Synthesis in Endometrial Stromal Cells by Malignant Endometrial Epithelial Cells. A PARACRINE EFFECT MEDIATED BY PROSTAGLANDIN E2 AND NUCLEAR FACTOR-kappa B. J. Biol. Chem. 277: 26208-26216 [Abstract] [Full Text]  
• Boffa, M. B., Hamill, J. D., Bastajian, N., Dillon, R., Nesheim, M. E., Koschinsky, M. L. (2002). A Role for CCAAT/Enhancer-binding Protein in Hepatic Expression of Thrombin-activable Fibrinolysis Inhibitor. J. Biol. Chem. 277: 25329-25336 [Abstract] [Full Text]  
• Christian, M., Zhang, X., Schneider-Merck, T., Unterman, T. G., Gellersen, B., White, J. O., Brosens, J. J. (2002). Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein beta in Differentiating Human Endometrial Stromal Cells. J. Biol. Chem. 277: 20825-20832 [Abstract] [Full Text]  
• GIRI, S., JATANA, M., RATTAN, R., WON, J.-S., SINGH, I., SINGH, A. K. (2002). Galactosylsphingosine (psychosine) -induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease. FASEB J. 16: 661-672 [Abstract] [Full Text]  
• Sen, E., Bromberg-White, J. L., Meyers, C. (2002). Genetic Analysis of cis Regulatory Elements within the 5' Region of the Human Papillomavirus Type 31 Upstream Regulatory Region during Different Stages of the Viral Life Cycle. J. Virol. 76: 4798-4809 [Abstract] [Full Text]  
• Xie, Y., Chen, C., Stevenson, M. A., Auron, P. E., Calderwood, S. K. (2002). Heat Shock Factor 1 Represses Transcription of the IL-1beta Gene through Physical Interaction with the Nuclear Factor of Interleukin 6. J. Biol. Chem. 277: 11802-11810 [Abstract] [Full Text]  
• Christian, M., Pohnke, Y., Kempf, R., Gellersen, B., Brosens, J. J. (2002). Functional Association of PR and CCAAT/Enhancer-Binding Protein {beta} Isoforms: Promoter-Dependent Cooperation between PR-B and Liver-Enriched Inhibitory Protein, or Liver-Enriched Activatory Protein and PR-A in Human Endometrial Stromal Cells. Mol. Endocrinol. 16: 141-154 [Abstract] [Full Text]  
• Chang, W.-J., Alvarez-Gonzalez, R. (2001). The Sequence-specific DNA Binding of NF-kappa B Is Reversibly Regulated by the Automodification Reaction of Poly (ADP-ribose) Polymerase 1. J. Biol. Chem. 276: 47664-47670 [Abstract] [Full Text]  
• Fan, J., Ye, R. D., Malik, A. B. (2001). Transcriptional mechanisms of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1037-L1050 [Abstract] [Full Text]  
• Wang, C.-D., Chang, G.-D., Lee, Y.-K., Chen, H. (2001). A Functional Composite Cis-Element for NF{kappa}B and RBPJ{kappa} in the Rat Pregnancy-Specific Glycoprotein Gene. Biol. Reprod. 65: 1437-1443 [Abstract] [Full Text]  
• Darville, M. I., Eizirik, D. L. (2001). Cytokine Induction of Fas Gene Expression in Insulin-Producing Cells Requires the Transcription Factors NF-{kappa}B and C/EBP. Diabetes 50: 1741-1748 [Abstract] [Full Text]  
• Mao, C.-s., Stavnezer, J. (2001). Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40. J. Immunol. 167: 1522-1534 [Abstract] [Full Text]  
• La, E., Fischer, S. M. (2001). Transcriptional Regulation of Intracellular IL-1 Receptor Antagonist Gene by IL-1{{alpha}} in Primary Mouse Keratinocytes. J. Immunol. 166: 6149-6155 [Abstract] [Full Text]  
• Agrawal, A., Cha-Molstad, H., Samols, D., Kushner, I. (2001). Transactivation of C-Reactive Protein by IL-6 Requires Synergistic Interaction of CCAAT/Enhancer Binding Protein {{beta}} (C/EBP{{beta}}) and Rel p50. J. Immunol. 166: 2378-2384 [Abstract] [Full Text]  
• Sugawara, I., Mizuno, S., Yamada, H., Matsumoto, M., Akira, S. (2001). Disruption of Nuclear Factor-Interleukin-6, a Transcription Factor, Results in Severe Mycobacterial Infection. Am. J. Pathol. 158: 361-366 [Abstract] [Full Text]  
• Shen, C.-H., Stavnezer, J. (2001). Activation of the Mouse Ig Germline {{epsilon}} Promoter by IL-4 Is Dependent on AP-1 Transcription Factors. J. Immunol. 166: 411-423 [Abstract] [Full Text]  
• Cha-Molstad, H., Agrawal, A., Zhang, D., Samols, D., Kushner, I. (2000). The Rel Family Member P50 Mediates Cytokine-Induced C-Reactive Protein Expression by a Novel Mechanism. J. Immunol. 165: 4592-4597 [Abstract] [Full Text]  
• Slomiany, B. A., D'Arigo, K. L., Kelly, M. M., Kurtz, D. T. (2000). C/EBPalpha Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription. Mol. Cell. Biol. 20: 5986-5997 [Abstract] [Full Text]  
• McKay, L. I., Cidlowski, J. A. (2000). CBP (CREB Binding Protein) Integrates NF-{kappa}B (Nuclear Factor-{kappa}B) and Glucocorticoid Receptor Physical Interactions and Antagonism. Mol. Endocrinol. 14: 1222-1234 [Abstract] [Full Text]  
• Roy, S. K., Wachira, S. J., Weihua, X., Hu, J., Kalvakolanu, D. V. (2000). CCAAT/Enhancer-binding Protein-beta Regulates Interferon-induced Transcription through a Novel Element. J. Biol. Chem. 275: 12626-12632 [Abstract] [Full Text]  
• Liu, H., Sidiropoulos, P., Song, G., Pagliari, L. J., Birrer, M. J., Stein, B., Anrather, J., Pope, R. M. (2000). TNF-{alpha} Gene Expression in Macrophages: Regulation by NF-{kappa}B Is Independent of c-Jun or C/EBP{beta}. J. Immunol. 164: 4277-4285 [Abstract] [Full Text]  
• Chang, M. M.-J., Harper, R., Hyde, D. M., Wu, R. (2000). A Novel Mechanism of Retinoic Acid-Enhanced Interleukin-8 Gene Expression in Airway Epithelium. Am. J. Respir. Cell Mol. Bio. 22: 502-510 [Abstract] [Full Text]  
• Chapman, N. R., Perkins, N. D. (2000). Inhibition of the RelA(p65) NF-kappa B Subunit by Egr-1. J. Biol. Chem. 275: 4719-4725 [Abstract] [Full Text]  
• Belsham, D. D., Mellon, P. L. (2000). Transcription Factors Oct-1 and C/EBP{beta} (CCAAT/Enhancer-Binding Protein-{beta}) Are Involved in the Glutamate/Nitric Oxide/cyclic-Guanosine 5'-Monophosphate-Mediated Repression of Gonadotropin-Releasing Hormone Gene Expression. Mol. Endocrinol. 14: 212-228 [Abstract] [Full Text]  
• Schwartz, C., Catez, P., Rohr, O., Lecestre, D., Aunis, D., Schaeffer, E. (2000). Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells. J. Virol. 74: 65-73 [Abstract] [Full Text]  
• Delfino, F. J., Walker, W. H. (1999). NF-kappa B Induces cAMP-response Element-binding Protein Gene Transcription in Sertoli Cells. J. Biol. Chem. 274: 35607-35613 [Abstract] [Full Text]  
• Liao, J., Piwien-Pilipuk, G., Ross, S. E., Hodge, C. L., Sealy, L., MacDougald, O. A., Schwartz, J. (1999). CCAAT/Enhancer-binding Protein beta (C/EBPbeta ) and C/EBPdelta Contribute to Growth Hormone-regulated Transcription of c-fos. J. Biol. Chem. 274: 31597-31604 [Abstract] [Full Text]  
• Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J., Suda, T. (1999). C/EBPbeta and GATA-1 Synergistically Regulate Activity of the Eosinophil Granule Major Basic Protein Promoter: Implication for C/EBPbeta Activity in Eosinophil Gene Expression. Blood 94: 1429-1439 [Abstract] [Full Text]  
• McKay, L. I., Cidlowski, J. A. (1999). Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-{kappa}B and Steroid Receptor-Signaling Pathways. Endocr. Rev. 20: 435-459 [Abstract] [Full Text]  
• Kim, S., Mao, P.-L., Gagliardi, M., Bedard, P.-A. (1999). C/EBPbeta (NF-M) Is Essential for Activation of the p20K Lipocalin Gene in Growth-Arrested Chicken Embryo Fibroblasts. Mol. Cell. Biol. 19: 5718-5731 [Abstract] [Full Text]  
• Moreno-Aliaga, M. J., Matsumura, F. (1999). Endrin Inhibits Adipocyte Differentiation by Selectively Altering Expression Pattern of CCAAT/Enhancer Binding Protein-alpha in 3T3-L1 Cells. Mol. Pharmacol. 56: 91-101 [Abstract] [Full Text]  
• GRASSL, C., LUCKOW, B., SCHLÖNDORFF, D., DENDORFER, U. (1999). Transcriptional Regulation of the Interleukin-6 Gene in Mesangial Cells. J. Am. Soc. Nephrol. 10: 1466-1477 [Abstract] [Full Text]  
• O'Rourke, J. P., Newbound, G. C., Hutt, J. A., DeWille, J. (1999). CCAAT/Enhancer-binding Protein delta  Regulates Mammary Epithelial Cell G0 Growth Arrest and Apoptosis. J. Biol. Chem. 274: 16582-16589 [Abstract] [Full Text]  
• Dlaska, M., Weiss, G. (1999). Central Role of Transcription Factor NF-IL6 for Cytokine and Iron-Mediated Regulation of Murine Inducible Nitric Oxide Synthase Expression. J. Immunol. 162: 6171-6177 [Abstract] [Full Text]  
• Webster, G. A., Perkins, N. D. (1999). Transcriptional Cross Talk between NF-kappa B and p53. Mol. Cell. Biol. 19: 3485-3495 [Abstract] [Full Text]  
• ROEBUCK, K. A, JACOBS, J. J., GLANT, T. T. (1999). New Horizons in Orthopaedic Research: Elucidation of Cellular Signal Transduction Pathways. JBJS 81: 599-602 [Full Text]  
• Schaffer, A., Cerutti, A., Shah, S., Zan, H., Casali, P. (1999). The Evolutionarily Conserved Sequence Upstream of the Human Ig Heavy Chain S{gamma}3 Region Is an Inducible Promoter: Synergistic Activation by CD40 Ligand and IL-4 Via Cooperative NF-{kappa}B and STAT-6 Binding Sites. J. Immunol. 162: 5327-5336 [Abstract] [Full Text]  
• Lai, C.-K., Ting, L.-P. (1999). Transcriptional Repression of Human Hepatitis B Virus Genes by a bZIP Family Member, E4BP4. J. Virol. 73: 3197-3209 [Abstract] [Full Text]  
• Safak, M., Gallia, G. L., Khalili, K. (1999). Reciprocal Interaction between Two Cellular Proteins, Puralpha and YB-1, Modulates Transcriptional Activity of JCVCY in Glial Cells. Mol. Cell. Biol. 19: 2712-2723 [Abstract] [Full Text]  
• Kuprash, D. V., Udalova, I. A., Turetskaya, R. L., Kwiatkowski, D., Rice, N. R., Nedospasov, S. A. (1999). Similarities and Differences Between Human and Murine TNF Promoters in Their Response to Lipopolysaccharide. J. Immunol. 162: 4045-4052 [Abstract] [Full Text]  
• Montaner, S., Perona, R., Saniger, L., Lacal, J. C. (1999). Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-kappa B and C/EBP Transcription Factors. J. Biol. Chem. 274: 8506-8515 [Abstract] [Full Text]  
• Pizarro-Cerda, J., Desjardins, M., Moreno, E., Akira, S., Gorvel, J.-P. (1999). Modulation of Endocytosis in Nuclear Factor IL-6(-/-) Macrophages Is Responsible for a High Susceptibility to Intracellular Bacterial Infection. J. Immunol. 162: 3519-3526 [Abstract] [Full Text]  
• Yamada, K., Duong, D. T., Scott, D. K., Wang, J.-C., Granner, D. K. (1999). CCAAT/Enhancer-binding Protein beta  Is an Accessory Factor for the Glucocorticoid Response from the cAMP Response Element in the Rat Phosphoenolpyruvate Carboxykinase Gene Promoter. J. Biol. Chem. 274: 5880-5887 [Abstract] [Full Text]  
• Umemori, H., Kadowaki, Y., Hirosawa, K., Yoshida, Y., Hironaka, K., Okano, H., Yamamoto, T. (1999). Stimulation of Myelin Basic Protein Gene Transcription by Fyn Tyrosine Kinase for Myelination. J. Neurosci. 19: 1393-1397 [Abstract] [Full Text]  
• Angerer, N. D., Du, Y., Nalbant, D., Williams, S. C. (1999). A Short Conserved Motif Is Required for Repressor Domain Function in the Myeloid-specific Transcription Factor CCAAT/Enhancer-binding Protein epsilon. J. Biol. Chem. 274: 4147-4154 [Abstract] [Full Text]  
• Choi, B. H., Park, G. T., Rho, H. M. (1999). Interaction of Hepatitis B Viral X Protein and CCAAT/ Enhancer-binding Protein alpha  Synergistically Activates the Hepatitis B Viral Enhancer II/Pregenomic Promoter. J. Biol. Chem. 274: 2858-2865 [Abstract] [Full Text]  
• Burgess-Beusse, B. L., Darlington, G. J. (1998). C/EBPalpha Is Critical for the Neonatal Acute-Phase Response to Inflammation. Mol. Cell. Biol. 18: 7269-7277 [Abstract] [Full Text]  
• Poli, V. (1998). The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions. J. Biol. Chem. 273: 29279-29282 [Full Text]  
• Mikita, T., Kurama, M., Schindler, U. (1998). Synergistic Activation of the Germline {epsilon} Promoter Mediated by Stat6 and C/EBP{beta}. J. Immunol. 161: 1822-1828 [Abstract] [Full Text]  
• Lundblad, J. R., Kwok, R. P. S., Laurance, M. E., Huang, M. S., Richards, J. P., Brennan, R. G., Goodman, R. H. (1998). The Human T-cell Leukemia Virus-1 Transcriptional Activator Tax Enhances cAMP-responsive Element-binding Protein (CREB) Binding Activity through Interactions with the DNA Minor Groove. J. Biol. Chem. 273: 19251-19259 [Abstract] [Full Text]  
• Taylor, B. S., de Vera, M. E., Ganster, R. W., Wang, Q., Shapiro, R. A., Morris Jr., S. M., Billiar, T. R., Geller, D. A. (1998). Multiple NF-kappa B Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene. J. Biol. Chem. 273: 15148-15156 [Abstract] [Full Text]  
• Ohtani, K., Tsujimoto, A., Tsukahara, T., Numata, N., Miura, S., Sugamura, K., Nakamura, M. (1998). Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I. J. Biol. Chem. 273: 14119-14129 [Abstract] [Full Text]  
• Shen, C.-H., Stavnezer, J. (1998). Interaction of Stat6 and NF-kappa B: Direct Association and Synergistic Activation of Interleukin-4-Induced Transcription. Mol. Cell. Biol. 18: 3395-3404 [Abstract] [Full Text]  
• Hansen, A. J., Lee, Y.-H., Sterneck, E., Gonzalez, F. J., Mackenzie, P. I. (1998). C/EBPalpha Is a Regulator of the UDP Glucuronosyltransferase UGT2B1 Gene. Mol. Pharmacol. 53: 1027-1033 [Abstract] [Full Text]  
• Parra, E., McGuire, K., Hedlund, G., Dohlsten, M. (1998). Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter. J. Immunol. 160: 5374-5381 [Abstract] [Full Text]  
• Williams, S. C., Du, Y., Schwartz, R. C., Weiler, S. R., Ortiz, M., Keller, J. R., Johnson, P. F. (1998). C/EBPepsilon Is a Myeloid-specific Activator of Cytokine, Chemokine, and Macrophage-Colony-stimulating Factor Receptor Genes. J. Biol. Chem. 273: 13493-13501 [Abstract] [Full Text]  
• Zagariya, A., Mungre, S., Lovis, R., Birrer, M., Ness, S., Thimmapaya, B., Pope, R. (1998). Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPbeta -Induced Activation by c-Jun. Mol. Cell. Biol. 18: 2815-2824 [Abstract] [Full Text]  
• Levesque, E., Beaulieu, M., Guillemette, C., Hum, D. W., Belanger, A. (1998). Effect of Interleukins on UGT2B15 and UGT2B17 Steroid Uridine Diphosphate-Glucuronosyltransferase Expression and Activity in the LNCaP Cell Line. Endocrinology 139: 2375-2381 [Abstract] [Full Text]  
• Miau, L.-H., Chang, C.-J., Shen, B.-J., Tsai, W.-H., Lee, S.-C. (1998). Identification of Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) as a Repressor of C/EBPbeta -mediated Gene Activation. J. Biol. Chem. 273: 10784-10791 [Abstract] [Full Text]  
• Ott, M., Lovett, J. L., Mueller, L., Verdin, E. (1998). Superinduction of IL-8 in T Cells by HIV-1 Tat Protein Is Mediated Through NF-{kappa}B Factors. J. Immunol. 160: 2872-2880 [Abstract] [Full Text]  
• Bauknecht, T., Shi, Y. (1998). Overexpression of C/EBPbeta Represses Human Papillomavirus Type 18 Upstream Regulatory Region Activity in HeLa Cells by Interfering with the Binding of TATA-Binding Protein. J. Virol. 72: 2113-2124 [Abstract] [Full Text]  
• Hiramoto, M., Shimizu, N., Sugimoto, K., Tang, J., Kawakami, Y., Ito, M., Aizawa, S., Tanaka, H., Makino, I., Handa, H. (1998). Nuclear Targeted Suppression of NF-{kappa}B Activity by the Novel Quinone Derivative E3330. J. Immunol. 160: 810-819 [Abstract] [Full Text]