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Mol Cell Biol. 1993 July; 13(7): 3999-4010

DNA-binding specificity of GATA family transcription factors.

M Merika and S H Orkin

Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.

ABSTRACT

GATA-binding proteins constitute a family of transcription factors that recognize a target site conforming to the consensus WGATAR (W = A or T and R = A or G). Here we have used the method of polymerase chain reaction-mediated random site selection to assess in an unbiased manner the DNA-binding specificity of GATA proteins. Contrary to our expectations, we show that GATA proteins bind a variety of motifs that deviate from the previously assigned consensus. Many of the nonconsensus sequences bind protein with high affinity, equivalent to that of conventional GATA motifs. By using the selected sequences as probes in the electrophoretic mobility shift assay, we demonstrate overlapping, but distinct, sequence preferences for GATA family members, specified by their respective DNA-binding domains. Furthermore, we provide additional evidence for interaction of amino and carboxy fingers of GATA-1 in defining its binding site. By performing cotransfection experiments, we also show that transactivation parallels DNA binding. A chimeric protein containing the finger domain of areA and the activation domains of GATA-1 is capable of activating transcription in mammalian cells through GATA motifs. Our findings suggest a mechanism by which GATA proteins might selectively regulate gene expression in cells in which they are coexpressed.

Mol Cell Biol. 1993 July; 13(7): 3999-4010




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  • Yang, D., Suzuki, S., Hao, L. J., Fujii, Y., Yamauchi, A., Yamamoto, M., Nakamura, M., Kumatori, A. (2000). Eosinophil-specific Regulation of gp91phox Gene Expression by Transcription Factors GATA-1 and GATA-2. J. Biol. Chem. 275: 9425-9432 [Abstract] [Full Text]  
  • Zhang, J., Zhang, Q.-Y., Guo, J., Zhou, Y., Ding, X. (2000). Identification and Functional Characterization of a Conserved, Nuclear Factor 1-like Element in the Proximal Promoter Region of CYP1A2 Gene Specifically Expressed in the Liver and Olfactory Mucosa. J. Biol. Chem. 275: 8895-8902 [Abstract] [Full Text]  
  • McFadden, D., Charite, J, Richardson, J., Srivastava, D, Firulli, A., Olson, E. (2000). A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-5341 [Abstract]  
  • Ulgiati, D., Subrata, L. S., Abraham, L. J. (2000). The Role of Sp Family Members, Basic Krupple-Like Factor, and E Box Factors in the Basal and IFN-{gamma} Regulated Expression of the Human Complement C4 Promoter. J. Immunol. 164: 300-307 [Abstract] [Full Text]  
  • Lepage, A., Uzan, G., Touche, N., Morales, M., Cazenave, J.-P., Lanza, F., de la Salle, C. (1999). Functional Characterization of the Human Platelet Glycoprotein V Gene Promoter: A Specific Marker of Late Megakaryocytic Differentiation. Blood 94: 3366-3380 [Abstract] [Full Text]  
  • Stojanovic, N., Florea, L., Riemer, C., Gumucio, D., Slightom, J., Goodman, M., Miller, W., Hardison, R. (1999). Comparison of five methods for finding conserved sequences in multiple alignments of gene regulatory regions. Nucleic Acids Res 27: 3899-3910 [Abstract] [Full Text]  
  • Sinn, P. L., Zhang, X., Sigmund, C. D. (1999). JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am. J. Physiol. Renal Physiol. 277: F634-F642 [Abstract] [Full Text]  
  • Pengue, G., Srivastava, A. K., Kere, J., Schlessinger, D., Durmowicz, M. C. (1999). Functional Characterization of the Promoter of the X-linked Ectodermal Dysplasia Gene. J. Biol. Chem. 274: 26477-26484 [Abstract] [Full Text]  
  • Mang, R., Goudsmit, J., van der Kuyl, A. C. (1999). Novel Endogenous Type C Retrovirus in Baboons: Complete Sequence, Providing Evidence for Baboon Endogenous Virus gag-pol Ancestry. J. Virol. 73: 7021-7026 [Abstract] [Full Text]  
  • Brodu, V., Mugat, B., Roignant, J.-Y., Lepesant, J.-A., Antoniewski, C. (1999). Dual Requirement for the EcR/USP Nuclear Receptor and the dGATAb Factor in an Ecdysone Response in Drosophila melanogaster. Mol. Cell. Biol. 19: 5732-5742 [Abstract] [Full Text]  
  • Rivkees, S. A., Chen, M., Kulkarni, J., Browne, J., Zhao, Z. (1999). Characterization of the Murine A1 Adenosine Receptor Promoter, Potent Regulation by GATA-4 and Nkx2.5. J. Biol. Chem. 274: 14204-14209 [Abstract] [Full Text]  
  • Sargent, T. G., DuBois, C. C., Buller, A. M., Lloyd, J. A. (1999). The Roles of 5'-HS2, 5'-HS3, and the gamma -Globin TATA, CACCC, and Stage Selector Elements in Suppression of beta -Globin Expression in Early Development. J. Biol. Chem. 274: 11229-11236 [Abstract] [Full Text]  
  • Tevosian, S. G., Deconinck, A. E., Cantor, A. B., Rieff, H. I., Fujiwara, Y., Corfas, G., Orkin, S. H. (1999). FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc. Natl. Acad. Sci. USA 96: 950-955 [Abstract] [Full Text]  
  • Svensson, E. C., Tufts, R. L., Polk, C. E., Leiden, J. M. (1999). Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes. Proc. Natl. Acad. Sci. USA 96: 956-961 [Abstract] [Full Text]  
  • Lakshmanan, G., Lieuw, K. H., Lim, K.-C., Gu, Y., Grosveld, F., Engel, J. D., Karis, A. (1999). Localization of Distant Urogenital System-, Central Nervous System-, and Endocardium-Specific Transcriptional Regulatory Elements in the GATA-3 Locus. Mol. Cell. Biol. 19: 1558-1568 [Abstract] [Full Text]  
  • Lien, C., Wu, C, Mercer, B, Webb, R, Richardson, J., Olson, E. (1999). Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 126: 75-84 [Abstract]  
  • Nony, P., Hannon, R., Gould, H., Felsenfeld, G. (1998). Alternate Promoters and Developmental Modulation of Expression of the Chicken GATA-2 Gene in Hematopoietic Progenitor Cells. J. Biol. Chem. 273: 32910-32919 [Abstract] [Full Text]  


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