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Mol Cell Biol. 1993 July; 13(7): 4029-4038

The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.

Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0502.

ABSTRACT

The alpha 2 protein of the yeast Saccharomyces cerevisiae normally represses a set of cell-type-specific genes (the a-specific genes) that are transcribed by RNA polymerase II. In this study, we determined whether alpha 2 can affect transcription by other RNA polymerases. We find that alpha 2 can repress transcription by RNA polymerase I but not by RNA polymerase III. Additional experiments indicate that alpha 2 represses RNA polymerase I transcription through the same pathway that it uses to repress RNA polymerase II transcription. These results implicate conserved components of the transcription machinery as mediators of alpha 2 repression and exclude several alternate models.

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