This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hagiwara, M
Right arrow Articles by Montminy, M R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hagiwara, M
Right arrow Articles by Montminy, M R

 Previous Article  |  Next Article 

Mol Cell Biol. 1993 August; 13(8): 4852-4859

Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

M Hagiwara, P Brindle, A Harootunian, R Armstrong, J Rivier, W Vale, R Tsien and M R Montminy

Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037.

ABSTRACT

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation and subsequent translocation of PKA catalytic subunit (C subunit) into the nucleus. Using fluorescence imaging techniques, we observed that PKA was activated in a stimulus-dependent fashion that led to nuclear entry of C subunit over a 30-min period. The degree of CREB phosphorylation, assessed with antiserum specific for CREB phosphorylated at Ser-133, correlated with the amount of PKA liberated. The time course of phosphorylation closely paralleled the nuclear entry of the catalytic subunit. There was a linear relationship between the subsequent induction of the cAMP-responsive somatostatin gene and the degree of CREB phosphorylation, suggesting that each event--kinase activation, CREB phosphorylation, and transcriptional induction--was tightly coupled to the next. In contrast to other PKA-mediated cellular responses which are rapid and quantitative, the slow, incremental regulation of CREB activity by cAMP suggests that multifunctional kinases like PKA may coordinate cellular responses by dictating the kinetics and stoichiometry of phosphorylation for key substrates like CREB.

Mol Cell Biol. 1993 August; 13(8): 4852-4859




This article has been cited by other articles:

  • Makkonen, K. M., Pasonen-Seppanen, S., Torronen, K., Tammi, M. I., Carlberg, C. (2009). Regulation of the Hyaluronan Synthase 2 Gene by Convergence in Cyclic AMP Response Element-binding Protein and Retinoid Acid Receptor Signaling. J. Biol. Chem. 284: 18270-18281 [Abstract] [Full Text]  
  • Wood, M. A., Walker, W. H. (2009). USF1/2 Transcription Factor DNA-Binding Activity Is Induced During Rat Sertoli Cell Differentiation. Biol. Reprod. 80: 24-33 [Abstract] [Full Text]  
  • Ciccone, N. A., Lacza, C. T., Hou, M. Y., Gregory, S. J., Kam, K.-Y., Xu, S., Kaiser, U. B. (2008). A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene. Mol. Endocrinol. 22: 1908-1923 [Abstract] [Full Text]  
  • Sugiura, T., Nakanishi, H., Roberts, J. D. Jr (2008). Proteolytic Processing of cGMP-Dependent Protein Kinase I Mediates Nuclear cGMP Signaling in Vascular Smooth Muscle Cells. Circ. Res. 103: 53-60 [Abstract] [Full Text]  
  • Lynch, G. S., Ryall, J. G. (2008). Role of {beta}-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease. Physiol. Rev. 88: 729-767 [Abstract] [Full Text]  
  • Humphries, K. M., Pennypacker, J. K., Taylor, S. S. (2007). Redox Regulation of cAMP-dependent Protein Kinase Signaling: KINASE VERSUS PHOSPHATASE INACTIVATION. J. Biol. Chem. 282: 22072-22079 [Abstract] [Full Text]  
  • Kolchanov, N. A., Merkulova, T. I., Ignatieva, E. V., Ananko, E. A., Oshchepkov, D. Yu., Levitsky, V. G., Vasiliev, G. V., Klimova, N. V., Merkulov, V. M., Hodgman, T. C. (2007). Combined experimental and computational approaches to study the regulatory elements in eukaryotic genes. Brief Bioinform 0: bbm027v1-9 [Abstract] [Full Text]  
  • Gervasi, N., Hepp, R., Tricoire, L., Zhang, J., Lambolez, B., Paupardin-Tritsch, D., Vincent, P. (2007). Dynamics of Protein Kinase A Signaling at the Membrane, in the Cytosol, and in the Nucleus of Neurons in Mouse Brain Slices. J. Neurosci. 27: 2744-2750 [Abstract] [Full Text]  
  • Yoon, M.-S., Koo, J. B., Jeong, Y. G., Kim, Y. S., Lee, J. H., Yun, H. J., Lee, K. S., Han, J.-S. (2007). Phospholipase D1 as a Key Enzyme for Decidualization in Human Endometrial Stromal Cells. Biol. Reprod. 76: 250-258 [Abstract] [Full Text]  
  • Gubbay, O, Rae, M T, McNeilly, A S, Donadeu, F X, Zeleznik, A J, Hillier, S G (2006). cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival.. J Endocrinol 191: 275-285 [Abstract] [Full Text]  
  • Fukuyama, K., Ichiki, T., Imayama, I., Ohtsubo, H., Ono, H., Hashiguchi, Y., Takeshita, A., Sunagawa, K. (2006). Thyroid Hormone Inhibits Vascular Remodeling Through Suppression of cAMP Response Element Binding Protein Activity. Arterioscler. Thromb. Vasc. Bio. 26: 2049-2055 [Abstract] [Full Text]  
  • Hazan-Eitan, Z., Weinstein, Y., Hadad, N., Konforty, A., Levy, R. (2006). Induction of Fc{gamma}RIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2. Blood 108: 1758-1766 [Abstract] [Full Text]  
  • Selkirk, J. V., Nottebaum, L. M., Ford, I. C., Santos, M., Malany, S., Foster, A. C., Lechner, S. M. (2006). A Novel Cell-Based Assay for G-Protein-Coupled Receptor-Mediated Cyclic Adenosine Monophosphate Response Element Binding Protein Phosphorylation. J Biomol Screen 11: 351-358 [Abstract]  
  • Krieghoff, E., Behrens, J., Mayr, B. (2006). Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention.. J. Cell Sci. 119: 1453-1463 [Abstract] [Full Text]  
  • Busch, C. J., Liu, H., Graveline, A. R., Bloch, K. D. (2006). Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L747-L753 [Abstract] [Full Text]  
  • Burkart, A. D., Mukherjee, A., Mayo, K. E. (2006). Mechanism of Repression of the Inhibin {alpha}-Subunit Gene by Inducible 3',5'-Cyclic Adenosine Monophosphate Early Repressor. Mol. Endocrinol. 20: 584-597 [Abstract] [Full Text]  
  • Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., Popoli, M. (2006). Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview.. Pharmacol. Rev. 58: 115-134 [Abstract] [Full Text]  
  • Chen, H.-C., Byrd, J. C., Muthusamy, N. (2006). Differential Role for Cyclic AMP Response Element Binding Protein-1 in Multiple Stages of B Cell Development, Differentiation, and Survival. J. Immunol. 176: 2208-2218 [Abstract] [Full Text]  
  • Aggarwal, S., Kim, S.-W., Cheon, K., Tabassam, F. H., Yoon, J.-H., Koo, J. S. (2006). Nonclassical Action of Retinoic Acid on the Activation of the cAMP Response Element-binding Protein in Normal Human Bronchial Epithelial Cells. Mol. Biol. Cell 17: 566-575 [Abstract] [Full Text]  
  • Viste, K., Kopperud, R. K., Christensen, A. E., Doskeland, S. O. (2005). Substrate Enhances the Sensitivity of Type I Protein Kinase A to cAMP. J. Biol. Chem. 280: 13279-13284 [Abstract] [Full Text]  
  • Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J. R., Emerson, B., Hogenesch, J. B., Unterman, T., Young, R. A., Montminy, M. (2005). Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl. Acad. Sci. USA 102: 4459-4464 [Abstract] [Full Text]  
  • Hongpaisan, J., Winters, C. A., Andrews, S. B. (2004). Strong Calcium Entry Activates Mitochondrial Superoxide Generation, Upregulating Kinase Signaling in Hippocampal Neurons. J. Neurosci. 24: 10878-10887 [Abstract] [Full Text]  
  • Cha-Molstad, H., Keller, D. M., Yochum, G. S., Impey, S., Goodman, R. H. (2004). Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc. Natl. Acad. Sci. USA 101: 13572-13577 [Abstract] [Full Text]  
  • Gao, M. H., Tang, T., Guo, T., Sun, S. Q., Feramisco, J. R., Hammond, H. K. (2004). Adenylyl Cyclase Type VI Gene Transfer Reduces Phospholamban Expression in Cardiac Myocytes via Activating Transcription Factor 3. J. Biol. Chem. 279: 38797-38802 [Abstract] [Full Text]  
  • Ono, H., Ichiki, T., Fukuyama, K., Iino, N., Masuda, S., Egashira, K., Takeshita, A. (2004). cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor-{alpha}-Induced Vascular Smooth Muscle Cell Migration. Arterioscler. Thromb. Vasc. Bio. 24: 1634-1639 [Abstract] [Full Text]  
  • Nguyen, T. L.-A., Calomme, C., Wijmeersch, G., Nizet, S., Veithen, E., Portetelle, D., de Launoit, Y., Burny, A., Van Lint, C. (2004). Deacetylase Inhibitors and the Viral Transactivator TaxBLV Synergistically Activate Bovine Leukemia Virus Gene Expression via a cAMP-responsive Element- and cAMP-responsive Element-binding Protein-dependent Mechanism. J. Biol. Chem. 279: 35025-35036 [Abstract] [Full Text]  
  • Kreibich, T. A., Chalasani, S. H., Raper, J. A. (2004). The Neurotransmitter Glutamate Reduces Axonal Responsiveness to Multiple Repellents through the Activation of Metabotropic Glutamate Receptor 1. J. Neurosci. 24: 7085-7095 [Abstract] [Full Text]  
  • Hum, D., Besnard, S., Sanchez, R., Devost, D., Gossard, F., Hamet, P., Tremblay, J. (2004). Characterization of a cGMP-Response Element in the Guanylyl Cyclase/Natriuretic Peptide Receptor A Gene Promoter. Hypertension 43: 1270-1278 [Abstract] [Full Text]  
  • Euskirchen, G., Royce, T. E., Bertone, P., Martone, R., Rinn, J. L., Nelson, F. K., Sayward, F., Luscombe, N. M., Miller, P., Gerstein, M., Weissman, S., Snyder, M. (2004). CREB Binds to Multiple Loci on Human Chromosome 22. Mol. Cell. Biol. 24: 3804-3814 [Abstract] [Full Text]  
  • Baker, J. G., Hall, I. P., Hill, S. J. (2004). Temporal Characteristics of cAMP Response Element-Mediated Gene Transcription: Requirement for Sustained cAMP Production. Mol. Pharmacol. 65: 986-998 [Abstract] [Full Text]  
  • Zippin, J. H., Farrell, J., Huron, D., Kamenetsky, M., Hess, K. C., Fischman, D. A., Levin, L. R., Buck, J. (2004). Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. JCB 164: 527-534 [Abstract] [Full Text]  
  • Abramovitch, R., Tavor, E., Jacob-Hirsch, J., Zeira, E., Amariglio, N., Pappo, O., Rechavi, G., Galun, E., Honigman, A. (2004). A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression. Cancer Res. 64: 1338-1346 [Abstract] [Full Text]  
  • Kronke, G., Bochkov, V. N., Huber, J., Gruber, F., Bluml, S., Furnkranz, A., Kadl, A., Binder, B. R., Leitinger, N. (2003). Oxidized Phospholipids Induce Expression of Human Heme Oxygenase-1 Involving Activation of cAMP-responsive Element-binding Protein. J. Biol. Chem. 278: 51006-51014 [Abstract] [Full Text]  
  • Bachir, L. K., Garrel, G., Lozach, A., Laverriere, J.-N., Counis, R. (2003). The Rat Pituitary Promoter of the Neuronal Nitric Oxide Synthase Gene Contains an Sp1-, LIM Homeodomain-Dependent Enhancer and a Distinct Bipartite Gonadotropin-Releasing Hormone-Responsive Region. Endocrinology 144: 3995-4007 [Abstract] [Full Text]  
  • Rosenberg, D., Groussin, L., Jullian, E., Perlemoine, K., Medjane, S., Louvel, A., Bertagna, X., Bertherat, J. (2003). Transcription Factor 3',5'-Cyclic Adenosine 5'-Monophosphate-Responsive Element-Binding Protein (CREB) Is Decreased during Human Adrenal Cortex Tumorigenesis and Fetal Development. J. Clin. Endocrinol. Metab. 88: 3958-3965 [Abstract] [Full Text]  
  • Chalasani, S. H., Baribaud, F., Coughlan, C. M., Sunshine, M. J., Lee, V. M. Y., Doms, R. W., Littman, D. R., Raper, J. A. (2003). The Chemokine Stromal Cell-Derived Factor-1 Promotes the Survival of Embryonic Retinal Ganglion Cells. J. Neurosci. 23: 4601-4612 [Abstract] [Full Text]  
  • Mahapatra, N. R., Mahata, M., O'Connor, D. T., Mahata, S. K. (2003). Secretin Activation of Chromogranin A Gene Transcription: IDENTIFICATION OF THE SIGNALING PATHWAYS IN CIS AND IN TRANS. J. Biol. Chem. 278: 19986-19994 [Abstract] [Full Text]  
  • Dwivedi, Y., Rao, J. S., Rizavi, H. S., Kotowski, J., Conley, R. R., Roberts, R. C., Tamminga, C. A., Pandey, G. N. (2003). Abnormal Expression and Functional Characteristics of Cyclic Adenosine Monophosphate Response Element Binding Protein in Postmortem Brain of Suicide Subjects. Arch Gen Psychiatry 60: 273-282 [Abstract] [Full Text]  
  • Chalasani, S. H., Sabelko, K. A., Sunshine, M. J., Littman, D. R., Raper, J. A. (2003). A Chemokine, SDF-1, Reduces the Effectiveness of Multiple Axonal Repellents and Is Required for Normal Axon Pathfinding. J. Neurosci. 23: 1360-1371 [Abstract] [Full Text]  
  • Norris, A. J., Stirland, J. A., McFerran, D. W., Seymour, Z. C., Spiller, D. G., Loudon, A. S. I., White, M. R. H., Davis, J. R. E. (2003). Dynamic Patterns of Growth Hormone Gene Transcription in Individual Living Pituitary Cells. Mol. Endocrinol. 17: 193-202 [Abstract] [Full Text]  
  • Sarkar, S., Lechan, R. M. (2003). Central Administration of Neuropeptide Y Reduces {alpha}-Melanocyte-Stimulating Hormone-Induced Cyclic Adenosine 5'-Monophosphate Response Element Binding Protein (CREB) Phosphorylation in Pro-Thyrotropin-Releasing Hormone Neurons and Increases CREB Phosphorylation in Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus. Endocrinology 144: 281-291 [Abstract] [Full Text]  
  • Chen, X., Dai, J.-C., Greenfield, E. M. (2002). Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol. Am. J. Physiol. Cell Physiol. 283: C1432-C1440 [Abstract] [Full Text]  
  • Zor, T., Mayr, B. M., Dyson, H. J., Montminy, M. R., Wright, P. E. (2002). Roles of Phosphorylation and Helix Propensity in the Binding of the KIX Domain of CREB-binding Protein by Constitutive (c-Myb) and Inducible (CREB) Activators. J. Biol. Chem. 277: 42241-42248 [Abstract] [Full Text]  
  • Dash, P. K., Mach, S. A., Blum, S., Moore, A. N. (2002). Intrahippocampal Wortmannin Infusion Enhances Long-Term Spatial and Contextual Memories. Learn. Mem. 9: 167-177 [Abstract] [Full Text]  
  • Rathee, P. K., Distler, C., Obreja, O., Neuhuber, W., Wang, G. K., Wang, S.-Y., Nau, C., Kress, M. (2002). PKA/AKAP/VR-1 Module: A Common Link of Gs-Mediated Signaling to Thermal Hyperalgesia. J. Neurosci. 22: 4740-4745 [Abstract] [Full Text]  
  • Kopperud, R., Christensen, A. E., Kjarland, E., Viste, K., Kleivdal, H., Doskeland, S. O. (2002). Formation of Inactive cAMP-saturated Holoenzyme of cAMP-dependent Protein Kinase under Physiological Conditions. J. Biol. Chem. 277: 13443-13448 [Abstract] [Full Text]  
  • Tokunou, T., Ichiki, T., Takeda, K., Funakoshi, Y., Iino, N., Takeshita, A. (2001). cAMP Response Element-Binding Protein Mediates Thrombin-Induced Proliferation of Vascular Smooth Muscle Cells. Arterioscler. Thromb. Vasc. Bio. 21: 1764-1769 [Abstract] [Full Text]  
  • Singh, L. P., Andy, J., Anyamale, V., Greene, K., Alexander, M., Crook, E. D. (2001). Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C. Diabetes 50: 2355-2362 [Abstract] [Full Text]  
  • Muller, F. U, Boknik, P., Knapp, J., Linck, B., Luss, H., Neumann, J., Schmitz, W. (2001). Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes. Cardiovasc Res 52: 95-102 [Abstract] [Full Text]  
  • Mayr, B. M., Canettieri, G., Montminy, M. R. (2001). Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. Proc. Natl. Acad. Sci. USA 10.1073/pnas.191152098v1 [Abstract] [Full Text]  
  • Yeh, J.-H., Lecine, P., Nunes, J. A., Spicuglia, S., Ferrier, P., Olive, D., Imbert, J. (2001). Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor {alpha}-Chain Locus. Mol. Cell. Biol. 21: 4515-4527 [Abstract] [Full Text]  
  • Pandey, S. C., Roy, A., Mittal, N. (2001). Effects of Chronic Ethanol Intake and Its Withdrawal on the Expression and Phosphorylation of the CREB Gene Transcription Factor in Rat Cortex. J. Pharmacol. Exp. Ther. 296: 857-868 [Abstract] [Full Text]  
  • Long, F, Schipani, E, Asahara, H, Kronenberg, H, Montminy, M (2001). The CREB family of activators is required for endochondral bone development. Development 128: 541-550 [Abstract]  
  • Yu, C.-T., Shih, H.-m., Lai, M.-Z. (2001). Multiple Signals Required for Cyclic AMP-Responsive Element Binding Protein (CREB) Binding Protein Interaction Induced by CD3/CD28 Costimulation. J. Immunol. 166: 284-292 [Abstract] [Full Text]  
  • Gangolli, E. A., Belyamani, M., Muchinsky, S., Narula, A., Burton, K. A., McKnight, G. S., Uhler, M. D., Idzerda, R. L. (2000). Deficient Gene Expression in Protein Kinase Inhibitor alpha Null Mutant Mice. Mol. Cell. Biol. 20: 3442-3448 [Abstract] [Full Text]  
  • Kovacs, K. J., Foldes, A., Sawchenko, P. E. (2000). Glucocorticoid Negative Feedback Selectively Targets Vasopressin Transcription in Parvocellular Neurosecretory Neurons. J. Neurosci. 20: 3843-3852 [Abstract] [Full Text]  
  • Michael, L. F., Asahara, H., Shulman, A. I., Kraus, W. L., Montminy, M. (2000). The Phosphorylation Status of a Cyclic AMP-Responsive Activator Is Modulated via a Chromatin-Dependent Mechanism. Mol. Cell. Biol. 20: 1596-1603 [Abstract] [Full Text]  
  • Pepperkok, R., Hotz-Wagenblatt, A., Konig, N., Girod, A., Bossemeyer, D., Kinzel, V. (2000). Intracellular Distribution of Mammalian Protein Kinase a Catalytic Subunit Altered by Conserved Asn2 Deamidation. JCB 148: 715-726 [Abstract] [Full Text]  
  • Pursiheimo, J.-P., Jalkanen, M., Tasken, K., Jaakkola, P. (2000). Involvement of protein kinase A in fibroblast growth factor-2-activated transcription. Proc. Natl. Acad. Sci. USA 97: 168-173 [Abstract] [Full Text]  
  • Groussin, L., Massias, J. F., Bertagna, X., Bertherat, J. (2000). Loss of Expression of the Ubiquitous Transcription Factor cAMP Response Element-Binding Protein (CREB) and Compensatory Overexpression of the Activator CREM{tau} in the Human Adrenocortical Cancer Cell Line H295R. J. Clin. Endocrinol. Metab. 85: 345-354 [Abstract] [Full Text]  
  • Cassano, S., Di Lieto, A., Cerillo, R., Avvedimento, E. V. (1999). Membrane-bound cAMP-dependent Protein Kinase Controls cAMP-induced Differentiation in PC12 Cells. J. Biol. Chem. 274: 32574-32579 [Abstract] [Full Text]  
  • Constantinescu, A., Diamond, I., Gordon, A. S. (1999). Ethanol-induced Translocation of cAMP-dependent Protein Kinase to the Nucleus. MECHANISM AND FUNCTIONAL CONSEQUENCES. J. Biol. Chem. 274: 26985-26991 [Abstract] [Full Text]  
  • Yin, J. C.-P. (1999). Location, location, location: The many addresses of memory formation. Proc. Natl. Acad. Sci. USA 96: 9985-9986 [Abstract] [Full Text]  
  • Movsesian, M. A. (1999). Beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate. J Am Coll Cardiol 34: 318-324 [Abstract] [Full Text]  
  • Taylor, C. T., Fueki, N., Agah, A., Hershberg, R. M., Colgan, S. P. (1999). Critical Role of cAMP Response Element Binding Protein Expression in Hypoxia-elicited Induction of Epithelial Tumor Necrosis Factor-alpha. J. Biol. Chem. 274: 19447-19454 [Abstract] [Full Text]  
  • Seternes, O. M., Johansen, B., Moens, U. (1999). A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth Factor-Induced CREB (cAMP-Responsive Element-Binding Protein) Activation, Uncoupled from Serine 133 Phosphorylation in NIH 3T3 Cells. Mol. Endocrinol. 13: 1071-1083 [Abstract] [Full Text]  
  • Schulz, S., Siemer, H., Krug, M., Hollt, V. (1999). Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat Dentate Gyrus In Vivo. J. Neurosci. 19: 5683-5692 [Abstract] [Full Text]  
  • Chen, J., Lin, R., Hu, Z.-W., Hoffman, B. B. (1999). alpha 1-Adrenergic Receptor Activation of c-fos Expression in Transfected Rat-1 Fibroblasts: Role of Ca2+ . J. Pharmacol. Exp. Ther. 289: 1376-1384 [Abstract] [Full Text]  
  • Sakaguchi, H., Wada, K., Maekawa, M., Watsuji, T., Hagiwara, M. (1999). Song-Induced Phosphorylation of cAMP Response Element-Binding Protein in the Songbird Brain. J. Neurosci. 19: 3973-3981 [Abstract] [Full Text]  
  • Wölfl, S., Martinez, C., Majzoub, J. A. (1999). Inducible Binding of Cyclic Adenosine 3',5'-Monophosphate (cAMP)-Responsive Element Binding Protein (CREB) to a cAMP-Responsive Promoter in Vivo. Mol. Endocrinol. 13: 659-669 [Abstract] [Full Text]  
  • Maronde, E., Pfeffer, M., Olcese, J., Molina, C. A., Schlotter, F., Dehghani, F., Korf, H.-W., Stehle, J. H. (1999). Transcription Factors in Neuroendocrine Regulation: Rhythmic Changes in pCREB and ICER Levels Frame Melatonin Synthesis. J. Neurosci. 19: 3326-3336 [Abstract] [Full Text]  
  • Blum, S., Moore, A. N., Adams, F., Dash, P. K. (1999). A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory. J. Neurosci. 19: 3535-3544 [Abstract] [Full Text]  
  • Collins, S. P., Uhler, M. D. (1999). Cyclic AMP- and Cyclic GMP-dependent Protein Kinases Differ in Their Regulation of Cyclic AMP Response Element-dependent Gene Transcription. J. Biol. Chem. 274: 8391-8404 [Abstract] [Full Text]  
  • Paolillo, M., Feliciello, A., Porcellini, A., Garbi, C., Bifulco, M., Schinelli, S., Ventra, C., Stabile, E., Ricciardelli, G., Schettini, G., Avvedimento, E. V. (1999). The Type and the Localization of cAMP-dependent Protein Kinase Regulate Transmission of cAMP Signals to the Nucleus in Cortical and Cerebellar Granule Cells. J. Biol. Chem. 274: 6546-6552 [Abstract] [Full Text]  
  • Zimmermann, B., Chiorini, J. A., Ma, Y., Kotin, R. M., Herberg, F. W. (1999). PrKX Is a Novel Catalytic Subunit of the cAMP-dependent Protein Kinase Regulated by the Regulatory Subunit Type I. J. Biol. Chem. 274: 5370-5378 [Abstract] [Full Text]  
  • Aldred, A., Nagy, L. E. (1999). Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G98-G106 [Abstract] [Full Text]  
  • Scheid, M. P., Foltz, I. N., Young, P. R., Schrader, J. W., Duronio, V. (1999). Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival. Blood 93: 217-225 [Abstract] [Full Text]  
  • Price, E. R., Horstmann, M. A., Wells, A. G., Weilbaecher, K. N., Takemoto, C. M., Landis, M. W., Fisher, D. E. (1998). alpha -Melanocyte-stimulating Hormone Signaling Regulates Expression of microphthalmia, a Gene Deficient in Waardenburg Syndrome. J. Biol. Chem. 273: 33042-33047 [Abstract] [Full Text]  
  • Ungefroren, H., Gellersen, B., Krull, N. B., Kalthoff, H. (1998). Biglycan Gene Expression in the Human Leiomyosarcoma Cell Line SK-UT-1. BASAL AND PROTEIN KINASE A-INDUCED TRANSCRIPTION INVOLVES BINDING OF Sp1-LIKE/Sp3 PROTEINS IN THE PROXIMAL PROMOTER REGION. J. Biol. Chem. 273: 29230-29240 [Abstract] [Full Text]  
  • Jean, D., Harbison, M., McConkey, D. J., Ronai, Z., Bar-Eli, M. (1998). CREB and Its Associated Proteins Act as Survival Factors for Human Melanoma Cells. J. Biol. Chem. 273: 24884-24890 [Abstract] [Full Text]  
  • Wu, X., Spiro, C., Owen, W. G., McMurray, C. T. (1998). cAMP Response Element-binding Protein Monomers Cooperatively Assemble to Form Dimers on DNA. J. Biol. Chem. 273: 20820-20827 [Abstract] [Full Text]  
  • Rogue, P. J., Humbert, J.-P., Meyer, A., Freyermuth, S., Krady, M.-M., Malviya, A. N. (1998). cAMP-dependent protein kinase phosphorylates and activates nuclear Ca2+-ATPase. Proc. Natl. Acad. Sci. USA 95: 9178-9183 [Abstract] [Full Text]  
  • Yeagley, D., Agati, J. M., Quinn, P. G. (1998). A Tripartite Array of Transcription Factor Binding Sites Mediates cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription and Its Inhibition by Insulin. J. Biol. Chem. 273: 18743-18750 [Abstract] [Full Text]  
  • Agati, J. M., Yeagley, D., Quinn, P. G. (1998). Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription. J. Biol. Chem. 273: 18751-18759 [Abstract] [Full Text]  
  • Cass, L. A., Meinkoth, J. L. (1998). Differential Effects of Cyclic Adenosine 3',5'-Monophosphate on p70 Ribosomal S6 Kinase. Endocrinology 139: 1991-1998 [Abstract] [Full Text]  
  • Jones, L. C., Scammell, J. G. (1998). The cAMP-response element mediates induction of secretogranin II by CHX and FSK in GH4C1 cells. Am. J. Physiol. Endocrinol. Metab. 274: E656-E664 [Abstract] [Full Text]  
  • Hatalski, C. G., Baram, T. Z. (1997). Stress-Induced Transcriptional Regulation in the Developing Rat Brain Involves Increased Cyclic Adenosine 3',5'-Monophosphate-Regulatory Element Binding Activity. Mol. Endocrinol. 11: 2016-2024 [Abstract] [Full Text]  
  • Telgmann, R., Maronde, E., Tasken, K., Gellersen, B. (1997). Activated Protein Kinase A Is Required for Differentiation-Dependent Transcription of the Decidual Prolactin Gene in Human Endometrial Stromal Cells. Endocrinology 138: 929-937 [Abstract] [Full Text]  
  • Murphy, D. D., Segal, M. (1997). Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein. Proc. Natl. Acad. Sci. USA 94: 1482-1487 [Abstract] [Full Text]  
  • Nielsen, M. D., Chan, G. C.K., Poser, S. W., Storm, D. R. (1996). Differential Regulation of Type I and Type VIII Ca2+-stimulated Adenylyl Cyclases by Gi-coupled Receptors in Vivo. J. Biol. Chem. 271: 33308-33316 [Abstract] [Full Text]  
  • Cassano, S., Gallo, A., Buccigrossi, V., Porcellini, A., Cerillo, R., Gottesman, M. E., Avvedimento, E. V. (1996). Membrane Localization of cAMP-dependent Protein Kinase Amplifies cAMP Signaling to the Nucleus in PC12 Cells. J. Biol. Chem. 271: 29870-29875 [Abstract] [Full Text]  
  • Feliciello, A., Giuliano, P., Porcellini, A., Garbi, C., Obici, S., Mele, E., Angotti, E., Grieco, D., Amabile, G., Cassano, S., Li, Y., Musti, A. M., Rubin, C. S., Gottesman, M. E., V. Avvedimento, E. (1996). The v-Ki-Ras Oncogene Alters cAMP Nuclear Signaling by Regulating the Location and the Expression of cAMP-dependent Protein Kinase IIbeta. J. Biol. Chem. 271: 25350-25359 [Abstract] [Full Text]  
  • Thomas, M. J., Umayahara, Y., Shu, H., Centrella, M., Rotwein, P., McCarthy, T. L. (1996). Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts. J. Biol. Chem. 271: 21835-21841 [Abstract] [Full Text]  
  • Shimomura, A., Ogawa, Y., Kitani, T., Fujisawa, H., Hagiwara, M. (1996). Calmodulin-dependent Protein Kinase II Potentiates Transcriptional Activation through Activating Transcription Factor 1but Not cAMP Response Element-binding Protein. J. Biol. Chem. 271: 17957-17960 [Abstract] [Full Text]  
  • Kee, B. L., Arias, J., Montminy, M. R. (1996). Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator. J. Biol. Chem. 271: 2373-2375 [Abstract] [Full Text]  
  • Villacres, E. C., Wu, Z., Hua, W., Nielsen, M. D., Watters, J. J., Yan, C., Beavo, J., Storm, D. R. (1995). Developmentally Expressed Ca[IMAGE]-sensitive Adenylyl Cyclase Activity Is Disrupted in the Brains of Type I Adenylyl Cyclase Mutant Mice. J. Biol. Chem. 270: 14352-14357 [Abstract] [Full Text]  
  • Schwaninger, M., Blume, R., Krüger, M., Lux, G., Oetjen, E., Knepel, W. (1995). Involvement of the Ca[IMAGE]-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements. J. Biol. Chem. 270: 8860-8866 [Abstract] [Full Text]  
  • Grewal, S. S., Fass, D. M., Yao, H., Ellig, C. L., Goodman, R. H., Stork, P. J. S. (2000). Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway. J. Biol. Chem. 275: 34433-34441 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»