This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sap, J
Right arrow Articles by Schlessinger, J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sap, J
Right arrow Articles by Schlessinger, J

Next Article 

Mol Cell Biol. 1994 January; 14(1): 1-9

Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.

J Sap, Y P Jiang, D Friedlander, M Grumet and J Schlessinger

Department of Pharmacology, New York University Medical Center, New York 10016.

ABSTRACT

Receptor tyrosine phosphatases (R-PTPases) feature PTPase domains in the context of a receptor-like transmembrane topology. The R-PTPase R-PTP-kappa displays an extracellular domain composed of fibronectin type III motifs, a single immunoglobulin domain, as well as a recently defined MAM domain (Y.-P. Jiang, H. Wang, P. D'Eustachio, J.M. Musacchio, J. Schlessinger, and J. Sap, Mol. Cell. Biol. 13:2942-2951, 1993). We report here that R-PTP-kappa can mediate homophilic intercellular interaction. Inducible expression of the R-PTP-kappa protein in heterologous cells results in formation of stable cellular aggregates strictly consisting of R-PTP-kappa-expressing cells. Moreover, the purified extracellular domain of R-PTP-kappa functions as a substrate for adhesion by cells expressing R-PTP-kappa and induces aggregation of coated synthetic beads. R-PTP-kappa-mediated intercellular adhesion does not require PTPase activity or posttranslational proteolytic cleavage of the R-PTP-kappa protein and is calcium independent. The results suggest that R-PTPases may provide a link between cell-cell contact and cellular signaling events involving tyrosine phosphorylation.

Mol Cell Biol. 1994 January; 14(1): 1-9




This article has been cited by other articles:

  • Yu, J., Becka, S., Zhang, P., Zhang, X., Brady-Kalnay, S. M., Wang, Z. (2008). Tumor-Derived Extracellular Mutations of PTPRT/PTP{rho} Are Defective in Cell Adhesion. Mol Cancer Res 6: 1106-1113 [Abstract] [Full Text]  
  • Flavell, J. R., Baumforth, K. R. N., Wood, V. H. J., Davies, G. L., Wei, W., Reynolds, G. M., Morgan, S., Boyce, A., Kelly, G. L., Young, L. S., Murray, P. G. (2008). Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood 111: 292-301 [Abstract] [Full Text]  
  • Aricescu, A. R., Siebold, C., Choudhuri, K., Chang, V. T., Lu, W., Davis, S. J., van der Merwe, P. A., Jones, E. Y. (2007). Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism. Science 317: 1217-1220 [Abstract] [Full Text]  
  • Sallee, J. L., Wittchen, E. S., Burridge, K. (2006). Regulation of Cell Adhesion by Protein-tyrosine Phosphatases: II. CELL-CELL ADHESION. J. Biol. Chem. 281: 16189-16192 [Abstract] [Full Text]  
  • Anders, L., Mertins, P., Lammich, S., Murgia, M., Hartmann, D., Saftig, P., Haass, C., Ullrich, A. (2006). Furin-, ADAM 10-, and {gamma}-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of {beta}-Catenin's Transcriptional Activity. Mol. Cell. Biol. 26: 3917-3934 [Abstract] [Full Text]  
  • Wang, S. E., Wu, F. Y., Shin, I., Qu, S., Arteaga, C. L. (2005). Transforming Growth Factor {beta} (TGF-{beta})-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-{beta} Function. Mol. Cell. Biol. 25: 4703-4715 [Abstract] [Full Text]  
  • Funatsu, N., Inoue, T., Nakamura, S. (2004). Gene Expression Analysis of the Late Embryonic Mouse Cerebral Cortex Using DNA Microarray: Identification of Several Region- and Layer-specific Genes. Cereb Cortex 14: 1031-1044 [Abstract] [Full Text]  
  • Cismasiu, V. B., Denes, S. A., Reilander, H., Michel, H., Szedlacsek, S. E. (2004). The MAM (Meprin/A5-protein/PTPmu) Domain Is a Homophilic Binding Site Promoting the Lateral Dimerization of Receptor-like Protein-tyrosine Phosphatase {micro}. J. Biol. Chem. 279: 26922-26931 [Abstract] [Full Text]  
  • Novellino, L., Renkvist, N., Rini, F., Mazzocchi, A., Rivoltini, L., Greco, A., Deho, P., Squarcina, P., Robbins, P. F., Parmiani, G., Castelli, C. (2003). Identification of a Mutated Receptor-Like Protein Tyrosine Phosphatase {kappa} as a Novel, Class II HLA-Restricted Melanoma Antigen. J. Immunol. 170: 6363-6370 [Abstract] [Full Text]  
  • Yang, T., Bernabeu, R., Xie, Y., Zhang, J. S., Massa, S. M., Rempel, H. C., Longo, F. M. (2003). Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth. J. Neurosci. 23: 3353-3363 [Abstract] [Full Text]  
  • Takahashi, T., Takahashi, K., St. John, P. L., Fleming, P. A., Tomemori, T., Watanabe, T., Abrahamson, D. R., Drake, C. J., Shirasawa, T., Daniel, T. O. (2003). A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development. Mol. Cell. Biol. 23: 1817-1831 [Abstract] [Full Text]  
  • Taddei, M. L., Chiarugi, P., Cirri, P., Buricchi, F., Fiaschi, T., Giannoni, E., Talini, D., Cozzi, G., Formigli, L., Raugei, G., Ramponi, G. (2002). {beta}-Catenin Interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase Leading to Cadherin-mediated Cell-Cell Adhesion Increase. Cancer Res. 62: 6489-6499 [Abstract] [Full Text]  
  • Aricescu, A. R., McKinnell, I. W., Halfter, W., Stoker, A. W. (2002). Heparan Sulfate Proteoglycans Are Ligands for Receptor Protein Tyrosine Phosphatase {sigma}. Mol. Cell. Biol. 22: 1881-1892 [Abstract] [Full Text]  
  • Stepanek, L., Sun, Q. L., Wang, J., Wang, C., Bixby, J. L. (2001). CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro. JCB 154: 867-878 [Abstract] [Full Text]  
  • Pixley, F. J., Lee, P. S. W., Condeelis, J. S., Stanley, E. R. (2001). Protein Tyrosine Phosphatase {phi} Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-Stimulating Factor 1-Induced Morphological Changes in Macrophages. Mol. Cell. Biol. 21: 1795-1809 [Abstract] [Full Text]  
  • Tsujikawa, K., Kawakami, N., Uchino, Y., Ichijo, T., Furukawa, T., Saito, H., Yamamoto, H. (2001). Distinct Functions of the Two Protein Tyrosine Phosphatase Domains of LAR (Leukocyte Common Antigen-Related) on Tyrosine Dephosphorylation of Insulin Receptor. Mol. Endocrinol. 15: 271-280 [Abstract] [Full Text]  
  • Feiken, E., van Etten, I., Gebbink, M. F. B. G., Moolenaar, W. H., Zondag, G. C. M. (2000). Intramolecular Interactions between the Juxtamembrane Domain and Phosphatase Domains of Receptor Protein-tyrosine Phosphatase RPTP{micro}. REGULATION OF CATALYTIC ACTIVITY. J. Biol. Chem. 275: 15350-15356 [Abstract] [Full Text]  
  • Wright, M. B., Seifert, R. A., Bowen-Pope, D. F. (2000). Protein-Tyrosine Phosphatases in the Vessel Wall : Differential Expression After Acute Arterial Injury. Arterioscler. Thromb. Vasc. Bio. 20: 1189-1198 [Abstract] [Full Text]  
  • Petrone, A, Sap, J (2000). Emerging issues in receptor protein tyrosine phosphatase function: lifting fog or simply shifting?. J. Cell Sci. 113: 2345-2354 [Abstract]  
  • Taniguchi, Y., London, R., Schinkmann, K., Jiang, S., Avraham, H. (1999). The Receptor Protein Tyrosine Phosphatase, PTP-RO, Is Upregulated During Megakaryocyte Differentiation and Is Associated With the c-Kit Receptor. Blood 94: 539-549 [Abstract] [Full Text]  
  • Seimiya, H., Tsuruo, T. (1998). Functional Involvement of PTP-U2L in Apoptosis Subsequent to Terminal Differentiation of Monoblastoid Leukemia Cells. J. Biol. Chem. 273: 21187-21193 [Abstract] [Full Text]  
  • Kokel, M., Borland, C. Z., DeLong, L., Horvitz, H. R., Stern, M. J. (1998). clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12: 1425-1437 [Abstract] [Full Text]  
  • Wallace, M. J., Fladd, C., Batt, J., Rotin, D. (1998). The Second Catalytic Domain of Protein Tyrosine Phosphatase delta  (PTPdelta ) Binds to and Inhibits the First Catalytic Domain of PTPsigma. Mol. Cell. Biol. 18: 2608-2616 [Abstract] [Full Text]  
  • Gershon, T. R., Baker, M. W., Nitabach, M., Wu, P., Macagno, E. R. (1998). Two Receptor Tyrosine Phosphatases of the LAR Family Are Expressed in the Developing Leech by Specific Central Neurons as well as Select Peripheral Neurons, Muscles, and Other Cells. J. Neurosci. 18: 2991-3002 [Abstract] [Full Text]  
  • Brady-Kalnay, S. M., Mourton, T., Nixon, J. P., Pietz, G. E., Kinch, M., Chen, H., Brackenbury, R., Rimm, D. L., Del Vecchio, R. L., Tonks, N. K. (1998). Dynamic Interaction of PTP{micro} with Multiple Cadherins In Vivo. JCB 141: 287-296 [Abstract] [Full Text]  
  • Jacob, K. K., Sap, J., Stanley, F. M. (1998). Receptor-like Protein-tyrosine Phosphatase alpha  Specifically Inhibits Insulin-increased Prolactin Gene Expression. J. Biol. Chem. 273: 4800-4809 [Abstract] [Full Text]  
  • Hoffmann, K. M. V., Tonks, N. K., Barford, D. (1997). The Crystal Structure of Domain 1 of Receptor Protein-tyrosine Phosphatase µ. J. Biol. Chem. 272: 27505-27508 [Abstract] [Full Text]  
  • McCloskey, P., Fridell, Y.-W., Attar, E., Villa, J., Jin, Y., Varnum, B., Liu, E. T. (1997). GAS6 Mediates Adhesion of Cells Expressing the Receptor Tyrosine Kinase Axl. J. Biol. Chem. 272: 23285-23291 [Abstract] [Full Text]  
  • Aicher, B., Lerch, M. M., Muller, T., Schilling, J., Ullrich, A. (1997). Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTP{sigma} by Inducible Proteolytic Processing. JCB 138: 681-696 [Abstract] [Full Text]  
  • Jallal, B., Mossie, K., Vasiloudis, G., Knyazev, P., Zachwieja, J., Clairvoyant, F., Schilling, J., Ullrich, A. (1997). The Receptor-like Protein-tyrosine Phosphatase DEP-1 Is Constitutively Associated with a 64-kDa Protein Serine/ Threonine Kinase. J. Biol. Chem. 272: 12158-12163 [Abstract] [Full Text]  
  • Cheng, J., Wu, K., Armanini, M., O'Rourke, N., Dowbenko, D., Lasky, L. A. (1997). A Novel Protein-Tyrosine Phosphatase Related to the Homotypically Adhering kappa andµReceptors. J. Biol. Chem. 272: 7264-7277 [Abstract] [Full Text]  
  • Biscardi, J. S., Denhez, F., Buehler, G. F., Chesnutt, D. A., Baragona, S. C., O'Bryan, J. P., Der, C. J., Fiordalisi, J. J., Fults, D. W., Maness, P. F. (1996). rek, a Gene Expressed in Retina and Brain, Encodes a Receptor Tyrosine Kinase of the Axl/Tyro3 Family. J. Biol. Chem. 271: 29049-29059 [Abstract] [Full Text]  
  • Borges, L. G., Seifert, R. A., Grant, F. J., Hart, C. E., Disteche, C. M., Edelhoff, S., Solca, F. F., Lieberman, M. A., Lindner, V., Fischer, E. H., Lok, S., Bowen-Pope, D. F. (1996). Cloning and Characterization of Rat Density-Enhanced Phosphatase-1, a Protein Tyrosine Phosphatase Expressed by Vascular Cells. Circ. Res. 79: 570-580 [Abstract] [Full Text]  
  • Fuchs, M., Muller, T., Lerch, M. M., Ullrich, A. (1996). Association of Human Protein-tyrosine Phosphatase kappa with Members of the Armadillo Family. J. Biol. Chem. 271: 16712-16719 [Abstract] [Full Text]  
  • Chiang, M., Flanagan, J. (1996). PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development 122: 2239-2250 [Abstract]  
  • Sörby, M., Ostman, A. (1996). Protein-tyrosine Phosphatase-mediated Decrease of Epidermal Growth Factor and Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation in High Cell Density Cultures. J. Biol. Chem. 271: 10963-10966 [Abstract] [Full Text]  
  • Kulas, D. T., Goldstein, B. J., Mooney, R. A. (1996). The Transmembrane Protein-tyrosine Phosphatase LAR Modulates Signaling by Multiple Receptor Tyrosine Kinases. J. Biol. Chem. 271: 748-754 [Abstract] [Full Text]  
  • Pixley, F. J., Lee, P. S. W., Dominguez, M. G., Einstein, D. B., Stanley, E. R. (1995). A Heteromorphic Protein-tyrosine Phosphatase, PTP[IMAGE], Is Regulated by CSF-1 in Macrophages. J. Biol. Chem. 270: 27339-27347 [Abstract] [Full Text]  
  • Zondag, G. C. M., Koningstein, G. M., Jiang, Y.-P., Sap, J., Moolenaar, W. H., Gebbink, M. F. B. G. (1995). Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases µ and [IMAGE]. J. Biol. Chem. 270: 14247-14250 [Abstract] [Full Text]  
  • Pulido, R., Krueger, N. X., Serra-Pagčs, C., Saito, H., Streuli, M. (1995). Molecular Characterization of the Human Transmembrane Protein-tyrosine Phosphatase [IMAGE]. J. Biol. Chem. 270: 6722-6728 [Abstract] [Full Text]  
  • Ogata, M., Sawada, M., Fujino, Y., Hamaoka, T. (1995). cDNA Cloning and Characterization of a Novel Receptor-type Protein Tyrosine Phosphatase Expressed Predominantly in the Brain. J. Biol. Chem. 270: 2337-2343 [Abstract] [Full Text]  
  • Stoker, A., Gehrig, B, Haj, F, Bay, B. (1995). Axonal localisation of the CAM-like tyrosine phosphatase CRYP alpha: a signalling molecule of embryonic growth cones. Development 121: 1833-1844 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»