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Mol Cell Biol. 1994 January; 14(1): 147-155

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

B S Cobb, M D Schaller, T H Leu and J T Parsons

Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908.

ABSTRACT

Changes in cellular growth and dramatic alterations in cell morphology and adhesion are common features of cells transformed by oncogenic protein tyrosine kinases, such as pp60src and other members of the Src family. In this report, we present evidence for the stable association of two Src family kinases (pp60src and pp59fyn) with tyrosine-phosphorylated forms of a focal adhesion-associated protein tyrosine kinase, pp125FAK. In Src-transformed chicken embryo cells, most of the pp125FAK was stably complexed with activated pp60src (e.g., pp60(527F). The stable association of pp125FAK with pp60(527F) in vivo required the structural integrity of the Src SH2 domain. The association of pp60(527F) and pp125FAK could be reconstituted in vitro by incubation of normal cell extracts with glutathione S-transferase fusion proteins containing SH2 or SH3/SH2 domains of pp60src. Furthermore, the association of isolated SH2 or SH3/SH2 domains with in vitro 32P-labeled pp125FAK protected the major site of pp125FAK autophosphorylation from digestion with a tyrosine phosphatase, indicating that the autophosphorylation site of pp125FAK participates in binding with Src. Immunoprecipitation of Src family kinases from extracts of normal chicken embryo cells revealed stable complexes of pp59fyn and tyrosine-phosphorylated pp125FAK. These data provide evidence for a direct interaction between two cytoplasmic nonreceptor protein tyrosine kinases and suggest that Src may contribute to changes in pp125FAK regulation in transformed cells. Furthermore, pp125FAK may directly participate in the targeting of pp59fyn or possibly other Src family kinases to focal adhesions in normal cells.

Mol Cell Biol. 1994 January; 14(1): 147-155




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  • Renshaw, M. W., Price, L. S., Schwartz, M. A. (1999). Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of MAP Kinase. JCB 147: 611-618 [Abstract] [Full Text]  
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  • Kumar, S., Avraham, S., Bharti, A., Goyal, J., Pandey, P., Kharbanda, S. (1999). Negative Regulation of PYK2/Related Adhesion Focal Tyrosine Kinase Signal Transduction by Hematopoietic Tyrosine Phosphatase SHPTP1. J. Biol. Chem. 274: 30657-30663 [Abstract] [Full Text]  
  • Salazar, E. P., Rozengurt, E. (1999). Bombesin and Platelet-derived Growth Factor Induce Association of Endogenous Focal Adhesion Kinase with Src in Intact Swiss 3T3 Cells. J. Biol. Chem. 274: 28371-28378 [Abstract] [Full Text]  
  • Schaller, M. D., Hildebrand, J. D., Parsons, J. T. (1999). Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases. Mol. Biol. Cell 10: 3489-3505 [Abstract] [Full Text]  
  • Chan, P.-C., Lai, J.-F., Cheng, C.-H., Tang, M.-J., Chiu, C.-C., Chen, H.-C. (1999). Suppression of Ultraviolet Irradiation-induced Apoptosis by Overexpression of Focal Adhesion Kinase in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 274: 26901-26906 [Abstract] [Full Text]  
  • Plattner, R., Kadlec, L., DeMali, K. A., Kazlauskas, A., Pendergast, A. M. (1999). c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev. 13: 2400-2411 [Abstract] [Full Text]  
  • Nolan, K., Lacoste, J., Parsons, J. T. (1999). Regulated Expression of Focal Adhesion Kinase-Related Nonkinase, the Autonomously Expressed C-Terminal Domain of Focal Adhesion Kinase. Mol. Cell. Biol. 19: 6120-6129 [Abstract] [Full Text]  
  • Han, D. C., Guan, J.-L. (1999). Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration. J. Biol. Chem. 274: 24425-24430 [Abstract] [Full Text]  
  • Shen, Y., Schaller, M. D. (1999). Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation. Mol. Biol. Cell 10: 2507-2518 [Abstract] [Full Text]  
  • Chen, K.-D., Li, Y.-S., Kim, M., Li, S., Yuan, S., Chien, S., Shyy, J. Y-J. (1999). Mechanotransduction in Response to Shear Stress. ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc. J. Biol. Chem. 274: 18393-18400 [Abstract] [Full Text]  
  • Scholle, F., Longnecker, R., Raab-Traub, N. (1999). Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase. J. Virol. 73: 4767-4775 [Abstract] [Full Text]  
  • Takahashi, N., Seko, Y., Noiri, E., Tobe, K., Kadowaki, T., Sabe, H., Yazaki, Y. (1999). Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes. Circ. Res. 84: 1194-1202 [Abstract] [Full Text]  
  • van de Water, B., Nagelkerke, J. F., Stevens, J. L. (1999). Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells. J. Biol. Chem. 274: 13328-13337 [Abstract] [Full Text]  
  • Reiske, H. R., Kao, S.-C., Cary, L. A., Guan, J.-L., Lai, J.-F., Chen, H.-C. (1999). Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration. J. Biol. Chem. 274: 12361-12366 [Abstract] [Full Text]  
  • Li, J., Lin, M.-L., Wiepz, G. J., Guadarrama, A. G., Bertics, P. J. (1999). Integrin-mediated Migration of Murine B82L Fibroblasts Is Dependent on the Expression of an Intact Epidermal Growth Factor Receptor. J. Biol. Chem. 274: 11209-11219 [Abstract] [Full Text]  
  • Manes, S., Mira, E., Gomez-Mouton, C., Zhao, Z. J., Lacalle, R. A., Martinez-A., C. (1999). Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility. Mol. Cell. Biol. 19: 3125-3135 [Abstract] [Full Text]  
  • Biscardi, J. S., Maa, M.-C., Tice, D. A., Cox, M. E., Leu, T.-H., Parsons, S. J. (1999). c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function. J. Biol. Chem. 274: 8335-8343 [Abstract] [Full Text]  
  • Wang, Z, Symons, J., Goldstein, S., McDonald, A, Miner, J., Kreidberg, J. (1999). (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization. J. Cell Sci. 112: 2925-2935 [Abstract]  
  • Madruga, J, Koritschoner, N., Diebold, S., Kurz, S., Zenke, M (1999). Polarised expression pattern of focal contact proteins in highly motile antigen presenting dendritic cells. J. Cell Sci. 112: 1685-1696 [Abstract]  
  • YEAMAN, C., GRINDSTAFF, K. K., NELSON, W. J. (1999). New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity. Physiol. Rev. 79: 73-98 [Abstract] [Full Text]  
  • Corey, S. J., Anderson, S. M. (1999). Src-Related Protein Tyrosine Kinases in Hematopoiesis. Blood 93: 1-14 [Full Text]  
  • Zhao, J.-H., Reiske, H., Guan, J.-L. (1998). Regulation of the Cell Cycle by Focal Adhesion Kinase. JCB 143: 1997-2008 [Abstract] [Full Text]  
  • Ott, V. L., Rapraeger, A. C. (1998). Tyrosine Phosphorylation of Syndecan-1 and -4 Cytoplasmic Domains in Adherent B82 Fibroblasts. J. Biol. Chem. 273: 35291-35298 [Abstract] [Full Text]  
  • Harder, K. W., Moller, N. P. H., Peacock, J. W., Jirik, F. R. (1998). Protein-tyrosine Phosphatase alpha  Regulates Src Family Kinases and Alters Cell-Substratum Adhesion. J. Biol. Chem. 273: 31890-31900 [Abstract] [Full Text]  
  • Alrutz, M. A., Isberg, R. R. (1998). Involvement of focal adhesion kinase in invasin-mediated uptake. Proc. Natl. Acad. Sci. USA 95: 13658-13663 [Abstract] [Full Text]  
  • Fujita, H., Kamiguchi, K., Cho, D., Shibanuma, M., Morimoto, C., Tachibana, K. (1998). Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase. J. Biol. Chem. 273: 26516-26521 [Abstract] [Full Text]  
  • Chen, H.-C., Chan, P.-C., Tang, M.-J., Cheng, C.-H., Chang, T.-J. (1998). Tyrosine Phosphorylation of Focal Adhesion Kinase Stimulated by Hepatocyte Growth Factor Leads to Mitogen-activated Protein Kinase Activation. J. Biol. Chem. 273: 25777-25782 [Abstract] [Full Text]  
  • Rodriguez-Fernandez, J. L., Rozengurt, E. (1998). Bombesin, Vasopressin, Lysophosphatidic Acid, and Sphingosylphosphorylcholine Induce Focal Adhesion Kinase Activation in Intact Swiss 3T3 Cells. J. Biol. Chem. 273: 19321-19328 [Abstract] [Full Text]  
  • Gervais, F. G., Thornberry, N. A., Ruffolo, S. C., Nicholson, D. W., Roy, S. (1998). Caspases Cleave Focal Adhesion Kinase during Apoptosis to Generate a FRNK-like Polypeptide. J. Biol. Chem. 273: 17102-17108 [Abstract] [Full Text]  
  • Puceat, M., Roche, S., Vassort, G. (1998). Src Family Tyrosine Kinase Regulates Intracellular pH in Cardiomyocytes. JCB 141: 1637-1646 [Abstract] [Full Text]  
  • LaVallee, T. M., Prudovsky, I. A., McMahon, G. A., Hu, X., Maciag, T. (1998). Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration. JCB 141: 1647-1658 [Abstract] [Full Text]  
  • Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]  
  • Tsuda, M., Matozaki, T., Fukunaga, K., Fujioka, Y., Imamoto, A., Noguchi, T., Takada, T., Yamao, T., Takeda, H., Ochi, F., Yamamoto, T., Kasuga, M. (1998). Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2. ROLES OF Fak AND Src FAMILY KINASES. J. Biol. Chem. 273: 13223-13229 [Abstract] [Full Text]  
  • Fernandez, R., Suchard, S. J. (1998). Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils. J. Immunol. 160: 5154-5162 [Abstract] [Full Text]  
  • Chellaiah, M., Fitzgerald, C., Alvarez, U., Hruska, K. (1998). c-Src Is Required for Stimulation of Gelsolin-associated Phosphatidylinositol 3-Kinase. J. Biol. Chem. 273: 11908-11916 [Abstract] [Full Text]  
  • Jeschke, M., Standke, G. J. R., Susa, M. (1998). Fluoroaluminate Induces Activation and Association of Src and Pyk2 Tyrosine Kinases in Osteoblastic MC3T3-E1 Cells. J. Biol. Chem. 273: 11354-11361 [Abstract] [Full Text]  
  • Stouffer, G. A., Hu, Z., Sajid, M., Li, H., Jin, G., Nakada, M. T., Hanson, S. R., Runge, M. S. (1998). ß3 Integrins Are Upregulated After Vascular Injury and Modulate Thrombospondin- and Thrombin-Induced Proliferation of Cultured Smooth Muscle Cells. Circulation 97: 907-915 [Abstract] [Full Text]  
  • Hu, X.-Q., Singh, N., Mukhopadhyay, D., Akbarali, H. I. (1998). Modulation of Voltage-dependent Ca2+ Channels in Rabbit Colonic Smooth Muscle Cells by c-Src and Focal Adhesion Kinase. J. Biol. Chem. 273: 5337-5342 [Abstract] [Full Text]  
  • Cary, L. A., Han, D. C., Polte, T. R., Hanks, S. K., Guan, J.-L. (1998). Identification of p130Cas as a Mediator of Focal Adhesion Kinase-promoted Cell Migration. JCB 140: 211-221 [Abstract] [Full Text]  
  • Matsuya, M., Sasaki, H., Aoto, H., Mitaka, T., Nagura, K., Ohba, T., Ishino, M., Takahashi, S., Suzuki, R., Sasaki, T. (1998). Cell Adhesion Kinase beta  Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions. J. Biol. Chem. 273: 1003-1014 [Abstract] [Full Text]  
  • Helmke, S, Lohse, K, Mikule, K, Wood, M., Pfenninger, K. (1998). SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent. J. Cell Sci. 111: 2465-2475 [Abstract]  
  • Panek, R. L., Lu, G. H., Klutchko, S. R., Batley, B. L., Dahring, T. K., Hamby, J. M., Hallak, H., Doherty, A. M., Keiser, J. A. (1997). In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor. J. Pharmacol. Exp. Ther. 283: 1433-1444 [Abstract] [Full Text]  


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