This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soltoff, S P Articles by Cantley, L C Search for Related Content PubMed PubMed Citation Articles by Soltoff, S P Articles by Cantley, L C

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02115.

ABSTRACT

Conflicting results concerning the ability of the epidermal growth factor (EGF) receptor to associate with and/or activate phosphatidylinositol (PtdIns) 3-kinase have been published. Despite the ability of EGF to stimulate the production of PtdIns 3-kinase products and to cause the appearance of PtdIns 3-kinase activity in antiphosphotyrosine immunoprecipitates in several cell lines, we did not detect EGF-stimulated PtdIns 3-kinase activity in anti-EGF receptor immunoprecipitates. This result is consistent with the lack of a phosphorylated Tyr-X-X-Met motif, the p85 Src homology 2 (SH2) domain recognition sequence, in this receptor sequence. The EGF receptor homolog, ErbB2 protein, also lacks this motif. However, the ErbB3 protein has seven repeats of the Tyr-X-X-Met motif in the carboxy-terminal unique domain. Here we show that in A431 cells, which express both the EGF receptor and ErbB3, PtdIns 3-kinase coprecipitates with the ErbB3 protein (p180erbB3) in response to EGF. p180erbB3 is also shown to be tyrosine phosphorylated in response to EGF. In contrast, a different mechanism for the activation of PtdIns 3-kinase in response to EGF occurs in certain cells (PC12 and A549 cells). Thus, we show for the first time that ErbB3 can mediate EGF responses in cells expressing both ErbB3 and the EGF receptor.

This article has been cited by other articles:

• Dourdin, N., Schade, B., Lesurf, R., Hallett, M., Munn, R. J., Cardiff, R. D., Muller, W. J. (2008). Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis. Cancer Res. 68: 2122-2131 [Abstract] [Full Text]  
• Yang, S., Raymond-Stintz, M. A., Ying, W., Zhang, J., Lidke, D. S., Steinberg, S. L., Williams, L., Oliver, J. M., Wilson, B. S. (2007). Mapping ErbB receptors on breast cancer cell membranes during signal transduction. J. Cell Sci. 120: 2763-2773 [Abstract] [Full Text]  
• Kopelovich, L., Fay, J. R., Sigman, C. C., Crowell, J. A. (2007). The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention. Cancer Epidemiol. Biomarkers Prev. 16: 1330-1340 [Abstract] [Full Text]  
• Yamasaki, F., Johansen, M. J., Zhang, D., Krishnamurthy, S., Felix, E., Bartholomeusz, C., Aguilar, R. J., Kurisu, K., Mills, G. B., Hortobagyi, G. N., Ueno, N. T. (2007). Acquired Resistance to Erlotinib in A-431 Epidermoid Cancer Cells Requires Down-regulation of MMAC1/PTEN and Up-regulation of Phosphorylated Akt. Cancer Res. 67: 5779-5788 [Abstract] [Full Text]  
• Abraham, R. T., Gibbons, J. J. (2007). The Mammalian Target of Rapamycin Signaling Pathway: Twists and Turns in the Road to Cancer Therapy. Clin. Cancer Res. 13: 3109-3114 [Abstract] [Full Text]  
• Schaefer, G., Shao, L., Totpal, K., Akita, R. W. (2007). Erlotinib Directly Inhibits HER2 Kinase Activation and Downstream Signaling Events in Intact Cells Lacking Epidermal Growth Factor Receptor Expression. Cancer Res. 67: 1228-1238 [Abstract] [Full Text]  
• Ono, M., Kuwano, M. (2006). Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs. Clin. Cancer Res. 12: 7242-7251 [Abstract] [Full Text]  
• Fleming, J. M., Desury, G., Polanco, T. A., Cohick, W. S. (2006). Insulin Growth Factor-I and Epidermal Growth Factor Receptors Recruit Distinct Upstream Signaling Molecules to Enhance AKT Activation in Mammary Epithelial Cells. Endocrinology 147: 6027-6035 [Abstract] [Full Text]  
• Buck, E., Eyzaguirre, A., Haley, J. D., Gibson, N. W., Cagnoni, P., Iwata, K. K. (2006). Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity.. Molecular Cancer Therapeutics 5: 2051-2059 [Abstract] [Full Text]  
• Coldren, C. D., Helfrich, B. A., Witta, S. E., Sugita, M., Lapadat, R., Zeng, C., Baron, A., Franklin, W. A., Hirsch, F. R., Geraci, M. W., Bunn, P. A. Jr. (2006). Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Res 4: 521-528 [Abstract] [Full Text]  
• Engelman, J. A., Cantley, L. C. (2006). The Role of the ErbB Family Members in Non-Small Cell "Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors".. Clin. Cancer Res. 12: 4372s-4376s [Abstract] [Full Text]  
• Shankaran, H., Wiley, H. S., Resat, H. (2006). Modeling the Effects of HER/ErbB1-3 Coexpression on Receptor Dimerization and Biological Response. Biophys. J 90: 3993-4009 [Abstract] [Full Text]  
• Gilbertson, R. J. (2005). ERBB2 in Pediatric Cancer: Innocent Until Proven Guilty. The Oncologist 10: 508-517 [Abstract] [Full Text]  
• Hu, Y. P., Venkateswarlu, S., Sergina, N., Howell, G., Clair, P. St., Humphrey, L. E., Li, W., Hauser, J., Zborowska, E., Willson, J. K. V., Brattain, M. G. (2005). Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells. J. Biol. Chem. 280: 27383-27392 [Abstract] [Full Text]  
• Wang, J.-M., Tseng, J. T., Chang, W.-C. (2005). Induction of Human NF-IL6{beta} by Epidermal Growth Factor Is Mediated through the p38 Signaling Pathway and cAMP Response Element-binding Protein Activation in A431 Cells. Mol. Biol. Cell 16: 3365-3376 [Abstract] [Full Text]  
• Liu, M., Howes, A., Lesperance, J., Stallcup, W. B., Hauser, C. A., Kadoya, K., Oshima, R. G., Abraham, R. T. (2005). Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer. Cancer Res. 65: 5325-5336 [Abstract] [Full Text]  
• Hirata, A., Hosoi, F., Miyagawa, M., Ueda, S.-i., Naito, S., Fujii, T., Kuwano, M., Ono, M. (2005). HER2 Overexpression Increases Sensitivity to Gefitinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, through Inhibition of HER2/HER3 Heterodimer Formation in Lung Cancer Cells. Cancer Res. 65: 4253-4260 [Abstract] [Full Text]  
• Engelman, J. A., Janne, P. A., Mermel, C., Pearlberg, J., Mukohara, T., Fleet, C., Cichowski, K., Johnson, B. E., Cantley, L. C. (2005). ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc. Natl. Acad. Sci. USA 102: 3788-3793 [Abstract] [Full Text]  
• Gambarotta, G., Garzotto, D., Destro, E., Mautino, B., Giampietro, C., Cutrupi, S., Dati, C., Cattaneo, E., Fasolo, A., Perroteau, I. (2004). ErbB4 Expression in Neural Progenitor Cells (ST14A) Is Necessary to Mediate Neuregulin-1{beta}1-induced Migration. J. Biol. Chem. 279: 48808-48816 [Abstract] [Full Text]  
• Metge, B., Ofori-Acquah, S., Stevens, T., Balczon, R. (2004). Stat3 Activity Is Required for Centrosome Duplication in Chinese Hamster Ovary Cells. J. Biol. Chem. 279: 41801-41806 [Abstract] [Full Text]  
• Sekiya, F., Poulin, B., Kim, Y. J., Rhee, S. G. (2004). Mechanism of Tyrosine Phosphorylation and Activation of Phospholipase C-{gamma}1: TYROSINE 783 PHOSPHORYLATION IS NOT SUFFICIENT FOR LIPASE ACTIVATION. J. Biol. Chem. 279: 32181-32190 [Abstract] [Full Text]  
• Salamanca, C. M., Maines-Bandiera, S. L., Leung, P. C. K., Hu, Y.-L., Auersperg, N. (2004). Effects of Epidermal Growth Factor/Hydrocortisone on the Growth and Differentiation of Human Ovarian Surface Epithelium. Reproductive Sciences 11: 241-251 [Abstract]  
• MacDougall, L. K., Gagou, M. E., Leevers, S. J., Hafen, E., Waterfield, M. D. (2004). Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways. Mol. Cell. Biol. 24: 796-808 [Abstract] [Full Text]  
• Grunwald, V., Hidalgo, M. (2003). Developing Inhibitors of the Epidermal Growth Factor Receptor for Cancer Treatment. JNCI J Natl Cancer Inst 95: 851-867 [Abstract] [Full Text]  
• Cho, H. J., Kim, W. K., Kim, E. J., Jung, K. C., Park, S., Lee, H. S., Tyner, A. L., Park, J. H. Y. (2003). Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G996-G1005 [Abstract] [Full Text]  
• Stoica, G. E., Franke, T. F., Wellstein, A., Czubayko, F., List, H.-J., Reiter, R., Morgan, E., Martin, M. B., Stoica, A. (2003). Estradiol Rapidly Activates Akt via the ErbB2 Signaling Pathway. Mol. Endocrinol. 17: 818-830 [Abstract] [Full Text]  
• Qiu, X.-B., Goldberg, A. L. (2002). Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc. Natl. Acad. Sci. USA 99: 14843-14848 [Abstract] [Full Text]  
• Matsuda, K., Idezawa, T., You, X. J., Kothari, N. H., Fan, H., Korc, M. (2002). Multiple Mitogenic Pathways in Pancreatic Cancer Cells Are Blocked by a Truncated Epidermal Growth Factor Receptor. Cancer Res. 62: 5611-5617 [Abstract] [Full Text]  
• Andrechek, E. R., Hardy, W. R., Girgis-Gabardo, A. A., Perry, R. L. S., Butler, R., Graham, F. L., Kahn, R. C., Rudnicki, M. A., Muller, W. J. (2002). ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival. Mol. Cell. Biol. 22: 4714-4722 [Abstract] [Full Text]  
• Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hugl, S. R., Twardzik, D. R., Rhodes, C. J. (2002). Activation of IRS-2--Mediated Signal Transduction by IGF-1, but not TGF-{alpha} or EGF, Augments Pancreatic {beta}-Cell Proliferation. Diabetes 51: 966-976 [Abstract] [Full Text]  
• Hellyer, N. J., Kim, M.-S., Koland, J. G. (2001). Heregulin-dependent Activation of Phosphoinositide 3-Kinase and Akt via the ErbB2/ErbB3 Co-receptor. J. Biol. Chem. 276: 42153-42161 [Abstract] [Full Text]  
• Moasser, M. M., Basso, A., Averbuch, S. D., Rosen, N. (2001). The Tyrosine Kinase Inhibitor ZD1839 (""Iressa"") Inhibits HER2-driven Signaling and Suppresses the Growth of HER2-overexpressing Tumor Cells. Cancer Res. 61: 7184-7188 [Abstract] [Full Text]  
• Sartor, C. I., Zhou, H., Kozlowska, E., Guttridge, K., Kawata, E., Caskey, L., Harrelson, J., Hynes, N., Ethier, S., Calvo, B., Earp, H. S. III (2001). HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer Cells. Mol. Cell. Biol. 21: 4265-4275 [Abstract] [Full Text]  
• Bali, M., Lipecka, J., Edelman, A., Fritsch, J. (2001). Regulation of ClC-2 chloride channels in T84 cells by TGF-{alpha}. Am. J. Physiol. Cell Physiol. 280: C1588-C1598 [Abstract] [Full Text]  
• O'Shea, S., Johnson, K., Clark, R., Sliwkowski, M. X., Erickson, S. L. (2001). Effects of in Vivo Heregulin {beta}1 Treatment in Wild-Type and ErbB Gene-Targeted Mice Depend on Receptor Levels and Pregnancy. Am. J. Pathol. 158: 1871-1880 [Abstract] [Full Text]  
• Arcaro, A., Zvelebil, M. J., Wallasch, C., Ullrich, A., Waterfield, M. D., Domin, J. (2000). Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors. Mol. Cell. Biol. 20: 3817-3830 [Abstract] [Full Text]  
• Jo, M., Stolz, D. B., Esplen, J. E., Dorko, K., Michalopoulos, G. K., Strom, S. C. (2000). Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells. J. Biol. Chem. 275: 8806-8811 [Abstract] [Full Text]  
• Ram, T. G., Schelling, M. E., Hosick, H. L. (2000). Blocking HER-2/HER-3 Function with a Dominant Negative Form of HER-3 in Cells Stimulated by Heregulin and in Breast Cancer Cells with HER-2 Gene Amplification. Cell Growth Differ. 11: 173-183 [Abstract] [Full Text]  
• Suprynowicz, F. A., Sparkowski, J., Baege, A., Schlegel, R. (2000). E5 Oncoprotein Mutants Activate Phosphoinositide 3-Kinase Independently of Platelet-derived Growth Factor Receptor Activation. J. Biol. Chem. 275: 5111-5119 [Abstract] [Full Text]  
• Rodrigues, G. A., Falasca, M., Zhang, Z., Ong, S. H., Schlessinger, J. (2000). A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling. Mol. Cell. Biol. 20: 1448-1459 [Abstract] [Full Text]  
• Laffargue, M., Raynal, P., Yart, A., Peres, C., Wetzker, R., Roche, S., Payrastre, B., Chap, H. (1999). An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid. J. Biol. Chem. 274: 32835-32841 [Abstract] [Full Text]  
• Muthuswamy, S. K., Gilman, M., Brugge, J. S. (1999). Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers. Mol. Cell. Biol. 19: 6845-6857 [Abstract] [Full Text]  
• Eagleson, K. L., Levitt, P. (1999). Complex Signaling Responsible for Molecular Regionalization of the Cerebral Cortex. Cereb Cortex 9: 562-568 [Abstract] [Full Text]  
• Gillham, H., Golding, M. C.H.M., Pepperkok, R., Gullick, W. J. (1999). Intracellular Movement of Green Fluorescent Protein–tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling. J. Cell Biol. 146: 869-880 [Abstract] [Full Text]  
• Ignatoski, K. M. W., LaPointe, A. J., Radany, E. H., Ethier, S. P. (1999). erbB-2 Overexpression in Human Mammary Epithelial Cells Confers Growth Factor Independence. Endocrinology 140: 3615-3622 [Abstract] [Full Text]  
• FRIESS, H., GUO, X.-Z., NAN, B.-C., KLEEFF, O., BUCHLER, M. W. (1999). Growth Factors and Cytokines in Pancreatic Carcinogenesis. Ann. N. Y. Acad. Sci. 880: 110-121 [Abstract] [Full Text]  
• Olayioye, M. A., Beuvink, I., Horsch, K., Daly, J. M., Hynes, N. E. (1999). ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases. J. Biol. Chem. 274: 17209-17218 [Abstract] [Full Text]  
• Lin, J., Adam, R. M., Santiestevan, E., Freeman, M. R. (1999). The Phosphatidylinositol 3'-kinase Pathway Is a Dominant Growth Factor-activated Cell Survival Pathway in LNCaP Human Prostate Carcinoma Cells. Cancer Res. 59: 2891-2897 [Abstract] [Full Text]  
• Polosa, R., Prosperini, G., Leir, S.-H., Holgate, S. T., Lackie, P. M., Davies, D. E. (1999). Expression of c-erbB Receptors and Ligands in Human Bronchial Mucosa. Am. J. Respir. Cell Mol. Bio. 20: 914-923 [Abstract] [Full Text]  
• Wang, Z., Zhang, L., Yeung, T. K., Chen, X. (1999). Endocytosis Deficiency of Epidermal Growth Factor (EGF) Receptor-ErbB2 Heterodimers in Response to EGF Stimulation. Mol. Biol. Cell 10: 1621-1636 [Abstract] [Full Text]  
• Krymskaya, V. P., Hoffman, R., Eszterhas, A., Kane, S., Ciocca, V., Panettieri, R. A. Jr. (1999). EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 276: L246-L255 [Abstract] [Full Text]  
• Jiang, D., Yang, H., Willson, J. K. V., Liang, J., Humphrey, L. E., Zborowska, E., Wang, D., Foster, J., Fan, R., Brattain, M. G. (1998). Autocrine Transforming Growth Factor alpha  Provides a Growth Advantage to Malignant Cells by Facilitating Re-entry into the Cell Cycle from Suboptimal Growth States. J. Biol. Chem. 273: 31471-31479 [Abstract] [Full Text]  
• Crovello, C. S., Lai, C., Cantley, L. C., Carraway III, K. L. (1998). Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2. J. Biol. Chem. 273: 26954-26961 [Abstract] [Full Text]  
• Guthridge, M. A., Stomski, F. C., Thomas, D., Woodcock, J. M., Bagley, C. J., Berndt, M. C., Lopez, A. F. (1998). Mechanism of Activation of the GM-CSF, IL-3, and IL-5 Family of Receptors. Stem Cells 16: 301-313 [Abstract] [Full Text]  
• Vijapurkar, U., Cheng, K., Koland, J. G. (1998). Mutation of a Shc Binding Site Tyrosine Residue in ErbB3/HER3 Blocks Heregulin-dependent Activation of Mitogen-activated Protein Kinase. J. Biol. Chem. 273: 20996-21002 [Abstract] [Full Text]  
• Waterman, H., Sabanai, I., Geiger, B., Yarden, Y. (1998). Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency. J. Biol. Chem. 273: 13819-13827 [Abstract] [Full Text]  
• Webster, M. A., Hutchinson, J. N., Rauh, M. J., Muthuswamy, S. K., Anton, M., Tortorice, C. G., Cardiff, R. D., Graham, F. L., Hassell, J. A., Muller, W. J. (1998). Requirement for Both Shc and Phosphatidylinositol 3' Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis. Mol. Cell. Biol. 18: 2344-2359 [Abstract] [Full Text]  
• Fiddes, R. J., Campbell, D. H., Janes, P. W., Sivertsen, S. P., Sasaki, H., Wallasch, C., Daly, R. J. (1998). Analysis of Grb7 Recruitment by Heregulin-activated erbB Receptors Reveals a Novel Target Selectivity for erbB3. J. Biol. Chem. 273: 7717-7724 [Abstract] [Full Text]  
• Habib, A. A., Hognason, T., Ren, J., Stefansson, K., Ratan, R. R. (1998). The Epidermal Growth Factor Receptor Associates with and Recruits Phosphatidylinositol 3-Kinase to the Platelet-derived Growth Factor beta  Receptor. J. Biol. Chem. 273: 6885-6891 [Abstract] [Full Text]  
• Burden, S. J. (1998). The formation of neuromuscular synapses. Genes Dev. 12: 133-148 [Full Text]  
• Emkey, R., Kahn, C. R. (1997). Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes. I. ACTIVATION OF PROTEIN KINASE C STIMULATES TYROSINE PHOSPHORYLATION AND ACTIVATION OF ErbB2 AND ErbB3. J. Biol. Chem. 272: 31172-31181 [Abstract] [Full Text]  
• Emkey, R., Kahn, C. R. (1997). Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes. II COMPARISON OF PHORBOL ESTER AND SPHINGOMYELINASE-INDUCED PHOSPHORYLATION OF ErbB2 AND ErbB3. J. Biol. Chem. 272: 31182-31189 [Abstract] [Full Text]  
• Krymskaya, V. P., Hoffman, R., Eszterhas, A., Ciocca, V., Panettieri, R. A. Jr. (1997). TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 273: L1220-L1227 [Abstract] [Full Text]  
• Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R., Wong, A. J. (1997). Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. USA 94: 12419-12424 [Abstract] [Full Text]  
• Yoon, S. O., Soltoff, S. P., Chao, M. V. (1997). A Dominant Role of the Juxtamembrane Region of the TrkA Nerve Growth Factor Receptor during Neuronal Cell Differentiation. J. Biol. Chem. 272: 23231-23238 [Abstract] [Full Text]  
• D'Mello, S. R., Borodezt, K., Soltoff, S. P. (1997). Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling. J. Neurosci. 17: 1548-1560 [Abstract] [Full Text]  
• Zrihan-Licht, S., Lim, J., Keydar, I., Sliwkowski, M. X., Groopman, J. E., Avraham, H. (1997). Association of Csk-homologous Kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in Breast Cancer Cells. J. Biol. Chem. 272: 1856-1863 [Abstract] [Full Text]  
• McCawley, L. J., O'Brien, P., Hudson, L. G. (1997). Overexpression of the Epidermal Growth Factor Receptor Contributes to Enhanced Ligand-Mediated Motility in Keratinocyte Cell Lines. Endocrinology 138: 121-127 [Abstract] [Full Text]  
• Reese, D. M., Slamon, D. J. (1997). HER-2/neu Signal Transduction in Human Breast and Ovarian Cancer. Stem Cells 15: 1-8 [Abstract] [Full Text]  
• Cohen, B. D., Kiener, P. A., Green, J. M., Foy, L., Fell, H. P., Zhang, K. (1996). The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells. J. Biol. Chem. 271: 30897-30903 [Abstract] [Full Text]  
• Uribe, J. M., Keely, S. J., Traynor-Kaplan, A. E., Barrett, K. E. (1996). Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion. J. Biol. Chem. 271: 26588-26595 [Abstract] [Full Text]  
• Grinspan, J. B., Marchionni, M. A., Reeves, M., Coulaloglou, M., Scherer, S. S. (1996). Axonal Interactions Regulate Schwann Cell Apoptosis in Developing Peripheral Nerve: Neuregulin Receptors and the Role of Neuregulins. J. Neurosci. 16: 6107-6118 [Abstract] [Full Text]  
• Si, J., Luo, Z., Mei, L. (1996). Induction of Acetylcholine Receptor Gene Expression by ARIA Requires Activation of Mitogen-activated Protein Kinase. J. Biol. Chem. 271: 19752-19759 [Abstract] [Full Text]  
• Riese, D. J. II, Kim, E. D., Elenius, K., Buckley, S., Klagsbrun, M., Plowman, G. D., Stern, D. F. (1996). The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-alpha , Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4. J. Biol. Chem. 271: 20047-20052 [Abstract] [Full Text]  
• Carver, R. S., Sliwkowski, M. X., Sitaric, S., Russell, W. E. (1996). Insulin Regulates Heregulin Binding and ErbB3 Expression in Rat Hepatocytes. J. Biol. Chem. 271: 13491-13496 [Abstract] [Full Text]  
• Khurana, S., Nath, S. K., Levine, S. A., Bowser, J. M., Tse, C.-M., Cohen, M. E., Donowitz, M. (1996). Brush Border Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor Stimulation of Intestinal NaCl Absorption and Na[IMAGE]/H[IMAGE] Exchange. J. Biol. Chem. 271: 9919-9927 [Abstract] [Full Text]  
• Chen, X., Levkowitz, G., Tzahar, E., Karunagaran, D., Lavi, S., Ben-Baruch, N., Leitner, O., Ratzkin, B. J., Bacus, S. S., Yarden, Y. (1996). An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4. J. Biol. Chem. 271: 7620-7629 [Abstract] [Full Text]  
• Beerli, R. R., Hynes, N. E. (1996). Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities. J. Biol. Chem. 271: 6071-6076 [Abstract] [Full Text]  
• Cohen, B. D., Green, J. M., Foy, L., Fell, H. P. (1996). HER4-mediated Biological and Biochemical Properties in NIH 3T3 Cells. J. Biol. Chem. 271: 4813-4818 [Abstract] [Full Text]  
• Zhang, K., Sun, J., Liu, N., Wen, D., Chang, D., Thomason, A., Yoshinaga, S. K. (1996). Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2. J. Biol. Chem. 271: 3884-3890 [Abstract] [Full Text]  
• Soltoff, S. P., Cantley, L. C. (1996). p120[IMAGE] Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells. J. Biol. Chem. 271: 563-567 [Abstract] [Full Text]  
• Kapeller, R., Toker, A., Cantley, L. C., Carpenter, C. L. (1995). Phosphoinositide 3-Kinase Binds Constitutively to alpha/beta-Tubulin and Binds to [IMAGE]-Tubulin in Response to Insulin. J. Biol. Chem. 270: 25985-25991 [Abstract] [Full Text]  
• Prigent, S. A., Pillay, T. S., Ravichandran, K. S., Gullick, W. J. (1995). Binding of Shc to the NPXY Motif Is Mediated by Its N-terminal Domain. J. Biol. Chem. 270: 22097-22100 [Abstract] [Full Text]  
• Gamett, D. C., Greene, T., Wagreich, A. R., Kim, H.-H., Koland, J. G., Cerione, R. A. (1995). Heregulin-stimulated Signaling in Rat Pheochromocytoma Cells. J. Biol. Chem. 270: 19022-19027 [Abstract] [Full Text]  
• Wright, J. D., Reuter, C. W. M., Weber, M. J. (1995). An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-defective Epidermal Growth Factor Receptors. J. Biol. Chem. 270: 12085-12093 [Abstract] [Full Text]  
• Carraway, K. L.:I., Soltoff, S. P., Cantley, L. C. (1995). Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3. J. Biol. Chem. 270: 7111-7116 [Abstract] [Full Text]  
• Okano, J.-i., Gaslightwala, I., Birnbaum, M. J., Rustgi, A. K., Nakagawa, H. (2000). Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation. J. Biol. Chem. 275: 30934-30942 [Abstract] [Full Text]  
• Kong, M., Mounier, C., Wu, J., Posner, B. I. (2000). Epidermal Growth Factor-induced Phosphatidylinositol 3-Kinase Activation and DNA Synthesis. IDENTIFICATION OF Grb2-ASSOCIATED BINDER 2 AS THE MAJOR MEDIATOR IN RAT HEPATOCYTES. J. Biol. Chem. 275: 36035-36042 [Abstract] [Full Text]  
• Sweeney, C., Fambrough, D., Huard, C., Diamonti, A. J., Lander, E. S., Cantley, L. C., Carraway, K. L. III (2001). Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors. J. Biol. Chem. 276: 22685-22698 [Abstract] [Full Text]