This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sell, C Articles by Baserga, R Search for Related Content PubMed PubMed Citation Articles by Sell, C Articles by Baserga, R

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

ABSTRACT

Fibroblast cell lines, designated R- and W cells, were generated, respectively, from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 insulin-like growth factor receptor, and from their wild-type littermates. W cells grow normally in serum-free medium supplemented with various combinations of purified growth factors, while pre- and postcrisis R- cells cannot grow, as they are arrested before entering the S phase. R- cells are able to grow in 10% serum, albeit more slowly than W cells, and with all phases of the cell cycle being elongated. An activated Ha-ras expressed from a stably transfected plasmid is unable to overcome the inability of R- cells to grow in serum-free medium supplemented with purified clones. Nevertheless, even in the presence of serum, R- cells stably transfected with Ha-ras, alone or in combination with simian virus 40 large T antigen, fail to form colonies in soft agar. Reintroduction into R- cells (or their derivatives) of a plasmid expressing the human insulin-like growth factor I receptor RNA and protein restores their ability to grow with purified growth factors or in soft agar. The signaling pathways participating in cell growth and transformation are discussed on the basis of these results.

This article has been cited by other articles:

• Sutherland, B. W., Knoblaugh, S. E., Kaplan-Lefko, P. J., Wang, F., Holzenberger, M., Greenberg, N. M. (2008). Conditional Deletion of Insulin-like Growth Factor-I Receptor in Prostate Epithelium. Cancer Res. 68: 3495-3504 [Abstract] [Full Text]  
• Chakraborty, A. K., Liang, K., DiGiovanna, M. P. (2008). Co-Targeting Insulin-Like Growth Factor I Receptor and HER2: Dramatic Effects of HER2 Inhibitors on Nonoverexpressing Breast Cancer. Cancer Res. 68: 1538-1545 [Abstract] [Full Text]  
• Surinya, K. H., Forbes, B. E., Occhiodoro, F., Booker, G. W., Francis, G. L., Siddle, K., Wallace, J. C., Cosgrove, L. J. (2008). An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors. J. Biol. Chem. 283: 5355-5363 [Abstract] [Full Text]  
• Floyd, S., Favre, C., Lasorsa, F. M., Leahy, M., Trigiante, G., Stroebel, P., Marx, A., Loughran, G., O'Callaghan, K., Marobbio, C. M.T., Slotboom, D. J., Kunji, E. R.S., Palmieri, F., O'Connor, R. (2007). The Insulin-like Growth Factor-I mTOR Signaling Pathway Induces the Mitochondrial Pyrimidine Nucleotide Carrier to Promote Cell Growth. Mol. Biol. Cell 18: 3545-3555 [Abstract] [Full Text]  
• Barnes, C. J., Ohshiro, K., Rayala, S. K., El-Naggar, A. K., Kumar, R. (2007). Insulin-like Growth Factor Receptor as a Therapeutic Target in Head and Neck Cancer. Clin. Cancer Res. 13: 4291-4299 [Abstract] [Full Text]  
• Xu, K., Zhang, Y., Ilalov, K., Carlson, C. S., Feng, J. Q., Di Cesare, P. E., Liu, C.-j. (2007). Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation. J. Biol. Chem. 282: 11347-11355 [Abstract] [Full Text]  
• Li, M., He, Z., Ermakova, S., Zheng, D., Tang, F., Cho, Y.-Y., Zhu, F., Ma, W.-Y., Sham, Y., Rogozin, E. A., Bode, A. M., Cao, Y., Dong, Z. (2007). Direct Inhibition of Insulin-Like Growth Factor-I Receptor Kinase Activity by (-)-Epigallocatechin-3-Gallate Regulates Cell Transformation. Cancer Epidemiol. Biomarkers Prev. 16: 598-605 [Abstract] [Full Text]  
• Sachdev, D., Yee, D. (2007). Disrupting insulin-like growth factor signaling as a potential cancer therapy. Molecular Cancer Therapeutics 6: 1-12 [Abstract] [Full Text]  
• Riedemann, J, Macaulay, V M (2006). IGF1R signalling and its inhibition. Endocr Relat Cancer 13: S33-S43 [Abstract] [Full Text]  
• Monami, G., Gonzalez, E. M., Hellman, M., Gomella, L. G., Baffa, R., Iozzo, R. V., Morrione, A. (2006). Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex.. Cancer Res. 66: 7103-7110 [Abstract] [Full Text]  
• Kiely, P. A., O'Gorman, D., Luong, K., Ron, D., O'Connor, R. (2006). Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and {beta}1 Integrin To Promote Cell Migration.. Mol. Cell. Biol. 26: 4041-4051 [Abstract] [Full Text]  
• Spence, S. L., Shaffer, A. L., Staudt, L. M., Amde, S., Manney, S., Terry, C., Weisz, K., Nissley, P. (2006). Transformation of Late Passage Insulin-Like Growth Factor-I Receptor Null Mouse Embryo Fibroblasts by SV40 T Antigen.. Cancer Res. 66: 4233-4239 [Abstract] [Full Text]  
• Martin, M. J., Melnyk, N., Pollard, M., Bowden, M., Leong, H., Podor, T. J., Gleave, M., Sorensen, P. H. B. (2006). The Insulin-Like Growth Factor I Receptor Is Required for Akt Activation and Suppression of Anoikis in Cells Transformed by the ETV6-NTRK3 Chimeric Tyrosine Kinase.. Mol. Cell. Biol. 26: 1754-1769 [Abstract] [Full Text]  
• Ma, Y., Zhang, L., Peng, T., Cheng, J., Taneja, S., Zhang, J., Delafontaine, P., Du, J. (2006). Angiotensin II Stimulates Transcription of Insulin-Like Growth Factor I Receptor in Vascular Smooth Muscle Cells: Role of Nuclear Factor-{kappa}B. Endocrinology 147: 1256-1263 [Abstract] [Full Text]  
• Denley, A., Brierley, G. V., Carroll, J. M., Lindenberg, A., Booker, G. W., Cosgrove, L. J., Wallace, J. C., Forbes, B. E., Roberts, C. T. Jr. (2006). Differential Activation of Insulin Receptor Isoforms by Insulin-Like Growth Factors Is Determined by the C Domain. Endocrinology 147: 1029-1036 [Abstract] [Full Text]  
• Stromberg, T., Ekman, S., Girnita, L., Dimberg, L. Y., Larsson, O., Axelson, M., Lennartsson, J., Hellman, U., Carlson, K., Osterborg, A., Vanderkerken, K., Nilsson, K., Jernberg-Wiklund, H. (2006). IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107: 669-678 [Abstract] [Full Text]  
• Goel, H. L., Breen, M., Zhang, J., Das, I., Aznavoorian-Cheshire, S., Greenberg, N. M., Elgavish, A., Languino, L. R. (2005). {beta}1A Integrin Expression Is Required for Type 1 Insulin-Like Growth Factor Receptor Mitogenic and Transforming Activities and Localization to Focal Contacts. Cancer Res. 65: 6692-6700 [Abstract] [Full Text]  
• Wang, Y., Hailey, J., Williams, D., Wang, Y., Lipari, P., Malkowski, M., Wang, X., Xie, L., Li, G., Saha, D., Ling, W. L. W., Cannon-Carlson, S., Greenberg, R., Ramos, R. A., Shields, R., Presta, L., Brams, P., Bishop, W. R., Pachter, J. A. (2005). Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Molecular Cancer Therapeutics 4: 1214-1221 [Abstract] [Full Text]  
• Vultur, A., Arulanandam, R., Turkson, J., Niu, G., Jove, R., Raptis, L. (2005). Stat3 Is Required for Full Neoplastic Transformation by the Simian Virus 40 Large Tumor Antigen. Mol. Biol. Cell 16: 3832-3846 [Abstract] [Full Text]  
• Meng, Z., King, P. H., Nabors, L. B., Jackson, N. L., Chen, C.-Y., Emanuel, P. D., Blume, S. W. (2005). The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation. Nucleic Acids Res 33: 2962-2979 [Abstract] [Full Text]  
• Lopez de Cicco, R., Bassi, D. E., Zucker, S., Seidah, N. G., Klein-Szanto, A. J.P. (2005). Human Carcinoma Cell Growth and Invasiveness Is Impaired by the Propeptide of the Ubiquitous Proprotein Convertase Furin. Cancer Res. 65: 4162-4171 [Abstract] [Full Text]  
• Loughran, G., Healy, N. C., Kiely, P. A., Huigsloot, M., Kedersha, N. L., O'Connor, R. (2005). Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth. Mol. Biol. Cell 16: 1811-1822 [Abstract] [Full Text]  
• Kiely, P. A., Leahy, M., O'Gorman, D., O'Connor, R. (2005). RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251. J. Biol. Chem. 280: 7624-7633 [Abstract] [Full Text]  
• Denley, A., Wang, C. C., McNeil, K. A., Walenkamp, M. J. E., van Duyvenvoorde, H., Wit, J. M., Wallace, J. C., Norton, R. S., Karperien, M., Forbes, B. E. (2005). Structural and Functional Characteristics of the Val44Met Insulin-Like Growth Factor I Missense Mutation: Correlation with Effects on Growth and Development. Mol. Endocrinol. 19: 711-721 [Abstract] [Full Text]  
• Ibrahim, Y. H., Yee, D. (2005). Insulin-Like Growth Factor-I and Breast Cancer Therapy. Clin. Cancer Res. 11: 944s-950s [Abstract] [Full Text]  
• Kuribayashi, A., Kataoka, K., Kurabayashi, T., Miura, M. (2004). Evidence that Basal Activity, But Not Transactivation, of the Epidermal Growth Factor Receptor Tyrosine Kinase Is Required for Insulin-like Growth Factor I-Induced Activation of Extracellular Signal-Regulated Kinase in Oral Carcinoma Cells. Endocrinology 145: 4976-4984 [Abstract] [Full Text]  
• Denley, A., Bonython, E. R., Booker, G. W., Cosgrove, L. J., Forbes, B. E., Ward, C. W., Wallace, J. C. (2004). Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR. Mol. Endocrinol. 18: 2502-2512 [Abstract] [Full Text]  
• Goel, H. L., Fornaro, M., Moro, L., Teider, N., Rhim, J. S., King, M., Languino, L. R. (2004). Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by {beta}1 integrins. J. Cell Biol. 166: 407-418 [Abstract] [Full Text]  
• Warshamana-Greene, G. S., Litz, J., Buchdunger, E., Hofmann, F., Garcia-Echeverria, C., Krystal, G. W. (2004). The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Molecular Cancer Therapeutics 3: 527-536 [Abstract] [Full Text]  
• Leahy, M., Lyons, A., Krause, D., O'Connor, R. (2004). Impaired Shc, Ras, and MAPK Activation but Normal Akt Activation in FL5.12 Cells Expressing an Insulin-like Growth Factor I Receptor Mutated at Tyrosines 1250 and 1251. J. Biol. Chem. 279: 18306-18313 [Abstract] [Full Text]  
• Wessells, J., Yakar, S., Johnson, P. F. (2004). Critical Prosurvival Roles for C/EBP{beta} and Insulin-Like Growth Factor I in Macrophage Tumor Cells. Mol. Cell. Biol. 24: 3238-3250 [Abstract] [Full Text]  
• Sachdev, D., Hartell, J. S., Lee, A. V., Zhang, X., Yee, D. (2004). A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells. J. Biol. Chem. 279: 5017-5024 [Abstract] [Full Text]  
• Sekharam, M., Zhao, H., Sun, M., Fang, Q., Zhang, Q., Yuan, Z., Dan, H. C., Boulware, D., Cheng, J. Q., Coppola, D. (2003). Insulin-like Growth Factor 1 Receptor Enhances Invasion and Induces Resistance to Apoptosis of Colon Cancer Cells through the Akt/Bcl-xL Pathway. Cancer Res. 63: 7708-7716 [Abstract] [Full Text]  
• Giovannone, B., Lee, E., Laviola, L., Giorgino, F., Cleveland, K. A., Smith, R. J. (2003). Two Novel Proteins That Are Linked to Insulin-like Growth Factor (IGF-I) Receptors by the Grb10 Adapter and Modulate IGF-I Signaling. J. Biol. Chem. 278: 31564-31573 [Abstract] [Full Text]  
• Yu, D., Watanabe, H., Shibuya, H., Miura, M. (2003). Redundancy of Radioresistant Signaling Pathways Originating from Insulin-like Growth Factor I Receptor. J. Biol. Chem. 278: 6702-6709 [Abstract] [Full Text]  
• Hailey, J., Maxwell, E., Koukouras, K., Bishop, W. R., Pachter, J. A., Wang, Y. (2002). Neutralizing Anti-Insulin-like Growth Factor Receptor 1 Antibodies Inhibit Receptor Function and Induce Receptor Degradation in Tumor Cells. Molecular Cancer Therapeutics 1: 1349-1353 [Abstract] [Full Text]  
• Tu, X., Batta, P., Innocent, N., Prisco, M., Casaburi, I., Belletti, B., Baserga, R. (2002). Nuclear Translocation of Insulin Receptor Substrate-1 by Oncogenes And Igf-I. EFFECT ON RIBOSOMAL RNA SYNTHESIS*. J. Biol. Chem. 277: 44357-44365 [Abstract] [Full Text]  
• Kido, Y., Nakae, J., Hribal, M. L., Xuan, S., Efstratiadis, A., Accili, D. (2002). Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J. Biol. Chem. 277: 36740-36747 [Abstract] [Full Text]  
• Sciacchitano, S., Orecchio, A., Lavra, L., Misiti, S., Giacchini, A., Zani, M., Danese, D., Gurtner, A., Soddu, S., Di Mario, U., Andreoli, M. (2002). Cloning of the Mouse Insulin Receptor Substrate-3 (mIRS-3) Promoter, and Its Regulation by p53. Mol. Endocrinol. 16: 1577-1589 [Abstract] [Full Text]  
• Kiely, P. A., Sant, A., O'Connor, R. (2002). RACK1 Is an Insulin-like Growth Factor 1 (IGF-1) Receptor-interacting Protein That Can Regulate IGF-1-mediated Akt Activation and Protection from Cell Death. J. Biol. Chem. 277: 22581-22589 [Abstract] [Full Text]  
• Greenhalgh, C. J., Bertolino, P., Asa, S. L., Metcalf, D., Corbin, J. E., Adams, T. E., Davey, H. W., Nicola, N. A., Hilton, D. J., Alexander, W. S. (2002). Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b). Mol. Endocrinol. 16: 1394-1406 [Abstract] [Full Text]  
• Lassak, A., Del Valle, L., Peruzzi, F., Wang, J. Y., Enam, S., Croul, S., Khalili, K., Reiss, K. (2002). Insulin Receptor Substrate 1 Translocation to the Nucleus by the Human JC Virus T-antigen. J. Biol. Chem. 277: 17231-17238 [Abstract] [Full Text]  
• Stull, M. A., Richert, M. M., Loladze, A. V., Wood, T. L. (2002). Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells. Endocrinology 143: 1872-1879 [Abstract] [Full Text]  
• Palmqvist, R, Hallmans, G, Rinaldi, S, Biessy, C, Stenling, R, Riboli, E, Kaaks, R (2002). Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. Gut 50: 642-646 [Abstract] [Full Text]  
• Hellawell, G. O., Turner, G. D. H., Davies, D. R., Poulsom, R., Brewster, S. F., Macaulay, V. M. (2002). Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease. Cancer Res. 62: 2942-2950 [Abstract] [Full Text]  
• Buckley, D. A., Cheng, A., Kiely, P. A., Tremblay, M. L., O'Connor, R. (2002). Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts. Mol. Cell. Biol. 22: 1998-2010 [Abstract] [Full Text]  
• Hensen, K., Van Valckenborgh, I. C. C., Kas, K., Van de Ven, W. J. M., Voz, M. L. (2002). The Tumorigenic Diversity of the Three PLAG Family Members Is Associated with Different DNA Binding Capacities. Cancer Res. 62: 1510-1517 [Abstract] [Full Text]  
• Wang, Z., Yu, R., Melmed, S. (2001). Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division. Mol. Endocrinol. 15: 1870-1879 [Abstract] [Full Text]  
• Bonnette, S. G., Hadsell, D. L. (2001). Targeted Disruption of the IGF-I Receptor Gene Decreases Cellular Proliferation in Mammary Terminal End Buds. Endocrinology 142: 4937-4945 [Abstract] [Full Text]  
• Tezuka, M., Watanabe, H., Nakamura, S., Yu, D., Aung, W., Sasaki, T., Shibuya, H., Miura, M. (2001). Antiapoptotic Activity Is Dispensable for Insulin-like Growth Factor I Receptor-mediated Clonogenic Radioresistance after {gamma}-Irradiation. Clin. Cancer Res. 7: 3206-3214 [Abstract] [Full Text]  
• Servoss, S. J., Lee, S. J., Gibney, G., Gozes, I., Brenneman, D. E., Hill, J. M. (2001). IGF-I as a Mediator of VIP/Activity-Dependent Neurotrophic Factor-Stimulated Embryonic Growth. Endocrinology 142: 3348-3353 [Abstract] [Full Text]  
• Zhu, B., Zhao, G., Witte, D. P., Hui, D. Y., Fagin, J. A. (2001). Targeted Overexpression of IGF-I in Smooth Muscle Cells of Transgenic Mice Enhances Neointimal Formation through Increased Proliferation and Cell Migration after Intraarterial Injury. Endocrinology 142: 3598-3606 [Abstract] [Full Text]  
• Oesterreich, S., Zhang, P., Guler, R. L., Sun, X., Curran, E. M., Welshons, W. V., Osborne, C. K., Lee, A. V. (2001). Re-expression of Estrogen Receptor {alpha} in Estrogen Receptor {alpha}-negative MCF-7 Cells Restores both Estrogen and Insulin-like Growth Factor-mediated Signaling and Growth. Cancer Res. 61: 5771-5777 [Abstract] [Full Text]  
• Reiss, K., Tu, X., Romano, G., Peruzzi, F., Wang, J. Y., Baserga, R. (2001). Intracellular Association of a Mutant Insulin-like Growth Factor Receptor with Endogenous Receptors. Clin. Cancer Res. 7: 2134-2144 [Abstract] [Full Text]  
• Valentinis, B, Baserga, R (2001). IGF-I receptor signalling in transformation and differentiation. Mol. Pathol. 54: 133-137 [Abstract] [Full Text]  
• Tsuruzoe, K., Emkey, R., Kriauciunas, K. M., Ueki, K., Kahn, C. R. (2001). Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling. Mol. Cell. Biol. 21: 26-38 [Abstract] [Full Text]  
• Playford, M. P., Bicknell, D., Bodmer, W. F., Macaulay, V. M. (2000). Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin. Proc. Natl. Acad. Sci. USA 10.1073/pnas.210394297v1 [Abstract] [Full Text]  
• Gatzka, M., Prisco, M., Baserga, R. (2000). Stabilization of the Ras Oncoprotein by the Insulin-like Growth Factor 1 Receptor during Anchorage-independent Growth. Cancer Res. 60: 4222-4230 [Abstract] [Full Text]  
• Daniel, R., He, Z., Carmichael, K. P., Halper, J., Bateman, A. (2000). Cellular Localization of Gene Expression for Progranulin. J. Histochem. Cytochem. 48: 999-1010 [Abstract] [Full Text]  
• Carayannopoulos, M. O., Chi, M. M.-Y., Cui, Y., Pingsterhaus, J. M., McKnight, R. A., Mueckler, M., Devaskar, S. U., Moley, K. H. (2000). GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proc. Natl. Acad. Sci. USA 97: 7313-7318 [Abstract] [Full Text]  
• Hernandez, E. R. (2000). Embryo implantation and GnRH antagonists: Embryo implantation: the Rubicon for GnRH antagonists. Hum Reprod 15: 1211-1216 [Abstract] [Full Text]  
• Fournier, M., Lewis, M. I. (2000). Influences of IGF-I gene disruption on the cellular profile of the diaphragm. Am. J. Physiol. Endocrinol. Metab. 278: E707-E715 [Abstract] [Full Text]  
• DiGiovanni, J., Bol, D. K., Wilker, E., Beltrán, L., Carbajal, S., Moats, S., Ramirez, A., Jorcano, J., Kiguchi, K. (2000). Constitutive Expression of Insulin-like Growth Factor-1 in Epidermal Basal Cells of Transgenic Mice Leads to Spontaneous Tumor Promotion. Cancer Res. 60: 1561-1570 [Abstract] [Full Text]  
• Vogt, A., Wang, A. S., Johnson, C. S., Fabisiak, J. P., Wipf, P., Lazo, J. S. (2000). In Vivo Antitumor Activity and Induction of Insulin-Like Growth Factor-1-Resistant Apoptosis by SC-alpha alpha delta 9. J. Pharmacol. Exp. Ther. 292: 530-537 [Abstract] [Full Text]  
• Nakamura, K., Hongo, A., Kodama, J., Miyagi, Y., Yoshinouchi, M., Kudo, T. (2000). Down-Regulation of the Insulin-like Growth Factor I Receptor by Antisense RNA Can Reverse the Transformed Phenotype of Human Cervical Cancer Cell Lines. Cancer Res. 60: 760-765 [Abstract] [Full Text]  
• Hallak, H., Seiler, A. E. M., Green, J. S., Ross, B. N., Rubin, R. (2000). Association of Heterotrimeric Gi with the Insulin-like Growth Factor-I Receptor. RELEASE OF Gbeta gamma SUBUNITS UPON RECEPTOR ACTIVATION. J. Biol. Chem. 275: 2255-2258 [Abstract] [Full Text]  
• Zanocco-Marani, T., Bateman, A., Romano, G., Valentinis, B., He, Z.-H., Baserga, R. (1999). Biological Activities and Signaling Pathways of the Granulin/Epithelin Precursor. Cancer Res. 59: 5331-5340 [Abstract] [Full Text]  
• Pestell, R. G., Albanese, C., Reutens, A. T., Segall, J. E., Lee, R. J., Arnold, A. (1999). The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation. Endocr. Rev. 20: 501-534 [Abstract] [Full Text]  
• Feldser, D., Agani, F., Iyer, N. V., Pak, B., Ferreira, G., Semenza, G. L. (1999). Reciprocal Positive Regulation of Hypoxia-inducible Factor 1{{alpha}} and Insulin-like Growth Factor 2. Cancer Res. 59: 3915-3918 [Abstract] [Full Text]  
• Swantek, J. L., Baserga, R. (1999). Prolonged Activation of ERK2 by Epidermal Growth Factor and Other Growth Factors Requires a Functional Insulin-Like Growth Factor 1 Receptor. Endocrinology 140: 3163-3169 [Abstract] [Full Text]  
• He, Z., Bateman, A. (1999). Progranulin Gene Expression Regulates Epithelial Cell Growth and Promotes Tumor Growth in Vivo. Cancer Res. 59: 3222-3229 [Abstract] [Full Text]  
• Coppola, D., Saunders, B., Fu, L., Mao, W., Nicosia, S. V. (1999). The Insulin-like Growth Factor 1 Receptor Induces Transformation and Tumorigenicity of Ovarian Mesothelial Cells and Down-Regulates Their Fas-Receptor Expression. Cancer Res. 59: 3264-3270 [Abstract] [Full Text]  
• Adesanya, O. O., Zhou, J., Samathanam, C., Powell-Braxton, L., Bondy, C. A. (1999). Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle. Proc. Natl. Acad. Sci. USA 96: 3287-3291 [Abstract] [Full Text]  
• Manes, S., Llorente, M., Lacalle, R. A., Gomez-Mouton, C., Kremer, L., Mira, E., Martinez-A, C. (1999). The Matrix Metalloproteinase-9 Regulates the Insulin-like Growth Factor-triggered Autocrine Response in DU-145 Carcinoma Cells. J. Biol. Chem. 274: 6935-6945 [Abstract] [Full Text]  
• Yoshimoto, H., Ishihara, H., Ohtsuru, A., Akino, K., Murakami, R., Kuroda, H., Namba, H., Ito, M., Fujii, T., Yamashita, S. (1999). Overexpression of Insulin-Like Growth Factor-1 (IGF-I) Receptor and the Invasiveness of Cultured Keloid Fibroblasts. Am. J. Pathol. 154: 883-889 [Abstract] [Full Text]  
• Georgii-Hemming, P., Stromberg, T., Janson, E. T., Stridsberg, M., Wiklund, H. J., Nilsson, K. (1999). The Somatostatin Analog Octreotide Inhibits Growth of Interleukin-6 (IL-6)-Dependent and IL-6-Independent Human Multiple Myeloma Cell Lines. Blood 93: 1724-1731 [Abstract] [Full Text]  
• Scheidegger, K. J., Du, J., Delafontaine, P. (1999). Distinct and Common Pathways in the Regulation of Insulin-like Growth Factor-1 Receptor Gene Expression by Angiotensin II and Basic Fibroblast Growth Factor. J. Biol. Chem. 274: 3522-3530 [Abstract] [Full Text]  
• Agani, F., Semenza, G. L. (1998). Mersalyl Is a Novel Inducer of Vascular Endothelial Growth Factor Gene Expression and Hypoxia-Inducible Factor 1 Activity. Mol. Pharmacol. 54: 749-754 [Abstract] [Full Text]  
• Li, W., Jiang, Y.-X., Zhang, J., Soon, L., Flechner, L., Kapoor, V., Pierce, J. H., Wang, L.-H. (1998). Protein Kinase C-delta Is an Important Signaling Molecule in Insulin-Like Growth Factor I Receptor-Mediated Cell Transformation. Mol. Cell. Biol. 18: 5888-5898 [Abstract] [Full Text]  
• Xu, S.-Q., Tang, D., Chamberlain, S., Pronk, G., Masiarz, F. R., Kaur, S., Prisco, M., Zanocco-Marani, T., Baserga, R. (1998). The Granulin/Epithelin Precursor Abrogates the Requirement for the Insulin-like Growth Factor 1 Receptor for Growth in Vitro. J. Biol. Chem. 273: 20078-20083 [Abstract] [Full Text]  
• Damon, S. E., Maddison, L., Ware, J. L., Plymate, S. R. (1998). Overexpression of an Inhibitory Insulin-Like Growth Factor Binding Protein (IGFBP), IGFBP-4, Delays Onset of Prostate Tumor Formation. Endocrinology 139: 3456-3464 [Abstract] [Full Text]  
• Blakesley, V. A., Koval, A. P., Stannard, B. S., Scrimgeour, A., LeRoith, D. (1998). Replacement of Tyrosine 1251 in the Carboxyl Terminus of the Insulin-like Growth Factor-I Receptor Disrupts the Actin Cytoskeleton and Inhibits Proliferation and Anchorage-independent Growth. J. Biol. Chem. 273: 18411-18422 [Abstract] [Full Text]  
• Resnicoff, M., Valentinis, B., Herbert, D., Abraham, D., Friesen, P. D., Alnemri, E. S., Baserga, R. (1998). The Baculovirus Anti-apoptotic p35 Protein Promotes Transformation of Mouse Embryo Fibroblasts. J. Biol. Chem. 273: 10376-10380 [Abstract] [Full Text]  
• RESNICOFF, M., BASERGA, R. (1998). The Role of the Insulin-like Growth Factor I Receptor in Transformation and Apoptosis. Ann. N. Y. Acad. Sci. 842: 76-81 [Abstract] [Full Text]  
• Toretsky, J. A., Kalebic, T., Blakesley, V., LeRoith, D., Helman, L. J. (1997). The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts. J. Biol. Chem. 272: 30822-30827 [Abstract] [Full Text]  
• Navarro, M., Barenton, B., Garandel, V., Schnekenburger, J., Bernardi, H. (1997). Insulin-Like Growth Factor I (IGF-I) Receptor Overexpression Abolishes the IGF Requirement for Differentiation and Induces a Ligand-Dependent Transformed Phenotype in C2 Inducible Myoblasts. Endocrinology 138: 5210-5219 [Abstract] [Full Text]  
• Liu, J.-L., Blakesley, V. A., Gutkind, J. S., LeRoith, D. (1997). The Constitutively Active Mutant Galpha 13 Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor. J. Biol. Chem. 272: 29438-29441 [Abstract] [Full Text]  
• Morrione, A., Valentinis, B., Resnicoff, M., Xu, S.-q., Baserga, R. (1997). The Role of mGrb10alpha in Insulin-like Growth Factor I-mediated Growth. J. Biol. Chem. 272: 26382-26387 [Abstract] [Full Text]  
• Baserga, R. (1997). Editorial: The Path Less Traveled By. Endocrinology 138: 2217-2218 [Full Text]  
• Scrimgeour, A. G., Blakesley, V. A., Stannard, B. S., LeRoith, D. (1997). Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways Are Not Sufficient for Insulin-Like Growth Factor I-Induced Mitogenesis and Tumorigenesis. Endocrinology 138: 2552-2558 [Abstract] [Full Text]  
• Morrione, A., Valentinis, B., Xu, S.-q., Yumet, G., Louvi, A., Efstratiadis, A., Baserga, R. (1997). Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc. Natl. Acad. Sci. USA 94: 3777-3782 [Abstract] [Full Text]  
• Manes, S., Kremer, L., Albar, J. P., Mark, C., Llopis, R., Martinez-A, C. (1997). Functional Epitope Mapping of Insulin-Like Growth Factor I (IGF-I) by Anti-IGF-I Monoclonal Antibodies. Endocrinology 138: 905-915 [Abstract] [Full Text]  
• Peterson, J. E., Kulik, G., Jelinek, T., Reuter, C. W.M., Shannon, J. A., Weber, M. J. (1996). Src Phosphorylates the Insulin-like Growth Factor Type I Receptor on the Autophosphorylation Sites. REQUIREMENT FOR TRANSFORMATION BY src. J. Biol. Chem. 271: 31562-31571 [Abstract] [Full Text]  
• Warren, R. S., Yuan, H., Matli, M. R., Ferrara, N., Donner, D. B. (1996). Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1in Colorectal Carcinoma. J. Biol. Chem. 271: 29483-29488 [Abstract] [Full Text]  
• Karnieli, E., Werner, H., Rauscher, F. J. III, Benjamin, L. E., LeRoith, D. (1996). The IGF-I Receptor Gene Promoter Is a Molecular Target for the Ewing's Sarcoma-Wilms' Tumor 1Fusion Protein. J. Biol. Chem. 271: 19304-19309 [Abstract] [Full Text]  
• Tanaka, S., Ito, T., Wands, J. R. (1996). Neoplastic Transformation Induced by Insulin Receptor Substrate-1 Overexpression Requires an Interaction with Both Grb2 and Syp Signaling Molecules. J. Biol. Chem. 271: 14610-14616 [Abstract] [Full Text]  
• Li, S., Resnicoff, M., Baserga, R. (1996). Effect of Mutations at Serines 1280-1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I Receptor. J. Biol. Chem. 271: 12254-12260 [Abstract] [Full Text]  
• Quinn, K. A., Treston, A. M., Unsworth, E. J., Miller, M.-J., Vos, M., Grimley, C., Battey, J., Mulshine, J. L., Cuttitta, F. (1996). Insulin-like Growth Factor Expression in Human Cancer Cell Lines. J. Biol. Chem. 271: 11477-11483 [Abstract] [Full Text]  
• Miura, M., Surmacz, E., Burgaud, J.-L., Baserga, R. (1995). Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor. J. Biol. Chem. 270: 22639-22644 [Abstract] [Full Text]  
• Krause, D., Lyons, A., Fennelly, C., O'Connor, R. (2001). Transient Activation of Jun N-terminal Kinases and Protection from Apoptosis by the Insulin-like Growth Factor I Receptor Can Be Suppressed by Dicumarol. J. Biol. Chem. 276: 19244-19252 [Abstract] [Full Text]