This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Molkentin, J D
Right arrow Articles by Markham, B E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Molkentin, J D
Right arrow Articles by Markham, B E

 Previous Article  |  Next Article 

Mol Cell Biol. 1994 July; 14(7): 4947-4957

Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.

J D Molkentin, D V Kalvakolanu and B E Markham

Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.

ABSTRACT

The alpha-myosin heavy-chain (alpha-MHC) gene is the major structural protein in the adult rodent myocardium. Its expression is restricted to the heart by a complex interplay of trans-acting factors and their cis-acting sites. However, to date, the factors that have been shown to regulate expression of this gene have also been found in skeletal muscle cells. Recently, transcription factor GATA-4, which has a tissue distribution limited to the heart and endodermally derived tissues, was identified. We recently found two putative GATA-binding sites within the proximal enhancer of the alpha-MHC gene, suggesting that GATA-4 might regulate its expression. In this study, we establish that GATA-4 interacts with the alpha-MHC GATA sites to stimulate cardiac muscle-specific expression. Mutation of the GATA-4-binding sites either individually or together decreased activity by 50 and 88% in the adult myocardium, respectively. GATA-4-dependent enhancement of activity from a heterologous promoter was mediated through the alpha-MHC GATA sites. Coinjection of an alpha-MHC promoter construct with a GATA-4 expression vector permitted ectopic expression in skeletal muscle but not in fibroblasts. Thus, the lack of alpha-MHC expression in skeletal muscle correlates with a lack of GATA-4. GATA-4 DNA binding activity was significantly up-regulated in triiodothyronine- or retinoic acid-treated cardiomyocytes. Putative GATA-4-binding sites are also found in the regulatory regions of other cardiac muscle-expressed structural genes. This indicates a mechanism whereby triiodothyronine and retinoic acid can exert coordinate control of the cardiac phenotype through a trans-acting regulatory factor.

Mol Cell Biol. 1994 July; 14(7): 4947-4957




This article has been cited by other articles:

  • Hwang, Y.-S., Chung, B. G., Ortmann, D., Hattori, N., Moeller, H.-C., Khademhosseini, A. (2009). Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc. Natl. Acad. Sci. USA 106: 16978-16983 [Abstract] [Full Text]  
  • Thurisch, B., Liang, S. Y, Sarioglu, N., Schomburg, L., Bungert, J., Dame, C. (2009). Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads. J Mol Endocrinol 43: 157-169 [Abstract] [Full Text]  
  • Takemura, G., Nakagawa, M., Kanamori, H., Minatoguchi, S., Fujiwara, H. (2009). Benefits of reperfusion beyond infarct size limitation. Cardiovasc Res 83: 269-276 [Abstract] [Full Text]  
  • Toischer, K., Kogler, H., Tenderich, G., Grebe, C., Seidler, T., Van, P. N., Jung, K., Knoll, R., Korfer, R., Hasenfuss, G. (2008). Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation. Circ Heart Fail 1: 265-271 [Abstract] [Full Text]  
  • Bovill, E., Westaby, S., Reji, S., Sayeed, R., Crisp, A., Shaw, T. (2008). Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. J. Thorac. Cardiovasc. Surg. 136: 709-716 [Abstract] [Full Text]  
  • Nakagawa, M., Takemura, G., Kanamori, H., Goto, K., Maruyama, R., Tsujimoto, A., Ohno, T., Okada, H., Ogino, A., Esaki, M., Miyata, S., Li, L., Ushikoshi, H., Aoyama, T., Kawasaki, M., Nagashima, K., Fujiwara, T., Minatoguchi, S., Fujiwara, H. (2008). Mechanisms by Which Late Coronary Reperfusion Mitigates Postinfarction Cardiac Remodeling. Circ. Res. 103: 98-106 [Abstract] [Full Text]  
  • Esaki, M., Takemura, G., Kosai, K.-i., Takahashi, T., Miyata, S., Li, L., Goto, K., Maruyama, R., Okada, H., Kanamori, H., Ogino, A., Ushikoshi, H., Minatoguchi, S., Fujiwara, T., Fujiwara, H. (2008). Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 294: H1048-H1057 [Abstract] [Full Text]  
  • Frazier, D. P., Wilson, A., Dougherty, C. J., Li, H., Bishopric, N. H., Webster, K. A. (2007). PKC-{alpha} and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 292: H1675-H1684 [Abstract] [Full Text]  
  • Xin, M., Davis, C. A., Molkentin, J. D., Lien, C.-L., Duncan, S. A., Richardson, J. A., Olson, E. N. (2006). A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc. Natl. Acad. Sci. USA 103: 11189-11194 [Abstract] [Full Text]  
  • Kogler, H., Schott, P., Toischer, K., Milting, H., Van, P. N., Kohlhaas, M., Grebe, C., Kassner, A., Domeier, E., Teucher, N., Seidler, T., Knoll, R., Maier, L. S., El-Banayosy, A., Korfer, R., Hasenfuss, G. (2006). Relevance of Brain Natriuretic Peptide in Preload-Dependent Regulation of Cardiac Sarcoplasmic Reticulum Ca2+ ATPase Expression. Circulation 113: 2724-2732 [Abstract] [Full Text]  
  • Li, L., Takemura, G., Li, Y., Miyata, S., Esaki, M., Okada, H., Kanamori, H., Khai, N. C., Maruyama, R., Ogino, A., Minatoguchi, S., Fujiwara, T., Fujiwara, H. (2006). Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy. Circulation 113: 535-543 [Abstract] [Full Text]  
  • Kathiriya, I. S., King, I. N., Murakami, M., Nakagawa, M., Astle, J. M., Gardner, K. A., Gerard, R. D., Olson, E. N., Srivastava, D., Nakagawa, O. (2004). Hairy-related Transcription Factors Inhibit GATA-dependent Cardiac Gene Expression through a Signal-responsive Mechanism. J. Biol. Chem. 279: 54937-54943 [Abstract] [Full Text]  
  • Wang, J., Feng, X.-h., Schwartz, R. J. (2004). SUMO-1 Modification Activated GATA4-dependent Cardiogenic Gene Activity. J. Biol. Chem. 279: 49091-49098 [Abstract] [Full Text]  
  • Vanpoucke, G., Goossens, S., De Craene, B., Gilbert, B., van Roy, F., Berx, G. (2004). GATA-4 and MEF2C transcription factors control the tissue-specific expression of the {alpha}T-catenin gene CTNNA3. Nucleic Acids Res 32: 4155-4165 [Abstract] [Full Text]  
  • Pikkarainen, S., Tokola, H., Kerkela, R., Ruskoaho, H. (2004). GATA transcription factors in the developing and adult heart. Cardiovasc Res 63: 196-207 [Abstract] [Full Text]  
  • Viger, R. S., Taniguchi, H., Robert, N. M., Tremblay, J. J. (2004). The 25th Volume: Role of the GATA Family of Transcription Factors in Andrology. J Androl 25: 441-452 [Full Text]  
  • Hall, J. L., Grindle, S., Han, X., Fermin, D., Park, S., Chen, Y., Bache, R. J., Mariash, A., Guan, Z., Ormaza, S., Thompson, J., Graziano, J., de Sam Lazaro, S. E., Pan, S., Simari, R. D., Miller, L. W. (2004). Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol. Genomics 17: 283-291 [Abstract] [Full Text]  
  • Latinkic, B. V., Cooper, B., Smith, S., Kotecha, S., Towers, N., Sparrow, D., Mohun, T. J. (2004). Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development. Development 131: 669-679 [Abstract] [Full Text]  
  • Gupta, M., Sueblinvong, V., Raman, J., Jeevanandam, V., Gupta, M. P. (2003). Single-stranded DNA-binding Proteins PUR{alpha} and PUR{beta} Bind to a Purine-rich Negative Regulatory Element of the {alpha}-Myosin Heavy Chain Gene and Control Transcriptional and Translational Regulation of the Gene Expression: IMPLICATIONS IN THE REPRESSION OF {alpha}-MYOSIN HEAVY CHAIN DURING HEART FAILURE. J. Biol. Chem. 278: 44935-44948 [Abstract] [Full Text]  
  • Suzuki, Y. J., Day, R. M., Tan, C. C., Sandven, T. H., Liang, Q., Molkentin, J. D., Fanburg, B. L. (2003). Activation of GATA-4 by Serotonin in Pulmonary Artery Smooth Muscle Cells. J. Biol. Chem. 278: 17525-17531 [Abstract] [Full Text]  
  • Sanbe, A., Gulick, J., Hanks, M. C., Liang, Q., Osinska, H., Robbins, J. (2003). Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain Promoter. Circ. Res. 92: 609-616 [Abstract] [Full Text]  
  • Gillio-Meina, C., Hui, Y. Y., LaVoie, H. A. (2003). GATA-4 and GATA-6 Transcription Factors: Expression, Immunohistochemical Localization, and Possible Function in the Porcine Ovary. Biol. Reprod. 68: 412-422 [Abstract] [Full Text]  
  • He, Q., Mendez, M., LaPointe, M. C. (2002). Regulation of the human brain natriuretic peptide gene by GATA-4. Am. J. Physiol. Endocrinol. Metab. 283: E50-E57 [Abstract] [Full Text]  
  • Dai, Y.-S., Cserjesi, P., Markham, B. E., Molkentin, J. D. (2002). The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism. J. Biol. Chem. 277: 24390-24398 [Abstract] [Full Text]  
  • Kerkela, R., Pikkarainen, S., Majalahti-Palviainen, T., Tokola, H., Ruskoaho, H. (2002). Distinct Roles of Mitogen-activated Protein Kinase Pathways in GATA-4 Transcription Factor-mediated Regulation of B-type Natriuretic Peptide Gene. J. Biol. Chem. 277: 13752-13760 [Abstract] [Full Text]  
  • Brand, N. J, Barton, P. J R (2002). Myocardial molecular biology: an introduction. Heart 87: 284-293 [Full Text]  
  • Liang, Q., Wiese, R. J., Bueno, O. F., Dai, Y.-S., Markham, B. E., Molkentin, J. D. (2001). The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes. Mol. Cell. Biol. 21: 7460-7469 [Abstract] [Full Text]  
  • Marttila, M., Hautala, N., Paradis, P., Toth, M., Vuolteenaho, O., Nemer, M., Ruskoaho, H. (2001). GATA4 Mediates Activation of the B-Type Natriuretic Peptide Gene Expression in Response to Hemodynamic Stress. Endocrinology 142: 4693-4700 [Abstract] [Full Text]  
  • Charron, F., Tsimiklis, G., Arcand, M., Robitaille, L., Liang, Q., Molkentin, J. D., Meloche, S., Nemer, M. (2001). Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev. 15: 2702-2719 [Abstract] [Full Text]  
  • Flesch, M. (2001). On the trail of cardiac specific transcription factors. Cardiovasc Res 50: 3-6 [Full Text]  
  • Fang, R., Olds, L. C., Santiago, N. A., Sibley, E. (2001). GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G58-G67 [Abstract] [Full Text]  
  • Belaguli, N. S., Sepulveda, J. L., Nigam, V., Charron, F., Nemer, M., Schwartz, R. J. (2000). Cardiac Tissue Enriched Factors Serum Response Factor and GATA-4 Are Mutual Coregulators. Mol. Cell. Biol. 20: 7550-7558 [Abstract] [Full Text]  
  • Williams, S. D., Hsu, F.-F., Ford, D. A. (2000). Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium. J. Lipid Res. 41: 1585-1595 [Abstract] [Full Text]  
  • Gupta, M. P., Kogut, P., Gupta, M. (2000). Protein kinase-A dependent phosphorylation of transcription enhancer factor-1 represses its DNA-binding activity but enhances its gene activation ability. Nucleic Acids Res 28: 3168-3177 [Abstract] [Full Text]  
  • Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Wada, H., Yanazume, T., Sasayama, S. (2000). Phosphorylation of GATA-4 Is Involved in alpha 1-Adrenergic Agonist-responsive Transcription of the Endothelin-1 Gene in Cardiac Myocytes. J. Biol. Chem. 275: 13721-13726 [Abstract] [Full Text]  
  • Lin, L., Aggarwal, S., Glover, T. W., Orringer, M. B., Hanash, S., Beer, D. G. (2000). A Minimal Critical Region of the 8p22-23 Amplicon in Esophageal Adenocarcinomas Defined Using Sequence Tagged Site-Amplification Mapping and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene. Cancer Res. 60: 1341-1347 [Abstract] [Full Text]  
  • Constam, D., Robertson, E. (2000). Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Development 127: 245-254 [Abstract]  
  • Kakita, T., Hasegawa, K., Morimoto, T., Kaburagi, S., Wada, H., Sasayama, S. (1999). p300 Protein as a Coactivator of GATA-5 in the Transcription of Cardiac-restricted Atrial Natriuretic Factor Gene. J. Biol. Chem. 274: 34096-34102 [Abstract] [Full Text]  
  • Vyas, D. R., McCarthy, J. J., Tsika, R. W. (1999). Nuclear Protein Binding at the beta -Myosin Heavy Chain A/T-rich Element Is Enriched following Increased Skeletal Muscle Activity. J. Biol. Chem. 274: 30832-30842 [Abstract] [Full Text]  
  • Monzen, K., Shiojima, I., Hiroi, Y., Kudoh, S., Oka, T., Takimoto, E., Hayashi, D., Hosoda, T., Habara-Ohkubo, A., Nakaoka, T., Fujita, T., Yazaki, Y., Komuro, I. (1999). Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4. Mol. Cell. Biol. 19: 7096-7105 [Abstract] [Full Text]  
  • Nicholas, S. B., Philipson, K. D. (1999). Cardiac expression of the Na+/Ca2+ exchanger NCX1 is GATA factor dependent. Am. J. Physiol. Heart Circ. Physiol. 277: H324-H330 [Abstract] [Full Text]  
  • Charron, F., Paradis, P., Bronchain, O., Nemer, G., Nemer, M. (1999). Cooperative Interaction between GATA-4 and GATA-6 Regulates Myocardial Gene Expression. Mol. Cell. Biol. 19: 4355-4365 [Abstract] [Full Text]  
  • Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Masutani, H., Kitsis, R. N., Matsumori, A., Sasayama, S. (1999). GATA-5 Is Involved in Leukemia Inhibitory Factor-responsive Transcription of the beta -Myosin Heavy Chain Gene in Cardiac Myocytes. J. Biol. Chem. 274: 12811-12818 [Abstract] [Full Text]  
  • Cheng, G., Hagen, T. P., Dawson, M. L., Barnes, K. V., Menick, D. R. (1999). The Role of GATA, CArG, E-box, and a Novel Element in the Regulation of Cardiac Expression of the Na+-Ca2+ Exchanger Gene. J. Biol. Chem. 274: 12819-12826 [Abstract] [Full Text]  
  • Tevosian, S. G., Deconinck, A. E., Cantor, A. B., Rieff, H. I., Fujiwara, Y., Corfas, G., Orkin, S. H. (1999). FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc. Natl. Acad. Sci. USA 96: 950-955 [Abstract] [Full Text]  
  • Svensson, E. C., Tufts, R. L., Polk, C. E., Leiden, J. M. (1999). Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes. Proc. Natl. Acad. Sci. USA 96: 956-961 [Abstract] [Full Text]  
  • Gajewski, K, Fossett, N, Molkentin, J., Schulz, R. (1999). The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development 126: 5679-5688 [Abstract]  
  • Reecy, J., Li, X, Yamada, M, DeMayo, F., Newman, C., Harvey, R., Schwartz, R. (1999). Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5. Development 126: 839-849 [Abstract]  
  • Lien, C., Wu, C, Mercer, B, Webb, R, Richardson, J., Olson, E. (1999). Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 126: 75-84 [Abstract]  
  • Skerjanc, I. S., Petropoulos, H., Ridgeway, A. G., Wilton, S. (1998). Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells. J. Biol. Chem. 273: 34904-34910 [Abstract] [Full Text]  
  • Gupta, M., Zak, R., Libermann, T. A., Gupta, M. P. (1998). Tissue-Restricted Expression of the Cardiac alpha -Myosin Heavy Chain Gene Is Controlled by a Downstream Repressor Element Containing a Palindrome of Two Ets-Binding Sites. Mol. Cell. Biol. 18: 7243-7258 [Abstract] [Full Text]  
  • Wang, G. F., Nikovits, W. Jr., Schleinitz, M., Stockdale, F. E. (1998). A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis. Mol. Cell. Biol. 18: 6023-6034 [Abstract] [Full Text]  
  • Di Lisi, R., Millino, C., Calabria, E., Altruda, F., Schiaffino, S., Ausoni, S. (1998). Combinatorial cis-Acting Elements Control Tissue-specific Activation of the Cardiac Troponin I Gene in Vitro and in Vivo. J. Biol. Chem. 273: 25371-25380 [Abstract] [Full Text]  
  • Lee, Y., Shioi, T., Kasahara, H., Jobe, S. M., Wiese, R. J., Markham, B. E., Izumo, S. (1998). The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression. Mol. Cell. Biol. 18: 3120-3129 [Abstract] [Full Text]  
  • Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C.-Y., Nemer, M., Schwartz, R. J. (1998). GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression. Mol. Cell. Biol. 18: 3405-3415 [Abstract] [Full Text]  
  • Lawson, M. A., Buhain, A. R., Jovenal, J. C., Mellon, P. L. (1998). Multiple Factors Interacting at the GATA Sites of the Gonadotropin-Releasing Hormone Neuron-Specific Enhancer Regulate Gene Expression. Mol. Endocrinol. 12: 364-377 [Abstract] [Full Text]  
  • Gallagher, P. G., Forget, B. G. (1998). An Alternate Promoter Directs Expression of a Truncated, Muscle-specific Isoform of the Human Ankyrin 1 Gene. J. Biol. Chem. 273: 1339-1348 [Abstract] [Full Text]  
  • Sykes, T., Rodaway, A., Walmsley, M., Patient, R. (1998). Suppression of GATA factor activity causes axis duplication in Xenopus. Development 125: 4595-4605 [Abstract]  
  • Searcy, R., Vincent, E., Liberatore, C., Yutzey, K. (1998). A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125: 4461-4470 [Abstract]  
  • Black, B. L., Molkentin, J. D., Olson, E. N. (1998). Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2. Mol. Cell. Biol. 18: 69-77 [Abstract] [Full Text]  
  • Nicholas, S. B., Yang, W., Lee, S.-L., Zhu, H., Philipson, K. D., Lytton, J. (1998). Alternative promoters and cardiac muscle cell-specific expression of the Na+/Ca2+ exchanger gene. Am. J. Physiol. Heart Circ. Physiol. 274: H217-H232 [Abstract] [Full Text]  
  • Hasegawa, K., Lee, S. J., Jobe, S. M., Markham, B. E., Kitsis, R. N. (1997). cis-Acting Sequences That Mediate Induction of ß-Myosin Heavy Chain Gene Expression During Left Ventricular Hypertrophy due to Aortic Constriction. Circulation 96: 3943-3953 [Abstract] [Full Text]  
  • Bishopric, N. H., Zeng, G.-Q., Sato, B., Webster, K. A. (1997). Adenovirus E1A Inhibits Cardiac Myocyte-specific Gene Expression through Its Amino Terminus. J. Biol. Chem. 272: 20584-20594 [Abstract] [Full Text]  
  • Hasegawa, K., Meyers, M. B., Kitsis, R. N. (1997). Transcriptional Coactivator p300 Stimulates Cell Type-specific Gene Expression in Cardiac Myocytes. J. Biol. Chem. 272: 20049-20054 [Abstract] [Full Text]  
  • Herzig, T. C., Jobe, S. M., Aoki, H., Molkentin, J. D., Cowley, A. W. Jr., Izumo, S., Markham, B. E. (1997). Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc. Natl. Acad. Sci. USA 94: 7543-7548 [Abstract] [Full Text]  
  • Barnes, K. V., Cheng, G., Dawson, M. M., Menick, D. R. (1997). Cloning of Cardiac, Kidney, and Brain Promoters of the Feline ncx1 Gene. J. Biol. Chem. 272: 11510-11517 [Abstract] [Full Text]  
  • Kuo, C T, Morrisey, E E, Anandappa, R, Sigrist, K, Lu, M M, Parmacek, M S, Soudais, C, Leiden, J M (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.. Genes Dev. 11: 1048-1060 [Abstract]  
  • Molkentin, J D, Lin, Q, Duncan, S A, Olson, E N (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.. Genes Dev. 11: 1061-1072 [Abstract]  
  • Morrisey, E. E., Ip, H. S., Tang, Z., Parmacek, M. S. (1997). GATA-4 Activates Transcription Via Two Novel Domains That Are Conserved within the GATA-4/5/6 Subfamily. J. Biol. Chem. 272: 8515-8524 [Abstract] [Full Text]  
  • Schultheiss, T M, Burch, J B, Lassar, A B (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis.. Genes Dev. 11: 451-462 [Abstract]  
  • Narita, N, Bielinska, M, Wilson, D. (1997). Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development 124: 3755-3764 [Abstract]  
  • Grepin, C, Nemer, G, Nemer, M (1997). Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124: 2387-2395 [Abstract]  
  • Wang, G. F., Nikovits, W. Jr., Schleinitz, M., Stockdale, F. E. (1996). Atrial Chamber-specific Expression of the Slow Myosin Heavy Chain 3Gene in the Embryonic Heart. J. Biol. Chem. 271: 19836-19845 [Abstract] [Full Text]  
  • Mably, J. D., Liew, C.-C. (1996). Factors Involved in Cardiogenesis and the Regulation of Cardiac-Specific Gene Expression. Circ. Res. 79: 4-13 [Abstract] [Full Text]  
  • Farrance, I. K. G., Ordahl, C. P. (1996). The Role of Transcription Enhancer Factor-1 (TEF-1) Related Proteins in the Formation of M-CAT Binding Complexes in Muscle and Non-muscle Tissues. J. Biol. Chem. 271: 8266-8274 [Abstract] [Full Text]  
  • LaPointe, M. C., Wu, G., Garami, M., Yang, X.-P., Gardner, D. G. (1996). Tissue-Specific Expression of the Human Brain Natriuretic Peptide Gene in Cardiac Myocytes. Hypertension 27: 715-722 [Abstract] [Full Text]  
  • Samaha, F. F., Ip, H. S., Morrisey, E. E., Seltzer, J., Tang, Z., Solway, J., Parmacek, M. S. (1996). Developmental Pattern of Expression and Genomic Organization of the Calponin-h1 Gene. J. Biol. Chem. 271: 395-403 [Abstract] [Full Text]  
  • Soudais, C, Bielinska, M, Heikinheimo, M, MacArthur, C., Narita, N, Saffitz, J., Simon, M., Leiden, J., Wilson, D. (1995). Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121: 3877-3888 [Abstract]  
  • Svensson, E. C., Huggins, G. S., Dardik, F. B., Polk, C. E., Leiden, J. M. (2000). A Functionally Conserved N-terminal Domain of the Friend of GATA-2 (FOG-2) Protein Represses GATA4-Dependent Transcription. J. Biol. Chem. 275: 20762-20769 [Abstract] [Full Text]  
  • Slepak, T. I., Webster, K. A., Zang, J., Prentice, H., O'Dowd, A., Hicks, M. N., Bishopric, N. H. (2001). Control of Cardiac-specific Transcription by p300 through Myocyte Enhancer Factor-2D. J. Biol. Chem. 276: 7575-7585 [Abstract] [Full Text]  
  • Morimoto, T., Hasegawa, K., Wada, H., Kakita, T., Kaburagi, S., Yanazume, T., Sasayama, S. (2001). Calcineurin-GATA4 Pathway Is Involved in beta -Adrenergic Agonist-responsive Endothelin-1 Transcription in Cardiac Myocytes. J. Biol. Chem. 276: 34983-34989 [Abstract] [Full Text]  
  • Liang, Q., De Windt, L. J., Witt, S. A., Kimball, T. R., Markham, B. E., Molkentin, J. D. (2001). The Transcription Factors GATA4 and GATA6 Regulate Cardiomyocyte Hypertrophy in Vitro and in Vivo. J. Biol. Chem. 276: 30245-30253 [Abstract] [Full Text]  
  • Morisco, C., Seta, K., Hardt, S. E., Lee, Y., Vatner, S. F., Sadoshima, J. (2001). Glycogen Synthase Kinase 3beta Regulates GATA4 in Cardiac Myocytes. J. Biol. Chem. 276: 28586-28597 [Abstract] [Full Text]  
  • Dai, Y.-S., Markham, B. E. (2001). p300 Functions as a Coactivator of Transcription Factor GATA-4. J. Biol. Chem. 276: 37178-37185 [Abstract] [Full Text]  
  • Molkentin, J. D. (2000). The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6. UBIQUITOUSLY EXPRESSED REGULATORS OF TISSUE-SPECIFIC GENE EXPRESSION. J. Biol. Chem. 275: 38949-38952 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»