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Mol Cell Biol. 1994 August; 14(8): 5349-5359

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

H C Liou, W C Sha, M L Scott and D Baltimore

Rockfeller University, New York, New York 10021.

ABSTRACT

The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function both as a developmental regulator in B cells and as a rapid response system in all cells. To examine this notion in more detail, we determined the protein contents of both the inducible and constitutive NF-kappa B/Rel activities in a pre-B-cell line, 70Z/3, and a mature B-cell line, WEHI 231. NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells. The constitutive and inducible complexes in WEHI 231 cells are mainly composed of p50 and Rel. The constitutive or induced activities are all sensitive to I kappa B-alpha, but this inhibitor is very short-lived in WEHI 231 cells, suggesting that the balance between synthesis and degradation of I kappa B-alpha determines whether a particular cell lineage has constitutive activity. A patterned expression of the NF-kappa B/Rel activator proteins emerges from an analysis of other B-lineage cell lines and splenic B cells: mainly p50 and p65 in pre-B (and non-B) cells, a predominance of Rel and p50 in mature B cells, and expression of p52 and RelB in plasmacytoma lines. This ordered pattern of regulators may reflect the requirement for expression of different genes during terminal B-cell differentiation because different combinations of NF-kappa B/Rel family members preferentially activate distinct kappa B sites in reporter constructs.

Mol Cell Biol. 1994 August; 14(8): 5349-5359




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  • McKay, L. I., Cidlowski, J. A. (1999). Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-{kappa}B and Steroid Receptor-Signaling Pathways. Endocr. Rev. 20: 435-459 [Abstract] [Full Text]  
  • Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G., Baldwin, A. S. Jr. (1999). NF-kappa B Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1. Mol. Cell. Biol. 19: 5785-5799 [Abstract] [Full Text]  
  • Doerre, S., Corley, R. B. (1999). Constitutive Nuclear Translocation of NF-{kappa}B in B Cells in the Absence of I{kappa}B Degradation. J. Immunol. 163: 269-277 [Abstract] [Full Text]  
  • Yazdanbakhsh, K., Lee, S., Yu, Q., Reid, M. E. (1999). Identification of a Defect in the Intracellular Trafficking of a Kell Blood Group Variant. Blood 94: 310-318 [Abstract] [Full Text]  
  • Zhang, P. F., Chen, X., Fu, D. W., Margolick, J. B., Quinnan, G. V. Jr. (1999). Primary Virus Envelope Cross-Reactivity of the Broadening Neutralizing Antibody Response during Early Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol. 73: 5225-5230 [Abstract] [Full Text]  
  • Pyatt, D. W., Stillman, W. S., Yang, Y., Gross, S., Zheng, J. h., Irons, R. D. (1999). An Essential Role for NF-{kappa}B in Human CD34+ Bone Marrow Cell Survival. Blood 93: 3302-3308 [Abstract] [Full Text]  
  • Liou, M.-L., Liou, H.-C. (1999). The Ubiquitin-homology Protein, DAP-1, Associates with Tumor Necrosis Factor Receptor (p60) Death Domain and Induces Apoptosis. J. Biol. Chem. 274: 10145-10153 [Abstract] [Full Text]  
  • Sheehy, A. M., Schlissel, M. S. (1999). Overexpression of RelA Causes G1 Arrest and Apoptosis in a Pro-B Cell Line. J. Biol. Chem. 274: 8708-8716 [Abstract] [Full Text]  
  • Liou, H.-C., Jin, Z., Tumang, J., Andjelic, S., Smith, K. A., Liou, M.-L. (1999). c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 11: 361-371 [Abstract] [Full Text]  
  • Saleque, S., Singh, M., Birshtein, B. K. (1999). Ig Heavy Chain Expression and Class Switching In Vitro from an Allele Lacking the 3' Enhancers DNase I-Hypersensitive hs3A and hs1,2. J. Immunol. 162: 2791-2803 [Abstract] [Full Text]  
  • Lee, H. H., Dempsey, P. W., Parks, T. P., Zhu, X., Baltimore, D., Cheng, G. (1999). Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-kappa B activation and intercellular adhesion molecule-1 up-regulation. Proc. Natl. Acad. Sci. USA 96: 1421-1426 [Abstract] [Full Text]  
  • Zong, W.-X., Edelstein, L. C., Chen, C., Bash, J., Gélinas, C. (1999). The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis. Genes Dev. 13: 382-387 [Abstract] [Full Text]  
  • Horwitz, B. H., Zelazowski, P., Shen, Y., Wolcott, K. M., Scott, M. L., Baltimore, D., Snapper, C. M. (1999). The p65 Subunit of NF-{kappa}B Is Redundant with p50 During B Cell Proliferative Responses, and Is Required for Germline CH Transcription and Class Switching to IgG3. J. Immunol. 162: 1941-1946 [Abstract] [Full Text]  
  • Khursigara, G., Orlinick, J. R., Chao, M. V. (1999). Association of the p75 Neurotrophin Receptor with TRAF6. J. Biol. Chem. 274: 2597-2600 [Abstract] [Full Text]  
  • Gupta, S., Xia, D., Jiang, M., Lee, S., Pernis, A. B. (1998). Signaling Pathways Mediated by the TNF- and Cytokine-Receptor Families Target a Common cis-Element of the IFN Regulatory Factor 1 Promoter. J. Immunol. 161: 5997-6004 [Abstract] [Full Text]  
  • Lee, J.-I., Burckart, G. J. (1998). Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target. J Clin Pharmacol 38: 981-993 [Abstract]  
  • Park, E. J., Vujcic, L. K., Anand, R., Theodore, T. S., Quinnan, G. V. Jr. (1998). Mutations in both gp120 and gp41 Are Responsible for the Broad Neutralization Resistance of Variant Human Immunodeficiency Virus Type 1 MN to Antibodies Directed at V3 and Non-V3 Epitopes. J. Virol. 72: 7099-7107 [Abstract] [Full Text]  
  • Gu, C., Castellino, A., Chan, J. Y-h., Chao, M. V. (1998). BRE: a modulator of TNF-{alpha} action. FASEB J. 12: 1101-1108 [Abstract] [Full Text]  
  • Zwollo, P., Rao, S., Wallin, J. J., Gackstetter, E. R., Koshland, M. E. (1998). The Transcription Factor NF-kappa B/p50 Interacts with the blk Gene during B Cell Activation. J. Biol. Chem. 273: 18647-18655 [Abstract] [Full Text]  
  • Baumann, B., Kistler, B., Kirillov, A., Bergman, Y., Wirth, T. (1998). The Mutant Plasmacytoma Cell Line S107 Allows the Identification of Distinct Pathways Leading to NF-kappa B Activation. J. Biol. Chem. 273: 11448-11455 [Abstract] [Full Text]  
  • Hirano, F., Chung, M., Tanaka, H., Maruyama, N., Makino, I., Moore, D. D., Scheidereit, C. (1998). Alternative Splicing Variants of Ikappa Bbeta Establish Differential NF-kappa B Signal Responsiveness in Human Cells. Mol. Cell. Biol. 18: 2596-2607 [Abstract] [Full Text]  
  • Gri, G., Savio, D., Trinchieri, G., Ma, X. (1998). Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFkappa B and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages. J. Biol. Chem. 273: 6431-6438 [Abstract] [Full Text]  
  • Grumont, R. J., Rourke, I. J., O'Reilly, L. A., Strasser, A., Miyake, K., Sha, W., Gerondakis, S. (1998). B Lymphocytes Differentially Use the Rel and Nuclear Factor {kappa}B1 (NF-{kappa}B1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells. JEM 187: 663-674 [Abstract] [Full Text]  
  • Kistler, B., Rolink, A., Marienfeld, R., Neumann, M., Wirth, T. (1998). Induction of Nuclear Factor-{kappa}B During Primary B Cell Differentiation. J. Immunol. 160: 2308-2317 [Abstract] [Full Text]  
  • Wang, W., Rath, S., Durdik, J. M., Sen, R. (1998). Pentoxifylline Inhibits Ig {kappa} Gene Transcription and Rearrangements in Pre-B Cells. J. Immunol. 160: 1789-1795 [Abstract] [Full Text]  
  • Yi, A.-K., Krieg, A. M. (1998). CpG DNA Rescue from Anti-IgM-Induced WEHI-231 B Lymphoma Apoptosis via Modulation of I{kappa}B{alpha} and I{kappa}B{beta} and Sustained Activation of Nuclear Factor-{kappa}B/c-Rel. J. Immunol. 160: 1240-1245 [Abstract] [Full Text]  
  • Caamano, J. H., Rizzo, C. A., Durham, S. K., Barton, D. S., Raventos-Suarez, C., Snapper, C. M., Bravo, R. (1998). Nuclear Factor (NF)-{kappa}B2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell-mediated Immune Responses. JEM 187: 185-196 [Abstract] [Full Text]  
  • Sha, W. C. (1998). Regulation of Immune Responses by NF-{kappa}B/Rel Transcription Factors. JEM 187: 143-146 [Full Text]  
  • Miyamoto, S., Seufzer, B. J., Shumway, S. D. (1998). Novel Ikappa Balpha Proteolytic Pathway in WEHI231 Immature B Cells. Mol. Cell. Biol. 18: 19-29 [Abstract] [Full Text]  
  • Simeonidis, S., Liang, S., Chen, G., Thanos, D. (1997). Cloning and functional characterization of mouse Ikappa Bvarepsilon. Proc. Natl. Acad. Sci. USA 94: 14372-14377 [Abstract] [Full Text]  
  • Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., Siebenlist, U. (1997). Requirement for NF-kappa B in osteoclast and B-cell development. Genes Dev. 11: 3482-3496 [Abstract] [Full Text]  
  • Bendall, H. H., Scherer, D. C., Edson, C. R., Ballard, D. W., Oltz, E. M. (1997). Transcription Factor NF-kappa B Regulates Inducible Oct-2 Gene Expression in Precursor B Lymphocytes. J. Biol. Chem. 272: 28826-28828 [Abstract] [Full Text]  
  • Weih, F., Durham, S. K., Barton, D. S., Sha, W. C., Baltimore, D., Bravo, R. (1997). p50-NF-{kappa}B Complexes Partially Compensate for the Absence of RelB: Severely Increased Pathology in p50-/-relB-/-Double-knockout Mice. JEM 185: 1359-1370 [Abstract] [Full Text]  
  • Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., Kaltschmidt, C. (1997). Transcription factor NF-kappa B is activated in primary neurons by amyloid beta  peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94: 2642-2647 [Abstract] [Full Text]  
  • Doi, T. S., Takahashi, T., Taguchi, O., Azuma, T., Obata, Y. (1997). NF-{kappa}B RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses. JEM 185: 953-962 [Abstract] [Full Text]  
  • Olashaw, N. E., Olashaw, N. E. (1996). Inducible Activation of RelB in Fibroblasts. J. Biol. Chem. 271: 30307-30310 [Abstract] [Full Text]  
  • Schmidt-Ullrich, R., Memet, S., Lilienbaum, A., Feuillard, J., Raphael, M., Israel, A. (1996). NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity. Development 122: 2117-2128 [Abstract]  
  • Verma, I M, Stevenson, J K, Schwarz, E M, Van Antwerp, D, Miyamoto, S (1995). Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.. Genes Dev. 9: 2723-2735  
  • Beg, A A, Sha, W C, Bronson, R T, Baltimore, D (1995). Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.. Genes Dev. 9: 2736-2746 [Abstract]  
  • Koromilas, A. E., Cantin, C., Craig, A. W. B., Jagus, R., Hiscott, J., Sonenberg, N. (1995). The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin kappa Gene. J. Biol. Chem. 270: 25426-25434 [Abstract] [Full Text]  
  • Li, J., Peet, G. W., Balzarano, D., Li, X., Massa, P., Barton, R. W., Marcu, K. B. (2001). Novel NEMO/Ikappa B Kinase and NF-kappa B Target Genes at the Pre-B to Immature B Cell Transition. J. Biol. Chem. 276: 18579-18590 [Abstract] [Full Text]  
  • Kurland, J. F., Kodym, R., Story, M. D., Spurgers, K. B., McDonnell, T. J., Meyn, R. E. (2001). NF-kappa B1 (p50) Homodimers Contribute to Transcription of the bcl-2 Oncogene. J. Biol. Chem. 276: 45380-45386 [Abstract] [Full Text]  
  • Solan, N. J., Miyoshi, H., Carmona, E. M., Bren, G. D., Paya, C. V. (2002). RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100. J. Biol. Chem. 277: 1405-1418 [Abstract] [Full Text]  


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