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Mol Cell Biol. 1994 August; 14(8): 5558-5568

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

I Nuchprayoon, S Meyers, L M Scott, J Suzow, S Hiebert and A D Friedman

Division of Pediatric Oncology, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21287.

ABSTRACT

The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer. This element binds two species, myeloid nuclear factors 1 alpha and 1 beta (MyNF1 alpha and -beta), present in 32D cl3 myeloid cell nuclear extracts. The levels of the MyNF1s increase during early 32D cl3 cell granulocytic differentiation. Both MyNF1 alpha and -beta supershift with an antiserum raised by using a peptide derived from the N terminus of polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) alpha subunit. The specific peptide inhibits these supershifts. In vitro-translated PEBP2/CBF DNA-binding domain binds the murine MPO PEBP2/CBF site. An alternate PEBP2/CBF consensus site, 5'-GACCGCA-3', but not a simian virus 40 enhancer core sequence, 5'-TTCCACA-3', binds the MyNF1s in vitro and activates a minimal murine MPO-thymidine kinase promoter in vivo. The murine neutrophil elastase gene 100-bp 5'-flanking sequences contain several functional elements, including potential binding sites for PU.1, C/EBP, c-Myb, and PEBP2/CBF. The functional element 5'-GGCCACA-3' located at positions -66 to 72 differs from the PEBP2/CBF consensus (5'-PuACCPuCA-3') only by an A-to-G transition at position 2. This DNA element binds MyNF1 alpha and -beta weakly. The N terminis of two PEBP2/CBF alpha subunit family members, PEBP2 alpha A and PEBP2 alpha B (murine AML1), are nearly identical, and 32D c13 cl3 cells contain both corresponding mRNAs. Since t(8;21), t(3;21), and inv(16), associated with myeloid leukemias, disrupt subunits of PEBP2/CBF, we speculate that the resulting oncoproteins, AML1-ETO, AML1-EAP, AML1-Evi1, and CBF beta-MYH11, inhibit early myeloid differentiation.

Mol Cell Biol. 1994 August; 14(8): 5558-5568




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  • Kogan, S. C., Lagasse, E., Atwater, S., Bae, S.-c., Weissman, I., Ito, Y., Bishop, J. M. (1998). The PEBP2beta MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc. Natl. Acad. Sci. USA 95: 11863-11868 [Abstract] [Full Text]  
  • Wigle, D. A., Thompson, K. E., Yablonsky, S., Zaidi, S. H. E., Coulber, C., Jones, P. L., Rabinovitch, M. (1998). AML1-like Transcription Factor Induces Serine Elastase Activity in Ovine Pulmonary Artery Smooth Muscle Cells. Circ. Res. 83: 252-263 [Abstract] [Full Text]  
  • Barat, C., Rassart, E. (1998). Members of the GATA Family of Transcription Factors Bind to the U3 Region of Cas-Br-E and Graffi Retroviruses and Transactivate Their Expression. J. Virol. 72: 5579-5588 [Abstract] [Full Text]  
  • Gamou, T., Kitamura, E., Hosoda, F., Shimizu, K., Shinohara, K., Hayashi, Y., Nagase, T., Yokoyama, Y., Ohki, M. (1998). The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family. Blood 91: 4028-4037 [Abstract] [Full Text]  
  • Okuda, T., Cai, Z., Yang, S., Lenny, N., Lyu, C.-j., van Deursen, J. M.A., Harada, H., Downing, J. R. (1998). Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors. Blood 91: 3134-3143 [Abstract] [Full Text]  
  • Ma, Y., Su, Q., Tempst, P. (1998). Differentiation-stimulated Activity Binds an ETS-like, Essential Regulatory Element in the Human Promyelocytic defensin-1 Promoter. J. Biol. Chem. 273: 8727-8740 [Abstract] [Full Text]  
  • Zaiman, A. L., Nieves, A., Lenz, J. (1998). CBF, Myb, and Ets Binding Sites Are Important for Activity of the Core I Element of the Murine Retrovirus SL3-3 in T Lymphocytes. J. Virol. 72: 3129-3137 [Abstract] [Full Text]  
  • Erman, B., Cortes, M., Nikolajczyk, B. S., Speck, N. A., Sen, R. (1998). ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers. Mol. Cell. Biol. 18: 1322-1330 [Abstract] [Full Text]  
  • Tanaka, K., Tanaka, T., Kurokawa, M., Imai, Y., Ogawa, S., Mitani, K., Yazaki, Y., Hirai, H. (1998). The AML1/ETO(MTG8) and AML1/Evi-1 Leukemia-Associated Chimeric Oncoproteins Accumulate PEBP2beta (CBFbeta ) in the Nucleus More Efficiently Than Wild-Type AML1. Blood 91: 1688-1699 [Abstract] [Full Text]  
  • Kitabayashi, I., Ida, K., Morohoshi, F., Yokoyama, A., Mitsuhashi, N., Shimizu, K., Nomura, N., Hayashi, Y., Ohki, M. (1998). The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1. Mol. Cell. Biol. 18: 846-858 [Abstract] [Full Text]  
  • Westendorf, J. J., Yamamoto, C. M., Lenny, N., Downing, J. R., Selsted, M. E., Hiebert, S. W. (1998). The t(8;21) Fusion Product, AML-1-ETO, Associates with C/EBP-alpha , Inhibits C/EBP-alpha -Dependent Transcription, and Blocks Granulocytic Differentiation. Mol. Cell. Biol. 18: 322-333 [Abstract] [Full Text]  
  • Orita, T., Shimozaki, K., Murakami, H., Nagata, S. (1997). Binding of NF-Y Transcription Factor to One of the Cis-elements in the Myeloperoxidase Gene Promoter That Responds to Granulocyte Colony-stimulating Factor. J. Biol. Chem. 272: 23216-23223 [Abstract] [Full Text]  
  • Tenen, D. G., Hromas, R., Licht, J. D., Zhang, D.-E. (1997). Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90: 489-519 [Full Text]  
  • Zeng, C., van Wijnen, A. J., Stein, J. L., Meyers, S., Sun, W., Shopland, L., Lawrence, J. B., Penman, S., Lian, J. B., Stein, G. S., Hiebert, S. W. (1997). Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc. Natl. Acad. Sci. USA 94: 6746-6751 [Abstract] [Full Text]  
  • Nuchprayoon, I., Simkevich, C. P., Luo, M., Friedman, A. D., Rosmarin, A. G. (1997). GABP Cooperates With c-Myb and C/EBP to Activate the Neutrophil Elastase Promoter. Blood 89: 4546-4554 [Abstract] [Full Text]  
  • Borregaard, N., Cowland, J. B. (1997). Granules of the Human Neutrophilic Polymorphonuclear Leukocyte. Blood 89: 3503-3521 [Full Text]  
  • Lauzurica, P., Zhong, X.-P., Krangel, M. S., Roberts, J. L. (1997). Regulation of T Cell Receptor {delta} Gene Rearrangement by CBF/PEBP2. JEM 185: 1193-1202 [Abstract] [Full Text]  
  • Corsetti, M. T., Calabi, F. (1997). Lineage- and Stage-Specific Expression of Runt Box Polypeptides in Primitive and Definitive Hematopoiesis. Blood 89: 2359-2368 [Abstract] [Full Text]  
  • Fears, S., Gavin, M., Zhang, D.-E., Hetherington, C., Ben-David, Y., Rowley, J. D., Nucifora, G. (1997). Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter. Proc. Natl. Acad. Sci. USA 94: 1949-1954 [Abstract] [Full Text]  
  • Sturrock, A., Franklin, K. F., Hoidal, J. R. (1996). Human Proteinase-3 Expression Is Regulated by PU.1 in Conjunction with a Cytidine-rich Element. J. Biol. Chem. 271: 32392-32402 [Abstract] [Full Text]  
  • Chen, H.-m., Zhang, P., Radomska, H. S., Hetherington, C. J., Zhang, D.-E., Tenen, D. G. (1996). Octamer Binding Factors and Their Coactivator Can Activate the Murine PU.1 (spi-1) Promoter. J. Biol. Chem. 271: 15743-15752 [Abstract] [Full Text]  
  • Armesilla, A. L., Calvo, D., Vega, M. A. (1996). Structural and Functional Characterization of the Human CD36 Gene Promoter. J. Biol. Chem. 271: 7781-7787 [Abstract] [Full Text]  
  • Shapiro, L. H., Shapiro, L. H. (1995). Myb and Ets Proteins Cooperate to Transactivate an Early Myeloid Gene. J. Biol. Chem. 270: 8763-8771 [Abstract] [Full Text]  
  • Puig-Kroger, A., Lopez-Rodriguez, C., Relloso, M., Sanchez-Elsner, T., Nueda, A., Munoz, E., Bernabeu, C., Corbi, A. L. (2000). Polyomavirus Enhancer-binding Protein 2/Core Binding Factor/Acute Myeloid Leukemia Factors Contribute to the Cell Type-specific Activity of the CD11a Integrin Gene Promoter. J. Biol. Chem. 275: 28507-28512 [Abstract] [Full Text]  


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