Previous Article | Next Article 
Mol Cell Biol. 1994 September; 14(9): 5671-5681
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.
R J Bohinski,
R Di Lauro and
J A Whitsett
Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-2899.
ABSTRACT
We used the lung epithelial cell-specific surfactant protein B (SPB) gene promoter as a model with which to investigate mechanisms involved in transcriptional control of lung-specific genes. In a previous study, we showed that the SPB promoter specifically activated expression of a linked reporter gene in the continuous H441 lung cell line and that H441 nuclear proteins specifically protected a region of this promoter from bp -111 to -73. In this study, we further show that this region is a complex binding site for thyroid transcription factor 1 (TTF-1) and hepatocyte nuclear factor 3 (HNF-3). Whereas TTF-1 bound two highly degenerate and closely spaced sites, HNF-3 proteins bound a TGT3 motif (TGTTTGT) that is also found in several liver-specific gene regulatory regions, where it appears to be a weak affinity site for HNF-3. Point mutations of these binding sites eliminated factor binding and resulted in significant decreases in transfected SPB promoter activity. In addition, we developed a cotransfection assay and showed that a family of lung-specific gene promoters that included the SPB, SPC, SPA, and Clara cell secretory protein (CCSP) gene promoters were specifically activated by cotransfected TTF-1. We conclude that TTF-1 and HNF-3 are major activators of lung-specific genes and propose that these factors are involved in a general mechanism of lung-specific gene transcription. Importantly, these data also show that common factors are involved in organ-specific gene expression along the mammalian foregut axis.
Mol Cell Biol. 1994 September; 14(9): 5671-5681
This article has been cited by other articles:
-
Carre, A., Szinnai, G., Castanet, M., Sura-Trueba, S., Tron, E., Broutin-L'Hermite, I., Barat, P., Goizet, C., Lacombe, D., Moutard, M.-L., Raybaud, C., Raynaud-Ravni, C., Romana, S., Ythier, H., Leger, J., Polak, M.
(2009). Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case. Hum Mol Genet
18: 2266-2276
[Abstract]
[Full Text]
-
Song, H.-D., Liang, J., Shi, J.-Y., Zhao, S.-X., Liu, Z., Zhao, J.-J., Peng, Y.-D., Gao, G.-Q., Tao, J., Pan, C.-M., Shao, L., Cheng, F., Wang, Y., Yuan, G.-Y., Xu, C., Han, B., Huang, W., Chu, X., Chen, Y., Sheng, Y., Li, R.-Y., Su, Q., Gao, L., Jia, W.-P., Jin, L., Chen, M.-D., Chen, S.-J., Chen, Z., Chen, J.-L.
(2009). Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. Hum Mol Genet
18: 1156-1170
[Abstract]
[Full Text]
-
Maquet, E., Costagliola, S., Parma, J., Christophe-Hobertus, C., Oligny, L. L., Fournet, J.-C., Robitaille, Y., Vuissoz, J.-M., Payot, A., Laberge, S., Vassart, G., Van Vliet, G., Deladoey, J.
(2009). Lethal Respiratory Failure and Mild Primary Hypothyroidism in a Term Girl with a de Novo Heterozygous Mutation in the TITF1/NKX2.1 Gene. J. Clin. Endocrinol. Metab.
94: 197-203
[Abstract]
[Full Text]
-
Kemp, S. J., Thorley, A. J., Gorelik, J., Seckl, M. J., O'Hare, M. J., Arcaro, A., Korchev, Y., Goldstraw, P., Tetley, T. D.
(2008). Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake. Am. J. Respir. Cell Mol. Bio.
39: 591-597
[Abstract]
[Full Text]
-
Gower, W. A., Wert, S. E., Nogee, L. M.
(2008). Inherited Surfactant Disorders. NeoReviews
9: e458-e467
[Abstract]
[Full Text]
-
Tomita, T., Kido, T., Kurotani, R., Iemura, S.-i., Sterneck, E., Natsume, T., Vinson, C., Kimura, S.
(2008). CAATT/Enhancer-binding Proteins {alpha} and {delta} Interact with NKX2-1 to Synergistically Activate Mouse Secretoglobin 3A2 Gene Expression. J. Biol. Chem.
283: 25617-25627
[Abstract]
[Full Text]
-
Kurotani, R., Tomita, T., Yang, Q., Carlson, B. A., Chen, C., Kimura, S.
(2008). Role of Secretoglobin 3A2 in Lung Development. Am. J. Respir. Crit. Care Med.
178: 389-398
[Abstract]
[Full Text]
-
Wan, H., Luo, F., Wert, S. E., Zhang, L., Xu, Y., Ikegami, M., Maeda, Y., Bell, S. M., Whitsett, J. A.
(2008). Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development
135: 2563-2572
[Abstract]
[Full Text]
-
Besnard, V., Xu, Y., Whitsett, J. A.
(2007). Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L1395-L1405
[Abstract]
[Full Text]
-
Minoo, P., Hu, L., Xing, Y., Zhu, N. L., Chen, H., Li, M., Borok, Z., Li, C.
(2007). Physical and Functional Interactions between Homeodomain NKX2.1 and Winged Helix/Forkhead FOXA1 in Lung Epithelial Cells. Mol. Cell. Biol.
27: 2155-2165
[Abstract]
[Full Text]
-
Kolla, V., Gonzales, L. W., Gonzales, J., Wang, P., Angampalli, S., Feinstein, S. I., Ballard, P. L.
(2007). Thyroid Transcription Factor in Differentiating Type II Cells: Regulation, Isoforms, and Target Genes. Am. J. Respir. Cell Mol. Bio.
36: 213-225
[Abstract]
[Full Text]
-
Stahlman, M. T., Besnard, V., Wert, S. E., Weaver, T. E., Dingle, S., Xu, Y., von Zychlin, K., Olson, S. J., Whitsett, J. A.
(2007). Expression of ABCA3 in Developing Lung and Other Tissues. J. Histochem. Cytochem.
55: 71-83
[Abstract]
[Full Text]
-
Maeda, Y., Dave, V., Whitsett, J. A.
(2007). Transcriptional Control of Lung Morphogenesis. Physiol. Rev.
87: 219-244
[Abstract]
[Full Text]
-
Fukazawa, T., Maeda, Y., Durbin, M. L., Nakai, T., Matsuoka, J., Tanaka, H., Naomoto, Y., Tanaka, N.
(2007). Pulmonary adenocarcinoma-targeted gene therapy by a cancer- and tissue-specific promoter system. Molecular Cancer Therapeutics
6: 244-252
[Abstract]
[Full Text]
-
Das, A., Boggaram, V.
(2007). Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol.
292: L74-L84
[Abstract]
[Full Text]
-
McDevitt, T. M., Gonzales, L. W., Savani, R. C., Ballard, P. L.
(2007). Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation. Am. J. Physiol. Lung Cell. Mol. Physiol.
292: L249-L257
[Abstract]
[Full Text]
-
Mastronardi, C., Smiley, G. G., Raber, J., Kusakabe, T., Kawaguchi, A., Matagne, V., Dietzel, A., Heger, S., Mungenast, A. E., Cabrera, R., Kimura, S., Ojeda, S. R.
(2006). Deletion of the Ttf1 Gene in Differentiated Neurons Disrupts Female Reproduction without Impairing Basal Ganglia Function. J. Neurosci.
26: 13167-13179
[Abstract]
[Full Text]
-
Jean, J.-C., Rich, C. B., Joyce-Brady, M.
(2006). Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol.
291: L950-L956
[Abstract]
[Full Text]
-
Mandeville, I., Aubin, J., LeBlanc, M., Lalancette-Hebert, M., Janelle, M.-F., Tremblay, G. M., Jeannotte, L.
(2006). Impact of the Loss of Hoxa5 Function on Lung Alveogenesis. Am. J. Pathol.
169: 1312-1327
[Abstract]
[Full Text]
-
Thomas, K. H., Meyn, P., Suttorp, N.
(2006). Single nucleotide polymorphism in 5'-flanking region reduces transcription of surfactant protein B gene in H441 cells. Am. J. Physiol. Lung Cell. Mol. Physiol.
291: L386-L390
[Abstract]
[Full Text]
-
D'Andrea, B., Iacone, R., Di Palma, T., Nitsch, R., Baratta, M. G., Nitsch, L., Di Lauro, R., Zannini, M.
(2006). Functional Inactivation of the Transcription Factor Pax8 through Oligomerization Chain Reaction. Mol. Endocrinol.
20: 1810-1824
[Abstract]
[Full Text]
-
Lin, S., Perl, A.-K. T., Shannon, J. M.
(2006). Erm/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription. J. Biol. Chem.
281: 16716-16726
[Abstract]
[Full Text]
-
Moya, C. M., Perez de Nanclares, G., Castano, L., Potau, N., Bilbao, J. R., Carrascosa, A., Bargada, M., Coya, R., Martul, P., Vicens-Calvet, E., Santisteban, P.
(2006). Functional Study of a Novel Single Deletion in the TITF1/NKX2.1 Homeobox Gene That Produces Congenital Hypothyroidism and Benign Chorea But Not Pulmonary Distress. J. Clin. Endocrinol. Metab.
91: 1832-1841
[Abstract]
[Full Text]
-
Islam, K. N., Mendelson, C. R.
(2006). Permissive Effects of Oxygen on Cyclic AMP and Interleukin-1 Stimulation of Surfactant Protein A Gene Expression Are Mediated by Epigenetic Mechanisms. Mol. Cell. Biol.
26: 2901-2912
[Abstract]
[Full Text]
-
Maeda, Y., Hunter, T. C., Loudy, D. E., Dave, V., Schreiber, V., Whitsett, J. A.
(2006). PARP-2 Interacts with TTF-1 and Regulates Expression of Surfactant Protein-B. J. Biol. Chem.
281: 9600-9606
[Abstract]
[Full Text]
-
Woltje, M., Tschoke, B., von Bulow, V., Westenfeld, R., Denecke, B., Graber, S., Jahnen-Dechent, W.
(2006). CCAAT enhancer binding protein beta and hepatocyte nuclear factor 3beta are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2HS-glycoprotein/fetuin-A gene expression.. J Mol Endocrinol
36: 261-277
[Abstract]
[Full Text]
-
van Tuyl, M., Liu, J., Groenman, F., Ridsdale, R., Han, R. N. N., Venkatesh, V., Tibboel, D., Post, M.
(2006). Iroquois genes influence proximo-distal morphogenesis during rat lung development. Am. J. Physiol. Lung Cell. Mol. Physiol.
290: L777-L789
[Abstract]
[Full Text]
-
Sparkman, L., Chandru, H., Boggaram, V.
(2006). Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. Am. J. Physiol. Lung Cell. Mol. Physiol.
290: L351-L358
[Abstract]
[Full Text]
-
Besnard, V., Wert, S. E., Kaestner, K. H., Whitsett, J. A.
(2005). Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1. Am. J. Physiol. Lung Cell. Mol. Physiol.
289: L750-L759
[Abstract]
[Full Text]
-
Reynolds, P. R., Hoidal, J. R.
(2005). Temporal-Spatial Expression and Transcriptional Regulation of {alpha}7 Nicotinic Acetylcholine Receptor by Thyroid Transcription Factor-1 and Early Growth Response Factor-1 during Murine Lung Development. J. Biol. Chem.
280: 32548-32554
[Abstract]
[Full Text]
-
Chapin, C. J., Ertsey, R., Yoshizawa, J., Hara, A., Sbragia, L., Greer, J. J., Kitterman, J. A.
(2005). Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation. Am. J. Physiol. Lung Cell. Mol. Physiol.
289: L44-L52
[Abstract]
[Full Text]
-
Ramos-Vara, J. A., Miller, M. A., Johnson, G. C.
(2005). Usefulness of Thyroid Transcription Factor-1 Immunohistochemical Staining in the Differential Diagnosis of Primary Pulmonary Tumors of Dogs. Vet Pathol
42: 315-320
[Abstract]
[Full Text]
-
Wan, H., Dingle, S., Xu, Y., Besnard, V., Kaestner, K. H., Ang, S.-L., Wert, S., Stahlman, M. T., Whitsett, J. A.
(2005). Compensatory Roles of Foxa1 and Foxa2 during Lung Morphogenesis. J. Biol. Chem.
280: 13809-13816
[Abstract]
[Full Text]
-
Yang, M.-C. W., Weissler, J. C., Terada, L. S., Deng, F., Yang, Y.-S.
(2005). Pleiomorphic Adenoma Gene-Like-2, a Zinc Finger Protein, Transactivates the Surfactant Protein-C Promoter. Am. J. Respir. Cell Mol. Bio.
32: 35-43
[Abstract]
[Full Text]
-
Srisodsai, A., Kurotani, R., Chiba, Y., Sheikh, F., Young, H. A., Donnelly, R. P., Kimura, S.
(2004). Interleukin-10 Induces Uteroglobin-related Protein (UGRP) 1 Gene Expression in Lung Epithelial Cells through Homeodomain Transcription Factor T/EBP/NKX2.1. J. Biol. Chem.
279: 54358-54368
[Abstract]
[Full Text]
-
Wan, H., Xu, Y., Ikegami, M., Stahlman, M. T., Kaestner, K. H., Ang, S.-L., Whitsett, J. A.
(2004). Foxa2 is required for transition to air breathing at birth. Proc. Natl. Acad. Sci. USA
101: 14449-14454
[Abstract]
[Full Text]
-
Yan, C., Du, H.
(2004). Alveolus formation: what have we learned from genetic studies?. J. Appl. Physiol.
97: 1543-1548
[Abstract]
[Full Text]
-
Whitsett, J. A., Wert, S. E., Trapnell, B. C.
(2004). Genetic disorders influencing lung formation and function at birth. Hum Mol Genet
13: R207-R215
[Abstract]
[Full Text]
-
Reynolds, P. R., Mucenski, M. L., Le Cras, T. D., Nichols, W. C., Whitsett, J. A.
(2004). Midkine Is Regulated by Hypoxia and Causes Pulmonary Vascular Remodeling. J. Biol. Chem.
279: 37124-37132
[Abstract]
[Full Text]
-
Whitsett, J. A., Bachurski, C. J., Barnes, K. C., Bunn, P. A. Jr., Case, L. M., Cook, D. N., Crooks, D., Duncan, M. W., Dwyer-Nield, L., Elston, R. C., Fessler, M. B., Franklin, W. A., Friedman, N., Garcia, J. G. N., Geraci, M. W., Glasgow, C., Glasser, S. W., Hardie, W. D., Henning, L. M., Johnson, G. L., Kawkitinarong, K., Keith, R. L., Korfhagen, T. R., Leikauf, G. D., Liggett, S. B., Malcolm, K. C., Malkinson, A. M., Mariani, T. J., McDowell, S. A., McGraw, D. W., Medvedovic, M., Moss, J., Nogee, L. M., Nonas, S., Pacheco-Rodriguez, G., Palmer, L. J., Peters, D. G., Prows, D. R., Redline, S., Regev, A., Sartor, M. A., Schwartz, D. A., Silverman, E. K., Steagall, W. K., Stearman, R. S., Taveira-DaSilva, A., Tichelaar, J. W., Tomlinson, C. R., Tsukada, K., Weaver, T. E., Wert, S. E., Wesselkamper, S. C., Worthen, G. S., Xu, Y., Zerbe, L., Zhang, Y., Zhang, Y., Choi, A. M. K., Kaminski, N.
(2004). Functional Genomics of Lung Disease. Am. J. Respir. Cell Mol. Bio.
31: S1-S81
[Full Text]
-
Kathuria, H., Cao, Y. X., Ramirez, M. I., Williams, M. C.
(2004). Transcription of the Caveolin-1 Gene Is Differentially Regulated in Lung Type I Epithelial and Endothelial Cell Lines: A ROLE FOR ETS PROTEINS IN EPITHELIAL CELL EXPRESSION. J. Biol. Chem.
279: 30028-30036
[Abstract]
[Full Text]
-
Halmos, B., Basseres, D. S., Monti, S., D'Alo, F., Dayaram, T., Ferenczi, K., Wouters, B. J., Huettner, C. S., Golub, T. R., Tenen, D. G.
(2004). A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3{beta} as a Novel Tumor Suppressor in Lung Cancer. Cancer Res.
64: 4137-4147
[Abstract]
[Full Text]
-
Yang, L., Lian, X., Cowen, A., Xu, H., Du, H., Yan, C.
(2004). Synergy between Signal Transducer and Activator of Transcription 3 and Retinoic Acid Receptor-{alpha} in Regulation of the Surfactant Protein B Gene in the Lung. Mol. Endocrinol.
18: 1520-1532
[Abstract]
[Full Text]
-
Ertsey, R., Chapin, C. J., Kitterman, J. A., Scavo, L. M.
(2004). Ontogeny of Poly(ADP-Ribose) Polymerase-1 in Lung and Developmental Implications. Am. J. Respir. Cell Mol. Bio.
30: 853-861
[Abstract]
[Full Text]
-
Park, K.-S., Whitsett, J. A., Di Palma, T., Hong, J.-H., Yaffe, M. B., Zannini, M.
(2004). TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C. J. Biol. Chem.
279: 17384-17390
[Abstract]
[Full Text]
-
Hokuto, I., Perl, A.-K. T., Whitsett, J. A.
(2004). FGF signaling is required for pulmonary homeostasis following hyperoxia. Am. J. Physiol. Lung Cell. Mol. Physiol.
286: L580-L587
[Abstract]
[Full Text]
-
Wan, H., Kaestner, K. H., Ang, S.-L., Ikegami, M., Finkelman, F. D., Stahlman, M. T., Fulkerson, P. C., Rothenberg, M. E., Whitsett, J. A.
(2004). Foxa2 regulates alveolarization and goblet cell hyperplasia. Development
131: 953-964
[Abstract]
[Full Text]
-
Li, S., Weidenfeld, J., Morrisey, E. E.
(2004). Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions. Mol. Cell. Biol.
24: 809-822
[Abstract]
[Full Text]
-
Bachurski, C. J., Yang, G. H., Currier, T. A., Gronostajski, R. M., Hong, D.
(2003). Nuclear Factor I/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription. Mol. Cell. Biol.
23: 9014-9024
[Abstract]
[Full Text]
-
Liu, C., Ikegami, M., Stahlman, M. T., Dey, C. R., Whitsett, J. A.
(2003). Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6. Am. J. Physiol. Lung Cell. Mol. Physiol.
285: L1246-L1254
[Abstract]
[Full Text]
-
deFelice, M., Silberschmidt, D., DiLauro, R., Xu, Y., Wert, S. E., Weaver, T. E., Bachurski, C. J., Clark, J. C., Whitsett, J. A.
(2003). TTF-1 Phosphorylation Is Required for Peripheral Lung Morphogenesis, Perinatal Survival, and Tissue-specific Gene Expression. J. Biol. Chem.
278: 35574-35583
[Abstract]
[Full Text]
-
Yoshizawa, J., Chapin, C. J., Sbragia, L., Ertsey, R., Gutierrez, J. A., Albanese, C. T., Kitterman, J. A.
(2003). Tracheal occlusion stimulates cell cycle progression and type I cell differentiation in lungs of fetal rats. Am. J. Physiol. Lung Cell. Mol. Physiol.
285: L344-L353
[Abstract]
[Full Text]
-
Bin, L.-H., Nielson, L. D., Liu, X., Mason, R. J., Shu, H.-B.
(2003). Identification of Uteroglobin-Related Protein 1 and Macrophage Scavenger Receptor with Collagenous Structure as a Lung-Specific Ligand-Receptor Pair. J. Immunol.
171: 924-930
[Abstract]
[Full Text]
-
Yang, L., Naltner, A., Kreiner, A., Yan, D., Cowen, A., Du, H., Yan, C.
(2003). An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
284: L481-L488
[Abstract]
[Full Text]
-
Di Palma, T., Nitsch, R., Mascia, A., Nitsch, L., Di Lauro, R., Zannini, M.
(2003). The Paired Domain-containing Factor Pax8 and the Homeodomain-containing Factor TTF-1 Directly Interact and Synergistically Activate Transcription. J. Biol. Chem.
278: 3395-3402
[Abstract]
[Full Text]
-
Ramsay, P. L., Luo, Z., Magdaleno, S. M., Whitbourne, S. K., Cao, X., Park, M. S., Welty, S. E., Yu-Lee, L.-Y., DeMayo, F. J.
(2003). Transcriptional regulation of CCSP by interferon-gamma in vitro and in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol.
284: L108-L118
[Abstract]
[Full Text]
-
Gonzales, L. W., Guttentag, S. H., Wade, K. C., Postle, A. D., Ballard, P. L.
(2002). Differentiation of human pulmonary type II cells in vitro by glucocorticoid plus cAMP. Am. J. Physiol. Lung Cell. Mol. Physiol.
283: L940-L951
[Abstract]
[Full Text]
-
Li, C., Zhu, N.-L., Tan, R. C., Ballard, P. L., Derynck, R., Minoo, P.
(2002). Transforming Growth Factor-beta Inhibits Pulmonary Surfactant Protein B Gene Transcription through SMAD3 Interactions with NKX2.1 and HNF-3 Transcription Factors. J. Biol. Chem.
277: 38399-38408
[Abstract]
[Full Text]
-
Cassel, T. N., Berg, T., Suske, G., Nord, M.
(2002). Synergistic Transactivation of the Differentiation-dependent Lung Gene Clara Cell Secretory Protein (Secretoglobin 1a1) by the Basic Region Leucine Zipper Factor CCAAT/Enhancer-binding Protein alpha and the Homeodomain Factor Nkx2.1/Thyroid Transcription Factor-1. J. Biol. Chem.
277: 36970-36977
[Abstract]
[Full Text]
-
Demayo, F., Minoo, P., Plopper, C. G., Schuger, L., Shannon, J., Torday, J. S.
(2002). Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?. Am. J. Physiol. Lung Cell. Mol. Physiol.
283: L510-L517
[Abstract]
[Full Text]
-
Ramos-Vara, J. A., Miller, M. A., Johnson, G. C., Pace, L. W.
(2002). Immunohistochemical Detection of Thyroid Transcription Factor-1, Thyroglobulin, and Calcitonin in Canine Normal, Hyperplastic, and Neoplastic Thyroid Gland. Vet Pathol
39: 480-487
[Abstract]
[Full Text]
-
Weidenfeld, J., Shu, W., Zhang, L., Millar, S. E., Morrisey, E. E.
(2002). The WNT7b Promoter Is Regulated by TTF-1, GATA6, and Foxa2 in Lung Epithelium. J. Biol. Chem.
277: 21061-21070
[Abstract]
[Full Text]
-
Nakamura, N., Yoshimi, T., Miura, T.
(2002). Increased Gene Expression of Lung Marker Proteins in the Homeobox B3-overexpressed Fetal Lung Cell Line M3E3/C3. Cell Growth Differ.
13: 195-203
[Abstract]
[Full Text]
-
Yan, C., Naltner, A., Martin, M., Naltner, M., Fangman, J. M., Gurel, O.
(2002). Transcriptional Stimulation of the Surfactant Protein B Gene by STAT3 in Respiratory Epithelial Cells. J. Biol. Chem.
277: 10967-10972
[Abstract]
[Full Text]
-
Strayer, M., Savani, R. C., Gonzales, L. W., Zaman, A., Cui, Z., Veszelovszky, E., Wood, E., Ho, Y.-S., Ballard, P. L.
(2002). Pre- and Postnatal Lung Development, Maturation, and Plasticity: Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation. Am. J. Physiol. Lung Cell. Mol. Physiol.
282: L394-L404
[Abstract]
[Full Text]
-
Harrod, K. S., Jaramillo, R. J.
(2002). Pseudomonas aeruginosa and Tumor Necrosis Factor-alpha Attenuate Clara Cell Secretory Protein Promoter Function. Am. J. Respir. Cell Mol. Bio.
26: 216-223
[Abstract]
[Full Text]
-
Johnston, S. D., Daniels, C. B., Cenzato, D., Whitsett, J. A., Orgeig, S.
(2002). The pulmonary surfactant system matures upon pipping in the freshwater turtle Chelydra serpentina. J. Exp. Biol.
205: 415-425
[Abstract]
[Full Text]
-
Liu, C., Glasser, S. W., Wan, H., Whitsett, J. A.
(2002). GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression. J. Biol. Chem.
277: 4519-4525
[Abstract]
[Full Text]
-
Yang, H., Lu, M. M., Zhang, L., Whitsett, J. A., Morrisey, E. E.
(2002). GATA6 regulates differentiation of distal lung epithelium. Development
129: 2233-2246
[Abstract]
[Full Text]
-
Lonigro, R., Donnini, D., Zappia, E., Damante, G., Bianchi, M. E., Guazzi, S.
(2001). Nestin Is a Neuroepithelial Target Gene of Thyroid Transcription Factor-1, a Homeoprotein Required for Forebrain Organogenesis. J. Biol. Chem.
276: 47807-47813
[Abstract]
[Full Text]
-
Look, D. C., Walter, M. J., Williamson, M. R., Pang, L., You, Y., Sreshta, J. N., Johnson, J. E., Zander, D. S., Brody, S. L.
(2001). Effects of Paramyxoviral Infection on Airway Epithelial Cell Foxj1 Expression, Ciliogenesis, and Mucociliary Function. Am. J. Pathol.
159: 2055-2069
[Abstract]
[Full Text]
-
Niimi, T., Nagashima, K., Ward, J. M., Minoo, P., Zimonjic, D. B., Popescu, N. C., Kimura, S.
(2001). claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol. Cell. Biol.
21: 7380-7390
[Abstract]
[Full Text]
-
Niimi, T., Keck-Waggoner, C. L., Popescu, N. C., Zhou, Y., Levitt, R. C., Kimura, S.
(2001). UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor. Mol. Endocrinol.
15: 2021-2036
[Abstract]
[Full Text]
-
Costa, R. H., Kalinichenko, V. V., Lim, L.
(2001). Transcription factors in mouse lung development and function. Am. J. Physiol. Lung Cell. Mol. Physiol.
280: L823-L838
[Abstract]
[Full Text]
-
Hines, R. N., Luo, Z., Cresteil, T., Ding, X., Prough, R. A., Fitzpatrick, J. L., Ripp, S. L., Falkner, K. C., Ge, N.-L., Levine, A., Elferink, C. J.
(2001). Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors. Drug Metab. Dispos.
29: 623-633
[Abstract]
[Full Text]
-
Doronin, K., Kuppuswamy, M., Toth, K., Tollefson, A. E., Krajcsi, P., Krougliak, V., Wold, W. S. M.
(2001). Tissue-Specific, Tumor-Selective, Replication-Competent Adenovirus Vector for Cancer Gene Therapy. J. Virol.
75: 3314-3324
[Abstract]
[Full Text]
-
Kalinichenko, V. V., Lim, L., Shin, B., Costa, R. H.
(2001). Differential expression of forkhead box transcription factors following butylated hydroxytoluene lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol.
280: L695-L704
[Abstract]
[Full Text]
-
Clark, J. C., Tichelaar, J. W., Wert, S. E., Itoh, N., Perl, A.-K. T., Stahlman, M. T., Whitsett, J. A.
(2001). FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol.
280: L705-L715
[Abstract]
[Full Text]
-
Gereben, B., Salvatore, D., Harney, J. W., Tu, H. M., Larsen, P. R.
(2001). The Human, but Not Rat, dio2 Gene Is Stimulated by Thyroid Transcription Factor-1 (TTF-1). Mol. Endocrinol.
15: 112-124
[Abstract]
[Full Text]
-
Yang, Y.-S., Yang, M.-C. W., Wang, B., Weissler, J. C.
(2001). BR22, a Novel Protein, Interacts with Thyroid Transcription Factor-1 and Activates the Human Surfactant Protein B Promoter. Am. J. Respir. Cell Mol. Bio.
24: 30-37
[Abstract]
[Full Text]
-
Pierce, R. A., Griffin, G. L., Miner, J. H., Senior, R. M.
(2000). Expression Patterns of Laminin alpha 1 and alpha 5 in Human Lung during Development. Am. J. Respir. Cell Mol. Bio.
23: 742-747
[Abstract]
[Full Text]
-
Denson, L. A., Karpen, S. J., Bogue, C. W., Jacobs, H. C.
(2000). Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. Am. J. Physiol. Gastrointest. Liver Physiol.
279: G347-G355
[Abstract]
[Full Text]
-
Palmarini, M., Datta, S., Omid, R., Murgia, C., Fan, H.
(2000). The Long Terminal Repeat of Jaagsiekte Sheep Retrovirus Is Preferentially Active in Differentiated Epithelial Cells of the Lungs. J. Virol.
74: 5776-5787
[Abstract]
[Full Text]
-
Losada, A., Tovar, J. A., Xia, H. M., Diez-Pardo, J. A., Santisteban, P.
(2000). Down-Regulation of Thyroid Transcription Factor-1 Gene Expression in Fetal Lung Hypoplasia Is Restored by Glucocorticoids. Endocrinology
141: 2166-2173
[Abstract]
[Full Text]
-
Glasser, S. W., Burhans, M. S., Eszterhas, S. K., Bruno, M. D., Korfhagen, T. R.
(2000). Human SP-C gene sequences that confer lung epithelium-specific expression in transgenic mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
278: L933-L945
[Abstract]
[Full Text]
-
Margana, R., Berhane, K., Alam, M. N., Boggaram, V.
(2000). Identification of functional TTF-1 and Sp1/Sp3 sites in the upstream promoter region of rabbit SP-B gene. Am. J. Physiol. Lung Cell. Mol. Physiol.
278: L477-L484
[Abstract]
[Full Text]
-
Bruno, M. D., Korfhagen, T. R., Liu, C., Morrisey, E. E., Whitsett, J. A.
(2000). GATA-6 Activates Transcription of Surfactant Protein A. J. Biol. Chem.
275: 1043-1049
[Abstract]
[Full Text]
-
Naltner, A., Ghaffari, M., Whitsett, J. A., Yan, C.
(2000). Retinoic Acid Stimulation of the Human Surfactant Protein B Promoter Is Thyroid Transcription Factor 1 Site-dependent. J. Biol. Chem.
275: 56-62
[Abstract]
[Full Text]
-
Ohmori, M., Harii, N., Endo, T., Onaya, T.
(1999). Tumor Necrosis Factor-{alpha} Regulation of Thyroid Transcription Factor-1 and Pax-8 in Rat Thyroid FRTL-5 Cells. Endocrinology
140: 4651-4658
[Abstract]
[Full Text]
-
Bruno, M. D., Whitsett, J. A., Ross, G. F., Korfhagen, T. R.
(1999). Transcriptional Regulation of the Murine Surfactant Protein-A Gene by B-Myb. J. Biol. Chem.
274: 27523-27528
[Abstract]
[Full Text]
-
Zhang, J., Ma, B., Marshak-Rothstein, A., Fine, A.
(1999). Characterization of a Novel Cis-element That Regulates Fas Ligand Expression in Corneal Endothelial Cells. J. Biol. Chem.
274: 26537-26542
[Abstract]
[Full Text]
-
Whitsett, J. A., Tichelaar, J. W.
(1999). Forkhead Transcription Factor HFH-4 and Respiratory Epithelial Cell Differentiation. Am. J. Respir. Cell Mol. Bio.
21: 153-154
[Full Text]
-
Blatt, E. N., Yan, X. H., Wuerffel, M. K., Hamilos, D. L., Brody, S. L.
(1999). Forkhead Transcription Factor HFH-4 Expression Is Temporally Related to Ciliogenesis. Am. J. Respir. Cell Mol. Bio.
21: 168-176
[Abstract]
[Full Text]
-
Skarin, T., Becher, R., Bucht, A., Duvefelt, K., Bohm, S., Ranneberg-Nilsen, T., Lilleaas, E. M., Schwarze, P. E., Toftgård, R.
(1999). Cis-Acting Sequences from the Rat Cytochrome P450 2B1 Gene Confer Pulmonary and Phenobarbital-Inducible Expression in Transgenic Mice. Am. J. Respir. Cell Mol. Bio.
21: 177-184
[Abstract]
[Full Text]
-
Sever-Chroneos, Z., Bachurski, C. J., Yan, C., Whitsett, J. A.
(1999). Regulation of mouse SP-B gene promoter by AP-1 family members. Am. J. Physiol. Lung Cell. Mol. Physiol.
277: L79-L88
[Abstract]
[Full Text]
-
Lewis, A. L., Xia, Y., Datta, S. K., McMillin, J., Kellems, R. E.
(1999). Combinatorial Interactions Regulate Cardiac Expression of the Murine Adenylosuccinate Synthetase 1 Gene. J. Biol. Chem.
274: 14188-14197
[Abstract]
[Full Text]
-
Lawson, P. R., Perkins, V. C., Holmskov, U., Reid, K. B. M.
(1999). Genomic Organization of the Mouse Gene for Lung Surfactant Protein D. Am. J. Respir. Cell Mol. Bio.
20: 953-963
[Abstract]
[Full Text]
-
Swenson, E. S., Mann, E. A., Jump, M. L., Giannella, R. A.
(1999). Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor. Am. J. Physiol. Gastrointest. Liver Physiol.
276: G728-G736
[Abstract]
[Full Text]
-
Ghaffari, M., Whitsett, J. A., Yan, C.
(1999). Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor. Am. J. Physiol. Lung Cell. Mol. Physiol.
276: L398-L404
[Abstract]
[Full Text]
-
Perrone, L., Tell, G., Di Lauro, R.
(1999). Calreticulin Enhances the Transcriptional Activity of Thyroid Transcription Factor-1 by Binding to Its Homeodomain. J. Biol. Chem.
274: 4640-4645
[Abstract]
[Full Text]