This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baniahmad, A.
Right arrow Articles by O'Malley, B. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baniahmad, A.
Right arrow Articles by O'Malley, B. W.

 Previous Article  |  Next Article 

Mol. Cell. Biol., Jan 1995, 76-86, Vol 15, No. 1
Copyright © 1995, American Society for Microbiology

The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing

A Baniahmad, X Leng, TP Burris, SY Tsai, MJ Tsai and BW O'Malley
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.

The C terminus of nuclear hormone receptors is a complex structure that contains multiple functions. We are interested in the mechanism by which thyroid hormone converts its receptor from a transcriptional silencer to an activator of transcription. Both regulatory functions are localized in the ligand binding domain of this receptor superfamily member. In this study, we have identified and characterized several functional domains within the ligand binding domain of the human thyroid hormone receptor (TR beta) conferring transactivation. Interestingly, these domains are localized adjacent to hormone binding sites. One activation domain, designated tau 4, is only 17 amino acids in length and is localized at the extreme C terminus of TR. Deletion of six amino acids of tau 4 resulted in a receptor that could still bind hormone but acted as a constitutive silencer, indicating that tau 4 is required for both transactivation and relief of the silencing functions. In addition, we performed in vivo competition experiments, the results of which suggest that in the absence of tau 4 or hormone, TR is bound by a corepressor protein(s) and that one role of hormone is to release corepressor from the receptor. We propose a general model in which the role of hormone is to induce a conformational change in the receptor that subsequently affects the action of tau 4, leading to both relief of silencing and transcriptional activation.


This article has been cited by other articles:

  • Chaudhuri, G. (2008). Nuclear Receptors and Female Reproduction: A Tale of 3 Scientists, Jensen, Gustafsson, and O'Malley. Reproductive Sciences 15: 110-120 [Abstract]  
  • Lonard, D. M., Lanz, R. B., O'Malley, B. W. (2007). Nuclear Receptor Coregulators and Human Disease. Endocr. Rev. 28: 575-587 [Abstract] [Full Text]  
  • O'Malley, B. W. (2007). Coregulators: From Whence Came These "Master Genes". Mol. Endocrinol. 21: 1009-1013 [Abstract] [Full Text]  
  • Germain, P., Staels, B., Dacquet, C., Spedding, M., Laudet, V. (2006). Overview of Nomenclature of Nuclear Receptors. Pharmacol. Rev. 58: 685-704 [Abstract] [Full Text]  
  • Brackertz, M., Gong, Z., Leers, J., Renkawitz, R. (2006). p66{alpha} and p66{beta} of the Mi-2/NuRD complex mediate MBD2 and histone interaction. Nucleic Acids Res 34: 397-406 [Abstract] [Full Text]  
  • O'Malley, B. W. (2005). A Life-Long Search for the Molecular Pathways of Steroid Hormone Action. Mol. Endocrinol. 19: 1402-1411 [Abstract] [Full Text]  
  • Moehren, U., Dressel, U., Reeb, C. A., Vaisanen, S., Dunlop, T. W., Carlberg, C., Baniahmad, A. (2004). The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien. Nucleic Acids Res 32: 2995-3004 [Abstract] [Full Text]  
  • Nawaz, Z., O'Malley, B. W. (2004). Urban Renewal in the Nucleus: Is Protein Turnover by Proteasomes Absolutely Required for Nuclear Receptor-Regulated Transcription?. Mol. Endocrinol. 18: 493-499 [Abstract] [Full Text]  
  • Smith, C. L., O'Malley, B. W. (2004). Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators. Endocr. Rev. 25: 45-71 [Abstract] [Full Text]  
  • Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kuhl, M., Behrens, J., von der Mark, K., Starzinski-Powitz, A., Wixler, V. (2002). The LIM-only protein FHL2 interacts with {beta}-catenin and promotes differentiation of mouse myoblasts. JCB 159: 113-122 [Abstract] [Full Text]  
  • Gizard, F., Lavallee, B., DeWitte, F., Teissier, E., Staels, B., Hum, D. W. (2002). The Transcriptional Regulating Protein of 132 kDa (TReP-132) Enhances P450scc Gene Transcription through Interaction with Steroidogenic Factor-1 in Human Adrenal Cells. J. Biol. Chem. 277: 39144-39155 [Abstract] [Full Text]  
  • Schulz, M., Eggert, M., Baniahmad, A., Dostert, A., Heinzel, T., Renkawitz, R. (2002). RU486-induced Glucocorticoid Receptor Agonism Is Controlled by the Receptor N Terminus and by Corepressor Binding. J. Biol. Chem. 277: 26238-26243 [Abstract] [Full Text]  
  • Marimuthu, A., Feng, W., Tagami, T., Nguyen, H., Jameson, J. L., Fletterick, R. J., Baxter, J. D., West, B. L. (2002). TR Surfaces and Conformations Required to Bind Nuclear Receptor Corepressor. Mol. Endocrinol. 16: 271-286 [Abstract] [Full Text]  
  • Yen, P. M. (2001). Physiological and Molecular Basis of Thyroid Hormone Action. Physiol. Rev. 81: 1097-1142 [Abstract] [Full Text]  
  • Aranda, A., Pascual, A. (2001). Nuclear Hormone Receptors and Gene Expression. Physiol. Rev. 81: 1269-1304 [Abstract] [Full Text]  
  • Slagsvold, T., Kraus, I., Bentzen, T., Palvimo, J., Saatcioglu, F. (2000). Mutational Analysis of the Androgen Receptor AF-2 (Activation Function 2) Core Domain Reveals Functional and Mechanistic Differences of Conserved Residues Compared with Other Nuclear Receptors. Mol. Endocrinol. 14: 1603-1617 [Abstract] [Full Text]  
  • BURKE, L. J., BANIAHMAD, A. (2000). Co-repressors 2000. FASEB J. 14: 1876-1888 [Abstract] [Full Text]  
  • Ren, Y., Behre, E., Ren, Z., Zhang, J., Wang, Q., Fondell, J. D. (2000). Specific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors. Mol. Cell. Biol. 20: 5433-5446 [Abstract] [Full Text]  
  • Li, M., Pascual, G., Glass, C. K. (2000). Peroxisome Proliferator-Activated Receptor gamma -Dependent Repression of the Inducible Nitric Oxide Synthase Gene. Mol. Cell. Biol. 20: 4699-4707 [Abstract] [Full Text]  
  • Lutz, M., Burke, L. J., Barreto, G., Goeman, F., Greb, H., Arnold, R., Schulthei{beta}, H., Brehm, A., Kouzarides, T., Lobanenkov, V., Renkawitz, R. (2000). Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res 28: 1707-1713 [Abstract] [Full Text]  
  • Altincicek, B., Tenbaum, S. P., Dressel, U., Thormeyer, D., Renkawitz, R., Baniahmad, A. (2000). Interaction of the Corepressor Alien with DAX-1 Is Abrogated by Mutations of DAX-1 Involved in Adrenal Hypoplasia Congenita. J. Biol. Chem. 275: 7662-7667 [Abstract] [Full Text]  
  • Oesterreich, S., Zhang, Q., Hopp, T., Fuqua, S. A. W., Michaelis, M., Zhao, H. H., Davie, J. R., Osborne, C. K., Lee, A. V. (2000). Tamoxifen-Bound Estrogen Receptor (ER) Strongly Interacts with the Nuclear Matrix Protein HET/SAF-B, a Novel Inhibitor of ER-Mediated Transactivation. Mol. Endocrinol. 14: 369-381 [Abstract] [Full Text]  
  • Gurnell, M., Wentworth, J. M., Agostini, M., Adams, M., Collingwood, T. N., Provenzano, C., Browne, P. O., Rajanayagam, O., Burris, T. P., Schwabe, J. W., Lazar, M. A., Chatterjee, V. K. K. (2000). A Dominant-negative Peroxisome Proliferator-activated Receptor gamma (PPARgamma ) Mutant Is a Constitutive Repressor and Inhibits PPARgamma -mediated Adipogenesis. J. Biol. Chem. 275: 5754-5759 [Abstract] [Full Text]  
  • Busch, K., Martin, B., Baniahmad, A., Martial, J. A., Renkawitz, R., Muller, M. (2000). Silencing Subdomains of v-ErbA Interact Cooperatively with Corepressors: Involvement of Helices 5/6. Mol. Endocrinol. 14: 201-211 [Abstract] [Full Text]  
  • Pei, L. (2000). Phosphorylation Modulates the Function of the Vasoactive Intestinal Polypeptide Receptor Transcriptional Repressor Protein. J. Biol. Chem. 275: 1176-1182 [Abstract] [Full Text]  
  • Yang, Z., Hong, S.-H., Privalsky, M. L. (1999). Transcriptional Anti-repression. THYROID HORMONE RECEPTOR beta -2 RECRUITS SMRT COREPRESSOR BUT INTERFERES WITH SUBSEQUENT ASSEMBLY OF A FUNCTIONAL COREPRESSOR COMPLEX. J. Biol. Chem. 274: 37131-37138 [Abstract] [Full Text]  
  • Szapary, D., Huang, Y., Simons, S. S. Jr. (1999). Opposing Effects of Corepressor and Coactivators in Determining the Dose-Response Curve of Agonists, and Residual Agonist Activity of Antagonists, for Glucocorticoid Receptor-Regulated Gene Expression. Mol. Endocrinol. 13: 2108-2121 [Abstract] [Full Text]  
  • Satoh, T., Ishizuka, T., Monden, T., Shibusawa, N., Hashida, T., Kishi, M., Yamada, M., Mori, M. (1999). Regulation of the Mouse Preprothyrotropin-Releasing Hormone Gene by Retinoic Acid Receptor. Endocrinology 140: 5004-5013 [Abstract] [Full Text]  
  • Li, D., Desai-Yajnik, V., Lo, E., Schapira, M., Abagyan, R., Samuels, H. H. (1999). NRIF3 Is a Novel Coactivator Mediating Functional Specificity of Nuclear Hormone Receptors. Mol. Cell. Biol. 19: 7191-7202 [Abstract] [Full Text]  
  • Zhang, J., Hu, X., Lazar, M. A. (1999). A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression. Mol. Cell. Biol. 19: 6448-6457 [Abstract] [Full Text]  
  • Kim, M. K., Lee, J.-S., Chung, J. H. (1999). In vivo transcription factor recruitment during thyroid hormone receptor-mediated activation. Proc. Natl. Acad. Sci. USA 96: 10092-10097 [Abstract] [Full Text]  
  • Wiebel, F. F., Steffensen, K. R., Treuter, E., Feltkamp, D., Gustafsson, J.-A. (1999). Ligand-Independent Coregulator Recruitment by the Triply Activatable OR1/Retinoid X Receptor-{alpha} Nuclear Receptor Heterodimer. Mol. Endocrinol. 13: 1105-1118 [Abstract] [Full Text]  
  • Wahlström, G. M., Vennström, B., Bolin, M. B. (1999). The Adenovirus E1A Protein Is a Potent Coactivator for Thyroid Hormone Receptors. Mol. Endocrinol. 13: 1119-1129 [Abstract] [Full Text]  
  • McKenna, N. J., Lanz, R. B., O’Malley, B. W. (1999). Nuclear Receptor Coregulators: Cellular and Molecular Biology. Endocr. Rev. 20: 321-344 [Abstract] [Full Text]  
  • Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., Rauscher, F. J. III (1999). KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Kruppel-Associated Box-Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing. Mol. Cell. Biol. 19: 4366-4378 [Abstract] [Full Text]  
  • Dressel, U., Thormeyer, D., Altincicek, B., Paululat, A., Eggert, M., Schneider, S., Tenbaum, S. P., Renkawitz, R., Baniahmad, A. (1999). Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily. Mol. Cell. Biol. 19: 3383-3394 [Abstract] [Full Text]  
  • Pipaon, C., Tsai, S. Y., Tsai, M.-J. (1999). COUP-TF Upregulates NGFI-A Gene Expression through an Sp1 Binding Site. Mol. Cell. Biol. 19: 2734-2745 [Abstract] [Full Text]  
  • Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N. B., Evans, R. M. (1999). Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc. Natl. Acad. Sci. USA 96: 2639-2644 [Abstract] [Full Text]  
  • Freebern, W. J., Osman, A., Niles, E. G., Christen, L., LoVerde, P. T. (1999). Identification of a cDNA Encoding a Retinoid X Receptor Homologue from Schistosoma mansoni. EVIDENCE FOR A ROLE IN FEMALE-SPECIFIC GENE EXPRESSION. J. Biol. Chem. 274: 4577-4585 [Abstract] [Full Text]  
  • Nomura, T., Khan, M. M., Kaul, S. C., Dong, H.-D., Wadhwa, R., Colmenares, C., Kohno, I., Ishii, S. (1999). Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13: 412-423 [Abstract] [Full Text]  
  • Nawaz, Z., Lonard, D. M., Smith, C. L., Lev-Lehman, E., Tsai, S. Y., Tsai, M.-J., O'Malley, B. W. (1999). The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily. Mol. Cell. Biol. 19: 1182-1189 [Abstract] [Full Text]  
  • Hong, S.-H., Privalsky, M. L. (1999). Retinoid Isomers Differ in the Ability to Induce Release of SMRT Corepressor from Retinoic Acid Receptor-alpha. J. Biol. Chem. 274: 2885-2892 [Abstract] [Full Text]  
  • Weiss, R. E., Murata, Y., Cua, K., Hayashi, Y., Seo, H., Refetoff, S. (1998). Thyroid Hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor {beta}-Deficient Mice. Endocrinology 139: 4945-4952 [Abstract] [Full Text]  
  • Safer, J. D., Cohen, R. N., Hollenberg, A. N., Wondisford, F. E. (1998). Defective Release of Corepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone. J. Biol. Chem. 273: 30175-30182 [Abstract] [Full Text]  
  • Boruk, M., Savory, J. G. A., Haché, R. J. G. (1998). AF-2-Dependent Potentiation of CCAAT Enhancer Binding Protein {beta}-Mediated Transcriptional Activation by Glucocorticoid Receptor. Mol. Endocrinol. 12: 1749-1763 [Abstract] [Full Text]  
  • Xiong, S., Chirala, S. S., Hsu, M. H., Wakil, S. J. (1998). Identification of thyroid hormone response elements in the human fatty acid synthase promoter. Proc. Natl. Acad. Sci. USA 95: 12260-12265 [Abstract] [Full Text]  
  • Wong, C.-W., Privalsky, M. L. (1998). Transcriptional Silencing Is Defined by Isoform- and Heterodimer-Specific Interactions between Nuclear Hormone Receptors and Corepressors. Mol. Cell. Biol. 18: 5724-5733 [Abstract] [Full Text]  
  • Leers, J., Treuter, E., Gustafsson, J.-A. (1998). Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2. Mol. Cell. Biol. 18: 6001-6013 [Abstract] [Full Text]  
  • Wong, C.-W., Privalsky, M. L. (1998). Transcriptional Repression by the SMRT-mSin3 Corepressor: Multiple Interactions, Multiple Mechanisms, and a Potential Role for TFIIB. Mol. Cell. Biol. 18: 5500-5510 [Abstract] [Full Text]  
  • Bartunek, P., Zenke, M. (1998). Retinoid X Receptor and c-erbA/Thyroid Hormone Receptor Regulate Erythroid Cell Growth and Differentiation. Mol. Endocrinol. 12: 1269-1279 [Abstract] [Full Text]  
  • Chinpaisal, C., Lee, C.-H., Wei, L.-N. (1998). Mechanisms of the Mouse Orphan Nuclear Receptor TR2-11-mediated Gene Suppression. J. Biol. Chem. 273: 18077-18085 [Abstract] [Full Text]  
  • Feng, W., Ribeiro, R. C., Wagner, R. L., Nguyen, H., Apriletti, J. W., Fletterick, R. J., Baxter, J. D., Kushner, P. J., West, B. L. (1998). Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors. Science 280: 1747-1749 [Abstract] [Full Text]  
  • Schulman, I. G., Shao, G., Heyman, R. A. (1998). Transactivation by Retinoid X Receptor-Peroxisome Proliferator-Activated Receptor gamma  (PPARgamma ) Heterodimers: Intermolecular Synergy Requires Only the PPARgamma Hormone-Dependent Activation Function. Mol. Cell. Biol. 18: 3483-3494 [Abstract] [Full Text]  
  • Treuter, E., Albrektsen, T., Johansson, L., Leers, J., Gustafsson, J.-A. (1998). A Regulatory Role for RIP140 in Nuclear Receptor Activation. Mol. Endocrinol. 12: 864-881 [Abstract] [Full Text]  
  • Crawford, P. A., Dorn, C., Sadovsky, Y., Milbrandt, J. (1998). Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1. Mol. Cell. Biol. 18: 2949-2956 [Abstract] [Full Text]  
  • Wahlström, G. M., Vennström, B. (1998). Requirements for Repression of Retinoid X Receptor by the Oncoprotein P75gag-v-erbA and the Thyroid Hormone Receptors. Mol. Endocrinol. 12: 645-653 [Abstract] [Full Text]  
  • Baniahmad, A., Dressel, U., Renkawitz, R. (1998). Cell-Specific Inhibition of Retinoic Acid Receptor-{alpha} Silencing by the AF2/{tau}c Activation Domain Can Be Overcome by the Corepressor SMRT, But Not by N-CoR. Mol. Endocrinol. 12: 504-512 [Abstract] [Full Text]  
  • Zhang, X., Jeyakumar, M., Petukhov, S., Bagchi, M. K. (1998). A Nuclear Receptor Corepressor Modulates Transcriptional Activity of Antagonist-Occupied Steroid Hormone Receptor. Mol. Endocrinol. 12: 513-524 [Abstract] [Full Text]  
  • Minucci, S., Wong, J., Blanco, J. C. G., Shi, Y.-B., Wolffe, A. P., Ozato, K. (1998). Retinoid Receptor-Induced Alteration of the Chromatin Assembled on a Ligand-Responsive Promoter in Xenopus Oocytes. Mol. Endocrinol. 12: 315-324 [Abstract] [Full Text]  
  • Olson, D. P., Sun, B., Koenig, R. J. (1998). Thyroid Hormone Response Element Architecture Affects Corepressor Release from Thyroid Hormone Receptor Dimers. J. Biol. Chem. 273: 3375-3380 [Abstract] [Full Text]  
  • Leong, G. M., Wang, K. S., Marton, M. J., Blanco, J. C. G., Wang, I-M., Rolfes, R. J., Ozato, K., Segars, J. H. (1998). Interaction between the Retinoid X Receptor and Transcription Factor IIB Is Ligand-dependent in Vivo. J. Biol. Chem. 273: 2296-2305 [Abstract] [Full Text]  
  • Thurmond, D. C., Goodridge, A. G. (1998). Characterization of Thyroid Hormone Response Elements in the Gene for Chicken Malic Enzyme. FACTORS THAT INFLUENCE TRIIODOTHYRONINE RESPONSIVENESS. J. Biol. Chem. 273: 1613-1622 [Abstract] [Full Text]  
  • Liu, Y., Takeshita, A., Nagaya, T., Baniahmad, A., Chin, W. W., Yen, P. M. (1998). An Inhibitory Region of the DNA-Binding Domain of Thyroid Hormone Receptor Blocks Hormone-Dependent Transactivation. Mol. Endocrinol. 12: 34-44 [Abstract] [Full Text]  
  • Lalli, E., Bardoni, B., Zazopoulos, E., Wurtz, J.-M., Strom, T. M., Moras, D., Sassone-Corsi, P. (1997). A Transcriptional Silencing Domain in DAX-1 Whose Mutation Causes Adrenal Hypoplasia Congenita. Mol. Endocrinol. 11: 1950-1960 [Abstract] [Full Text]  
  • Li, H., Leo, C., Schroen, D. J., Chen, J. D. (1997). Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT. Mol. Endocrinol. 11: 2025-2037 [Abstract] [Full Text]  
  • Wilkinson, J. R., Towle, H. C. (1997). Identification and Characterization of the AF-1 Transactivation Domain of Thyroid Hormone Receptor beta 1. J. Biol. Chem. 272: 23824-23832 [Abstract] [Full Text]  
  • Weiss, R. E., Forrest, D., Pohlenz, J., Cua, K., Curran, T., Refetoff, S. (1997). Thyrotropin Regulation by Thyroid Hormone in Thyroid Hormone Receptor {beta}-Deficient Mice. Endocrinology 138: 3624-3629 [Abstract] [Full Text]  
  • Li, H., Gomes, P. J., Chen, J. D. (1997). RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94: 8479-8484 [Abstract] [Full Text]  
  • Chassande, O., Fraichard, A., Gauthier, K., Flamant, F., Legrand, C., Savatier, P., Laudet, V., Samarut, J. (1997). Identification of Transcripts Initiated from an Internal Promoter in the c-erbA{alpha} Locus That Encode Inhibitors of Retinoic Acid Receptor-{alpha} and Triiodothyronine Receptor Activities. Mol. Endocrinol. 11: 1278-1290 [Abstract] [Full Text]  
  • Söderström, M., Vo, A., Heinzel, T., Lavinsky, R. M., Yang, W.-M., Seto, E., Peterson, D. A., Rosenfeld, M. G., Glass, C. K. (1997). Differential Effects of Nuclear Receptor Corepressor (N-CoR) Expression Levels on Retinoic Acid Receptor-Mediated Repression Support the Existence of Dynamically Regulated Corepressor Complexes. Mol. Endocrinol. 11: 682-692 [Abstract] [Full Text]  
  • Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L., Horwitz, K. B. (1997). The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT. Mol. Endocrinol. 11: 693-705 [Abstract] [Full Text]  
  • Shibata, H., Nawaz, Z., Tsai, S. Y., O’Malley, B. W., Tsai, M.-J. (1997). Gene Silencing by Chicken Ovalbumin Upstream Promoter-Transcription Factor I (COUP-TFI) Is Mediated by Transcriptional Corepressors, Nuclear Receptor-Corepressor (N-CoR) and Silencing Mediator for Retinoic Acid Receptor and Thyroid Hormone Receptor (SMRT). Mol. Endocrinol. 11: 714-724 [Abstract] [Full Text]  
  • Jeyakumar, M., Tanen, M. R., Bagchi, M. K. (1997). Analysis of the Functional Role of Steroid Receptor Coactivator-1 in Ligand-Induced Transactivation by Thyroid Hormone Receptor. Mol. Endocrinol. 11: 755-767 [Abstract] [Full Text]  
  • Collingwood, T. N., Butler, A., Tone, Y., Clifton-Bligh, R. J., Parker, M. G., Chatterjee, V. K. K. (1997). Thyroid Hormone-mediated Enhancement of Heterodimer Formation between Thyroid Hormone Receptor beta  and Retinoid X Receptor. J. Biol. Chem. 272: 13060-13065 [Abstract] [Full Text]  
  • Yagi, H., Pohlenz, J., Hayashi, Y., Sakurai, A., Refetoff, S. (1997). Resistance to Thyroid Hormone Caused by Two Mutant Thyroid Hormone Receptors {beta}, R243Q and R243W, with Marked Impairment of Function That Cannot Be Explained by Altered in Vitro 3,5,3'-Triiodothyroinine Binding Affinity. J. Clin. Endocrinol. Metab. 82: 1608-1614 [Abstract] [Full Text]  
  • Yoh, S. M., Chatterjee, V. K. K., Privalsky, M. L. (1997). Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors. Mol. Endocrinol. 11: 470-480 [Abstract] [Full Text]  
  • Zamir, I, Zhang, J, Lazar, M A (1997). Stoichiometric and steric principles governing repression by nuclear hormone receptors.. Genes Dev. 11: 835-846 [Abstract]  
  • Busch, K., Martin, B., Baniahmad, A., Renkawitz, R., Muller, M. (1997). At Least Three Subdomains of v-erbA Are Involved in Its Silencing Function. Mol. Endocrinol. 11: 379-389 [Abstract] [Full Text]  
  • Willy, P J, Mangelsdorf, D J (1997). Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.. Genes Dev. 11: 289-298 [Abstract]  
  • Collingwood, T. N., Rajanayagam, O., Adams, M., Wagner, R., Cavailles, V., Kalkhoven, E., Matthews, C., Nystrom, E., Stenlof, K., Lindstedt, G., Tisell, L., Fletterick, R. J., Parker, M. G., Chatterjee, V. K. K. (1997). A natural transactivation mutation in the thyroid hormone beta  receptor: Impaired interaction with putative transcriptional mediators. Proc. Natl. Acad. Sci. USA 94: 248-253 [Abstract] [Full Text]  
  • Lu, H., Eichele, G, Thaller, C (1997). Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 124: 195-203 [Abstract]  
  • Friedman, J R, Fredericks, W J, Jensen, D E, Speicher, D W, Huang, X P, Neilson, E G, Rauscher, F J (1996). KAP-1, a novel corepressor for the highly conserved KRAB repression domain.. Genes Dev. 10: 2067-2078 [Abstract]  
  • Zhang, X., Jeyakumar, M., Bagchi, M. K. (1996). Ligand-dependent Cross-talk between Steroid and Thyroid Hormone Receptors. EVIDENCE FOR COMMON TRANSCRIPTIONAL COACTIVATOR(S). J. Biol. Chem. 271: 14825-14833 [Abstract] [Full Text]  
  • Tong, G.-X., Tanen, M. R., Bagchi, M. K. (1995). Ligand Modulates the Interaction of Thyroid Hormone Receptor [IMAGE] with the Basal Transcription Machinery. J. Biol. Chem. 270: 10601-10611 [Abstract] [Full Text]  
  • Peng, H., Begg, G. E., Harper, S. L., Friedman, J. R., Speicher, D. W., Rauscher, F. J. III (2000). Biochemical Analysis of the Kruppel-associated Box (KRAB) Transcriptional Repression Domain. SPECTRAL, KINETIC, AND STOICHIOMETRIC PROPERTIES OF THE KRAB{middle dot}KAP-1 COMPLEX. J. Biol. Chem. 275: 18000-18010 [Abstract] [Full Text]  
  • Boeke, J., Ammerpohl, O., Kegel, S., Moehren, U., Renkawitz, R. (2000). The Minimal Repression Domain of MBD2b Overlaps with the Methyl-CpG-binding Domain and Binds Directly to Sin3A. J. Biol. Chem. 275: 34963-34967 [Abstract] [Full Text]  
  • Bastie, C., Luquet, S., Holst, D., Jehl-Pietri, C., Grimaldi, P. A. (2000). Alterations of Peroxisome Proliferator-activated Receptor delta Activity Affect Fatty Acid-controlled Adipose Differentiation. J. Biol. Chem. 275: 38768-38773 [Abstract] [Full Text]  
  • Wu, Y., Delerive, P., Chin, W. W., Burris, T. P. (2002). Requirement of Helix 1 and the AF-2 Domain of the Thyroid Hormone Receptor for Coactivation by PGC-1. J. Biol. Chem. 277: 8898-8905 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»