Regulation of interleukin 12 p40 expression through an NF-kappa B half- site

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Mol. Cell. Biol., 10 1995, 5258-5267, Vol 15, No. 10
Copyright © 1995, American Society for Microbiology

Regulation of interleukin 12 p40 expression through an NF-kappa B half- site

TL Murphy, MG Cleveland, P Kulesza, J Magram and KM Murphy
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Interleukin 12 (IL-12) is an inducible cytokine composed of 35- and 40- kDa subunits that is critical for promoting T helper type 1 development and cell-mediated immunity against pathogens. The 40-kDa subunit, expressed by activated macrophages and B cells, is induced by several pathogens in vivo and in vitro and is augmented or inhibited by gamma interferon (IFN-gamma) or IL-10, respectively. Control of IL-12 p40 expression is therefore important for understanding resistance and susceptibility to a variety of pathogens, including Leishmania major and perhaps human immunodeficiency virus. In this report, we provide the first characterization of IL-12 p40 gene regulation in macrophages. We localize inducible activity of the promoter to the sequence - 122GGGGAATTTTA-132 not previously recognized to bind Rel family transcription factors. We demonstrate binding of this sequence to NF- kappa B (p50/p65 and p50/c-Rel) complexes in macrophages activated by several p40-inducing pathogens and provide functional data to support a role for NF-kappa B family members in IL-12 p40 activation. Finally, we find that IFN-gamma treatment of cells enhances this binding interaction, thus potentially providing a mechanism for IFN-gamma augmentation of IL-12 production by macrophages.

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LAI, P.-C., COOK, H. T., SMITH, J., KEITH, J. C. JR., PUSEY, C. D., TAM, F. W. K. (2001). Interleukin-11 Attenuates Nephrotoxic Nephritis in Wistar Kyoto Rats. J. Am. Soc. Nephrol. 12: 2310-2320 [Abstract] [Full Text]
Grumont, R., Hochrein, H., O'Keeffe, M., Gugasyan, R., White, C., Caminschi, I., Cook, W., Gerondakis, S. (2001). c-Rel Regulates Interleukin 12 p70 Expression in CD8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription. J. Exp. Med. 194: 1021-1032 [Abstract] [Full Text]
Puig-Kroger, A., Relloso, M., Fernandez-Capetillo, O., Zubiaga, A., Silva, A., Bernabeu, C., Corbi, A. L. (2001). Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98: 2175-2182 [Abstract] [Full Text]
Becker, C., Wirtz, S., Ma, X., Blessing, M., Galle, P. R., Neurath, M. F. (2001). Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-{kappa}B, CCAAT/Enhancer-Binding Protein {beta}, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2. J. Immunol. 167: 2608-2618 [Abstract] [Full Text]
Butcher, B. A., Kim, L., Johnson, P. F., Denkers, E. Y. (2001). Toxoplasma gondii Tachyzoites Inhibit Proinflammatory Cytokine Induction in Infected Macrophages by Preventing Nuclear Translocation of the Transcription Factor NF-{kappa}B. J. Immunol. 167: 2193-2201 [Abstract] [Full Text]
Wesa, A. K., Galy, A. (2001). IL-1{beta} induces dendritic cells to produce IL-12. Int Immunol 13: 1053-1061 [Abstract] [Full Text]
Weaver, D. J. Jr., Poligone, B., Bui, T., Abdel-Motal, U. M., Baldwin, A. S. Jr., Tisch, R. (2001). Dendritic Cells from Nonobese Diabetic Mice Exhibit a Defect in NF-{kappa}B Regulation Due to a Hyperactive I{kappa}B Kinase. J. Immunol. 167: 1461-1468 [Abstract] [Full Text]
Grazia Cappiello, M., Sutterwala, F. S., Trinchieri, G., Mosser, D. M., Ma, X. (2001). Suppression of IL-12 Transcription in Macrophages Following Fc{{gamma}} Receptor Ligation. J. Immunol. 166: 4498-4506 [Abstract] [Full Text]
Yin, L., Wu, L., Wesche, H., Arthur, C. D., White, J. M., Goeddel, D. V., Schreiber, R. D. (2001). Defective Lymphotoxin-beta Receptor-Induced NF-kappa B Transcriptional Activity in NIK-Deficient Mice. Science 291: 2162-2165 [Abstract] [Full Text]
Ropert, C., Almeida, I. C., Closel, M., Travassos, L. R., Ferguson, M. A. J., Cohen, P., Gazzinelli, R. T. (2001). Requirement of Mitogen-Activated Protein Kinases and I{{kappa}}B Phosphorylation for Induction of Proinflammatory Cytokines Synthesis by Macrophages Indicates Functional Similarity of Receptors Triggered by Glycosylphosphatidylinositol Anchors from Parasitic Protozoa and Bacterial Lipopolysaccharide. J. Immunol. 166: 3423-3431 [Abstract] [Full Text]
Walter, M. J., Kajiwara, N., Karanja, P., Castro, M., Holtzman, M. J. (2001). Interleukin 12 p40 Production by Barrier Epithelial Cells during Airway Inflammation. J. Exp. Med. 193: 339-352 [Abstract] [Full Text]
Malmgaard, L., Paludan, S. R., Mogensen, S. C., Ellermann-Eriksen, S. (2000). Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B. J. Gen. Virol. 81: 3011-3020 [Abstract] [Full Text]
Sanjabi, S., Hoffmann, A., Liou, H.-C., Baltimore, D., Smale, S. T. (2000). Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 10.1073/pnas.230436397v1 [Abstract] [Full Text]
Ozinsky, A., Smith, K.D., Hume, D., Underhill, D.M. (2000). Co-operative induction of pro-inflammatory signaling by Toll-like receptors. Innate Immunity 6: 393-396 [Abstract]
Goodbourn, S., Didcock, L., Randall, R. E. (2000). Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 81: 2341-2364 [Full Text]
Salkowski, C. A., Thomas, K. E., Cody, M. J., Vogel, S. N. (2000). Impaired IFN-{gamma} Production in IFN Regulatory Factor-1 Knockout Mice During Endotoxemia Is Secondary to a Loss of Both IL-12 and IL-12 Receptor Expression. J. Immunol. 165: 3970-3977 [Abstract] [Full Text]
Ma, X., Montaner, L. J. (2000). Proinflammatory response and IL-12 expression in HIV-1 infection. J. Leukoc. Biol. 68: 383-390 [Abstract] [Full Text]
Hacker, H., Vabulas, R. M., Takeuchi, O., Hoshino, K., Akira, S., Wagner, H. (2000). Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF)6. J. Exp. Med. 192: 595-600 [Abstract] [Full Text]
Wang, I-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., Ozato, K. (2000). An IFN-{gamma}-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages. J. Immunol. 165: 271-279 [Abstract] [Full Text]
Wang, X., Chen, M., Wandinger, K. P., Williams, G., Dhib-Jalbut, S. (2000). IFN-{beta}-1b Inhibits IL-12 Production in Peripheral Blood Mononuclear Cells in an IL-10-Dependent Mechanism: Relevance to IFN-{beta}-1b Therapeutic Effects in Multiple Sclerosis. J. Immunol. 165: 548-557 [Abstract] [Full Text]

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