This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by White, R. J.
Right arrow Articles by Jackson, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by White, R. J.
Right arrow Articles by Jackson, S. P.

 Previous Article  |  Next Article 

Mol. Cell. Biol., Dec 1995, 6653-6662, Vol 15, No. 12
Copyright © 1995, American Society for Microbiology

Cell cycle regulation of RNA polymerase III transcription

RJ White, TM Gottlieb, CS Downes and SP Jackson
Wellcome/CRC Institute, University of Cambridge, United Kingdom.

Inactivation of the TATA-binding protein-containing complex TFIIIB contributes to the mitotic repression of RNA polymerase III transcription, both in frogs and in humans (J. M. Gottesfeld, V. J. Wolf, T. Dang, D. J. Forbes, and P. Hartl, Science 263:81-84, 1994; R. J. White, T. M. Gottlieb, C. S. Downes, and S. P. Jackson, Mol. Cell. Biol. 15:1983-1992, 1995). Using extracts of synchronized proliferating HeLa cells, we show that TFIIIB activity remains low during the early part of G1 phase and increases only gradually as cells approach S phase. As a result, the transcription of all class III genes tested is significantly less active in early G1 than it is in S or G2 phase, both in vitro and in vivo. The increased activity of TFIIIB as cells progress through interphase appears to be due to changes in the TATA- binding protein-associated components of this complex. The data suggest that TFIIIB is an important target for the cell cycle regulation of RNA polymerase III transcription during both mitosis and interphase of actively proliferating HeLa cells.


This article has been cited by other articles:

  • Woiwode, A., Johnson, S. A. S., Zhong, S., Zhang, C., Roeder, R. G., Teichmann, M., Johnson, D. L. (2008). PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex. Mol. Cell. Biol. 28: 4204-4214 [Abstract] [Full Text]  
  • Felton-Edkins, Z. A., Kondrashov, A., Karali, D., Fairley, J. A., Dawson, C. W., Arrand, J. R., Young, L. S., White, R. J. (2006). Epstein-Barr Virus Induces Cellular Transcription Factors to Allow Active Expression of EBER Genes by RNA Polymerase III. J. Biol. Chem. 281: 33871-33880 [Abstract] [Full Text]  
  • Reiner, R., Ben-Asouli, Y., Krilovetzky, I., Jarrous, N. (2006). A role for the catalytic ribonucleoprotein RNase P in RNA polymerase III transcription.. Genes Dev. 20: 1621-1635 [Abstract] [Full Text]  
  • Ernens, I., Goodfellow, S. J., Innes, F., Kenneth, N. S., Derblay, L. E., White, R. J., Scott, P. H. (2006). Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Nucleic Acids Res 34: 286-294 [Abstract] [Full Text]  
  • Felton-Edkins, Z. A., White, R. J. (2002). Multiple Mechanisms Contribute to the Activation of RNA Polymerase III Transcription in Cells Transformed by Papovaviruses. J. Biol. Chem. 277: 48182-48191 [Abstract] [Full Text]  
  • Johnston, I. M., Allison, S. J., Morton, J. P., Schramm, L., Scott, P. H., White, R. J. (2002). CK2 Forms a Stable Complex with TFIIIB and Activates RNA Polymerase III Transcription in Human Cells. Mol. Cell. Biol. 22: 3757-3768 [Abstract] [Full Text]  
  • Vee, S, Lafanechere, L, Fisher, D, Wehland, J, Job, D, Picard, A (2001). Evidence for a role of the (alpha)-tubulin C terminus in the regulation of cyclin B synthesis in developing oocytes. J. Cell Sci. 114: 887-898 [Abstract]  
  • Hirsch, H. A., Gu, L., Henry, R. W. (2000). The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression. Mol. Cell. Biol. 20: 9182-9191 [Abstract] [Full Text]  
  • Schramm, L., Pendergrast, P. S., Sun, Y., Hernandez, N. (2000). Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. Genes Dev. 14: 2650-2663 [Abstract] [Full Text]  
  • Spencer, C. A., Kruhlak, M. J., Jenkins, H. L., Sun, X., Bazett-Jones, D. P. (2000). Mitotic Transcription Repression in Vivo in the Absence of Nucleosomal Chromatin Condensation. JCB 150: 13-26 [Abstract] [Full Text]  
  • Kashanchi, F., Agbottah, E. T., Pise-Masison, C. A., Mahieux, R., Duvall, J., Kumar, A., Brady, J. N. (2000). Cell Cycle-Regulated Transcription by the Human Immunodeficiency Virus Type 1 Tat Transactivator. J. Virol. 74: 652-660 [Abstract] [Full Text]  
  • Larminie, C. G. C., Sutcliffe, J. E., Tosh, K., Winter, A. G., Felton-Edkins, Z. A., White, R. J. (1999). Activation of RNA Polymerase III Transcription in Cells Transformed by Simian Virus 40. Mol. Cell. Biol. 19: 4927-4934 [Abstract] [Full Text]  
  • Klein, J., Grummt, I. (1999). Cell cycle-dependent regulation of RNA polymerase I transcription: The nucleolar transcription factor UBF is inactive in mitosis and early G1. Proc. Natl. Acad. Sci. USA 96: 6096-6101 [Abstract] [Full Text]  
  • Altheim, B. A., Schultz, M. C. (1999). Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 96: 1345-1350 [Abstract] [Full Text]  
  • Dundr, M., Olson, M. O.J. (1998). Partially Processed pre-rRNA Is Preserved in Association with Processing Components in Nucleolus-derived Foci during Mitosis. Mol. Biol. Cell 9: 2407-2422 [Abstract] [Full Text]  
  • Zaragoza, D., Ghavidel, A., Heitman, J., Schultz, M. C. (1998). Rapamycin Induces the G0 Program of Transcriptional Repression in Yeast by Interfering with the TOR Signaling Pathway. Mol. Cell. Biol. 18: 4463-4470 [Abstract] [Full Text]  
  • Alzuherri, H. M., White, R. J. (1998). Regulation of a TATA-binding Protein-associated Factor during Cellular Differentiation. J. Biol. Chem. 273: 17166-17171 [Abstract] [Full Text]  
  • Ghavidel, A., Schultz, M. C. (1997). Casein kinase II regulation of yeast TFIIIB is mediated by the TATA-binding protein. Genes Dev. 11: 2780-2789 [Abstract] [Full Text]  
  • Kupfer, G. M., Yamashita, T., Naf, D., Suliman, A., Asano, S., D'Andrea, A. D. (1997). The Fanconi Anemia Polypeptide, FAC, Binds to the Cyclin-Dependent Kinase, cdc2. Blood 90: 1047-1054 [Abstract] [Full Text]  
  • Chu, W.-M., Wang, Z., Roeder, R. G., Schmid, C. W. (1997). RNA Polymerase III Transcription Repressed by Rb through Its Interactions with TFIIIB and TFIIIC2. J. Biol. Chem. 272: 14755-14761 [Abstract] [Full Text]  
  • Piras, G., Dittmer, J., Radonovich, M. F., Brady, J. N. (1996). Human T-cell Leukemia Virus Type I Tax Protein Transactivates RNA Polymerase III Promoter in Vitro and in Vivo. J. Biol. Chem. 271: 20501-20506 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»